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Concomitant antihypertensive medication and outcome of patients with metastatic castration-resistant prostate cancer receiving enzalutamide or abiraterone acetate

original article

open access

published version

Fiala, Ondřej

;

Hošek, Petr

;

Korunková, Hana

;

Hora, Milan

;

Kolář, Jiří

;

Šorejs, Ondřej

;

Topolčan, Ondřej

;

Filipovský, Jan

;

Liška, Václav

;

Santoni, Matteo

;

Buti, Sebastiano

;

Fínek, Jindřich

2024

,

Cancer Medicine

,

13

(1)

BACKGROUND: The introduction of novel hormonal therapies represented by enzalutamide (ENZ) and abiraterone acetate (ABI) has reached a great progress in the treatment of metastatic castration-resistant prostate cancer ...

Giant Cell Temporal Arteritis Followed by Severe Encephalopathy Induced by Immunotherapy in a Patient with Metastatic Renal Cell Carcinoma Achieving Durable Partial Response: A Case Report

casuistics

open access

published version

Fiala, Ondřej

;

Tkadlecová, Michaela

;

Pivovarčíková, Kristýna

;

Baxa, Jan

;

Stránský, Petr

;

Šiková, Dominika

;

Hora, Milan

;

Fínek, Jindřich

2024

,

Case Reports in Oncology

,

17

(1)

Introduction: Combined immuno-oncology (IO) regimens are the cornerstone of the current front-line systemic therapy for metastatic renal cell carcinoma (mRCC). Despite the fact that combined IO regimens show high efficacy, ...

Prognostic Role of Prostate-specific Antigen Isoforms and Their Early Kinetics in Patients With Metastatic Castration-resistant Prostate Cancer Receiving New Generation Androgen Receptor Targeted Agents

original article

open access

published version

Fiala, Ondřej

;

Hošek, Petr

;

Korunková, Hana

;

Tkadlecová, Michaela

;

Hora, Milan

;

Šiková, Dominika

;

Stránský, Petr

;

Fínek, Jindřich

;

Kučera, Radek

;

Windrichová, Jindra

;

Topolčan, Ondřej

2025

,

Iōannīs G. Delīnasios

,

In Vivo

,

39

(2)

BACKGROUND/AIM: New generation androgen receptor-targeting agents (ARTA) have been in the spotlight for their efficacy in metastatic castration-resistant prostate cancer (mCRPC). Prostate-specific antigen (PSA) represents ...

Association of long-term treatment outcomes with changes in PET/MRI characteristics and the type of early treatment response during concurrent radiochemotherapy in patients with locally advanced cervical cancer

original article

open access

published version

Vojtíšek, Radovan

;

Baxa, Jan

;

Hošek, Petr

;

Kovářová, Petra

;

Vítovec, Martin

;

Sukovská, Emília

;

Kosťun, Jan

;

Vlasák, Pavel

;

Presl, Jiří

;

Ferda, Jiří

;

Fínek, Jindřich

2025

,

Urban u. Vogel

,

Strahlentherapie und Onkologie

,

201

(5)

PURPOSE: We aimed to find predictive tumour characteristics as detected by interim positron-emission tomography/magnetic resonance imaging (PET/MRI) in cervical cancer patients. We also investigated the type of interim ...

Pembrolizumab versus Pembrolizumab plus Chemotherapy in Non-small Cell Lung Cancer with High PD-L1 Expression - Multicenter Real-world Evidence Study

original article

open access

published version

Svatoň, Martin

;

Knetki-Wroblewska, Magdalena

;

Hošek, Petr

;

Chowaniecova, Gabriela

;

Špaček, Jan

;

Fischer, Ondřej

;

Bílek, Ondřej

;

Hrnčiarik, Michal

;

Kauffmann-Guerrero, Diego

2025

,

Ivyspring International Publisher

,

Journal of Cancer

,

16

(10)

Background: Patients with non-small cell lung cancer (NSCLC) with PD-Ll expression ~ 50% can be treated with immunotherapy alone or with a combination of immunotherapy and chemotherapy. One of these options is treatment ...

Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases

original article

open access

published version

Heczko, Lucie

;

Hlaváč, Viktor

;

Holý, Petr

;

Dvořák, Pavel

;

Liška, Václav

;

Vyčítal, Ondřej

;

Fiala, Ondřej

;

Souček, Pavel

2023

,

Cancer Cell International

,

23

(1)

Background: Colorectal cancer is a highly prevalent and deadly. The most common metastatic site is the liver. We performed a whole exome sequencing analysis of a series of metachronous colorectal cancer liver metastases ...

Impact of concomitant use of proton pump inhibitors or cardiovascular medication on survival outcomes of patients with metastatic renal cell carcinoma treated with nivolumab

original article

open access

published version

Fiala, Ondřej

;

Hošek, Petr

;

Tkadlecová, Michaela

;

Melichar, Bohuslav

;

Zemánková, Anežka

;

Kopecký, Jindřich

;

Vočka, Michal

;

Matějů, Martin

;

Lohynská, Radka

;

Šiková, Dominika

;

Stránský, Petr

;

Študentová, Hana

;

Spisarová, Martina

;

Nováková, Hana

;

Priester, Peter

;

Kryštofová, Dominika

;

Grmelová, Lucie

;

Büchler, Tomáš

;

Poprach, Alexandr

2025

,

Clinical & Experimental Metastasis

,

42

(5)

Renal cell cancer (RCC) is typically a disease of older adults, who often have comorbidities requiring the use of multiple concomitant medications. Even though the patients with metastatic RCC (mRCC) are often exposed to ...

Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab

original article

open access

submitted version

Fiala, Ondřej

;

Rejleková, Katarína

;

Büchler, Tomáš

;

Študentová, Hana

;

Poprach, Alexandr

;

Vočka, Michal

;

Hošek, Petr

;

Kopecký, Jindřich

;

Matějů, Martin

;

Zemánková, Anežka

;

Spisarová, Martina

;

Tkadlecová, Michaela

;

Priester, Peter

;

Kouřil, Jan

;

Lohynská, Radka

;

Grmelová, Lucie

;

Savka, Alexander

;

Štefániková, Katarína

;

Obertová, Jana

;

Šiková, Dominika

;

Stránský, Petr

;

Melichar, Bohuslav

;

Palacka, Patrik

2025

,

Springer Nature

,

Scientific Reports

The role of eosinophils in patients with cancer receiving systemic therapy based on immune checkpoint inhibitors (ICIs) has become a subject of increasing interest. The aim of the present study was to assess the prognostic ...