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Learning Support Systems: A Practical Guide to E-learning at CU

uncertified methodology

open access

draft

Ovesleová, Hana

;

Posavec-Malok, Dean

;

Javůrková, Jana

;

Polášková, Alexandra

;

Pěnička, Jaroslav

;

Nikl, Tomáš

;

Fuglík, Viktor

;

Švejda, Vít

;

Moravcová, Alžběta

2024

,

Praha

,

Univerzita Karlova, Nakladatelství Karolinum

This guide introduces the e-learning support tools that are used most frequently at Charles University and that you may encounter during your studies. It will also help you to avoid the most common obstacles associated ...

Multidrug-resistant ESBL-producing Klebsiella pneumoniae complex in Czech hospitals, wastewaters and surface waters

original article

open access

accepted version

Davidova-Gerzova, Lenka

;

Lausova, Jarmila

;

Sukkar, Iva

;

Nechutná, Lucie

;

Kubackova, Petra

;

Krůtová, Marcela

;

Bezdicek, Matej

;

Dolejská, Monika

2024

,

Antimicrobial Resistance and Infection Control

,

13

(1)

BACKGROUND: Multidrug-resistant (MDR) bacteria pose a significant challenge to the treatment of infectious diseases. Of particular concern are members of the Klebsiella pneumoniae species complex (KpSC), which are frequently ...

Impact of concomitant use of proton pump inhibitors or cardiovascular medication on survival outcomes of patients with metastatic renal cell carcinoma treated with nivolumab

original article

open access

published version

Fiala, Ondřej

;

Hošek, Petr

;

Tkadlecová, Michaela

;

Melichar, Bohuslav

;

Zemánková, Anežka

;

Kopecký, Jindřich

;

Vočka, Michal

;

Matějů, Martin

;

Lohynská, Radka

;

Šiková, Dominika

;

Stránský, Petr

;

Študentová, Hana

;

Spisarová, Martina

;

Nováková, Hana

;

Priester, Peter

;

Kryštofová, Dominika

;

Grmelová, Lucie

;

Büchler, Tomáš

;

Poprach, Alexandr

2025

,

Clinical & Experimental Metastasis

,

42

(5)

Renal cell cancer (RCC) is typically a disease of older adults, who often have comorbidities requiring the use of multiple concomitant medications. Even though the patients with metastatic RCC (mRCC) are often exposed to ...

Integrative miRNOMe profiling reveals the miR-195-5p–CHEK1 axis and its impact on luminal breast cancer outcomes

original article

open access

published version

Boušková, Veronika

;

Ehrlichová, Marie

;

Spálenková, Alžběta

;

Krus, Ivona

;

Šůsová, Simona

;

Hlaváč, Viktor

;

Němcová, Vlasta

;

Koževnikovová, Renata

;

Trnková, Markéta

;

Vrána, David

;

Gatěk, Jiří

;

Kopečková, Kateřina

;

Mrhalová, Marcela

;

Měšťáková, Soňa

;

Souček, Pavel

2025

,

John Wiley & Sons

,

Molecular Oncology

,

19

(11)

The luminal subtype (estrogen receptor-positive, ER+) is the most common and the most heterogeneous type of breast carcinoma (BC) in women. During our study, we determined expression levels of all microRNAs (miRNome) in ...

Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression

original article

open access

published version

Holý, Petr

;

Hlaváč, Viktor

;

Šeborová, Karolína

;

Šůsová, Simona

;

Tesařová, Tereza

;

Rob, Lukáš

;

Hruda, Martin

;

Bouda, Jiří

;

Bartáková, Alena

;

Mrhalová, Marcela

;

Kopečková, Kateřina

;

Al Obeed Allah, Mohammad Moufaq Khatar

;

Špaček, Jiří

;

Sedláková, Iva

;

Souček, Pavel

;

Václavíková, Radka

2024

,

International Journal of Cancer

,

155

(1)

High-grade serous ovarian carcinoma (HGSC) is the most common subtype of ovarian cancer and is among the most fatal gynecological malignancies worldwide, due to late diagnosis at advanced stages and frequent therapy ...

