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Investigating antibacterial and anti-inflammatory properties of synthetic curcuminoids

dc.contributor.authorVeselá, Kateřina
dc.contributor.authorKejík, Zdeněk
dc.contributor.authorAbramenko, Nikita
dc.contributor.authorKaplánek, Robert
dc.contributor.authorJakubek, Milan
dc.contributor.authorPetrlova, Jitka
dc.date.accessioned2024-12-11T10:10:48Z
dc.date.available2024-12-11T10:10:48Z
dc.date.issued2024
dc.identifier.urihttps://hdl.handle.net/20.500.14178/2753
dc.description.abstractThe concept of intratumoral microbiota is gaining attention in current research. Tumor-associated microbiota can activate oncogenic signaling pathways such as NF-kappa B, thereby promoting tumor development and progression. Numerous studies have demonstrated that curcumin and its analogs possess strong antitumor effects by targeting the NF-kappa B signaling pathway, along with potent antibacterial properties. In this study, we tested the antibacterial activity of two curcuminoids, Py-cPen and V-cPen, against the Gram-negative bacterial strains Pseudomonas aeruginosa and Escherichia coli and the Gram-positive bacterial strain Streptococcus aureus using in vitro assays and fluorescent microscopy. We observed that both Py-cPen and V-cPen reduced NF-kappa B activation upon lipopolysacharide (LPS) challenge in cell assays. In addition, our findings indicate that Py-cPen and V-cPen interact with LPS, as demonstrated by transmission electron microscopy and confirmed using in silico analyses, thereby modulating LPS activity. Overall, our data indicate that Py-cPen and V-cPen exhibit strong antibacterial and antiinflammatory properties, suggesting their potential as candidates for new multitarget therapeutic strategies.en
dc.language.isoen
dc.relation.urlhttps://doi.org/10.3389/fmed.2024.1478122
dc.rightsCreative Commons Uveďte původ 4.0 Internationalcs
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titleInvestigating antibacterial and anti-inflammatory properties of synthetic curcuminoidsen
dcterms.accessRightsopenAccess
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/legalcode
dc.date.updated2025-01-15T10:11:15Z
dc.subject.keywordcurcuminoidsen
dc.subject.keywordantibacterialen
dc.subject.keywordanti-inflammatoryen
dc.subject.keywordimmunomodulatoryen
dc.subject.keywordlipopolysaccharideen
dc.subject.keyworden
dc.identifier.eissn2296-858X
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//LX22NPO5102
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//LX22NPO5107
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//SVV260637
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//SVV260521
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/UK/UNCE/MED/UNCE/MED/007
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/UK/COOP/COOP
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM/LM/LM2023053
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/TA0/TN/TN02000109
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MZ0/NU/NU22-08-00160
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MZ0/NU/NU21-08-00407
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/TA0/TN/TN02000109
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MZ0/NU/NU21-08-00407
dc.date.embargoStartDate2025-01-15
dc.type.obd73
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.3389/fmed.2024.1478122
dc.identifier.utWos001352016800001
dc.identifier.eidScopus2-s2.0-85208788038
dc.identifier.obd656303
dc.identifier.pubmed39534226
dc.subject.rivPrimary30000::30100
dcterms.isPartOf.nameFrontiers in Medicine
dcterms.isPartOf.issn2296-858X
dcterms.isPartOf.journalYear2024
dcterms.isPartOf.journalVolume11
dcterms.isPartOf.journalIssueOctober
uk.faculty.primaryId108
uk.faculty.primaryName1. lékařská fakultacs
uk.faculty.primaryNameFirst Faculty of Medicineen
uk.department.primaryId100025448551
uk.department.primaryNameBIOCEV 1. lékařské fakultycs
uk.department.primaryNameBIOCEV of the 1st Faculty of Medicineen
uk.department.secondaryId1522
uk.department.secondaryNameKlinika pediatrie a dědičných poruch metabolismu 1. LF a VFNcs
uk.department.secondaryNameDepartment of Paediatrics and Inherited Metabolic Disorders 1. LF UK a VFNen
dc.type.obdHierarchyCsČLÁNEK V ČASOPISU::článek v časopisu::původní článekcs
dc.type.obdHierarchyEnJOURNAL ARTICLE::journal article::original articleen
dc.type.obdHierarchyCode73::152::206en
uk.displayTitleInvestigating antibacterial and anti-inflammatory properties of synthetic curcuminoidsen


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