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Gut Microbiome Diversity of Porcine Peritonitis Model of Sepsis

abstract in conference proceedings

embargoed access

published version

Chalupová, Miroslava

;

Horák, Jan

;

Kramná, Lenka

;

Nalos, Lukáš

;

Štengl, Milan

;

Chudějová, Kateřina

;

Kraftová, Lucie

;

Cinek, Ondřej

;

Klein, Pavel

;

Matějovič, Martin

;

Hrabák, Jaroslav

2022

Czech Chemical Society Symposium Series

20 (6)

Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant ...

Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases

abstract in conference proceedings

embargoed access

published version

Študentová, Vendula

;

Sudová, Vendula

;

Bitar, Ibrahim

;

Pašková, Veronika

;

Moravec, Jiří

;

Pompach, Petr

;

Volný, Michael

;

Novák, Petr

;

Hrabák, Jaroslav

2022

Czech Chemical Society Symposium Series

20 (6)

The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems ...

Analysis of bacterial lipopolysaccharides ("serotyping") by MALDI-TOF mass spectometry: mission impossible?

abstract in conference proceedings

open access

published version

Ďaďovská, Lucia

;

Hrabák, Jaroslav

2023

Czech Chemical Society Symposium Series

21 In the last decade, the use of Matrix-Assisted Laser Desorption/Ionization Time Time-of-Flight mass spectrometry ( MALDI-TOF MS) revolutionary changed clinical microbiology. The technology allowed significant shortening ...

EPIDEMIOLOGY OF CARB APENEMASE PRODUCING ENTEROBACTERALES IN THE CZECH REPUBLIC

abstract in conference proceedings

open access

published version

Bitar, Ibrahim

;

Dolejská, Monika

;

Papagiannitsis, Costa

;

Hrabák, Jaroslav

2024

NIVB Meeting - Book of abstracts

Carbapenemases are versatile β-lactamases capable of hydrolyzing carbapenem antibiotics. They are classified into Ambler classes A, B, and D. Class A carbapenemases, such as Klebsiella pneumoniaecarbapenemase (KPC) ...

Monitoring the Alternative Pathway of Meropenem Degradation by OXA-48-Type Carbapenemases

abstract in conference proceedings

open access

published version

Študentová, Vendula

;

Pašková, Veronika

;

Ďaďovská, Lucia

;

Hrabák, Jaroslav

2025

Praha

Česká společnost chemická

Czech Chemical Society Symposium Series

23 (4)

Background:Overuse of carbapenems has been associated with an increasing prevalence of resistance, particularly among the Enterobacterales, Pseudomonasspp., and Acinetobacter spp. Resistance is mediated by the ...

Epidemic spread of KPC-producing bacteria in the Czech Republic

abstract in conference proceedings

embargoed access

published version

Kraftová, Lucie

;

Finianos, Marc

;

Heringová, Vendula

;

Chudějová, Kateřina

;

Jakubů, Vladislav

;

Žemličková, Helena

;

Costas, Papagiannitsis

;

Bitar, Ibrahim

;

Hrabák, Jaroslav

2022

Czech Chemical Society Symposium Series

20 (6)

Carbapenems are currently last-resort antibiotics for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. Therefore, the resistence to those drugs represents a significant threat of current ...

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Gut Microbiome Diversity of Porcine Peritonitis Model of Sepsis

abstract in conference proceedings

embargoed access

published version

Chalupová, Miroslava

Horák, Jan

Kramná, Lenka

Nalos, Lukáš

Štengl, Milan

Chudějová, Kateřina

Kraftová, Lucie

Cinek, Ondřej

Klein, Pavel

Matějovič, Martin

Hrabák, Jaroslav

2022

Czech Chemical Society Symposium Series

20

(6)

Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant ...

Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases

abstract in conference proceedings

embargoed access

published version

Študentová, Vendula

Sudová, Vendula

Bitar, Ibrahim

Pašková, Veronika

Moravec, Jiří

Pompach, Petr

Volný, Michael

Novák, Petr

Hrabák, Jaroslav

2022

Czech Chemical Society Symposium Series

20

(6)

The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems ...

Analysis of bacterial lipopolysaccharides ("serotyping") by MALDI-TOF mass spectometry: mission impossible?

abstract in conference proceedings

open access

published version

Ďaďovská, Lucia

Hrabák, Jaroslav

2023

Czech Chemical Society Symposium Series

21

In the last decade, the use of Matrix-Assisted Laser Desorption/Ionization Time Time-of-Flight mass spectrometry ( MALDI-TOF MS) revolutionary changed clinical microbiology. The technology allowed significant shortening ...

EPIDEMIOLOGY OF CARB APENEMASE PRODUCING ENTEROBACTERALES IN THE CZECH REPUBLIC

abstract in conference proceedings

open access

published version

Bitar, Ibrahim

Dolejská, Monika

Papagiannitsis, Costa

Hrabák, Jaroslav

2024

NIVB Meeting - Book of abstracts

Carbapenemases are versatile β-lactamases capable of hydrolyzing carbapenem antibiotics. They are classified into Ambler classes A, B, and D. Class A carbapenemases, such as Klebsiella pneumoniaecarbapenemase (KPC) ...

Monitoring the Alternative Pathway of Meropenem Degradation by OXA-48-Type Carbapenemases

abstract in conference proceedings

open access

published version

Študentová, Vendula

Pašková, Veronika

Ďaďovská, Lucia

Hrabák, Jaroslav

2025

Praha

Česká společnost chemická

Czech Chemical Society Symposium Series

23

(4)

Background:Overuse of carbapenems has been associated with an increasing prevalence of resistance, particularly among the Enterobacterales, Pseudomonasspp., and Acinetobacter spp. Resistance is mediated by the ...

Epidemic spread of KPC-producing bacteria in the Czech Republic

abstract in conference proceedings

embargoed access

published version