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Nonprocedural bleeding after left atrial appendage closure versus direct oral anticoagulants: A subanalysis of the randomized PRAGUE-17 trial

original article

open access

published version

Branny, Marian

;

Osmančík, Pavel

;

Kala, Petr

;

Poloczek, Martin

;

Heřman, Dalibor

;

Neužil, Petr

;

Hála, Pavel

;

Táborský, Miloš

;

Šťásek, Josef

;

Haman, Luděk

;

Chovančík, Jan

;

Červinka, Pavel

;

Holý, Jiří

;

Kovárník, Tomáš

;

Zemánek, David

;

Havránek, Štěpán

;

Vančura, Vlastimil

;

Peichl, Petr

;

Toušek, Petr

;

Hozman, Marek

;

Lekešová, Veronika

;

Jarkovský, Jiří

;

Nováčková, Martina

;

Benešová, Klára

;

Widimský, Petr

;

Reddy, Vivek Y

2023

,

Journal of Cardiovascular Electrophysiology

,

34

(9)

INTRODUCTION: Observational studies have shown low bleeding rates in patients with atrial fibrillation (AF) treated by left atrial appendage closure (LAAC); however, data from randomized studies are lacking. This study ...

Outcomes Of Patients With Myocardial Infarction And Cardiogenic Shock Treated With Culprit Vessel-Only Versus Multivessel Primary PCI

original article

open access

published version

Hlinomaz, Ota

;

Moťovská, Zuzana

;

Kala, Petr

;

Hromádka, Milan

;

Přeček, Jan

;

Mrózek, Jan

;

Červinka, Pavel

;

Kettner, Jiří

;

Matějka, Jan

;

Zohoor, Ahmad

;

Bis, Josef

;

Jarkovský, Jiří

2024

,

Hellenic Journal of Cardiology

,

76

(MAR-APR)

INTRODUCTION AND OBJECTIVES: Multivessel primary percutaneous coronary intervention (pPCI) is still often used in patients with ST-elevation myocardial infarction (STEMI) and cardiogenic shock (CS). The study aimed to ...

The Czech National MS Registry (ReMuS): Data trends in multiple sclerosis patients whose first disease-modifying therapies were initiated from 2013 to 2021

original article

open access

published version

Šťastná, Dominika

;

Drahota, Jiří

;

Lauer, Michal

;

Mazouchová, Aneta

;

Meňkyová, Ingrid

;

Adámková, Jana

;

Ampapa, Radek

;

Dufek, Michal

;

Grunermelova, Marketa

;

Hradilek, Pavel

;

Kubala Havrdová, Eva

;

Mareš, Jan

;

Martínková, Alena

;

Pavelek, Zbyšek

;

Peterka, Marek

;

Recmanová, Eva

;

Ročková, Petra

;

Štětkářová, Ivana

;

Štourač, Pavel

;

Vachová, Marta

;

Horáková, Dana

2024

,

Palacký University

,

Biomedical Papers

,

168

(3)

AIMS: Multiple sclerosis treatment strategies are changing in the Czech Republic. According to data from 2013-2021, the proportion of patients starting high-efficacy disease-modifying therapies is increasing. In this survey, ...

Pembrolizumab versus Pembrolizumab plus Chemotherapy in Non-small Cell Lung Cancer with High PD-L1 Expression - Multicenter Real-world Evidence Study

original article

open access

published version

Svatoň, Martin

;

Knetki-Wroblewska, Magdalena

;

Hošek, Petr

;

Chowaniecova, Gabriela

;

Špaček, Jan

;

Fischer, Ondřej

;

Bílek, Ondřej

;

Hrnčiarik, Michal

;

Kauffmann-Guerrero, Diego

2025

,

Ivyspring International Publisher

,

Journal of Cancer

,

16

(10)

Background: Patients with non-small cell lung cancer (NSCLC) with PD-Ll expression ~ 50% can be treated with immunotherapy alone or with a combination of immunotherapy and chemotherapy. One of these options is treatment ...

Utilization of healthcare services in acute myocardial infarction and the risk of out-of-hospital cardiac death

letter to the editors

open access

published version

Moťovská, Zuzana

;

Hlinomaz, Ota

;

Hromádka, Milan

;

Mrózek, Jan

;

Přeček, Jan

;

Kala, Petr

;

Muzafarova, Tamilla

;

Kettner, Jiří

;

Matějka, Jan

;

Bis, Josef

;

Červinka, Pavel

;

Tomašov, Pavol

;

Klechová, Anna

;

Šanca, Ondřej

;

Jarkovský, Jiří

2024

,

Panminerva Medica

,

66

(1)

COVID-19 represented a significant challenge to cardiovascular (cV) medicine research, treatment, prevention, and, to a considerable extent, case management. The global pandemic viral infection increased the risk of ...

