Carbapenemases are versatile β-lactamases capable of hydrolyzing carbapenem antibiotics. They are classified into Ambler classes A, B, and D. Class A carbapenemases, such as Klebsiella pneumoniaecarbapenemase (KPC) ...
Background:Overuse of carbapenems has been associated with an increasing prevalence of resistance, particularly among the Enterobacterales, Pseudomonasspp., and Acinetobacter spp. Resistance is mediated by the ...
Carbapenems are currently last-resort antibiotics for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. Therefore, the resistence to those drugs represents a significant threat of current ...