Fakulty: Poslední příspěvky
Zobrazují se záznamy 1-20 z 776
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Czech Language Acquisition Seen by a Russian-speaking Learner
(2022)The paper discusses teaching Czech language to Russian speaking adolescent learners. The article is based on a research which focuses on the learners subjective perception of their second language acquisition. The topic, ... -
Editorial
(2021)Editorial představuje čtyři studie obsažené v prvním čísle patnáctého ročníku. Podrobněji se věnuje osobnosti zesnulého profesora Jana Průchy. -
Heterogeneous Response of Tumor Cell Lines to Inhibition of Aspartate β-hydroxylase
(2024)Background: Cancer development involves alterations in key cellular pathways, with aspartate β-hydroxylase (ASPH) emerging as an important player in tumorigenesis. ASPH is upregulated in various cancer types, where it ... -
Varroa destructor parasitism and Deformed wing virus infection in honey bees are linked to peroxisome-induced pathways
(2024)The ectoparasitic mite Varroa destructor transmits and triggers viral infections that have deleterious effects on honey bee colonies worldwide. We performed a manipulative experiment in which worker bees collected at ... -
Leaky Bodies, Vaccination and Three Layers of Memory: Bio-Immune, Social-Collective and Lived Experience
(2024)This paper focuses on the omnipresent yet analytically almost invisible role of memory and bodily experiences in childhood vaccination. Previous scholarship on the sociocultural aspects of vaccination has primarily focused ... -
Genomic characterization of ST38 NDM-5-producing Escherichia coli isolates from an outbreak in the Czech Republic
(2024)A 2-year national genomic screening in the Czech Republic identified a notable prevalence of the New Delhi metallo-β-lactamase 5 (NDM-5)-producing Escherichia coli sequence type 38 (ST38) in the city of Brno. Forty-two ... -
Agency in urgency and uncertainty. Vaccines and vaccination in European media discourses
(2024)Although Covid-19 was not the first pandemic, it was unique in the scale and intensity with which societies responded. Countries reacted differently to the threat posed by the new virus. The public health crisis affected ... -
Role of cryptic rearrangements of human chromosomes in the aetiology of schizophrenia
(2023)Schizophrenia (SZ) is a highly inherited disease that affects similar to 0.5% of the population. The genetic and environmental factors are involved in its aetiology and they interact with each other. Combination of symptoms ... -
Validated WGS and WES protocols proved saliva-derived gDNA as an equivalent to blood-derived gDNA for clinical and population genomic analyses
(2024)Background: Whole exome sequencing (WES) and whole genome sequencing (WGS) have become standard methods in human clinical diagnostics as well as in population genomics (POPGEN). Blood-derived genomic DNA (gDNA) is routinely ... -
DNA from BK polyomavirus is sensed during infection of reservoir cells via cGAS-STING pathway
(Nizozemsko, Nizozemsko, 2024)Human polyomaviruses (HPyVs) include 14 species that cause primary asymptomatic infections after which the virus persists in the host by a mechanism that is not well understood. Reactivation of the infection in immunosuppressed ... -
STING agonist induced-monocyte death combines apoptosis, pyroptosis and caspase 8 activation
(Nizozemsko, Nizozemsko, 2024)The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway isimportant for recognition of double-stranded DNA, a marker of infection or cell damage. ThecGAS-STING pathway activation leads to production ... -
HBV-induced microenvironment reduces pDC response to TLR9 stimulation
(Nizozemsko, Nizozemsko, 2024)Hepatitis B virus (HBV) is a non-cytopathogenic virus with DNA genome. It causes an acute hepatitis that may develop into chronic hepatitis B, liver cirrhosis and hepatocellular carcinoma. HBV is described as "stealth ... -
Increased burden of rare protein-truncating variants in constrained, brain-specific and synaptic genes in extremely impulsively violent males with antisocial personality disorder
(2024)The genetic correlates of extreme impulsive violence are poorly understood, and there have been few studies that have characterized a large group of affected individuals both clinically and genetically. We performed whole ... -
METABOLOMIC ANALYSIS OF THE HUMAN PLACENTA REVEALS PERTURBATIONS IN AMINO ACIDS, PURINE METABOLITES, AND SMALL ORGANIC ACIDS IN SPONTANEOUS PRETERM BIRTH
(2024)Spontaneous preterm delivery presents one of the most complex challenges in obstetrics and is a leading cause of perinatal morbidity and mortality. Although it is a common endpoint for multiple pathological processes, the ... -
Pathological shifts in tryptophan metabolism in human term placenta exposed to LPS or poly I:C
(2024)Maternal immune activation during pregnancy is a risk factor for offspring neuropsychiatric disorders. Among the mechanistic pathways by which maternal inflammation can affect fetal brain development and programming, those ... -
The Europeanisation of Clean Sport: How the Council of Europe and the European Union Shape the Proportionality of Ineligibility in the World Anti-Doping Code
(Hart Publishing, Oxford, 2024)This chapter examines the role of the Council of Europe (CoE) and the European Union (EU) in shaping the proportionality of ineligibility for doping in the World Anti-Doping Code (WADC). It employs an empirical study of ... -
Digitisation and EU Competition Law - Time to Rethink the Basics?
(2024)The article reflects on the question to what extent the complex reality of online platforms undermines the foundations of EU competition law, which are the presuppositions of neoclassical economics and the targeting of ... -
Proportionality during Times of Crisis: Precautionary Application of Proportionality Analysis in the Judicial Review of Emergency Measures
(2024)The need for a standard of review even during times of crisis - proportionality analysis as the ideal and universally applicable standard of review - the problem of excessive stringency of proportionality analysis during ... -
ASSESSMENT OF PHYSICAL CAPACITY LEVEL IN RECREATIONAL ATHLETES
(2023)Introduction: In the majority of the available source materials, research on the level of physical capacity of athletes concernsmembers of sports clubs and national teams, in a word, professional athletes. Does this mean ... -
Simultaneous PCR detection of Paenibacillus larvae targeting insertion sequence IS256 and Melissococcus plutonius targeting pMP1 plasmid from hive specimens
(2024)Paenibacillus larvae and Melissococcus plutonius represent the most threatening bacterial diseases of honeybee (Apis mellifera)-American and European foulbrood, respectively. For efficient control of those diseases, rapid ...