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Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer

original article

open access

published version

Piccinno, Gianmarco

;

Thompson, Kelsey N.

;

Manghi, Paolo

;

Ghazi, Andrew R.

;

Thomas, Andrew Maltez

;

Blanco-Miguez, Aitor

;

Asnicar, Francesco

;

Mladenovic, Katarina

;

Pinto, Federica

;

Armanini, Federica

;

Puncochar, Michal

;

Piperni, Elisa

;

Heidrich, Vitor

;

Fackelmann, Gloria

;

Ferrero, Giulio

;

Tarallo, Sonia

;

Nguyen, Long H.

;

Yan, Yan

;

Keles, Nazim A.

;

Tuna, Bilge G.

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Vymetálková, Veronika

;

Trompetto, Mario

;

Liška, Václav

;

Hucl, Tomáš

;

Vodička, Pavel

;

Bencsikova, Beatrix

;

Carnogurska, Martina

;

Popovici, Vlad

;

Marmorino, Federica

;

Cremolini, Chiara

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Pardini, Barbara

;

Cordero, Francesca

;

Song, Mingyang

;

Chan, Andrew T.

;

Derosa, Lisa

;

Zitvogel, Laurence

;

Huttenhower, Curtis

;

Naccarati, Alessio

;

Budinska, Eva

;

Segata, Nicola

2025

,

Nature Medicine

,

31

(7)

Associations between the gut microbiome and colorectal cancer (CRC) have been uncovered, but larger and more diverse studies are needed to assess their potential clinical use. We expanded upon 12 metagenomic datasets of ...

Percutaneous transthoracic needle biopsy of lung lesions is a safe method associated with a very low risk of pleural recurrence

original article

open access

published version

Svatoň, Martin

;

Havel, David

;

Burešová, Marcela

;

Baxa, Jan

;

Hošek, Petr

2025

,

Biomedical Papers

,

169

(1)

AIM: Percutaneous transthoracic needle biopsy (PTNB), an alternative to bronchoscopic confirmation of lung lesions, is today being associated with a risk of pneumothorax and hemorrhage. Further, there are no data on the ...

Prognostic Role of Prostate-specific Antigen Isoforms and Their Early Kinetics in Patients With Metastatic Castration-resistant Prostate Cancer Receiving New Generation Androgen Receptor Targeted Agents

original article

open access

published version

Fiala, Ondřej

;

Hošek, Petr

;

Korunková, Hana

;

Tkadlecová, Michaela

;

Hora, Milan

;

Šiková, Dominika

;

Stránský, Petr

;

Fínek, Jindřich

;

Kučera, Radek

;

Windrichová, Jindra

;

Topolčan, Ondřej

2025

,

Iōannīs G. Delīnasios

,

In Vivo

,

39

(2)

BACKGROUND/AIM: New generation androgen receptor-targeting agents (ARTA) have been in the spotlight for their efficacy in metastatic castration-resistant prostate cancer (mCRPC). Prostate-specific antigen (PSA) represents ...

Association of long-term treatment outcomes with changes in PET/MRI characteristics and the type of early treatment response during concurrent radiochemotherapy in patients with locally advanced cervical cancer

original article

open access

published version

Vojtíšek, Radovan

;

Baxa, Jan

;

Hošek, Petr

;

Kovářová, Petra

;

Vítovec, Martin

;

Sukovská, Emília

;

Kosťun, Jan

;

Vlasák, Pavel

;

Presl, Jiří

;

Ferda, Jiří

;

Fínek, Jindřich

2025

,

Urban u. Vogel

,

Strahlentherapie und Onkologie

,

201

(5)

PURPOSE: We aimed to find predictive tumour characteristics as detected by interim positron-emission tomography/magnetic resonance imaging (PET/MRI) in cervical cancer patients. We also investigated the type of interim ...

Non-viral HCC miRNA profiling reveals miR-1972 as a potential positive prognostic marker

original article

open access

published version

Mallela, Venkata Ramana

;

Rajtmajerová, Marie

;

Ali, Esraa

;

Červenková, Lenka

;

Trailin, Andriy

;

Hošek, Petr

;

Pálek, Richard

;

Daum, Ondřej

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Ambrożkiewicz, Filip

2025

,

Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

,

Non-coding RNA Research

,

15

(December)

Background & Aims: Hepatocellular carcinoma (HCC) is the third deadliest cancer worldwide. Its high mortality is primarily attributed to late-stage diagnosis. While mutations in driver genes, such as those encoding β-catenin ...

