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Concomitant antihypertensive medication and outcome of patients with metastatic castration-resistant prostate cancer receiving enzalutamide or abiraterone acetate

original article

open access

published version

Fiala, Ondřej

;

Hošek, Petr

;

Korunková, Hana

;

Hora, Milan

;

Kolář, Jiří

;

Šorejs, Ondřej

;

Topolčan, Ondřej

;

Filipovský, Jan

;

Liška, Václav

;

Santoni, Matteo

;

Buti, Sebastiano

;

Fínek, Jindřich

2024

,

Cancer Medicine

,

13

(1)

BACKGROUND: The introduction of novel hormonal therapies represented by enzalutamide (ENZ) and abiraterone acetate (ABI) has reached a great progress in the treatment of metastatic castration-resistant prostate cancer ...

Giant Cell Temporal Arteritis Followed by Severe Encephalopathy Induced by Immunotherapy in a Patient with Metastatic Renal Cell Carcinoma Achieving Durable Partial Response: A Case Report

casuistics

open access

published version

Fiala, Ondřej

;

Tkadlecová, Michaela

;

Pivovarčíková, Kristýna

;

Baxa, Jan

;

Stránský, Petr

;

Šiková, Dominika

;

Hora, Milan

;

Fínek, Jindřich

2024

,

Case Reports in Oncology

,

17

(1)

Introduction: Combined immuno-oncology (IO) regimens are the cornerstone of the current front-line systemic therapy for metastatic renal cell carcinoma (mRCC). Despite the fact that combined IO regimens show high efficacy, ...

The Prognostic Role of Baseline and Early Dynamics of Peripheral Blood Cell Ratios in Metastatic Renal Cell Carcinoma Patients Treated With Nivolumab

original article

open access

published version

Fiala, Ondřej

;

Tkadlecová, Michaela

;

Kopecký, Jindřich

;

Hošek, Petr

;

Studentova, Hana

;

Vočka, Michal

;

Matějů, Martin

;

Lohynská, Radka

;

Šiková, Dominika

;

Stránský, Petr

;

Kučera, Radek

;

Zemankova, Anezka

;

Spisarova, Martina

;

Priester, Peter

;

Kouril, Jan

;

Büchler, Tomáš

;

Grmelova, Lucie

;

Melichar, Bohuslav

;

Poprach, Alexandr

2026

,

Iōannīs G. Delīnasios

,

In Vivo

,

40

(2)

BACKGROUND/AIM: Immune checkpoint inhibitors (ICI), including nivolumab, have become the cornerstone of systemic treatment in metastatic renal cell carcinoma (mRCC). Blood-derived biomarkers including neutrophil-to-lymphocyte ...

Prognostic Role of Prostate-specific Antigen Isoforms and Their Early Kinetics in Patients With Metastatic Castration-resistant Prostate Cancer Receiving New Generation Androgen Receptor Targeted Agents

original article

open access

published version

Fiala, Ondřej

;

Hošek, Petr

;

Korunková, Hana

;

Tkadlecová, Michaela

;

Hora, Milan

;

Šiková, Dominika

;

Stránský, Petr

;

Fínek, Jindřich

;

Kučera, Radek

;

Windrichová, Jindra

;

Topolčan, Ondřej

2025

,

Iōannīs G. Delīnasios

,

In Vivo

,

39

(2)

BACKGROUND/AIM: New generation androgen receptor-targeting agents (ARTA) have been in the spotlight for their efficacy in metastatic castration-resistant prostate cancer (mCRPC). Prostate-specific antigen (PSA) represents ...

Association of long-term treatment outcomes with changes in PET/MRI characteristics and the type of early treatment response during concurrent radiochemotherapy in patients with locally advanced cervical cancer

original article

open access

published version

Vojtíšek, Radovan

;

Baxa, Jan

;

Hošek, Petr

;

Kovářová, Petra

;

Vítovec, Martin

;

Sukovská, Emília

;

Kosťun, Jan

;

Vlasák, Pavel

;

Presl, Jiří

;

Ferda, Jiří

;

Fínek, Jindřich

2025

,

Urban u. Vogel

,

Strahlentherapie und Onkologie

,

201

(5)

PURPOSE: We aimed to find predictive tumour characteristics as detected by interim positron-emission tomography/magnetic resonance imaging (PET/MRI) in cervical cancer patients. We also investigated the type of interim ...