Faecal bacteriome and metabolome profiles associated with decreased mucosal inflammatory activity upon anti-TNF therapy in paediatric Crohn's disease

original article

open access

published version

Hurych, Jakub

;

Mascellani Bergo, Anna

;

Lerchová, Tereza

;

Hlináková, Lucie

;

Kubát, Michal

;

Malcová, Hana

;

Cebecauerová, Dita

;

Schwarz, Jan

;

Karaskova, Eva

;

Hecht, Tomáš

;

Vyhnánek, Radim

;

Toukalkova, Lenka

;

Dotlačil, Vojtěch

;

Greinerova, Katerina

;

Cizkova, Anabela

;

Horváth, Rudolf

;

Bronský, Jiří

;

Havlik, Jaroslav

;

Hradský, Ondřej

;

Cinek, Ondřej

2024

,

Oxford University Press

,

Journal of Crohn's and Colitis

,

18

(1)

BACKGROUND AND AIMS: Treatment by anti-TNFα antibodies (anti-TNF) changes the dysbiotic faecal bacteriome in Crohn's disease (CD). However, it is not known whether these changes are due to decreasing mucosal inflammatory ...

Developing molecular surveillance of SARS-CoV-2 in the Czech Republic (2021–2022)

original article

open access

published version

Šúri, Timotej

;

Pfeiferová, Lucie

;

Bezdíček, Matěj

;

Svatoň, Jan

;

Hampl, Vladimír

;

Berka, Karel

;

Jiřincová, Helena

;

Lengerová, Martina

;

Kolísko, Martin

;

Nagy, Alexander

;

Tachezy, Ruth

;

Kolář, Michal

;

Pačes, Jan

2025

,

Springer Nature

,

Scientific Reports

,

15

(1)

Molecular surveillance was widely used during the COVID-19 pandemic to detect rapidly emerging variants and monitor the transmission of SARS-CoV-2 within communities. In 2021, the Czech COVID-19 Genomics Consortium (COG-CZ) ...

A post-COVID-19 upsurge in Group A Streptococcus in the Czech Republic was driven by emm1 and emm12 with shared virulence factors

original article

open access

published version

Štefan, Marek

;

Prasad, Suhanya Veronica

;

Vitkova, Ivana

;

Nycova, Elka

;

Ryšková, Lenka

;

Kucova, Pavla

;

Geigerová, Lenka

;

Vesela, Denisa

;

Balejova, Magda

;

Bartonikova, Natasa

;

Havlinova, Lenka

;

Czyzova, Erika

;

Kubele, Jan

;

Dratvová, Barbora

;

Antušková, Milena

;

Zíková, Jaroslava

;

Brajerová, Marie

;

Nyč, Otakar

;

Dřevínek, Pavel

;

Trojánek, Milan

;

Krůtová, Marcela

2025

,

Elsevier

,

Journal of Infection and Public Health

,

18

(10)

BACKGROUND: In 2023, a significant increase in Streptococcus pyogenes, Group A Streptococcus (GAS) culture positivity was observed in Czech microbiological laboratories. We conducted a multicentre study to obtain epidemiological ...

Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab

original article

open access

submitted version

Fiala, Ondřej

;

Rejleková, Katarína

;

Büchler, Tomáš

;

Študentová, Hana

;

Poprach, Alexandr

;

Vočka, Michal

;

Hošek, Petr

;

Kopecký, Jindřich

;

Matějů, Martin

;

Zemánková, Anežka

;

Spisarová, Martina

;

Tkadlecová, Michaela

;

Priester, Peter

;

Kouřil, Jan

;

Lohynská, Radka

;

Grmelová, Lucie

;

Savka, Alexander

;

Štefániková, Katarína

;

Obertová, Jana

;

Šiková, Dominika

;

Stránský, Petr

;

Melichar, Bohuslav

;

Palacka, Patrik

2026

,

Springer Nature

,

Scientific Reports

,

16

(1)

The role of eosinophils in patients with cancer receiving systemic therapy based on immune checkpoint inhibitors (ICIs) has become a subject of increasing interest. The aim of the present study was to assess the prognostic ...

Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer

original article

open access

published version

Danešová, Natálie

;

Horak, Josef

;

Valíčková, Anna

;

Gil-Korilis, Adrian

;

Ergui-Arbizu, Jorge

;

Pálek, Richard

;

Brůha, Jan

;

Levý, Miroslav

;

Škrobánek, Pavel

;

Král, Jan

;

Jungwirth, Jiří

;

Neužil, Jiří

;

Vymetálková, Veronika

;

Vodička, Pavel

;

Vodenková, Soňa

;

Tomášová, Kristýna

2025

,

North Shore-Long Island Jewish Research Institute

,

Molecular Medicine

,

31

(November)

BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...

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