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Learning Support Systems: A Practical Guide to E-learning at CU

uncertified methodology

open access

draft

Ovesleová, Hana

;

Posavec-Malok, Dean

;

Javůrková, Jana

;

Polášková, Alexandra

;

Pěnička, Jaroslav

;

Nikl, Tomáš

;

Fuglík, Viktor

;

Švejda, Vít

;

Moravcová, Alžběta

2024

,

Praha

,

Univerzita Karlova, Nakladatelství Karolinum

This guide introduces the e-learning support tools that are used most frequently at Charles University and that you may encounter during your studies. It will also help you to avoid the most common obstacles associated ...

The Prognostic Role of Baseline and Early Dynamics of Peripheral Blood Cell Ratios in Metastatic Renal Cell Carcinoma Patients Treated With Nivolumab

original article

open access

published version

Fiala, Ondřej

;

Tkadlecová, Michaela

;

Kopecký, Jindřich

;

Hošek, Petr

;

Studentova, Hana

;

Vočka, Michal

;

Matějů, Martin

;

Lohynská, Radka

;

Šiková, Dominika

;

Stránský, Petr

;

Kučera, Radek

;

Zemankova, Anezka

;

Spisarova, Martina

;

Priester, Peter

;

Kouril, Jan

;

Büchler, Tomáš

;

Grmelova, Lucie

;

Melichar, Bohuslav

;

Poprach, Alexandr

2026

,

Iōannīs G. Delīnasios

,

In Vivo

,

40

(2)

BACKGROUND/AIM: Immune checkpoint inhibitors (ICI), including nivolumab, have become the cornerstone of systemic treatment in metastatic renal cell carcinoma (mRCC). Blood-derived biomarkers including neutrophil-to-lymphocyte ...

Comparative analysis of telomere length in peripheral blood of breast cancer BRCA1 mutation carriers and non-carriers

original article

open access

published version

Uttarilli, Anusha

;

Balounová, Kateřina

;

Tomášová, Kristýna

;

Hanak, Petr

;

Šašková, Kateřina

;

Vodička, Pavel

;

Vodičková, Ludmila

;

Hemminki, Kari Jussi

;

Lubinski, Jan

;

Kroupa, Michal

2026

,

Springer

,

Discover Oncology

,

17

(1)

INTRODUCTION: Breast cancer is the most prevalent malignancy among women worldwide. A significant portion of patients possess homologous recombination deficiency (HRD), often caused by BRCA1/2 mutations, which may sensitize ...

Does motherhood increase the risk of developing subsequent malignant neoplasms after childhood cancer treatment?

original article

open access

published version

Blagodárná, Sarah

;

Hošek, Petr

;

Jelínková, Kristýna

;

Korbelová, Lucie

;

Eckschlager, Tomáš

;

Lischke, Robert

;

Šrámková, Lucie

;

Kruseová, Jarmila

2026

,

Elsevier Ltd.

,

Cancer Epidemiology

,

101

(April)

BACKGROUND: Most young women who have survived childhood cancer express a desire to have children. Many of them are concerned about the potential adverse impact of pregnancy on their health, which has been affected by prior ...

Unraveling the telomere-mitochondrial axis in colorectal cancer: Results from a prospectively followed cohort

original article

open access

published version

Gil-Korilis, Adrián

;

Ergui-Arbizu, Jorge

;

Hanák, Petr

;

Danešová, Natálie

;

Tomášová, Kristýna

;

Valíčková, Anna

;

Horák, Josef

;

Gentiluomo, Manuel

;

Levý, Miroslav

;

Křivonosková, Soňa

;

Král, Jan

;

Jungwirth, Jiří

;

Vodičková, Ľudmila

;

Vymetálková, Veronika

;

Azqueta, Amaya

;

Campa, Daniele

;

Vodička, Pavel

;

Vodenková, Soňa

2026

,

North Shore-Long Island Jewish Research Institute

,

Molecular Medicine

,

32

(1)

Background Telomere shortening and mitochondrial dysfunction are well-known independent contributors to many diseases, but emerging evidence suggests a reciprocal relationship between the two processes. The role of the ...

