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Small nucleolar RNA expression profiles: A potential prognostic biomarker for non-viral Hepatocellular carcinoma

original article

open access

published version

Mallela, Venkata Ramana

;

Kasi, Phanindra Babu

;

Shetti, Dattatrya

;

Trailin, Andriy

;

Červenková, Lenka

;

Pálek, Richard

;

Daum, Ondřej

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Ambrożkiewicz, Filip

2024

,

Non-coding RNA Research

,

9

(4)

Hepatocellular carcinoma (HCC) is a challenging cancer with high mortality rates, limited predictability, and a lack of effective prognostic indicators. The relationship between small nucleolar RNAs (snoRNAs) and HCC is ...

Giant Cell Temporal Arteritis Followed by Severe Encephalopathy Induced by Immunotherapy in a Patient with Metastatic Renal Cell Carcinoma Achieving Durable Partial Response: A Case Report

casuistics

open access

published version

Fiala, Ondřej

;

Tkadlecová, Michaela

;

Pivovarčíková, Kristýna

;

Baxa, Jan

;

Stránský, Petr

;

Šiková, Dominika

;

Hora, Milan

;

Fínek, Jindřich

2024

,

Case Reports in Oncology

,

17

(1)

Introduction: Combined immuno-oncology (IO) regimens are the cornerstone of the current front-line systemic therapy for metastatic renal cell carcinoma (mRCC). Despite the fact that combined IO regimens show high efficacy, ...

Epigenetic Characterization of Squamous Cell Carcinoma and Mucoepidermoid Carcinoma Based on DNA Methylation Data: An In-Silico Study

abstract in journal

open access

published version

Othman, Bacem Abdullah Essam Othman Khalele

;

Skálová, Alena

2025

,

Oxford

,

Elsevier Ltd.

,

EJC Skin Cancer

,

3

(S1)

Background: A recent study demonstrated that parotid squamous cell carcinomas (SCCs) are most potentially metastatic cutaneous SCCs. To define whether epigenetic alterations may explain the different molecular events between ...

Oral presentation of paraneoplastic pemphigus as the first sign of tonsillar HPV associated squamous cell carcinoma. A case report

casuistics

open access

published version

Liška, Jan

;

Lišková, Veronika

;

Trčka, Ondřej

;

Ondič, Ondrej

;

Hauer, Lukáš

;

Baxa, Jan

;

Kacerovská, Denisa

2022

,

Biomedical Papers

,

166

(4)

Background: Paraneoplastic pemphigus (PNP) in the oral cavity is a rare variant of blistering pemphigus disease closely associated with mostly malignant tumors. The diagnosis may even precede an underlying malignancy ...

Non-viral HCC miRNA profiling reveals miR-1972 as a potential positive prognostic marker

original article

open access

published version

Mallela, Venkata Ramana

;

Rajtmajerová, Marie

;

Ali, Esraa

;

Červenková, Lenka

;

Trailin, Andriy

;

Hošek, Petr

;

Pálek, Richard

;

Daum, Ondřej

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Ambrożkiewicz, Filip

2025

,

Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

,

Non-coding RNA Research

,

15

(December)

Background & Aims: Hepatocellular carcinoma (HCC) is the third deadliest cancer worldwide. Its high mortality is primarily attributed to late-stage diagnosis. While mutations in driver genes, such as those encoding β-catenin ...

One-Step Nucleic Acid Amplification Analysis of Sentinel Lymphatic Nodes in Endometrial Cancer Patients (EU-OSNA): A European Multicenter Diagnostic Accuracy Study

original article

open access

published version

Kosťun, Jan

;

Nowosielski, Krzysztof

;

Jedryka, Marcin A

;

Hardisson, David

;

Restaino, Stefano

;

Gatius, Sonia

;

Novak, Zoltan

;

Lacalle, Amaia Sagasta

;

Lopez, Susana

;

Pešta, Martin

;

Zebalski, Marcin

;

Lepka, Piotr

;

Diestro, María Dolores

;

Vizzielli, Giuseppe

;

Matias-Guiu, Xavier

;

Echim, Tímea

;

Urkaray, Emma Natalia Camacho

;

Rienda, Iván

;

Slunečko, Robert

;

Czekanski, Andrzej

;

Berjón, Alberto

;

Mariuzzi, Laura

;

Velasco, Ana

;

Betenbuk, Judit

;

Merino, Isabel Guerra

;

Padilla-Iserte, Pablo

;

Stráník, Petr

;

Smoligová, Vendula

;

Presl, Jiří

2025

,

Blackwell Publishing

,

Cancer Medicine

,

14

(18)

OBJECTIVE: This European multicenter study aimed to assess the diagnostic accuracy of one-step nucleic acid amplification (OSNA) as the primary endpoint by comparing this method with ultrastaging for the detection of ...

Molecular pathology in diagnosis and prognostication of head and neck tumors

summarizing article

open access

published version

Skálová, Alena

;

Bradová, Martina

;

Michal, Michael

;

Mosaieby, Elaheh

;

Klubíčková, Natálie

;

Vaněček, Tomáš

;

Leivo, Ilmo

2024

,

Virchows Archiv

,

484

(2)

Classification of head and neck tumors has evolved in recent decades including a widespread application of molecular testing in tumors of the salivary glands, sinonasal tract, oropharynx, nasopharynx, and soft tissue. ...

Spatial Patterns and Prognostic Relevance of CD1a Immature and CD208 Mature Dendritic Cells in Colorectal Cancer From Tumour-adjacent Mucosa to Liver

original article

open access

submitted version

Pavlov, Sergii

;

Ali, Esraa

;

Ye, Wenjing

;

Červenková, Lenka

;

Ambrożkiewicz, Filip

;

Vyčítal, Ondřej

;

Daum, Ondřej

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Trailin, Andriy

2026

,

Springer

,

Cancer Immunology, Immunotherapy

,

75

(1)

Background. The prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired livermetastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a+ and matureCD208+ subsets across ...

Spatial patterns and prognostic relevance of CD1a⁺ immature and CD208⁺ mature dendritic cells in colorectal cancer from non-tumor adjacent mucosa to liver metastases

original article

open access

published version

Pavlov, Sergii

;

Ali, Esraa

;

Ye, Wenjing

;

Červenková, Lenka

;

Ambrożkiewicz, Filip

;

Vyčítal, Ondřej

;

Daum, Ondřej

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Trailin, Andriy

2026

,

Springer

,

Cancer Immunology, Immunotherapy

,

75

(1)

Background. The prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired livermetastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a+ and matureCD208+ subsets across ...

Mutational landscape of lung adenocarcinoma in Czechia

original article

open access

published version

Ambrożkiewicz, Filip

;

Ali, Esraa

;

Bradová, Martina

;

Slavík, Petr

;

Martínek, Petr

;

Svatoň, Martin

;

Hemminki, Akseli

;

Hemminki, Kari Jussi

2026

,

Elsevier Inc.

,

Cancer Treatment and Research Communications

,

46

Limited DNA sequencing data on lung cancer (LC) patients are available from Eastern Europe where male smoking is commonest in Europe. As sequence analysis is the prerequisite for targeted therapy we provide such data from ...

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