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Emerging Role of Circulating Cell-Free RNA as a Non-Invasive Biomarker for Hepatocellular Carcinoma

original article

open access

published version

Shetti, Dattatrya

;

Mallela, Venkata Ramana

;

Ye, Wenjing

;

Sharif Bagheri, Mahyar

;

Ambrożkiewicz, Filip

;

Trailin, Andriy

;

Liška, Václav

;

Hemminki, Kari Jussi

2024

,

Critical Reviews in Oncology/Hematology

,

200

(August)

Hepatocellular carcinoma (HCC) is a severe neoplastic disease associated with high morbidity and mortality rates. HCC is often detected at advanced stages leading to ineffective curative treatments. Recently, liquid biopsy ...

Concomitant antihypertensive medication and outcome of patients with metastatic castration-resistant prostate cancer receiving enzalutamide or abiraterone acetate

original article

open access

published version

Fiala, Ondřej

;

Hošek, Petr

;

Korunková, Hana

;

Hora, Milan

;

Kolář, Jiří

;

Šorejs, Ondřej

;

Topolčan, Ondřej

;

Filipovský, Jan

;

Liška, Václav

;

Santoni, Matteo

;

Buti, Sebastiano

;

Fínek, Jindřich

2024

,

Cancer Medicine

,

13

(1)

BACKGROUND: The introduction of novel hormonal therapies represented by enzalutamide (ENZ) and abiraterone acetate (ABI) has reached a great progress in the treatment of metastatic castration-resistant prostate cancer ...

Small nucleolar RNA expression profiles: A potential prognostic biomarker for non-viral Hepatocellular carcinoma

original article

open access

published version

Mallela, Venkata Ramana

;

Kasi, Phanindra Babu

;

Shetti, Dattatrya

;

Trailin, Andriy

;

Červenková, Lenka

;

Pálek, Richard

;

Daum, Ondřej

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Ambrożkiewicz, Filip

2024

,

Non-coding RNA Research

,

9

(4)

Hepatocellular carcinoma (HCC) is a challenging cancer with high mortality rates, limited predictability, and a lack of effective prognostic indicators. The relationship between small nucleolar RNAs (snoRNAs) and HCC is ...

Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer

original article

open access

published version

Piccinno, Gianmarco

;

Thompson, Kelsey N.

;

Manghi, Paolo

;

Ghazi, Andrew R.

;

Thomas, Andrew Maltez

;

Blanco-Miguez, Aitor

;

Asnicar, Francesco

;

Mladenovic, Katarina

;

Pinto, Federica

;

Armanini, Federica

;

Puncochar, Michal

;

Piperni, Elisa

;

Heidrich, Vitor

;

Fackelmann, Gloria

;

Ferrero, Giulio

;

Tarallo, Sonia

;

Nguyen, Long H.

;

Yan, Yan

;

Keles, Nazim A.

;

Tuna, Bilge G.

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Vymetálková, Veronika

;

Trompetto, Mario

;

Liška, Václav

;

Hucl, Tomáš

;

Vodička, Pavel

;

Bencsikova, Beatrix

;

Carnogurska, Martina

;

Popovici, Vlad

;

Marmorino, Federica

;

Cremolini, Chiara

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Pardini, Barbara

;

Cordero, Francesca

;

Song, Mingyang

;

Chan, Andrew T.

;

Derosa, Lisa

;

Zitvogel, Laurence

;

Huttenhower, Curtis

;

Naccarati, Alessio

;

Budinska, Eva

;

Segata, Nicola

2025

,

Nature Medicine

,

31

(7)

Associations between the gut microbiome and colorectal cancer (CRC) have been uncovered, but larger and more diverse studies are needed to assess their potential clinical use. We expanded upon 12 metagenomic datasets of ...

Anatomical biliary reconstruction as an ultimum refugium for selective cases-History and current state of knowledge

summarizing article

open access

published version

Ševčík, Jan

;

Massaro, Maria Stefania

;

Pálek, Richard

;

Moulisová, Vladimíra

;

Liška, Václav

2024

,

Journal of Hepato-Biliary-Pancreatic Sciences

,

31

(11)

Reconstruction of extrahepatic bile ducts is a staple procedure of HPB surgery. The current standard for most cases is a nonanatomical bilioenteric reconstruction, a satisfactory option for the majority of patients. However, ...

