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Adenosine promotes trophoblast proliferation without inducing differentiation or apoptosis

original article

open access

published version

Ali, Mohammed N. H.

;

Adler, Mariia

;

Novotná, Magdaléna

;

Gala, Viktor

;

Abad, Cilia

;

Štaud, František

;

Červený, Lukáš

2025

,

Harcourt

,

Placenta

,

172

(December)

Objective: Adenosine and other nucleosides are essential regulators of cellular processes, but their specific roles in trophoblast growth and regulation remain incompletely defined. This study investigated the effects of ...

Structure-Activity Relationships of Novel Pyrimidine Derivatives as potential antimycobacterial Agents

abstract in conference proceedings

open access

published version

Kufa, Martin

;

Kovář, Ondřej

;

Finger, Vladimír

;

Korábečný, Jan

;

Krátký, Martin

;

Roh, Jaroslav

2025

,

Praha

,

Česká společnost chemická

,

Czech Chemical Society Symposium Series

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains the leading cause of death from a single infectious agent, exerting severe health and economic burdens, particularly in Sub-Saharan Africa and South-East ...

Metabolic dysfunction-associated steatotic liver disease-induced changes in the antioxidant system: a review

summarizing article

open access

published version

Svobodová, Gabriela

;

Horní, Martin

;

Velecká, Eva

;

Boušová, Iva

2025

,

Archives of Toxicology

,

99

(January)

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition characterized by liver steatosis, inflammation, consequent fibrosis, and cirrhosis. Chronic impairment of lipid metabolism is ...

Revolutionizing tuberculosis treatment: Breakthroughs, challenges, and hope on the horizon

summarizing article

open access

submitted version

Kufa, Martin

;

Finger, Vladimír

;

Kovář, Ondřej

;

Soukup, Ondřej

;

Torruellas, Carilyn

;

Roh, Jaroslav

;

Korábečný, Jan

2025

,

Acta Pharmaceutica Sinica B

,

15

(3)

Tuberculosis (TB), an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb), was responsible for the deaths of approximately 1.3 million people in 2022. In addition, 7.5 million new cases of TB have ...

5-(3,5-Dinitrophenyl)-1,3,4-oxadiazol-2-amine derivatives, their precursors, and analogues: Synthesis and evaluation of novel highly potent antitubercular agent

original article

open access

accepted version

Pflégr, Václav

;

Stolaříková, Jiřina

;

Karabanovich, Galina

;

Maixnerová, Jana

;

Pál, Adrián

;

Korduláková, Jana

;

Šanderová, Zuzana

;

Liegertová, Michaela

;

Roh, Jaroslav

;

Trejtnar, František

;

Vinšová, Jarmila

;

Krátký, Martin

2025

,

PLoS One

,

20

(5)

Drug resistance is a growing problem for many pathogens, including mycobacteria. Small heterocyclic molecules are among the leading scaffolds for developing potential antimycobacterial agents. Therefore, based on the ...

Different behavior of food-related benzoic acids toward iron and copper

original article

open access

published version

Harčárová, Patrícia

;

Lomozová, Zuzana

;

Kallivretaki, Maria

;

Karlíčková, Jana

;

Kučera, Radim

;

Mladěnka, Přemysl

2025

,

Elsevier Ttd

,

Food Chemistry

,

462

(January)

Benzoic acids are commonly found in food and are also produced by human microbiota from other dietary phenolics. The aim was to investigate the interactions of 8 food-related benzoic acids with the physiological metals ...

Investigating the Mechanism of Antimycobacterial and Antiproliferative Activity of (E)-N'-Benzylidenepyrazine-2-Carbohydrazides and their Derivatives

original article

open access

published version

Houngbedji, Priam-Amedeo

;

Nawrot, Daria Elżbieta

;

Janďourek, Ondřej

;

Konečná, Klára

;

Novák, Martin

;

Paterová, Pavla

;

Bárta, Pavel

;

Hrast Rambaher, Martina

;

Novotná, Eva

;

Castellano, Carlo

;

Mori, Matteo

;

Meneghetti, Fiorella

;

Záhorszká, Monika

;

Korduláková, Jana

;

Zitko, Jan

2025

,

Wiley-VCH-Verl.

,

ChemMedChem

,

20

(18)

A series of 33 (E)-N'-benzylidenepyrazine-2-carbohydrazides and their derivatives were synthesized and tested for biological activity. Benzylidene derivatives with 2-OH substitution on the phenyl ring (18: R = 2-OH, 21: R ...

The discovery of a new nonbile acid modulator of Takeda G protein-coupled receptor 5: An integrated computational approach

original article

open access

published version

Salam, Rudy

;

Bakker, Michael

;

Krutáková, Mária

;

Štefela, Alžbeta

;

Pávek, Petr

;

Duintjer Tebbens, Jurjen

;

Zitko, Jan

2025

,

Wiley-VCH-Verl.

,

Archiv der Pharmazie

,

358

(1)

The Takeda G protein-coupled receptor 5 (TGR5), also known as GPBAR1 (G protein-coupled bile acid receptor), is a membrane-type bile acid receptor that regulates blood glucose levels and energy expenditure. These essential ...

Antimicrobial and Antiproliferative Properties of 2-Phenyl-N-(Pyridin-2-yl)acetamides

original article

open access

published version

Nawrot, Daria

;

Koutníková, Barbora

;

Janďourek, Ondřej

;

Konečná, Klára

;

Novák, Martin

;

Paterová, Pavla

;

Bárta, Pavel

;

Bouz, Ghada

;

Zitko, Jan

;

Doležal, Martin

2025

,

Blackwell Munksgaard

,

Chemical Biology and Drug Design

,

105

(1)

Infectious diseases, including bacterial, fungal, and viral, have once again gained urgency in the drug development pipeline after the recent COVID-19 pandemic. Tuberculosis (TB) is an old infectious disease for which ...

Alkaloids from the genus Vinca L. (Apocynaceae): a comprehensive biological and structural review

summarizing article

open access

published version

Vrabec, Rudolf

;

Drašar, Pavel

;

Opletal, Lubomír

;

Kosturko, Štefan

;

Blunden, Gerald

;

Cahlíková, Lucie

2025

,

SPRINGER

,

Phytochemistry Reviews

,

24

(5)

This review provides a comprehensive overview of the alkaloids in the genus Vinca L. (Apocynaceae), which is renowned for its rich content of monoterpene indole alkaloids and widespread occurrence in Europe, northwest ...

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