One-Step Nucleic Acid Amplification Analysis of Sentinel Lymphatic Nodes in Endometrial Cancer Patients (EU-OSNA): A European Multicenter Diagnostic Accuracy Study

original article

open access

published version

Kosťun, Jan

;

Nowosielski, Krzysztof

;

Jedryka, Marcin A

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Hardisson, David

;

Restaino, Stefano

;

Gatius, Sonia

;

Novak, Zoltan

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Lacalle, Amaia Sagasta

;

Lopez, Susana

;

Pešta, Martin

;

Zebalski, Marcin

;

Lepka, Piotr

;

Diestro, María Dolores

;

Vizzielli, Giuseppe

;

Matias-Guiu, Xavier

;

Echim, Tímea

;

Urkaray, Emma Natalia Camacho

;

Rienda, Iván

;

Slunečko, Robert

;

Czekanski, Andrzej

;

Berjón, Alberto

;

Mariuzzi, Laura

;

Velasco, Ana

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Betenbuk, Judit

;

Merino, Isabel Guerra

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Padilla-Iserte, Pablo

;

Stráník, Petr

;

Smoligová, Vendula

;

Presl, Jiří

2025

,

Blackwell Publishing

,

Cancer Medicine

,

14

(18)

OBJECTIVE: This European multicenter study aimed to assess the diagnostic accuracy of one-step nucleic acid amplification (OSNA) as the primary endpoint by comparing this method with ultrastaging for the detection of ...

Pembrolizumab versus Pembrolizumab plus Chemotherapy in Non-small Cell Lung Cancer with High PD-L1 Expression - Multicenter Real-world Evidence Study

original article

open access

published version

Svatoň, Martin

;

Knetki-Wroblewska, Magdalena

;

Hošek, Petr

;

Chowaniecova, Gabriela

;

Špaček, Jan

;

Fischer, Ondřej

;

Bílek, Ondřej

;

Hrnčiarik, Michal

;

Kauffmann-Guerrero, Diego

2025

,

Ivyspring International Publisher

,

Journal of Cancer

,

16

(10)

Background: Patients with non-small cell lung cancer (NSCLC) with PD-Ll expression ~ 50% can be treated with immunotherapy alone or with a combination of immunotherapy and chemotherapy. One of these options is treatment ...

Monitoring the Alternative Pathway of Meropenem Degradation by OXA-48-Type Carbapenemases

abstract in conference proceedings

open access

published version

Študentová, Vendula

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Pašková, Veronika

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Ďaďovská, Lucia

;

Hrabák, Jaroslav

2025

,

Praha

,

Česká společnost chemická

,

Czech Chemical Society Symposium Series

,

23

(4)

Background:Overuse of carbapenems has been associated with an increasing prevalence of resistance, particularly among the Enterobacterales, Pseudomonasspp., and Acinetobacter spp. Resistance is mediated by the ...

A post-COVID-19 upsurge in Group A Streptococcus in the Czech Republic was driven by emm1 and emm12 with shared virulence factors

original article

open access

published version

Štefan, Marek

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Prasad, Suhanya Veronica

;

Vitkova, Ivana

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Nycova, Elka

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Ryšková, Lenka

;

Kucova, Pavla

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Geigerová, Lenka

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Vesela, Denisa

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Balejova, Magda

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Bartonikova, Natasa

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Havlinova, Lenka

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Czyzova, Erika

;

Kubele, Jan

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Dratvová, Barbora

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Antušková, Milena

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Zíková, Jaroslava

;

Brajerová, Marie

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Nyč, Otakar

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Dřevínek, Pavel

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Trojánek, Milan

;

Krůtová, Marcela

2025

,

Elsevier

,

Journal of Infection and Public Health

,

18

(10)

BACKGROUND: In 2023, a significant increase in Streptococcus pyogenes, Group A Streptococcus (GAS) culture positivity was observed in Czech microbiological laboratories. We conducted a multicentre study to obtain epidemiological ...

Impact of concomitant use of proton pump inhibitors or cardiovascular medication on survival outcomes of patients with metastatic renal cell carcinoma treated with nivolumab

original article

open access

published version

Fiala, Ondřej

;

Hošek, Petr

;

Tkadlecová, Michaela

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Melichar, Bohuslav

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Zemánková, Anežka

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Kopecký, Jindřich

;

Vočka, Michal

;

Matějů, Martin

;

Lohynská, Radka

;

Šiková, Dominika

;

Stránský, Petr

;

Študentová, Hana

;

Spisarová, Martina

;

Nováková, Hana

;

Priester, Peter

;

Kryštofová, Dominika

;

Grmelová, Lucie

;

Büchler, Tomáš

;

Poprach, Alexandr

2025

,

Clinical & Experimental Metastasis

,

42

(5)

Renal cell cancer (RCC) is typically a disease of older adults, who often have comorbidities requiring the use of multiple concomitant medications. Even though the patients with metastatic RCC (mRCC) are often exposed to ...