Poslední příspěvky

  • Mitochondrial metabolism and hypoxic signaling in differentiated human cardiomyocyte AC16 cell line 

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    Alán, Lukáš

    ;

    Opletalová, Barbora

    ;

    Hayat, Habiba

    ;

    Marković, Aleksandra

    ;

    Hlaváčková, Markéta

    ;

    Vrbacký, Marek

    ;

    Mráček, Tomáš

    ;

    Alánová, Petra

    2025

    ,

    American Physiological Society

    ,

    American Journal of Physiology - Cell Physiology

    ,

    328

    (5)

    Cardiovascular diseases are associated with an altered cardiomyocyte metabolism. Because of a shortage of human heart tissue, experimental studies mostly rely on alternative approaches including animal and cell culture ...

  • Polyglutamylation of microtubules drives neuronal remodeling 

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    Gavoci, Antoneta

    ;

    Zhiti, Anxhela

    ;

    Rusková, Michaela

    ;

    Magiera, Maria M.

    ;

    Wang, Mengzhe

    ;

    Ziegler, Karin A.

    ;

    Hausrat, Torben J.

    ;

    Ugwuja, Anselm I.

    ;

    Chakraborty, Shreyangi

    ;

    Engelhardt, Stefan

    ;

    Kneussel, Matthias

    ;

    Balaštík, Martin

    ;

    Janke, Carsten

    ;

    Misgeld, Thomas

    ;

    Brill, Monika S.

    2025

    ,

    Nature Publishing Group

    ,

    Nature Communications

    ,

    16

    (1)

    Developmental remodeling shapes neural circuits via activity-dependent pruning of synapses and axons. Regulation of the cytoskeleton is critical for this process, as microtubule loss via enzymatic severing is an early step ...

  • Praktikum správního práva: Územní plánování a stavební řád - Letecké právo - Právo pozemních komunikací - Vyvlastnění pro účely strategické infrastruktury 

    VŠ skriptum

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    Handrlica, Jakub

    ;

    Adamec, Martin

    ;

    Klimentová, Eliška

    ;

    Nešpor, Jan

    ;

    Sharp, Vladimír

    ;

    Vosečková, Lucie

    2025

    ,

    Praha

    ,

    Univerzita Karlova, Právnická fakulta

    Učební pomůclka pro studenty v oblastech: Územní plánování a stavební řád, Letecké právo, Právo pozemních komunikací, Vyvlastnění pro účely strategické infrastruktury

  • Familial risks and incidence rates for childhood nervous system tumors in Sweden 

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    Hemminki, Kari Jussi

    ;

    Li, Xinjun

    ;

    Sundquist, Kristina

    ;

    Sundquist, Jan

    ;

    Hirsch, Steffen

    ;

    Ji, Jianguang

    ;

    Hemminki, Akseli

    ;

    Försti, Asta

    2025

    ,

    Elsevier Ltd.

    ,

    EJC Paediatric Oncology

    ,

    6

    (December)

    Background: Childhood (< 20 years) nervous system tumors manifest in some rare cancer syndromes but how commonly they present with familial clustering between various histological types is not well known at a nation-wide ...

  • Nucleotide composition shapes gene expression in Wolbachia pipientis: a role for MidA methyltransferase? 

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    Papaleo, Stella

    ;

    Panelli, Simona

    ;

    Bitar, Ibrahim

    ;

    Sterzi, Lodovico

    ;

    Nodari, Riccardo

    ;

    Comandatore, Francesco

    2025

    ,

    American Society for Microbiology

    ,

    mSystems

    Wolbachia pipientis is an obligate intracellular bacterium, associated with several arthropods and filarial nematodes. Wolbachia establishes a variety of symbiotic relationships with its hosts, with consequent genomic ...

  • Antibacterial activity of the novel peptide Pac-525 with the RGD motif against intracellular Escherichia coli 

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    Coufalova, Martina

    ;

    Rodrigo, Miguel A M

    ;

    Michalkova, Hana

    ;

    Milosavljevic, Vedran

    ;

    Hrazdilová, Kristýna

    ;

    Zurek, Ludek

    ;

    Cihalova, Kristyna

    2025

    ,

    Springer Nature

    ,

    Scientific Reports

    ,

    15

    (1)

    Infections caused by invasive intracellular bacteria pose major therapeutic challenges due to pathogen survival and growth inside of host cells as well as the low intracellular accessibility for conventional antibiotics. ...

