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SMARCA4-deficient carcinoma of the head and neck region: report of 8 new sinonasal and non-sinonasal cases and literature review

original article

open access

published version

Farkas, Mihaela

;

Agaimy, Abbas

;

Švajdler, Marián

;

Hauer, Lukáš

;

Martínek, Petr

;

Vaněček, Tomáš

;

Pivovarčíková, Kristýna

;

Prchlíková, Barbora

;

Simpson, Roderick H W

;

Gočárová, Klaudia

;

Vereš, Peter

;

Slavík, Petr

;

Behenská, Kristýna

;

Marjanovic, Ksenija

;

Michal, Michal

;

Skálová, Alena

;

Bradová, Martina

2026

,

Springer

,

Virchows Archiv

,

488

(5)

Neoplasms with inactivating mutations in SWI/SNF chromatin remodeling complex subunits gained attention in the head and neck (H&N) region due to their poor clinical outcomes. The sinonasal tract is a recognized "hot-spot" ...

The Prognostic Role of Baseline and Early Dynamics of Peripheral Blood Cell Ratios in Metastatic Renal Cell Carcinoma Patients Treated With Nivolumab

original article

open access

published version

Fiala, Ondřej

;

Tkadlecová, Michaela

;

Kopecký, Jindřich

;

Hošek, Petr

;

Studentova, Hana

;

Vočka, Michal

;

Matějů, Martin

;

Lohynská, Radka

;

Šiková, Dominika

;

Stránský, Petr

;

Kučera, Radek

;

Zemankova, Anezka

;

Spisarova, Martina

;

Priester, Peter

;

Kouril, Jan

;

Büchler, Tomáš

;

Grmelova, Lucie

;

Melichar, Bohuslav

;

Poprach, Alexandr

2026

,

Iōannīs G. Delīnasios

,

In Vivo

,

40

(2)

BACKGROUND/AIM: Immune checkpoint inhibitors (ICI), including nivolumab, have become the cornerstone of systemic treatment in metastatic renal cell carcinoma (mRCC). Blood-derived biomarkers including neutrophil-to-lymphocyte ...

SHARED AND NON-SHARED MUTATIONS IN APC AND TP53 GENES IN PAIRED PRIMARY AND METASTATIC COLORECTAL CANCER FROM SYNCHRONOUS AND METACHRONOUS PATIENTS

original article

open access

submitted version

Ambrożkiewicz, Filip

;

Rajtmajerová, Marie

;

Hlaváč, Viktor

;

Trailin, Andriy

;

Červenková, Lenka

;

Brůha, Jan

;

Šůsová, Simona

;

Souček, Pavel

;

Vodička, Pavel

;

Vodičková, Ľudmila

;

Kubeček, Ondřej

;

Filip, Stanislav

;

Mallela, Venkata Ramana

;

Ye, Wenjing

;

Liška, Václav

;

Hemminki, Kari Jussi

2026

BackgroundMutational cascades in colorectal cancer (CRC) between the primary tumor (pCRC) and liver metasta-sis (LM) are poorly understood in individual patients. We focused on differences in specific APC and TP53 mutations ...

Mutational landscape of lung adenocarcinoma in Czechia

original article

open access

published version

Ambrożkiewicz, Filip

;

Ali, Esraa

;

Bradová, Martina

;

Slavík, Petr

;

Martínek, Petr

;

Svatoň, Martin

;

Hemminki, Akseli

;

Hemminki, Kari Jussi

2026

,

Elsevier Inc.

,

Cancer Treatment and Research Communications

,

46

(January)

Limited DNA sequencing data on lung cancer (LC) patients are available from Eastern Europe where male smoking is commonest in Europe. As sequence analysis is the prerequisite for targeted therapy we provide such data from ...

Clonal outbreak of an extensively drug-resistant NDM-1 producing Pseudomonas aeruginosa in a local hospital in the Czech Republic

original article

open access

published version

Chudějová, Kateřina

;

Sourenian-Samuelian, Tsolaire

;

Finianos, Marc

;

Šrámková, Anna

;

Papagiannitsis, Costas C

;

Hrabák, Jaroslav

;

Bitar, Ibrahim

2026

,

ASM Press

,

Microbiology Spectrum

,

14

(1)

A clonal outbreak of 18 ST773 NDM-1 producing Pseudomonas aeruginosa strains has been detected for the first time in the Czech Republic. The strains were extremely drug-resistant (XDR) and resistant to serum killing. ...

Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab

original article

open access

accepted version

Fiala, Ondřej

;

Rejleková, Katarína

;

Büchler, Tomáš

;

Študentová, Hana

;

Poprach, Alexandr

;

Vočka, Michal

;

Hošek, Petr

;

Kopecký, Jindřich

;

Matějů, Martin

;

Zemánková, Anežka

;

Spisarová, Martina

;

Tkadlecová, Michaela

;

Priester, Peter

;

Kouřil, Jan

;

Lohynská, Radka

;

Grmelová, Lucie

;

Savka, Alexander

;

Štefániková, Katarína

;

Obertová, Jana

;

Šiková, Dominika

;

Stránský, Petr

;

Melichar, Bohuslav

;

Palacka, Patrik

2026

,

Springer Nature

,

Scientific Reports

,

16

(1)

The role of eosinophils in patients with cancer receiving systemic therapy based on immune checkpoint inhibitors (ICIs) has become a subject of increasing interest. The aim of the present study was to assess the prognostic ...

Distribution and prognostic value of macrophages in colorectal cancer and adjacent mucosa in patient stages I-III vs IV

original article

open access

published version

Ye, Wenjing

;

Ali, Esraa

;

Pavlov, Sergii

;

Červenková, Lenka

;

Ambrożkiewicz, Filip

;

Vyčítal, Ondřej

;

Hošek, Petr

;

Zitrický, František

;

Daum, Ondřej

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Trailin, Andriy

2026

,

Baishideng Publishing Group

,

World Journal of Gastroenterology

,

32

(10)

BACKGROUND: Synchronous and metachronous liver metastases (LM) of colorectal cancer (CRC) drastically worsen the patient's survival. The biological and immunological mechanisms underlying these distinct metastatic ...

Clinicopathologic features of KRAS G12C-mutated non-small cell lung carcinomas:insights from 279 retrospective cases

original article

open access

published version

Bradová, Martina

;

Slavík, Petr

;

Vaněček, Tomáš

;

Martínek, Petr

;

Grossmann, Petr

;

Kormunda, Stanislav

;

Behenská, Kristýna

;

Svatoň, Martin

;

Pešek, Miloš

;

Jirásek, Tomáš

;

Špůrková, Zuzana

;

Hroudová, Petra

;

Mrázková, Hana

;

Hořavová, Barbora

;

Roubec, Jaromír

;

Baník, Martin

;

Mukenšnabl, Petr

;

Michal, Michal

;

Švajdler, Marián

2026

,

Springer

,

Virchows Archiv

,

489

(1)

KRAS G12C-mutated non-small cell lung carcinoma (NSCLC), caused by a glycine-to-cysteine substitution at codon 12, is associated with poor prognosis and is now targetable with specific inhibitors. We retrospectively analyzed ...

Prognostic Role of Serum Neuron-Specific Enolase at Baseline and its Early Dynamics in Metastatic Castration-Resistant Prostate Cancer Treated With Androgen Receptor Signaling Inhibitors

original article

open access

published version

Fiala, Ondřej

;

Tkadlecová, Michaela

;

Váchalová, Zuzana

;

Hora, Milan

;

Králíček, Jan

;

Stránský, Petr

;

Liška, Václav

;

Santoni, Matteo

;

Banna, Giuseppe Luigi

;

Pivovarčíková, Kristýna

;

Topolčan, Ondřej

;

Fínek, Jindřich

2026

,

Wiley

,

Prostate

,

86

(11)

BACKGROUND: Outcomes of metastatic castration-resistant prostate cancer (mCRPC) treated with androgen receptor signaling inhibitors (ARSIs) vary widely and may not be fully reflected by PSA and standard clinicopathologic ...

Evolving Concepts in Salivary Duct Carcinoma: A Narrative Review

original article

open access

published version

Masalunga, Marvin C

;

Bradley, Patrick J

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van Herpen, Carla

;

Nagao, Toshitaka

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Stenman, Göran

;

Vander Poorten, Vincent

;

Hellquist, Henrik

;

Di Palma, Silvana

;

Bradová, Martina

;

Leivo, Ilmo

;

Ferlito, Alfio

;

Skálová, Alena

2026

,

Springer Internat. Publ.

,

Oncology and Therapy

Salivary duct carcinoma (SDC) is an aggressive neoplasm that typically involves the major salivary glands. This rapidly growing tumor is known to recur and metastasize to the neck nodes and to distant sites. Given its poor ...

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