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Red fox (Vulpes vulpes) play an important role in the propagation of tick-borne pathogens

original article

open access

published version

Lesiczka, Paulina Maria

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Rudenko, Natalia

;

Golovchenko, Maryna

;

Juránková, Jana

;

Daněk, Ondřej

;

Modrý, David

;

Hrazdilová, Kristýna

2023

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Ticks and Tick-Borne Diseases

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14

(1)

The red fox (Vulpes vulpes) is the most widespread free-living carnivore in the world. Over the years, foxes have been recognized as hosts for a number of tick-borne pathogens. However, their role as reservoirs for zoonotic ...

Distant genetic variants of Anaplasma phagocytophilum from Ixodes ricinus attached to people

original article

embargoed access

published version

Lesiczka, Paulina Maria

;

Hrazdilová, Kristýna

;

Hönig, Václav

;

Modrý, David

;

Zurek, Ludek

2023

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Parasites & Vectors

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16

(1)

Background: Although the tick-borne pathogen Anaplasma phagocytophilum is currently described as a single species, studies using genetic markers can distinguish groups of variants associated with different hosts, pathogenicity, ...

Personal comorbidities and their subsequent risks for liver, gallbladder and bile duct cancers

original article

open access

published version

Hemminki, Kari Jussi

;

Sundquist, Kristina

;

Sundquist, Jan

;

Foersti, Asta

;

Liška, Václav

;

Hemminki, Akseli

;

Li, Xinjun

2023

,

International Journal of Cancer

,

152

(6)

Many environmental risk factors for hepatobiliary cancers are known but whether they are associated with specific cancer types is unclear. We present here a novel approach of assessing standardized incidence ratios (SIRs) ...

Whole Exome Sequencing of Epithelial Ovarian Carcinomas Differing in Resistance to Platinum Therapy

original article

embargoed access

published version

Hlaváč, Viktor

;

Holý, Petr

;

Václavíková, Radka

;

Rob, Lukáš

;

Hruda, Martin

;

Mrhalová, Marcela

;

Černaj, Petr

;

Bouda, Jiří

;

Souček, Pavel

2022

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Life Science Alliance

,

5

(12)

Epithelial ovarian carcinoma (EOC) is highly fatal because of the risk of resistance to therapy and recurrence. We performed whole-exome sequencing of blood and tumor tissue pairs of 50 patients with surgically resected ...

Serum Metabolite Biomarkers for Pancreatic Tumors: Neuroendocrine and Pancreatic Ductal Adenocarcinomas-A Preliminary Study

original article

open access

published version

Skubisz, Karolina

;

Dąbkowski, Krzysztof

;

Samborowska, Emilia

;

Starzyńska, Teresa

;

Deskur, Anna

;

Ambrożkiewicz, Filip

;

Karczmarski, Jakub

;

Radkiewicz, Mariusz

;

Kusnierz, Katarzyna

;

Kos-Kudła, Beata

;

Sulikowski, Tadeusz

;

Cybula, Patrycja

;

Paziewska, Agnieszka

2023

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Cancers

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15

(12)

BACKGROUND: Pancreatic cancer is the most common pancreatic solid malignancy with an aggressive clinical course and low survival rate. There are a limited number of reliable prognostic biomarkers and a need to understand ...

Gut microbiome diversity of porcine peritonitis model of sepsis

original article

embargoed access

published version

Chalupová, Miroslava

;

Horák, Jan

;

Kramná, Lenka

;

Nalos, Lukáš

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Štengl, Milan

;

Chudějová, Kateřina

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Kraftová, Lucie

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Cinek, Ondřej

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Klein, Pavel

;

Matějovič, Martin

;

Hrabák, Jaroslav

2022

,

Scientific Reports

,

12

(1)

Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant variability in the ...

Polyclonal Spread of Fosfomycin Resistance among Carbapenemase-Producing Members of the Enterobacterales in the Czech Republic

original article

embargoed access

accepted version

Mattioni Marchetti, Vittoria

;

Kraftová, Lucie

;

Finianos, Marc

;

Sourenian-Samuelian, Tsolaire

;

Hrabák, Jaroslav

;

Bitar, Ibrahim

2023

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Microbiology spectrum

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11

(3)

Fosfomycin (FOS) has been recently reintroduced into clinical practice, but its effectiveness against multidrug-resistant (MDR) Enterobacterales is reduced due to the emergence of FOS resistance. The copresence of ...

DNA Repair Pathway in Ovarian Cancer Patients Treated with HIPEC

original article

open access

published version

Flasarova, Dominika

;

Urban, Katerina

;

Strouhal, Ondrej

;

Klos, Dusan

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Lemstrova, Radmila

;

Dvořák, Pavel

;

Souček, Pavel

;

Mohelnikova-Duchonova, Beatrice

2023

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International Journal of Molecular Sciences

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24

(10)

DNA repair pathways are essential for maintaining genome stability, and understanding the regulation of these mechanisms may help in the design of new strategies for treatments, the prevention of platinum-based chemoresistance, ...

Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases

original article

embargoed access

published version

Študentová, Vendula

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Sudová, Vendula

;

Bitar, Ibrahim

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Pašková, Veronika

;

Moravec, Jiří

;

Pompach, Petr

;

Volný, Michael

;

Novák, Petr

;

Hrabák, Jaroslav

2022

,

Scientific Reports

,

12

(1)

The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems ...

Type 1 diabetes incidence increased during the COVID-19 pandemic years 2020-2021 in Czechia: results from a large population-based paediatric register

original article

embargoed access

published version

Cinek, Ondřej

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Slavenko, Matvei

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Pomahačová, Renata

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Venháčová, Petra

;

Petruželková, Lenka

;

Škvor, Jaroslav

;

Neumann, David

;

Konečná, Petra

;

Vosáhlo, Jan

;

Kocourková, Kamila

;

Strnadel, Jiří

;

Průhová, Štěpánka

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Šumník, Zdeněk

2022

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Pediatric Diabetes

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23

(7)

OBJECTIVE: To explore type 1 diabetes incidence patterns during the pandemic years 2020 and 2021 in Czechia, to compare them to the trends from previous decade, and to test its association with indicators of containment ...

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