  • Rapid trend towards larger and more moisture-limited trees in Central-European temperate forests 

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    Treml, Václav

    ;

    Tumajer, Jan

    ;

    Oulehle, Filip

    ;

    Altman, Jan

    ;

    Doležal, Jiří

    ;

    Vejpustkova, Monika

    ;

    Rydval, Miloš

    ;

    Altmanová, Nela

    ;

    Brůha, Lukáš

    ;

    Čada, Vojtěch

    ;

    Fibich, Pavel

    ;

    Kaczka, Ryszard

    ;

    Kašpar, Jakub

    ;

    Kolář, Tomáš

    ;

    Krejza, Jan

    ;

    Mašek, Jiří

    ;

    Mikhailov, Sergei

    ;

    Šamonil, Pavel

    ;

    Rybníček, Michal

    ;

    Stojanović, Marko

    ;

    Svoboda, Jan

    ;

    Svoboda, Miroslav

    ;

    Vašíčková, Iva

    2025

    ,

    Institute of Physics and IOP Publishing

    ,

    Environmental Research Letters

    ,

    20

    (8)

    Tree stems represent a long-lived biomass compartment for atmospheric carbon sequestration. While terrestrial biosphere models predict rising carbon sequestration in forests, direct observations of tree growth are inconclusive ...

  • Expanding Blue Intensity applications: Exploring compression wood proportions in cross-sections of treeline Picea abies seedlings 

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    Romero Perez, Isabel Eunice

    ;

    Gonzalez, Edgar J.

    ;

    Rydval, Milos

    ;

    Treml, Václav

    2025

    ,

    Urban u. Fischer

    ,

    Dendrochronologia

    ,

    93

    (October 2025)

    Blue Intensity (BI) has been widely used as a proxy for wood density in dendrochronology, yet its applications remain underexplored in treeline ecology. Moving beyond traditional growth ring analyses, we expanded the Blue ...

  • Variable expressivity of KMT2B variants at codon 2565 in patients with dystonia and developmental disorders 

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    Stehr, Antonia M.

    ;

    Fischer, Jan

    ;

    Mirza-Schreiber, Nazanin

    ;

    Bernardi, Katerina

    ;

    Porrmann, Joseph

    ;

    Harrer, Philip

    ;

    Kaiser, Frank

    ;

    Abou Jamra, Rami

    ;

    Winkelmann, Juliane

    ;

    Jech, Robert

    ;

    Koy, Anne

    ;

    Oexle, Konrad

    ;

    Zech, Michael

    2025

    ,

    Parkinsonism and Related Disorders

    ,

    133

    (April)

    Introduction: Variable expressivity is an emerging characteristic of KMT2B-related dystonia. However, it remains poorly understood whether variants reoccurring at specific sites of lysine-specific methlytransferase-2B ...

  • Adjective-based qualitative comparative analysis: Relating immobility situations across contexts 

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    postprint

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    Novotný, Josef

    ;

    Stoker, Aneta

    ;

    Nakagawa, Takuya

    ;

    Kvasničková, Kristýna

    ;

    Masná, Eliška

    ;

    Mohammed, Yeboah

    2025

    ,

    Institute of British Geographers

    ,

    Area

    This paper introduces a novel adjective-based approach for conducting structured yet interpretive comparisons of case studies that explore the situated lived realities of diverse population groups. The method derives salient ...

