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Pembrolizumab versus Pembrolizumab plus Chemotherapy in Non-small Cell Lung Cancer with High PD-L1 Expression - Multicenter Real-world Evidence Study

original article

open access

published version

Svatoň, Martin

;

Knetki-Wroblewska, Magdalena

;

Hošek, Petr

;

Chowaniecova, Gabriela

;

Špaček, Jan

;

Fischer, Ondřej

;

Bílek, Ondřej

;

Hrnčiarik, Michal

;

Kauffmann-Guerrero, Diego

2025

,

Ivyspring International Publisher

,

Journal of Cancer

,

16

(10)

Background: Patients with non-small cell lung cancer (NSCLC) with PD-Ll expression ~ 50% can be treated with immunotherapy alone or with a combination of immunotherapy and chemotherapy. One of these options is treatment ...

Impact of concomitant use of proton pump inhibitors or cardiovascular medication on survival outcomes of patients with metastatic renal cell carcinoma treated with nivolumab

original article

open access

published version

Fiala, Ondřej

;

Hošek, Petr

;

Tkadlecová, Michaela

;

Melichar, Bohuslav

;

Zemánková, Anežka

;

Kopecký, Jindřich

;

Vočka, Michal

;

Matějů, Martin

;

Lohynská, Radka

;

Šiková, Dominika

;

Stránský, Petr

;

Študentová, Hana

;

Spisarová, Martina

;

Nováková, Hana

;

Priester, Peter

;

Kryštofová, Dominika

;

Grmelová, Lucie

;

Büchler, Tomáš

;

Poprach, Alexandr

2025

,

Clinical & Experimental Metastasis

,

42

(5)

Renal cell cancer (RCC) is typically a disease of older adults, who often have comorbidities requiring the use of multiple concomitant medications. Even though the patients with metastatic RCC (mRCC) are often exposed to ...

Integrative miRNOMe profiling reveals the miR-195-5p–CHEK1 axis and its impact on luminal breast cancer outcomes

original article

open access

published version

Boušková, Veronika

;

Ehrlichová, Marie

;

Spálenková, Alžběta

;

Krus, Ivona

;

Šůsová, Simona

;

Hlaváč, Viktor

;

Němcová, Vlasta

;

Koževnikovová, Renata

;

Trnková, Markéta

;

Vrána, David

;

Gatěk, Jiří

;

Kopečková, Kateřina

;

Mrhalová, Marcela

;

Měšťáková, Soňa

;

Souček, Pavel

2025

,

John Wiley & Sons

,

Molecular Oncology

,

19

(11)

The luminal subtype (estrogen receptor-positive, ER+) is the most common and the most heterogeneous type of breast carcinoma (BC) in women. During our study, we determined expression levels of all microRNAs (miRNome) in ...

Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab

original article

open access

submitted version

Fiala, Ondřej

;

Rejleková, Katarína

;

Büchler, Tomáš

;

Študentová, Hana

;

Poprach, Alexandr

;

Vočka, Michal

;

Hošek, Petr

;

Kopecký, Jindřich

;

Matějů, Martin

;

Zemánková, Anežka

;

Spisarová, Martina

;

Tkadlecová, Michaela

;

Priester, Peter

;

Kouřil, Jan

;

Lohynská, Radka

;

Grmelová, Lucie

;

Savka, Alexander

;

Štefániková, Katarína

;

Obertová, Jana

;

Šiková, Dominika

;

Stránský, Petr

;

Melichar, Bohuslav

;

Palacka, Patrik

2025

,

Springer Nature

,

Scientific Reports

The role of eosinophils in patients with cancer receiving systemic therapy based on immune checkpoint inhibitors (ICIs) has become a subject of increasing interest. The aim of the present study was to assess the prognostic ...

Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer

original article

open access

published version

Danešová, Natálie

;

Horak, Josef

;

Valíčková, Anna

;

Gil-Korilis, Adrian

;

Ergui-Arbizu, Jorge

;

Pálek, Richard

;

Brůha, Jan

;

Levý, Miroslav

;

Škrobánek, Pavel

;

Král, Jan

;

Jungwirth, Jiří

;

Neužil, Jiří

;

Vymetálková, Veronika

;

Vodička, Pavel

;

Vodenková, Soňa

;

Tomášová, Kristýna

2025

,

North Shore-Long Island Jewish Research Institute

,

Molecular Medicine

,

31

(November)

BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...

Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer

original article

open access

accepted version

Danešová, Natálie

;

Horak, Josef

;

Valíčková, Anna

;

Gil-Korilis, Adrian

;

Ergui-Arbizu, Jorge

;

Pálek, Richard

;

Brůha, Jan

;

Levý, Miroslav

;

Škrobánek, Pavel

;

Král, Jan

;

Jungwirth, Jiří

;

Neužil, Jiří

;

Vymetálková, Veronika

;

Vodička, Pavel

;

Vodenková, Soňa

;

Tomášová, Kristýna

2025

,

North Shore-Long Island Jewish Research Institute

,

Molecular Medicine

,

31

(November)

BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...