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Preoperative cognitive profile predictive of cognitive decline after subthalamic deep brain stimulation in Parkinson's disease

dc.contributor.authorMana, Josef
dc.contributor.authorBezdíček, Ondřej
dc.contributor.authorRůžička, Filip
dc.contributor.authorLasica, Andrej
dc.contributor.authorŠmídová, Anna
dc.contributor.authorKlempířová, Olga
dc.contributor.authorNikolai, Tomáš
dc.contributor.authorUhrová, Tereza
dc.contributor.authorRůžička, Evžen
dc.contributor.authorUrgošík, Dušan
dc.contributor.authorJech, Robert
dc.date.accessioned2024-11-12T11:41:06Z
dc.date.available2024-11-12T11:41:06Z
dc.date.issued2024
dc.identifier.urihttps://hdl.handle.net/20.500.14178/2689
dc.description.abstractCognitive decline represents a severe non-motor symptom of Parkinson's disease (PD) that can significantly reduce the benefits of subthalamic deep brain stimulation (STN DBS). Here, we aimed to describe post-surgery cognitive decline and identify pre-surgery cognitive profile associated with faster decline in STN DBS-treated PD patients. A retrospective observational study of 126 PD patients treated by STN DBS combined with oral dopaminergic therapy followed for 3.54 years on average (SD = 2.32) with repeated assessments of cognition was conducted. Pre-surgery cognitive profile was obtained via a comprehensive neuropsychological examination and data analysed using exploratory factor analysis and Bayesian generalized linear mixed models. On the whole, we observed a mild annual cognitive decline of 0.90 points from a total of 144 points in the Mattis Dementia Rating Scale (95% posterior probability interval [-1.19, -0.62]) with high inter-individual variability. However, true score changes did not reach previously reported reliable change cut-offs. Executive deficit was the only pre-surgery cognitive variable to reliably predict the rate of post-surgery cognitive decline. On the other hand, exploratory analysis of electrode localization did not yield any statistically clear results. Overall, our data and models imply mild gradual average annual post-surgery cognitive decline with high inter-individual variability in STN DBS-treated PD patients. Nonetheless, patients with worse long-term cognitive prognosis can be reliably identified via pre-surgery examination of executive functions. To further increase the utility of our results, we demonstrate how our models can help with disentangling true score changes from measurement error in future studies of post-surgery cognitive changes.en
dc.language.isoen
dc.relation.urlhttps://doi.org/10.1111/ejn.16521
dc.rightsCreative Commons Uveďte původ 4.0 Internationalcs
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titlePreoperative cognitive profile predictive of cognitive decline after subthalamic deep brain stimulation in Parkinson's diseaseen
dcterms.accessRightsopenAccess
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/legalcode
dc.date.updated2024-11-12T11:41:06Z
dc.subject.keywordcognitionen
dc.subject.keyworddeep brain stimulationen
dc.subject.keywordhierarchical modellingen
dc.subject.keywordlongitudinalen
dc.subject.keywordmeasurement erroren
dc.subject.keywordParkinson's diseaseen
dc.identifier.eissn1460-9568
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MZ0/NV/NV19-04-00233
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM/8F/8F21005
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/UK/GAUK/GAUK254121
dc.date.embargoStartDate2024-11-12
dc.type.obd73
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1111/ejn.16521
dc.identifier.utWos001303971600001
dc.identifier.eidScopus2-s2.0-85202877770
dc.identifier.obd651637
dc.identifier.pubmed39212074
dc.subject.rivPrimary30000::30100::30103
dc.subject.rivSecondary30000::30100::30103
dcterms.isPartOf.nameEuropean Journal of Neuroscience
dcterms.isPartOf.issn0953-816X
dcterms.isPartOf.journalYear2024
dcterms.isPartOf.journalVolume60
dcterms.isPartOf.journalIssue7
uk.faculty.primaryId108
uk.faculty.primaryName1. lékařská fakultacs
uk.faculty.primaryNameFirst Faculty of Medicineen
uk.faculty.secondaryId53
uk.faculty.secondaryNameVšeobecná fakultní nemocnice v Prazecs
uk.faculty.secondaryNameVšeobecná fakultní nemocnice v Prazeen
uk.department.primaryId1527
uk.department.primaryNameNeurologická klinika 1. LF UK a VFNcs
uk.department.primaryNameDepartment of Neurologyen
uk.department.secondaryId5000002609
uk.department.secondaryNameNeurologická klinika 1.LF a VFNcs
uk.department.secondaryNameNeurologická klinika 1.LF a VFNen
dc.description.pageRange5764-5784
dc.type.obdHierarchyCsČLÁNEK V ČASOPISU::článek v časopisu::původní článekcs
dc.type.obdHierarchyEnJOURNAL ARTICLE::journal article::original articleen
dc.type.obdHierarchyCode73::152::206en
uk.displayTitlePreoperative cognitive profile predictive of cognitive decline after subthalamic deep brain stimulation in Parkinson's diseaseen


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