In this project, we will study mechanisms of hepatitis B virus escape from adaptive and innate immunity to discover novel antiviral therapeutic targets for the development of drugs to treat chronically infected patients
Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant ...
Our research is focused on two objectives, first, the study of interactions between nuclear proteins and viral components which could result in the restriction or establishment of the infection, and second, the elucidation ...
Arboviruses of the genus Phlebovirusare currently represented by 67 species found in Eurasia, Africa, and the Americas1. Although they have a great impact on human and animal health, information about their biology ...
The group is composed of the team of Laboratory of Molecular and Tumor Virology (headed by Ruth Tachezy) and Laboratory of Immunotherapy (headed by Michal Šmahel). While the research of the team led by Ruth Tachezy focuses ...
Carbapenems are currently last-resort antibiotics for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. Therefore, the resistence to those drugs represents a significant threat of current ...
We previously described that Murine polyomavirus MPyV induces type I interferon (IFN) responses via the sensors, p204 (human IFI16 homolog) and cGAS which sense viral genomes and micronucleus-like bodies generated during ...
The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems ...
The project led by Prof. Dřevinek at the 2nd Faculty ofMedicine has two main research objectives (see below).Active collaboration with the groups in the consortium isplanned.Research objective 1: Molecular epidemiology ...
The possible restriction function of promyelocytic nuclear bodies (PML NBs) and their associated proteins in polyomavirus infection was studied. At first, We found that the absence of PML protein positively affects the ...