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Long Non-Coding RNA and microRNA Interplay in Colorectal Cancer and Their Effect on the Tumor Microenvironment

summarizing article

embargoed access

published version

Rajtmajerová, Marie

;

Trailin, Andriy

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Ambrożkiewicz, Filip

2022

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Cancers

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14

(21)

As the current staging and grading systems are not sufficient to stratify patients for therapy and predict the outcome of the disease, there is an urgent need to understand cancer in its complexity. The mutual relationship ...

Fosfomycin resistance mechanisms in Enterobacterales: an increasing threat

summarizing article

embargoed access

published version

Mattioni Marchetti, Vittoria

;

Hrabák, Jaroslav

;

Bitar, Ibrahim

2023

,

Frontiers in Cellular and Infection Microbiology

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13

(July)

Antimicrobial resistance is well-known to be a global health and development threat. Due to the decrease of effective antimicrobials, re-evaluation in clinical practice of old antibiotics, as fosfomycin (FOS), have been ...

Unicentric form of Castleman´s disease, pitfalls of diagnosis and surgical treatment

summarizing article

open access

published version

Moláček, Jiří

;

Třeška, Vladislav

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Skalický, Tomáš

;

Vodička, Josef

;

Ferda, Jiří

;

Ferdová, Eva

;

Baxa, Jan

;

Mach, Christiana

;

Jungová, Alexandra

;

Michal, Michael

2023

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Frontiers in Oncology

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13

(January)

Background:Castleman's disease is an extremely rare heterogenous lymphoproliferative pathology with a mostly benign behavior. It is a localized or generalized lymph node enlargement of an unknown aetiology. Unicentric form ...

miRNA and lncRNA as Potential Tissue Biomarkers in Hepatocellular Carcinoma

summarizing article

open access

published version

Mallela, Venkata Ramana

;

Rajtmajerová, Marie

;

Trailin, Andriy

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Ambrożkiewicz, Filip

2024

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Non-coding RNA Research

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9

(1)

Hepatocellular carcinoma (HCC) is primary liver cancer, frequently diagnosed at advanced stages with limited therapeutic options. MicroRNAs (miRNAs) regulate target gene expression and through inhibitory competitive binding ...

Activated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role as a Potential Target for Future Therapies

summarizing article

embargoed access

published version

Ali, Esraa

;

Trailin, Andriy

;

Ambrożkiewicz, Filip

;

Liška, Václav

;

Hemminki, Kari Jussi

2022

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International Journal of Molecular Sciences

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23

(23)

Hepatocellular carcinoma (HCC) is a global healthcare challenge, which affects more than 815,000 new cases every year. Activated hepatic stellate cells (aHSCs) remain the principal cells that drive HCC onset and growth. ...

Anatomical biliary reconstruction as an ultimum refugium for selective cases-History and current state of knowledge

summarizing article

open access

published version

Ševčík, Jan

;

Massaro, Maria Stefania

;

Pálek, Richard

;

Moulisová, Vladimíra

;

Liška, Václav

2024

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Journal of Hepato-Biliary-Pancreatic Sciences

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31

(11)

Reconstruction of extrahepatic bile ducts is a staple procedure of HPB surgery. The current standard for most cases is a nonanatomical bilioenteric reconstruction, a satisfactory option for the majority of patients. However, ...

Age-specific familial risks in cancer as clues to germline genetic and environmental causes: focus on colorectal, endometrial, prostate, kidney, breast and lung cancers

summarizing article

open access

published version

Hemminki, Kari Jussi

;

Försti, Asta

;

Hemminki, Otto

;

Scott, Rodney J

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Hemminki, Akseli

2025

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Termedia

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Hereditary Cancer in Clinical Practice

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23

(1)

BACKGROUND: The Swedish Family-Cancer Database (FCD) is the largest source of data on familial cancer in the world, including practically complete family structures and individual cancer diagnoses from the high-quality ...

Genetic And Environmental Associations Of Nonspecific Chromosomal Aberrations

summarizing article

open access

published version

Hemminki, Kari Jussi

;

Niazi, Yasmeen

;

Vodičková, Ludmila

;

Vodička, Pavel

;

Försti, Asta

2025

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Mutagenesis

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40

(1)

Nonspecific structural chromosomal aberrations (CAs) are found in around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. CAs ...

Lurcher Mouse as a Model of Cerebellar Syndromes

summarizing article

open access

published version

Roy Choudhury, Nilpawan

;

Hilber, Pascal

;

Cendelín, Jan

2025

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The Cerebellum

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24

(2)

Cerebellar extinction lesions can manifest themselves with cerebellar motor and cerebellar cognitive affective syndromes. For investigation of the functions of the cerebellum and the pathogenesis of cerebellar diseases, ...

Macrophages in Colorectal Cancer: From Normal Mucosa to Distant Metastasis: Beyond the M1/M2 Paradigm

summarizing article

open access

submitted version

Pavlov, Sergii

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Sobhe Abdelhamid Mahmoud, Esraa

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Ambrożkiewicz, Filip

;

Ye, Wenjing

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Rajtmajerová, Marie

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Trailin, Andriy

2025

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Ivyspring International Publisher

,

Journal of Cancer

,

17

(1)

Colorectal cancer (CRC) is the third most common malignancy and a leading cause of mortality worldwide. The tumor microenvironment (TME) strongly influences CRC growth, immune evasion, and metastasis. Among various immune ...

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