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Hidden potential of hydrazinecarboxamides (semicarbazides) as potential antimicrobial agents: A review

dc.contributor.authorKrátký, Martin
dc.contributor.authorHoungbedji, Neto-Honorius
dc.contributor.authorVinšová, Jarmila
dc.date.accessioned2024-10-15T07:45:47Z
dc.date.available2024-10-15T07:45:47Z
dc.date.issued2024
dc.identifier.urihttps://hdl.handle.net/20.500.14178/2665
dc.description.abstractHydrazinecarboxamides (semicarbazides) are increasingly recognized as a versatile scaffold in developing potential antimicrobial agents. In addition to a brief overview of the synthetic methods to prepare them, this review comprehensively analyses their antimicrobial properties. These derivatives have demonstrated potent activity against a broad spectrum of mycobacteria, bacterial and fungal pathogens, highlighting their potential to address critical human health challenges, including neglected diseases, and to combat growing antimicrobial resistance. They have also been investigated for their antiviral and antiparasitic properties. The review also summarizes structure-activity relationships, known mechanisms of action and emphasizes the crucial role of the hydrazinecarboxamide moiety in facilitating interactions with biological targets. The combination of hydrazinecarboxamides with other bioactive scaffolds (primaquine, isoniazid, etc.) has led to an identification of promising drug candidates, including those active against resistant strains, offering a promising approach for future innovations in the field of antimicrobial therapy. Attention is also drawn to limitations of hydrazinecarboxamides (poor physicochemical properties, cytotoxicity to human cells, and insufficient target selectivity), which may hinder their clinical application.en
dc.language.isoen
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0753332224014422
dc.rightsCreative Commons Uveďte původ 4.0 Internationalcs
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titleHidden potential of hydrazinecarboxamides (semicarbazides) as potential antimicrobial agents: A reviewen
dcterms.accessRightsopenAccess
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/legalcode
dc.date.updated2024-12-11T10:40:49Z
dc.subject.keywordAntibacterial activityen
dc.subject.keywordAntifungal activityen
dc.subject.keywordAntimycobacterial activityen
dc.subject.keywordAntiprotozoal activityen
dc.subject.keywordHydrazinecarboxamidesen
dc.subject.keywordStructure-activity relationshipen
dc.identifier.eissn1950-6007
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//LX22NPO5103
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/UK/COOP/COOP
dc.date.embargoStartDate2024-12-11
dc.type.obd73
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.biopha.2024.117556
dc.identifier.eidScopus2-s2.0-85206151882
dc.identifier.obd653847
dc.identifier.pubmed39405901
dc.subject.rivPrimary30000::30100::30104
dcterms.isPartOf.nameBiomedicine & Pharmacotherapy
dcterms.isPartOf.issn0753-3322
dcterms.isPartOf.journalYear2024
dcterms.isPartOf.journalVolume180
dcterms.isPartOf.journalIssueNovember
uk.faculty.primaryId113
uk.faculty.primaryNameFarmaceutická fakulta v Hradci Královécs
uk.faculty.primaryNameFaculty of Pharmacy in Hradec Kraloveen
uk.department.primaryId366
uk.department.primaryNameKatedra organické a bioorganické chemiecs
uk.department.primaryNameDepartment of Organic and Bioorganic Chemistryen
dc.description.pageRangenestránkováno
dc.type.obdHierarchyCsČLÁNEK V ČASOPISU::článek v časopisu::přehledový článekcs
dc.type.obdHierarchyEnJOURNAL ARTICLE::journal article::summarizing articleen
dc.type.obdHierarchyCode73::152::205en
uk.displayTitleHidden potential of hydrazinecarboxamides (semicarbazides) as potential antimicrobial agents: A reviewen


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