dc.contributor.author | Hlaváč, Viktor | |
dc.contributor.author | Holý, Petr | |
dc.contributor.author | Václavíková, Radka | |
dc.contributor.author | Rob, Lukáš | |
dc.contributor.author | Hruda, Martin | |
dc.contributor.author | Mrhalová, Marcela | |
dc.contributor.author | Černaj, Petr | |
dc.contributor.author | Bouda, Jiří | |
dc.contributor.author | Souček, Pavel | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/1755 | |
dc.description.abstract | Epithelial ovarian carcinoma (EOC) is highly fatal because of the risk of resistance to therapy and recurrence. We performed whole-exome sequencing of blood and tumor tissue pairs of 50 patients with surgically resected EOC. Compared with sensitive patients, platinum-resistant patients had a significantly higher somatic mutational rate in TP53 and lower in several genes from the Hippo pathway. We confirmed the pivotal role of somatic mutations in homologous recombination repair genes in platinum sensitivity and favorable prognosis of EOC patients. Implementing the germline homologous recombination repair profile significantly improved the prediction. In addition, distinct mutational signatures, for example, SBS6, and overall mutational load, somatic mutations in PABPC1, PABPC3, and TFAM co-segregated with the resistance status, high-grade serous carcinoma subtype, or overall survival of patients. We generated germline and somatic genetic landscapes of prognostically different subgroups of EOC patients for further follow-up studies focused on utilizing the observed associations in precision oncology. | en |
dc.language.iso | en | |
dc.relation.url | https://doi.org/10.26508/lsa.202201551 | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | Whole Exome Sequencing of Epithelial Ovarian Carcinomas Differing in Resistance to Platinum Therapy | en |
dcterms.accessRights | embargoedAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2023-10-02T06:14:45Z | |
dc.subject.keyword | Exome Sequencing | en |
dc.subject.keyword | Epithelial Ovarian Carcinoma | en |
dc.subject.keyword | Platinum Therapy | en |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MZ0/NV/NV19-08-00113 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/COOP/COOP | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM/EF/EF18_046/0015515 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/FN/I-FN/I-FNP-03 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/FN/I-FN/I-FNM | |
dc.date.embargoStartDate | 2023-10-02 | |
dc.date.embargoEndDate | 2023-02-24 | |
dc.type.obd | 73 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | 10.26508/lsa.202201551 | |
dc.identifier.utWos | 000966879400001 | |
dc.identifier.eidScopus | 2-s2.0-85140143993 | |
dc.identifier.obd | 615378 | |
dc.identifier.riv | RIV/00216208:11140/22:10447719 | |
dc.identifier.riv | RIV/00216208:11130/22:10447719 | |
dc.identifier.riv | RIV/00216208:11120/22:43924071 | |
dc.identifier.riv | RIV/00669806:_____/22:10447719 | |
dc.identifier.pubmed | 36229065 | |
dc.subject.rivPrimary | 30000::30200::30204 | |
dc.relation.datasetUrl | https://www.ncbi.nlm.nih.gov/sra/PRJNA814851 | |
dcterms.isPartOf.name | Life Science Alliance | |
dcterms.isPartOf.issn | 2575-1077 | |
dcterms.isPartOf.journalYear | 2022 | |
dcterms.isPartOf.journalVolume | 5 | |
dcterms.isPartOf.journalIssue | 12 | |
uk.faculty.primaryId | 111 | |
uk.faculty.primaryName | Lékařská fakulta v Plzni | cs |
uk.faculty.primaryName | Faculty of Medicine in Pilsen | en |
uk.faculty.secondaryId | 109 | |
uk.faculty.secondaryId | 54 | |
uk.faculty.secondaryId | 110 | |
uk.faculty.secondaryId | 52 | |
uk.faculty.secondaryName | 2. lékařská fakulta | cs |
uk.faculty.secondaryName | Second Faculty of Medicine | en |
uk.faculty.secondaryName | Fakultní nemocnice Plzeň | cs |
uk.faculty.secondaryName | University Hospital in Pilsen | en |
uk.faculty.secondaryName | 3. lékařská fakulta | cs |
uk.faculty.secondaryName | Third Faculty of Medicine | en |
uk.faculty.secondaryName | Fakultní nemocnice v Motole | cs |
uk.faculty.secondaryName | Motol University Hospital | en |
uk.department.primaryId | 100012968318 | |
uk.department.primaryName | Biomedicínské centrum | cs |
uk.department.primaryName | Biomedical Center | en |
uk.department.secondaryId | 5000002699 | |
uk.department.secondaryId | 110 | |
uk.department.secondaryId | 1705 | |
uk.department.secondaryId | 1398 | |
uk.department.secondaryId | 100010693933 | |
uk.department.secondaryId | 619 | |
uk.department.secondaryName | Gynekologicko-porodnická klinika | cs |
uk.department.secondaryName | Department of Obstetrics and Gynecology | en |
uk.department.secondaryName | 3. lékařská fakulta | cs |
uk.department.secondaryName | Third Faculty of Medicine | en |
uk.department.secondaryName | Ústav patologie a molekulární medicíny | cs |
uk.department.secondaryName | Ústav patologie a molekulární medicíny | en |
uk.department.secondaryName | Gynekologicko-porodnická klinika | cs |
uk.department.secondaryName | Department of Gynaecology and Obstetrics | en |
uk.department.secondaryName | Ústav patologie a molekulární medicíny 2. LF UK a FN Motol | cs |
uk.department.secondaryName | Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine and Motol University Hospit | en |
uk.department.secondaryName | Gynekologicko-porodnická klinika 3. LF UK a FNKV | cs |
uk.department.secondaryName | Department of Gynecology and Obstetrics 3FM CU and UHKV | en |
dc.description.pageRange | nestránkováno | |
dc.type.obdHierarchyCs | ČLÁNEK V ČASOPISU::článek v časopisu::původní článek | cs |
dc.type.obdHierarchyEn | JOURNAL ARTICLE::journal article::original article | en |
dc.type.obdHierarchyCode | 73::152::206 | en |
uk.displayTitle | Whole Exome Sequencing of Epithelial Ovarian Carcinomas Differing in Resistance to Platinum Therapy | en |