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Poslední příspěvky
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Mitochondrial metabolism and hypoxic signaling in differentiated human cardiomyocyte AC16 cell line
původní článek
open access
vydavatelská verze
2025
,American Physiological Society
,American Journal of Physiology - Cell Physiology
,328
(5)
Cardiovascular diseases are associated with an altered cardiomyocyte metabolism. Because of a shortage of human heart tissue, experimental studies mostly rely on alternative approaches including animal and cell culture ...
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Polyglutamylation of microtubules drives neuronal remodeling
původní článek
open access
vydavatelská verze
2025
,Nature Publishing Group
,Nature Communications
,16
(1)
Developmental remodeling shapes neural circuits via activity-dependent pruning of synapses and axons. Regulation of the cytoskeleton is critical for this process, as microtubule loss via enzymatic severing is an early step ...
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Praktikum správního práva: Územní plánování a stavební řád - Letecké právo - Právo pozemních komunikací - Vyvlastnění pro účely strategické infrastruktury
VŠ skriptum
open access
vydavatelská verze
2025
,Praha
,Univerzita Karlova, Právnická fakulta
Učební pomůclka pro studenty v oblastech: Územní plánování a stavební řád, Letecké právo, Právo pozemních komunikací, Vyvlastnění pro účely strategické infrastruktury
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Familial risks and incidence rates for childhood nervous system tumors in Sweden
původní článek
open access
vydavatelská verze
2025
,Elsevier Ltd.
,EJC Paediatric Oncology
,6
(December)
Background: Childhood (< 20 years) nervous system tumors manifest in some rare cancer syndromes but how commonly they present with familial clustering between various histological types is not well known at a nation-wide ...
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Nucleotide composition shapes gene expression in Wolbachia pipientis: a role for MidA methyltransferase?
původní článek
open access
vydavatelská verze
2025
,American Society for Microbiology
,mSystems
Wolbachia pipientis is an obligate intracellular bacterium, associated with several arthropods and filarial nematodes. Wolbachia establishes a variety of symbiotic relationships with its hosts, with consequent genomic ...
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Antibacterial activity of the novel peptide Pac-525 with the RGD motif against intracellular Escherichia coli
původní článek
open access
vydavatelská verze
2025
,Springer Nature
,Scientific Reports
,15
(1)
Infections caused by invasive intracellular bacteria pose major therapeutic challenges due to pathogen survival and growth inside of host cells as well as the low intracellular accessibility for conventional antibiotics. ...
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Rapid trend towards larger and more moisture-limited trees in Central-European temperate forests
původní článek
open access
vydavatelská verze
2025
,Institute of Physics and IOP Publishing
,Environmental Research Letters
,20
(8)
Tree stems represent a long-lived biomass compartment for atmospheric carbon sequestration. While terrestrial biosphere models predict rising carbon sequestration in forests, direct observations of tree growth are inconclusive ...
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Expanding Blue Intensity applications: Exploring compression wood proportions in cross-sections of treeline Picea abies seedlings
původní článek
open access
vydavatelská verze
2025
,Urban u. Fischer
,Dendrochronologia
,93
(October 2025)
Blue Intensity (BI) has been widely used as a proxy for wood density in dendrochronology, yet its applications remain underexplored in treeline ecology. Moving beyond traditional growth ring analyses, we expanded the Blue ...
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Variable expressivity of KMT2B variants at codon 2565 in patients with dystonia and developmental disorders
původní článek
open access
vydavatelská verze
2025
,Parkinsonism and Related Disorders
,133
(April)
Introduction: Variable expressivity is an emerging characteristic of KMT2B-related dystonia. However, it remains poorly understood whether variants reoccurring at specific sites of lysine-specific methlytransferase-2B ...
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Adjective-based qualitative comparative analysis: Relating immobility situations across contexts
původní článek
open access
postprint
2025
,Institute of British Geographers
,Area
This paper introduces a novel adjective-based approach for conducting structured yet interpretive comparisons of case studies that explore the situated lived realities of diverse population groups. The method derives salient ...