Non-viral HCC miRNA profiling reveals miR-1972 as a potential positive prognostic marker

original article

open access

published version

Mallela, Venkata Ramana

;

Rajtmajerová, Marie

;

Ali, Esraa

;

Červenková, Lenka

;

Trailin, Andriy

;

Hošek, Petr

;

Pálek, Richard

;

Daum, Ondřej

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Ambrożkiewicz, Filip

2025

,

Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

,

Non-coding RNA Research

,

15

(December)

Background & Aims: Hepatocellular carcinoma (HCC) is the third deadliest cancer worldwide. Its high mortality is primarily attributed to late-stage diagnosis. While mutations in driver genes, such as those encoding β-catenin ...

SHARED AND NON-SHARED MUTATIONS IN APC AND TP53 GENES IN PAIRED PRIMARY AND METASTATIC COLORECTAL CANCER FROM SYNCHRONOUS AND METACHRONOUS PATIENTS

original article

open access

submitted version

Ambrożkiewicz, Filip

;

Rajtmajerová, Marie

;

Hlaváč, Viktor

;

Trailin, Andriy

;

Červenková, Lenka

;

Brůha, Jan

;

Šůsová, Simona

;

Souček, Pavel

;

Vodička, Pavel

;

Vodičková, Ľudmila

;

Kubeček, Ondřej

;

Filip, Stanislav

;

Mallela, Venkata Ramana

;

Ye, Wenjing

;

Liška, Václav

;

Hemminki, Kari Jussi

2026

BackgroundMutational cascades in colorectal cancer (CRC) between the primary tumor (pCRC) and liver metasta-sis (LM) are poorly understood in individual patients. We focused on differences in specific APC and TP53 mutations ...

Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases

original article

open access

published version

Heczko, Lucie

;

Hlaváč, Viktor

;

Holý, Petr

;

Dvořák, Pavel

;

Liška, Václav

;

Vyčítal, Ondřej

;

Fiala, Ondřej

;

Souček, Pavel

2023

,

Cancer Cell International

,

23

(1)

Background: Colorectal cancer is a highly prevalent and deadly. The most common metastatic site is the liver. We performed a whole exome sequencing analysis of a series of metachronous colorectal cancer liver metastases ...

Distribution and prognostic value of macrophages in colorectal cancer and adjacent mucosa in patient stages I-III vs IV

original article

open access

published version

Ye, Wenjing

;

Ali, Esraa

;

Pavlov, Sergii

;

Červenková, Lenka

;

Ambrożkiewicz, Filip

;

Vyčítal, Ondřej

;

Hošek, Petr

;

Zitrický, František

;

Daum, Ondřej

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Trailin, Andriy

2026

,

Baishideng Publishing Group

,

World Journal of Gastroenterology

,

32

(10)

BACKGROUND: Synchronous and metachronous liver metastases (LM) of colorectal cancer (CRC) drastically worsen the patient's survival. The biological and immunological mechanisms underlying these distinct metastatic ...

Prognostic Role of Serum Neuron-Specific Enolase at Baseline and its Early Dynamics in Metastatic Castration-Resistant Prostate Cancer Treated With Androgen Receptor Signaling Inhibitors

original article

open access

published version

Fiala, Ondřej

;

Tkadlecová, Michaela

;

Váchalová, Zuzana

;

Hora, Milan

;

Králíček, Jan

;

Stránský, Petr

;

Liška, Václav

;

Santoni, Matteo

;

Banna, Giuseppe Luigi

;

Pivovarčíková, Kristýna

;

Topolčan, Ondřej

;

Fínek, Jindřich

2026

,

Wiley

,

Prostate

,

86

(11)

BACKGROUND: Outcomes of metastatic castration-resistant prostate cancer (mCRPC) treated with androgen receptor signaling inhibitors (ARSIs) vary widely and may not be fully reflected by PSA and standard clinicopathologic ...

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