  • Colour discrimination deficit in REM sleep behavior disorder: an analysis of dopaminergic depletion, cognition, and brain morphology 

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    Havlík, Filip

    ;

    Mala, Christiane

    ;

    Dušek, Petr

    ;

    Mana, Josef

    ;

    Ibarburu Lorenzo y Losada, Veronika

    ;

    Dostálová, Simona

    ;

    Nepožitek, Jiří

    ;

    Peřinová, Pavla

    ;

    Růžička, Evžen

    ;

    Krupička, Radim

    ;

    Šonka, Karel

    ;

    Bezdíček, Ondřej

    2025

    ,

    Journal of Neural Transmission

    ,

    online AoP

    (06 June 2025)

    Isolated REM sleep behavior disorder (iRBD) is associated with impaired colour discrimination, cognitive deficits and morphological changes. This study evaluates whether colour discrimination deficits in iRBD are mediated ...

  • TOR1AIP2 as a candidate gene for dystonia-hemichorea/hemiballism 

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    Kafantari, Efthymia

    ;

    Hernandez, Victoria J.

    ;

    Necpál, Ján

    ;

    Leonidou, Marina

    ;

    Baureder, Regina

    ;

    Hedberg-Oldfors, Carola

    ;

    Jech, Robert

    ;

    Zech, Michael

    ;

    Schwartz, Thomas U.

    ;

    Puschmann, Andreas

    2025

    ,

    Parkinsonism and Related Disorders

    ,

    134

    (May)

    Dystonia is a movement disorder characterized by genetic and clinical heterogeneity. A recurring p.(Glu303del)-deletion in TOR1A is a well-established cause for DYT-TOR1A (DYT1), an autosomal dominant early-onset isolated ...

  • SENIOŘI NA PRACOVNÍM TRHU V JIŽNÍ KOREJI: VÝZVY DEMOGRAFICKÉHO STÁRNUTÍ 

    SENIORS IN THE SOUTH KOREAN WORKFORCE: THE CHALLENGES OF AN AGEING POPULATION

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    Pavlátová, Jolana

    ;

    Hulíková Tesárková, Klára

    2025

    ,

    Český statistický úřad

    ,

    Demografie

    ,

    67

    (1)

    Stárnutí populace je spojeno s mnoha výzvami, jednou z nejdiskutovanějších je udržitelnost sociálních a důchodových systémů. V souvislosti s prodlužující se střední délkou života je častým tématem například věk nároku na ...

  • Comparison of Different Sensor Locations on Freezing-of-Gait Ratio Results 

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    Netukova, Slavka

    ;

    Horáková, Lucie

    ;

    Růžička, Evžen

    ;

    Dušek, Petr

    ;

    Szabo, Zoltan

    ;

    Krupicka, Radim

    2025

    ,

    IRBM

    ,

    46

    (2)

    Background: Freezing of gait (FoG) is a walking disturbance in the Parkinson's disease (PD). The freezing ratio (FoG-ratio) is a parameter used to quantify overall freezing severity rather than to assess single freezing ...

  • Clinical risk stratification: Prague validation of the DAAE score, a clinical tool for estimating risk of disesase progression in multiple sclerosis 

    původní článek

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    Jelgerhuis, Julia R.

    ;

    Uher, Tomáš

    ;

    Kubala Havrdová, Eva

    ;

    Horáková, Dana

    ;

    Schoonheim, Menno M.

    ;

    Fuchs, Tom A.

    2025

    ,

    Multiple Sclerosis and Related Disorders

    ,

    98

    (June)

    Background: Secondary progressive MS is associated with a worse prognosis, warranting the need for early predictive tools. The DAAE score estimates the five-year risk of transition to clinical diagnosis of SPMS, showing a ...

  • Abnormal neuronal activity in the subthalamic nucleus contributes to dysarthria in patients with Parkinson's disease 

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    Diao, Yu

    ;

    Yin, Zixiao

    ;

    Zhao, Baotian

    ;

    Xu, Yichen

    ;

    Jiang, Yin

    ;

    Yin, Yanling

    ;

    Yang, Anchao

    ;

    Zhu, Yanming

    ;

    Hlavnička, Jan

    ;

    Zhang, Jianguo

    2025

    ,

    Neurobiology of Disease

    ,

    207

    (April)

    Background: This study investigated the subthalamic nucleus (STN) function and deep brain stimulation (DBS) effects on single-unit activity (SUA) in Parkinson's disease (PD) patients with dysarthria. Methods: After presurgical ...

