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Learning Support Systems: A Practical Guide to E-learning at CU

uncertified methodology

open access

draft

Ovesleová, Hana

;

Posavec-Malok, Dean

;

Javůrková, Jana

;

Polášková, Alexandra

;

Pěnička, Jaroslav

;

Nikl, Tomáš

;

Fuglík, Viktor

;

Švejda, Vít

;

Moravcová, Alžběta

2024

,

Praha

,

Univerzita Karlova, Nakladatelství Karolinum

This guide introduces the e-learning support tools that are used most frequently at Charles University and that you may encounter during your studies. It will also help you to avoid the most common obstacles associated ...

Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer

original article

open access

published version

Piccinno, Gianmarco

;

Thompson, Kelsey N.

;

Manghi, Paolo

;

Ghazi, Andrew R.

;

Thomas, Andrew Maltez

;

Blanco-Miguez, Aitor

;

Asnicar, Francesco

;

Mladenovic, Katarina

;

Pinto, Federica

;

Armanini, Federica

;

Puncochar, Michal

;

Piperni, Elisa

;

Heidrich, Vitor

;

Fackelmann, Gloria

;

Ferrero, Giulio

;

Tarallo, Sonia

;

Nguyen, Long H.

;

Yan, Yan

;

Keles, Nazim A.

;

Tuna, Bilge G.

;

Vymetálková, Veronika

;

Trompetto, Mario

;

Liška, Václav

;

Hucl, Tomáš

;

Vodička, Pavel

;

Bencsikova, Beatrix

;

Carnogurska, Martina

;

Popovici, Vlad

;

Marmorino, Federica

;

Cremolini, Chiara

;

Pardini, Barbara

;

Cordero, Francesca

;

Song, Mingyang

;

Chan, Andrew T.

;

Derosa, Lisa

;

Zitvogel, Laurence

;

Huttenhower, Curtis

;

Naccarati, Alessio

;

Budinska, Eva

;

Segata, Nicola

2025

,

Nature Medicine

,

31

(7)

Associations between the gut microbiome and colorectal cancer (CRC) have been uncovered, but larger and more diverse studies are needed to assess their potential clinical use. We expanded upon 12 metagenomic datasets of ...

Genetic And Environmental Associations Of Nonspecific Chromosomal Aberrations

summarizing article

open access

published version

Hemminki, Kari Jussi

;

Niazi, Yasmeen

;

Vodičková, Ludmila

;

Vodička, Pavel

;

Försti, Asta

2025

,

Mutagenesis

,

40

(1)

Nonspecific structural chromosomal aberrations (CAs) are found in around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. CAs ...

Nonprocedural bleeding after left atrial appendage closure versus direct oral anticoagulants: A subanalysis of the randomized PRAGUE-17 trial

original article

open access

published version

Branny, Marian

;

Osmančík, Pavel

;

Kala, Petr

;

Poloczek, Martin

;

Heřman, Dalibor

;

Neužil, Petr

;

Hála, Pavel

;

Táborský, Miloš

;

Šťásek, Josef

;

Haman, Luděk

;

Chovančík, Jan

;

Červinka, Pavel

;

Holý, Jiří

;

Kovárník, Tomáš

;

Zemánek, David

;

Havránek, Štěpán

;

Vančura, Vlastimil

;

Peichl, Petr

;

Toušek, Petr

;

Hozman, Marek

;

Lekešová, Veronika

;

Jarkovský, Jiří

;

Nováčková, Martina

;

Benešová, Klára

;

Widimský, Petr

;

Reddy, Vivek Y

2023

,

Journal of Cardiovascular Electrophysiology

,

34

(9)

INTRODUCTION: Observational studies have shown low bleeding rates in patients with atrial fibrillation (AF) treated by left atrial appendage closure (LAAC); however, data from randomized studies are lacking. This study ...

Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk

original article

open access

published version

Ünal, Pelin

;

Lu, Ye

;

Bueno-de-Mesquita, Bas

;

van Eijck, Casper H. J.

;

Talar-Wojnarowska, Renata

;

Szentesi, Andrea

;

Gazouli, Maria

;

Kreivenaite, Edita

;

Tavano, Francesca

;

Małecka-Wojciesko, Ewa

;

Erőss, Bálint

;

Oliverius, Martin

;

Bunduc, Stefania

;

Nóbrega Aoki, Mateus

;

Vodičková, Ludmila

;

Boggi, Ugo

;

Giaccherini, Matteo

;

Kondrackiene, Jurate

;

Chammas, Roger

;

Palmieri, Orazio

;

Theodoropoulos, George E.

;

Bijlsma, Maarten F.

;

Basso, Daniela

;

Mohelníková-Duchoňová, Beatrice

;

Souček, Pavel

;

Izbicki, Jakob R

;

Kiudelis, Vytautas

;

Vanella, Giuseppe

;

Arcidiacono, Paolo Giorgio

;

Włodarczyk, Barbara

;

Hackert, Thilo

;

Schöttker, Ben

;

Uzunoglu, Faik G.

;

Bambi, Franco

;

Goetz, Mara

;

Hlaváč, Viktor

;

Brenner, Hermann

;

Perri, Francesco

;

Carrara, Silvia

;

Landi, Stefano

;

Hegyi, Péter

;

Dijk, Frederike

;

Maiello, Evaristo

;

Capretti, Giovanni

;

Testoni, Sabrina Gloria Giulia

;

Petrone, Maria Chiara

;

Stocker, Hannah

;

Ermini, Stefano

;

Archibugi, Livia

;

Gentiluomo, Manuel

;

Cavestro, Giulia Martina

;

Pezzilli, Raffaele

;

Di Franco, Gregorio

;

Milanetto, Anna Caterina

;

Sperti, Cosimo

;

Neoptolemos, John P.

