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Enhancing abdominal wall healing using an oriented polycaprolactone microfibrous scaffold prepared using the fiber drawing method: A rabbit model study

original article

open access

published version

Klusáček Rampichová, Michala

;

Strnadová, Kateřina

;

Plencner, M

;

Stanislav, L

;

Litvinec, A

;

Tonar, Zbyněk

;

Blassová, Tereza

;

Otáhal, M

;

Filová, E

;

Lukáš, D

;

Jenčová, V

2026

,

Springer-Verlag France

,

Hernia

,

30

(1)

PURPOSE: Incisional hernia is a common postoperative complication following abdominal surgery. Despite the use of synthetic meshes, recurrence rates remain high. This study aimed to develop and evaluate a biodegradable, ...

Spatial Patterns and Prognostic Relevance of CD1a Immature and CD208 Mature Dendritic Cells in Colorectal Cancer From Tumour-adjacent Mucosa to Liver

original article

open access

submitted version

Pavlov, Sergii

;

Ali, Esraa

;

Ye, Wenjing

;

Červenková, Lenka

;

Ambrożkiewicz, Filip

;

Vyčítal, Ondřej

;

Daum, Ondřej

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Trailin, Andriy

2026

,

Springer

,

Cancer Immunology, Immunotherapy

,

75

(1)

Background. The prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired livermetastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a+ and matureCD208+ subsets across ...

Spatial patterns and prognostic relevance of CD1a⁺ immature and CD208⁺ mature dendritic cells in colorectal cancer from non-tumor adjacent mucosa to liver metastases

original article

open access

published version

Pavlov, Sergii

;

Ali, Esraa

;

Ye, Wenjing

;

Červenková, Lenka

;

Ambrożkiewicz, Filip

;

Vyčítal, Ondřej

;

Daum, Ondřej

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Trailin, Andriy

2026

,

Springer

,

Cancer Immunology, Immunotherapy

,

75

(1)

Background. The prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired livermetastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a+ and matureCD208+ subsets across ...

EVIDENCE BASED SELECTION OF HYPERPARAMETERS FOR EPITHELIAL SEGMENTATION IN WHOLE SLIDE IMMUNOHISTOCHEMISTRY IMAGES: FROM NORMAL MUCOSA TO COLORECTAL CANCER

original article

open access

submitted version

Pavlov, Sergii

;

Burlaka, Bogdan

;

Sobhe Abdelhamid Mahmoud, Esraa

;

Ye, Wenjing

;

Robota, Dmytro

;

Ambrożkiewicz, Filip

;

Hošek, Petr

;

Jiřík, Miroslav

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Trailin, Andriy

2026

Background. Accurate delineation of the epithelial compartment is a critical prerequisite for reproducible quantitative analysis in digital pathology, particularly in colorectal cancer (CRC) where malignant glands determine ...

Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab

original article

open access

submitted version

Fiala, Ondřej

;

Rejleková, Katarína

;

Büchler, Tomáš

;

Študentová, Hana

;

Poprach, Alexandr

;

Vočka, Michal

;

Hošek, Petr

;

Kopecký, Jindřich

;

Matějů, Martin

;

Zemánková, Anežka

;

Spisarová, Martina

;

Tkadlecová, Michaela

;

Priester, Peter

;

Kouřil, Jan

;

Lohynská, Radka

;

Grmelová, Lucie

;

Savka, Alexander

;

Štefániková, Katarína

;

Obertová, Jana

;

Šiková, Dominika

;

Stránský, Petr

;

Melichar, Bohuslav

;

Palacka, Patrik

2026

,

Springer Nature

,

Scientific Reports

,

16

(1)

The role of eosinophils in patients with cancer receiving systemic therapy based on immune checkpoint inhibitors (ICIs) has become a subject of increasing interest. The aim of the present study was to assess the prognostic ...

Clonal outbreak of an extensively drug-resistant NDM-1 producing Pseudomonas aeruginosa in a local hospital in the Czech Republic

original article

open access

published version

Chudějová, Kateřina

;

Sourenian-Samuelian, Tsolaire

;

Finianos, Marc

;

Šrámková, Anna

;

Papagiannitsis, Costas C

;

Hrabák, Jaroslav

;

Bitar, Ibrahim

2026

,

ASM Press

,

Microbiology Spectrum

,

14

(1)

A clonal outbreak of 18 ST773 NDM-1 producing Pseudomonas aeruginosa strains has been detected for the first time in the Czech Republic. The strains were extremely drug-resistant (XDR) and resistant to serum killing. ...

Mutational landscape of lung adenocarcinoma in Czechia

original article

open access

published version

Ambrożkiewicz, Filip

;

Ali, Esraa

;

Bradová, Martina

;

Slavík, Petr

;

Martínek, Petr

;

Svatoň, Martin

;

Hemminki, Akseli

;

Hemminki, Kari Jussi

2026

,

Elsevier Inc.

,

Cancer Treatment and Research Communications

,

46

Limited DNA sequencing data on lung cancer (LC) patients are available from Eastern Europe where male smoking is commonest in Europe. As sequence analysis is the prerequisite for targeted therapy we provide such data from ...

Spatial Profiling and Prognostic Role of Tumor-Infiltrating CD8+T and CD20+B Cells in Metastatic Clear Cell Renal Cell Carcinoma Treated with Sequential Tyrosine Kinase Inhibitors and Nivolumab

original article

open access

published version

Trailin, Andriy

;

Červenková, Lenka

;

Hošek, Petr

;

Pivovarčíková, Kristýna

;

Tkadlecová, Michaela

;

Stránský, Petr

;

Hemminki, Kari Jussi

;

Fiala, Ondřej

2026

,

Ivyspring International Publisher

,

Journal of Cancer

,

17

(2)

Background: Tumor-infiltrating lymphocytes (TILs) are known to influence disease progression and treatment response in clear cell renal cell carcinoma. This study aimed at evaluating the prognostic and predictive relevance ...

Familial colorectal cancer: search for novel predisposition genes

original article

open access

published version

Försti, Asta

;

Miao, Beiping

;

Kumar, Abhishek

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Dymerska Zaremba, Dagmara

;

Marciniak, Magdalena

;

Lubinski, Jan

;

Hemminki, Kari Jussi

2026

,

Henry Stewart Publications

,

Human Genomics

,

20

(1)

BACKGROUND: Family history of colorectal cancer (CRC) and multiple primary CRCs in a single person may indicate inherited CRC predisposition. METHODS: In the present study, we performed whole exome/genome sequencing on ...