  • Unravelling head tremor mechanisms: insights from speech analysis in essential tremor and cervical dystonia 

    původní článek

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    Rusz, Jan

    ;

    Hollý, Petr

    ;

    Tykalova, Tereza

    ;

    Simek, Michal

    ;

    Hubena, Tereza

    ;

    Ulmanová, Olga

    ;

    Jech, Robert

    ;

    Krupicka, Radim

    ;

    Růžička, Evžen

    2025

    ,

    Springer

    ,

    Journal of Neural Transmission

    ,

    online AoP

    (07 June 2025)

    Head tremor is a common symptom in both essential tremor (ET) and cervical dystonia (CD). Distinguishing between these two conditions can be challenging in clinical practice, particularly when head tremor is the dominant ...

  • Deep Brain Stimulation for VPS16-Related Dystonia: A Multicenter Study 

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    Svorenova, Tatiana

    ;

    Romito, Luigi M.

    ;

    Kaymak, Ahmet

    ;

    Mulroy, Eoin

    ;

    Cif, Laura

    ;

    Moro, Elena

    ;

    Zeuner, Kirsten E.

    ;

    Zittel, Simone

    ;

    Petry-Schmelzer, Jan Niklas

    ;

    Gruber, Doreen

    ;

    Centen, Liesanne

    ;

    Albanese, Alberto

    ;

    Ostrozovicova, Miriama

    ;

    Han, Vladimir

    ;

    Magocova, Veronika

    ;

    Knorovsky, Kamil

    ;

    Kollova, Aurelia

    ;

    Garavaglia, Barbara

    ;

    Golfre-Andreasi, Nico

    ;

    Reale, Chiara

    ;

    Mazzoni, Alberto

    ;

    Zorzi, Giovanna

    ;

    Eleopra, Roberto

    ;

    Levi, Vincenzo

    ;

    Foltynie, Thomas

    ;

    Limousin, Patricia

    ;

    Akram, Harith

    ;

    Zrinzo, Ludvic

    ;

    Magrinelli, Francesca

    ;

    Murphy, David

    ;

    Houlden, Henry

    ;

    Kurian, Manju A.

    ;

    Baiata, Claudio

    ;

    Paschen, Steffen

    ;

    Lohmann, Katja

    ;

    Volkmann, Jens

    ;

    Hamel, Wolfgang

    ;

    Barbe, Michael T.

    ;

    van Egmond, Martje E.

    ;

    Tijssen, Maj

    ;

    Ambro, Lubos

    ;

    Jurkova, Veronika

    ;

    Jech, Robert

    ;

    Havránková, Petra

    ;

    Winkelmann, Juliane

    ;

    Zech, Michael

    ;

    Skorvanek, Matej

    2025

    ,

    Annals of Neurology

    ,

    online AoP

    (20 June 2025)

    Objective: The objective was to evaluate the effects of deep brain stimulation (DBS) in an international cohort of patients with VPS16-related dystonia. Methods: This observational study collected preoperative and postoperative ...

  • Nutritional and Clinical Status of Czech Adolescents with Anorexia Nervosa before and during the SARS-CoV-2 Pandemic 

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    Floriánková, Marcela

    ;

    Uhlíková, Petra

    ;

    Dostálová, Veronika

    ;

    Vecka, Marek

    ;

    Szitányi, Peter

    ;

    Žák, Aleš

    2025

    ,

    Bratislavské lekárske listy / Bratislava Medical Journal

    ,

    126

    (4)

    Objectives: This study assessed the nutritional and clinical status of Czech adolescents with anorexia nervosa (AN) during the SARS-CoV-2 pandemic (3/2020-3/2022), comparing them with those diagnosed before the pandemic ...

  • Legislative Turnover in Latin America: Introducing a New Dataset and Analyzing Its Temporal Dynamics 

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    Kouba, Karel

    ;

    Weiss, Michael

    2025

    ,

    Blackwell Publishing

    ,

    Latin American Politics and Society

    ,

    67

    (3)

    The article examines the patterns of turnover of Latin American legislators. It contributes (1) by introducing a large original dataset of turnover rates in 204 elections between 1985 and 2023 based on manually coded lists ...

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