Impact of concomitant use of proton pump inhibitors or cardiovascular medication on survival outcomes of patients with metastatic renal cell carcinoma treated with nivolumab

original article

open access

published version

Fiala, Ondřej

;

Hošek, Petr

;

Tkadlecová, Michaela

;

Melichar, Bohuslav

;

Zemánková, Anežka

;

Kopecký, Jindřich

;

Vočka, Michal

;

Matějů, Martin

;

Lohynská, Radka

;

Šiková, Dominika

;

Stránský, Petr

;

Študentová, Hana

;

Spisarová, Martina

;

Nováková, Hana

;

Priester, Peter

;

Kryštofová, Dominika

;

Grmelová, Lucie

;

Büchler, Tomáš

;

Poprach, Alexandr

2025

,

Clinical & Experimental Metastasis

,

42

(5)

Renal cell cancer (RCC) is typically a disease of older adults, who often have comorbidities requiring the use of multiple concomitant medications. Even though the patients with metastatic RCC (mRCC) are often exposed to ...

Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases

original article

open access

published version

Heczko, Lucie

;

Hlaváč, Viktor

;

Holý, Petr

;

Dvořák, Pavel

;

Liška, Václav

;

Vyčítal, Ondřej

;

Fiala, Ondřej

;

Souček, Pavel

2023

,

Cancer Cell International

,

23

(1)

Background: Colorectal cancer is a highly prevalent and deadly. The most common metastatic site is the liver. We performed a whole exome sequencing analysis of a series of metachronous colorectal cancer liver metastases ...

Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab

original article

open access

accepted version

Fiala, Ondřej

;

Rejleková, Katarína

;

Büchler, Tomáš

;

Študentová, Hana

;

Poprach, Alexandr

;

Vočka, Michal

;

Hošek, Petr

;

Kopecký, Jindřich

;

Matějů, Martin

;

Zemánková, Anežka

;

Spisarová, Martina

;

Tkadlecová, Michaela

;

Priester, Peter

;

Kouřil, Jan

;

Lohynská, Radka

;

Grmelová, Lucie

;

Savka, Alexander

;

Štefániková, Katarína

;

Obertová, Jana

;

Šiková, Dominika

;

Stránský, Petr

;

Melichar, Bohuslav

;

Palacka, Patrik

2026

,

Springer Nature

,

Scientific Reports

,

16

(1)

The role of eosinophils in patients with cancer receiving systemic therapy based on immune checkpoint inhibitors (ICIs) has become a subject of increasing interest. The aim of the present study was to assess the prognostic ...

Prognostic Role of Serum Neuron-Specific Enolase at Baseline and its Early Dynamics in Metastatic Castration-Resistant Prostate Cancer Treated With Androgen Receptor Signaling Inhibitors

original article

open access

published version

Fiala, Ondřej

;

Tkadlecová, Michaela

;

Váchalová, Zuzana

;

Hora, Milan

;

Králíček, Jan

;

Stránský, Petr

;

Liška, Václav

;

Santoni, Matteo

;

Banna, Giuseppe Luigi

;

Pivovarčíková, Kristýna

;

Topolčan, Ondřej

;

Fínek, Jindřich

2026

,

Wiley

,

Prostate

,

86

(11)

BACKGROUND: Outcomes of metastatic castration-resistant prostate cancer (mCRPC) treated with androgen receptor signaling inhibitors (ARSIs) vary widely and may not be fully reflected by PSA and standard clinicopathologic ...

Spatial Profiling and Prognostic Role of Tumor-Infiltrating CD8+T and CD20+B Cells in Metastatic Clear Cell Renal Cell Carcinoma Treated with Sequential Tyrosine Kinase Inhibitors and Nivolumab

original article

open access

published version

Trailin, Andriy

;

Červenková, Lenka

;

Hošek, Petr

;

Pivovarčíková, Kristýna

;

Tkadlecová, Michaela

;

Stránský, Petr

;

Hemminki, Kari Jussi

;

Fiala, Ondřej

2026

,

Ivyspring International Publisher

,

Journal of Cancer

,

17

(2)

Background: Tumor-infiltrating lymphocytes (TILs) are known to influence disease progression and treatment response in clear cell renal cell carcinoma. This study aimed at evaluating the prognostic and predictive relevance ...