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Colour discrimination deficit in REM sleep behavior disorder: an analysis of dopaminergic depletion, cognition, and brain morphology
původní článek
open access
vydavatelská verze
2025
,Journal of Neural Transmission
,online AoP
(06 June 2025)
Isolated REM sleep behavior disorder (iRBD) is associated with impaired colour discrimination, cognitive deficits and morphological changes. This study evaluates whether colour discrimination deficits in iRBD are mediated ...
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TOR1AIP2 as a candidate gene for dystonia-hemichorea/hemiballism
původní článek
open access
vydavatelská verze
2025
,Parkinsonism and Related Disorders
,134
(May)
Dystonia is a movement disorder characterized by genetic and clinical heterogeneity. A recurring p.(Glu303del)-deletion in TOR1A is a well-established cause for DYT-TOR1A (DYT1), an autosomal dominant early-onset isolated ...
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SENIOŘI NA PRACOVNÍM TRHU V JIŽNÍ KOREJI: VÝZVY DEMOGRAFICKÉHO STÁRNUTÍ
SENIORS IN THE SOUTH KOREAN WORKFORCE: THE CHALLENGES OF AN AGEING POPULATION
původní článek
open access
vydavatelská verze
2025
,Český statistický úřad
,Demografie
,67
(1)
Stárnutí populace je spojeno s mnoha výzvami, jednou z nejdiskutovanějších je udržitelnost sociálních a důchodových systémů. V souvislosti s prodlužující se střední délkou života je častým tématem například věk nároku na ...
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Comparison of Different Sensor Locations on Freezing-of-Gait Ratio Results
původní článek
open access
vydavatelská verze
2025
,IRBM
,46
(2)
Background: Freezing of gait (FoG) is a walking disturbance in the Parkinson's disease (PD). The freezing ratio (FoG-ratio) is a parameter used to quantify overall freezing severity rather than to assess single freezing ...
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Clinical risk stratification: Prague validation of the DAAE score, a clinical tool for estimating risk of disesase progression in multiple sclerosis
původní článek
open access
vydavatelská verze
2025
,Multiple Sclerosis and Related Disorders
,98
(June)
Background: Secondary progressive MS is associated with a worse prognosis, warranting the need for early predictive tools. The DAAE score estimates the five-year risk of transition to clinical diagnosis of SPMS, showing a ...
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Abnormal neuronal activity in the subthalamic nucleus contributes to dysarthria in patients with Parkinson's disease
původní článek
open access
vydavatelská verze
2025
,Neurobiology of Disease
,207
(April)
Background: This study investigated the subthalamic nucleus (STN) function and deep brain stimulation (DBS) effects on single-unit activity (SUA) in Parkinson's disease (PD) patients with dysarthria. Methods: After presurgical ...
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Unravelling head tremor mechanisms: insights from speech analysis in essential tremor and cervical dystonia
původní článek
open access
vydavatelská verze
2025
,Springer
,Journal of Neural Transmission
,online AoP
(07 June 2025)
Head tremor is a common symptom in both essential tremor (ET) and cervical dystonia (CD). Distinguishing between these two conditions can be challenging in clinical practice, particularly when head tremor is the dominant ...
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Deep Brain Stimulation for VPS16-Related Dystonia: A Multicenter Study
původní článek
open access
vydavatelská verze
2025
,Annals of Neurology
,online AoP
(20 June 2025)
Objective: The objective was to evaluate the effects of deep brain stimulation (DBS) in an international cohort of patients with VPS16-related dystonia. Methods: This observational study collected preoperative and postoperative ...
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Nutritional and Clinical Status of Czech Adolescents with Anorexia Nervosa before and during the SARS-CoV-2 Pandemic
původní článek
open access
vydavatelská verze
2025
,Bratislavské lekárske listy / Bratislava Medical Journal
,126
(4)
Objectives: This study assessed the nutritional and clinical status of Czech adolescents with anorexia nervosa (AN) during the SARS-CoV-2 pandemic (3/2020-3/2022), comparing them with those diagnosed before the pandemic ...
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Legislative Turnover in Latin America: Introducing a New Dataset and Analyzing Its Temporal Dynamics
původní článek
open access
vydavatelská verze
2025
,Blackwell Publishing
,Latin American Politics and Society
,67
(3)
The article examines the patterns of turnover of Latin American legislators. It contributes (1) by introducing a large original dataset of turnover rates in 204 elections between 1985 and 2023 based on manually coded lists ...
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