;

Morelli, Luca

;

Vokáčová, Klára

;

Pasquali, Claudio

;

Lawlor, Rita T

;

Bazzocchi, Francesca

;

Kupcinskas, Juozas

;

Capurso, Gabriele

;

Campa, Daniele

;

Canzian, Federico

2024

,

Henry Stewart Publications

,

Human Genomics

,

18

(February)

Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). ...

Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance

original article

open access

published version

Thomsen, Hauke

;

Chattopadhyay, Subhayan

;

Weinhold, Niels

;

Vodička, Pavel

;

Vodičková, Ludmila

;

Hoffmann, Per

;

Nöthen, Markus M

;

Jöckel, Karl-Heinz

;

Schmidt, Börge

;

Hajek, Roman

;

Hallmans, Göran

;

Pettersson-Kymmer, Ulrika

;

Späth, Florentin

;

Goldschmidt, Hartmut

;

Hemminki, Kari Jussi

;

Försti, Asta

2024

,

Nature Publishing

,

Blood Cancer Journal

,

14

(1)

Genome-wide association studies (GWASs) based on common single nucleotide polymorphisms (SNPs) have identified several loci associated with the risk of monoclonal gammopathy of unknown significance (MGUS), a precursor ...

The Czech National MS Registry (ReMuS): Data trends in multiple sclerosis patients whose first disease-modifying therapies were initiated from 2013 to 2021

original article

open access

published version

Šťastná, Dominika

;

Drahota, Jiří

;

Lauer, Michal

;

Mazouchová, Aneta

;

Meňkyová, Ingrid

;

Adámková, Jana

;

Ampapa, Radek

;

Dufek, Michal

;

Grunermelova, Marketa

;

Hradilek, Pavel

;

Kubala Havrdová, Eva

;

Mareš, Jan

;

Martínková, Alena

;

Pavelek, Zbyšek

;

Peterka, Marek

;

Recmanová, Eva

;

Ročková, Petra

;

Štětkářová, Ivana

;

Štourač, Pavel

;

Vachová, Marta

;

Horáková, Dana

2024

,

Palacký University

,

Biomedical Papers

,

168

(3)

AIMS: Multiple sclerosis treatment strategies are changing in the Czech Republic. According to data from 2013-2021, the proportion of patients starting high-efficacy disease-modifying therapies is increasing. In this survey, ...

Pembrolizumab versus Pembrolizumab plus Chemotherapy in Non-small Cell Lung Cancer with High PD-L1 Expression - Multicenter Real-world Evidence Study

original article

open access

published version

Svatoň, Martin

;

Knetki-Wroblewska, Magdalena

;

Hošek, Petr

;

Chowaniecova, Gabriela

;

Špaček, Jan

;

Fischer, Ondřej

;

Bílek, Ondřej

;

Hrnčiarik, Michal

;

Kauffmann-Guerrero, Diego

2025

,

Ivyspring International Publisher

,

Journal of Cancer

,

16

(10)

Background: Patients with non-small cell lung cancer (NSCLC) with PD-Ll expression ~ 50% can be treated with immunotherapy alone or with a combination of immunotherapy and chemotherapy. One of these options is treatment ...

SHARED AND NON-SHARED MUTATIONS IN APC AND TP53 GENES IN PAIRED PRIMARY AND METASTATIC COLORECTAL CANCER FROM SYNCHRONOUS AND METACHRONOUS PATIENTS

original article

open access

submitted version

Ambrożkiewicz, Filip

;

Rajtmajerová, Marie

;

Hlaváč, Viktor

;

Trailin, Andriy

;

Červenková, Lenka

;

Brůha, Jan

;

Šůsová, Simona

;

Souček, Pavel

;

Vodička, Pavel

;

Vodičková, Ľudmila

;

Kubeček, Ondřej

;

Filip, Stanislav

;

Mallela, Venkata Ramana

;

Ye, Wenjing

;

Liška, Václav

;

Hemminki, Kari Jussi

2026

BackgroundMutational cascades in colorectal cancer (CRC) between the primary tumor (pCRC) and liver metasta-sis (LM) are poorly understood in individual patients. We focused on differences in specific APC and TP53 mutations ...

Impact of concomitant use of proton pump inhibitors or cardiovascular medication on survival outcomes of patients with metastatic renal cell carcinoma treated with nivolumab

original article

open access

published version

Fiala, Ondřej

;

Hošek, Petr

;

Tkadlecová, Michaela

;

Melichar, Bohuslav

;

Zemánková, Anežka

;

Kopecký, Jindřich

;

Vočka, Michal

;

Matějů, Martin

;

Lohynská, Radka

;

Šiková, Dominika

;

Stránský, Petr

;

Študentová, Hana

;

Spisarová, Martina

;

Nováková, Hana

;

Priester, Peter

;

Kryštofová, Dominika

;

Grmelová, Lucie

;

Büchler, Tomáš

;

Poprach, Alexandr

2025

,

Clinical & Experimental Metastasis

,

42

(5)

Renal cell cancer (RCC) is typically a disease of older adults, who often have comorbidities requiring the use of multiple concomitant medications. Even though the patients with metastatic RCC (mRCC) are often exposed to ...

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