SHARED AND NON-SHARED MUTATIONS IN APC AND TP53 GENES IN PAIRED PRIMARY AND METASTATIC COLORECTAL CANCER FROM SYNCHRONOUS AND METACHRONOUS PATIENTS

original article

open access

submitted version

Ambrożkiewicz, Filip

;

Rajtmajerová, Marie

;

Hlaváč, Viktor

;

Trailin, Andriy

;

Červenková, Lenka

;

Brůha, Jan

;

Šůsová, Simona

;

Souček, Pavel

;

Vodička, Pavel

;

Vodičková, Ľudmila

;

Kubeček, Ondřej

;

Filip, Stanislav

;

Mallela, Venkata Ramana

;

Ye, Wenjing

;

Liška, Václav

;

Hemminki, Kari Jussi

2026

BackgroundMutational cascades in colorectal cancer (CRC) between the primary tumor (pCRC) and liver metasta-sis (LM) are poorly understood in individual patients. We focused on differences in specific APC and TP53 mutations ...

A post-COVID-19 upsurge in Group A Streptococcus in the Czech Republic was driven by emm1 and emm12 with shared virulence factors

original article

open access

published version

Štefan, Marek

;

Prasad, Suhanya Veronica

;

Vitkova, Ivana

;

Nycova, Elka

;

Ryšková, Lenka

;

Kucova, Pavla

;

Geigerová, Lenka

;

Vesela, Denisa

;

Balejova, Magda

;

Bartonikova, Natasa

;

Havlinova, Lenka

;

Czyzova, Erika

;

Kubele, Jan

;

Dratvová, Barbora

;

Antušková, Milena

;

Zíková, Jaroslava

;

Brajerová, Marie

;

Nyč, Otakar

;

Dřevínek, Pavel

;

Trojánek, Milan

;

Krůtová, Marcela

2025

,

Elsevier

,

Journal of Infection and Public Health

,

18

(10)

BACKGROUND: In 2023, a significant increase in Streptococcus pyogenes, Group A Streptococcus (GAS) culture positivity was observed in Czech microbiological laboratories. We conducted a multicentre study to obtain epidemiological ...

Impact of concomitant use of proton pump inhibitors or cardiovascular medication on survival outcomes of patients with metastatic renal cell carcinoma treated with nivolumab

original article

open access

published version

Fiala, Ondřej

;

Hošek, Petr

;

Tkadlecová, Michaela

;

Melichar, Bohuslav

;

Zemánková, Anežka

;

Kopecký, Jindřich

;

Vočka, Michal

;

Matějů, Martin

;

Lohynská, Radka

;

Šiková, Dominika

;

Stránský, Petr

;

Študentová, Hana

;

Spisarová, Martina

;

Nováková, Hana

;

Priester, Peter

;

Kryštofová, Dominika

;

Grmelová, Lucie

;

Büchler, Tomáš

;

Poprach, Alexandr

2025

,

Clinical & Experimental Metastasis

,

42

(5)

Renal cell cancer (RCC) is typically a disease of older adults, who often have comorbidities requiring the use of multiple concomitant medications. Even though the patients with metastatic RCC (mRCC) are often exposed to ...

Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression

original article

open access

published version

Holý, Petr

;

Hlaváč, Viktor

;

Šeborová, Karolína

;

Šůsová, Simona

;

Tesařová, Tereza

;

Rob, Lukáš

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Hruda, Martin

;

Bouda, Jiří

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Bartáková, Alena

;

Mrhalová, Marcela

;

Kopečková, Kateřina

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Al Obeed Allah, Mohammad Moufaq Khatar

;

Špaček, Jiří

;

Sedláková, Iva

;

Souček, Pavel

;

Václavíková, Radka

2024

,

International Journal of Cancer

,

155

(1)

High-grade serous ovarian carcinoma (HGSC) is the most common subtype of ovarian cancer and is among the most fatal gynecological malignancies worldwide, due to late diagnosis at advanced stages and frequent therapy ...

Developing molecular surveillance of SARS-CoV-2 in the Czech Republic (2021–2022)

original article

open access

published version

Šúri, Timotej

;

Pfeiferová, Lucie

;

Bezdíček, Matěj

;

Svatoň, Jan

;

Hampl, Vladimír

;

Berka, Karel

;

Jiřincová, Helena

;

Lengerová, Martina

;

Kolísko, Martin

;

Nagy, Alexander

;

Tachezy, Ruth

;

Kolář, Michal

;

Pačes, Jan

2025

,

Springer Nature

,

Scientific Reports

,

15

(1)

Molecular surveillance was widely used during the COVID-19 pandemic to detect rapidly emerging variants and monitor the transmission of SARS-CoV-2 within communities. In 2021, the Czech COVID-19 Genomics Consortium (COG-CZ) ...

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