Multidrug-resistant ESBL-producing Klebsiella pneumoniae complex in Czech hospitals, wastewaters and surface waters

original article

open access

accepted version

Davidova-Gerzova, Lenka

;

Lausova, Jarmila

;

Sukkar, Iva

;

Nechutná, Lucie

;

Kubackova, Petra

;

Krůtová, Marcela

;

Bezdicek, Matej

;

Dolejská, Monika

2024

,

Antimicrobial Resistance and Infection Control

,

13

(1)

BACKGROUND: Multidrug-resistant (MDR) bacteria pose a significant challenge to the treatment of infectious diseases. Of particular concern are members of the Klebsiella pneumoniae species complex (KpSC), which are frequently ...

A post-COVID-19 upsurge in Group A Streptococcus in the Czech Republic was driven by emm1 and emm12 with shared virulence factors

original article

open access

published version

Štefan, Marek

;

Prasad, Suhanya Veronica

;

Vitkova, Ivana

;

Nycova, Elka

;

Ryšková, Lenka

;

Kucova, Pavla

;

Geigerová, Lenka

;

Vesela, Denisa

;

Balejova, Magda

;

Bartonikova, Natasa

;

Havlinova, Lenka

;

Czyzova, Erika

;

Kubele, Jan

;

Dratvová, Barbora

;

Antušková, Milena

;

Zíková, Jaroslava

;

Brajerová, Marie

;

Nyč, Otakar

;

Dřevínek, Pavel

;

Trojánek, Milan

;

Krůtová, Marcela

2025

,

Elsevier

,

Journal of Infection and Public Health

,

18

(10)

BACKGROUND: In 2023, a significant increase in Streptococcus pyogenes, Group A Streptococcus (GAS) culture positivity was observed in Czech microbiological laboratories. We conducted a multicentre study to obtain epidemiological ...

Impact of concomitant use of proton pump inhibitors or cardiovascular medication on survival outcomes of patients with metastatic renal cell carcinoma treated with nivolumab

original article

open access

published version

Fiala, Ondřej

;

Hošek, Petr

;

Tkadlecová, Michaela

;

Melichar, Bohuslav

;

Zemánková, Anežka

;

Kopecký, Jindřich

;

Vočka, Michal

;

Matějů, Martin

;

Lohynská, Radka

;

Šiková, Dominika

;

Stránský, Petr

;

Študentová, Hana

;

Spisarová, Martina

;

Nováková, Hana

;

Priester, Peter

;

Kryštofová, Dominika

;

Grmelová, Lucie

;

Büchler, Tomáš

;

Poprach, Alexandr

2025

,

Clinical & Experimental Metastasis

,

42

(5)

Renal cell cancer (RCC) is typically a disease of older adults, who often have comorbidities requiring the use of multiple concomitant medications. Even though the patients with metastatic RCC (mRCC) are often exposed to ...

Integrative miRNOMe profiling reveals the miR-195-5p–CHEK1 axis and its impact on luminal breast cancer outcomes

original article

open access

published version

Boušková, Veronika

;

Ehrlichová, Marie

;

Spálenková, Alžběta

;

Krus, Ivona

;

Šůsová, Simona

;

Hlaváč, Viktor

;

Němcová, Vlasta

;

Koževnikovová, Renata

;

Trnková, Markéta

;

Vrána, David

;

Gatěk, Jiří

;

Kopečková, Kateřina

;

Mrhalová, Marcela

;

Měšťáková, Soňa

;

Souček, Pavel

2025

,

John Wiley & Sons

,

Molecular Oncology

,

19

(11)

The luminal subtype (estrogen receptor-positive, ER+) is the most common and the most heterogeneous type of breast carcinoma (BC) in women. During our study, we determined expression levels of all microRNAs (miRNome) in ...

Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression

original article

open access

published version

Holý, Petr

;

Hlaváč, Viktor

;

Šeborová, Karolína

;

Šůsová, Simona

;

Tesařová, Tereza

;

Rob, Lukáš

;

Hruda, Martin

;

Bouda, Jiří

;

Bartáková, Alena

;

Mrhalová, Marcela

;

Kopečková, Kateřina

;

Al Obeed Allah, Mohammad Moufaq Khatar

;

Špaček, Jiří

;

Sedláková, Iva

;

Souček, Pavel

;

Václavíková, Radka

2024

,

International Journal of Cancer

,

155

(1)

High-grade serous ovarian carcinoma (HGSC) is the most common subtype of ovarian cancer and is among the most fatal gynecological malignancies worldwide, due to late diagnosis at advanced stages and frequent therapy ...

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