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Dexamethasone Acetate-Loaded PLGA Nanospheres Targeting Liver Macrophages

original article

open access

published version

Boltnarová, Barbora

;

Ďurinová, Anna

;

Jandová, Lenka

;

Mičuda, Stanislav

;

Kučera, Otto

;

Pávková, Ivona

;

Macháček, Miloslav

;

Němečková, Ivana

;

Vojta, Marek

;

Dušek, Jan

;

Krutáková, Mária

;

Nachtigal, Petr

;

Pávek, Petr

;

Holas, Ondřej

2025

,

Wiley-VCH-Verl.

,

Macromolecular Bioscience

,

25

(2)

Glucocorticoids are potent anti-inflammatory drugs, although their use is associated with severe side effects. Loading glucocorticoids into suitable nanocarriers can significantly reduce these undesirable effects. Macrophages ...

Adenosine promotes trophoblast proliferation without inducing differentiation or apoptosis

original article

open access

published version

Ali, Mohammed N. H.

;

Adler, Mariia

;

Novotná, Magdaléna

;

Gala, Viktor

;

Abad, Cilia

;

Štaud, František

;

Červený, Lukáš

2025

,

Harcourt

,

Placenta

,

172

(December)

Objective: Adenosine and other nucleosides are essential regulators of cellular processes, but their specific roles in trophoblast growth and regulation remain incompletely defined. This study investigated the effects of ...

Prenatal paroxetine dysregulates monoamine homeostasis and affects placental hemodynamics in the rat fetoplacental unit

original article

open access

published version

Horáčková, Hana

;

Musilová-Kacerovská, Ivana

;

Abad, Cilia

;

Karahoda, Rona

;

Váchalová, Veronika

;

Portillo, Ramón

;

Viňas-Noguera, Mireia

;

Yadunandam, Kasin

;

Heblík, Daniel

;

Cífková, Eva

;

Lísa, Miroslav

;

Štěrba, Martin

;

Stráník, Jaroslav

;

Bonnin, Alexandre

;

Štaud, František

2025

,

Elsevier

,

Biomedicine & Pharmacotherapy

,

192

(November)

Antidepressant use during pregnancy is increasingly common, with selective serotonin reuptake inhibitors (SSRIs) widely prescribed for maternal depression. However, growing evidence links prenatal SSRI exposure to adverse ...

Structure-Activity Relationships of Novel Pyrimidine Derivatives as potential antimycobacterial Agents

abstract in conference proceedings

open access

published version

Kufa, Martin

;

Kovář, Ondřej

;

Finger, Vladimír

;

Korábečný, Jan

;

Krátký, Martin

;

Roh, Jaroslav

2025

,

Praha

,

Česká společnost chemická

,

Czech Chemical Society Symposium Series

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains the leading cause of death from a single infectious agent, exerting severe health and economic burdens, particularly in Sub-Saharan Africa and South-East ...

Dynamic shifts in trophoblast nucleos(t)ide metabolism, transport, and adenosine signaling during gestation and preterm birth

original article

open access

published version

Ali, Mohammed

;

Adler, Mariia

;

Libra, Antonín

;

Vokřál, Ivan

;

Karahoda, Rona

;

Cífková, Eva

;

Lísa, Miroslav

;

Tomek, Jakub

;

Novotná, Magdaléna

;

Štaud, František

;

Červený, Lukáš

2025

,

Springer Nature

,

Scientific Reports

,

15

(1)

Nucleos(t)ides are essential for DNA/RNA synthesis, energy metabolism, and signaling, yet their roles in placental development remain poorly understood. The placenta undergoes dynamic metabolic adaptations throughout ...

Anticholinergic and Sedative Medication Burden in Croatian Older Adults: EuroAgeism Cohort Findings

original article

open access

published version

Držaić, Margita

;

Bužančić, Iva

;

Kummer, Ingrid

;

Bošković, Andrea

;

Glavaš, Dragan

;

Ortner Hadžiabdić, Maja

;

Brkić, Jovana

;

Fialová, Daniela

2025

,

MDPI AG

,

Pharmacy

,

13

(5)

Use of anticholinergic and sedative medications is potentially inappropriate in older adults due to associated adverse effects, including impaired cognitive and physical function. This study evaluated anticholinergic and ...

Scaffold Hopping in Tuberculosis Drug Discovery: Principles, Applications, and Case Studies

summarizing article

open access

published version

Kovář, Ondřej

;

Kufa, Martin

;

Finger, Vladimír

;

Soukup, Ondřej

;

Krátký, Martin

;

Torruellas, Carilyn

;

Roh, Jaroslav

;

Korábečný, Jan

2025

,

ACS Publications

,

Journal of Medicinal Chemistry

,

68

(20)

Tuberculosis (TB) imposes a major global health challenge, aggravated by the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains. Scaffold hopping, a medicinal chemistry approach that modifies the molecular ...

Effects of prenatal cannabinoid use on the monoamine system in the fetoplacental unit: A systematic review of animal and human studies

summarizing article

open access

published version

Portillo, Ramón

;

Synova, Tetiana

;

Štaud, František

2025

,

Elsevier

,

Drug and Alcohol Dependence

,

268

(March)

Background: The rapid increase in cannabis use during pregnancy - up by 170 % between 2009 and 2016 - raises pressing concerns about its effects on fetal health, particularly on the delicate monoamine system within the ...

Assessing potentially inappropriate medication use among older adults in Central and Eastern Europe

original article

open access

published version

Brkić, Jovana

;

Reissigová, Jindra

;

Okuyan, Betül

;

Ortner Hadžiabdić, Maja

;

Marinković, Valentina

;

Somers, Annemie

;

Onder, Graziano

;

Šesto, Sofija

;

Altiparmak, Öznur

;

Kummer, Ingrid

;

Držaić, Margita

;

Fialová, Daniela

2025

,

Published for the Finnish Medical Society Duodecim by the Royal Society of Medicine Press

,

Annals of Medicine

,

57

(1)

Objective The aim of this study was to examine the prevalence of potentially inappropriate medication (PIM) use and its associated risk factors in community-dwelling older adults from five Central and Eastern European (CEE) ...

Novel Quinazolinones Active against Multidrug-Resistant Mycobacterium Tuberculosis: Synthesis, Antimicrobial Evaluation, and in Silico Exploration of Penicillin-Binding Protein 1A as a Potential Target

original article

open access

published version

Kerda, Marek

;

Nawrot, Daria

;

Šlechta, Petr

;

Domanský, Miroslav

;

Askari, Asal

;

Kamangar, Hanieh

;

Janďourek, Ondřej

;

Konečná, Klára

;

Paterová, Pavla

;

Hlbočanová, Ingrid

;

Macháček, Miloslav

;

Mori, Matteo

;

Meneghetti, Fiorella

;

Doležal, Martin

;

Zitko, Jan

;

Bouz, Ghada

2025

,

Wiley-VCH-Verl.

,

ChemMedChem

,

20

(13)

Quinazolinone derivatives have emerged as promising scaffolds in antimicrobial drug discovery. This work focuses on the design, synthesis, and evaluation of novel quinazolinone-based compounds and predicts their potential ...

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