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Validated WGS and WES protocols proved saliva-derived gDNA as an equivalent to blood-derived gDNA for clinical and population genomic analyses
(2024)Background: Whole exome sequencing (WES) and whole genome sequencing (WGS) have become standard methods in human clinical diagnostics as well as in population genomics (POPGEN). Blood-derived genomic DNA (gDNA) is routinely ... -
DNA from BK polyomavirus is sensed during infection of reservoir cells via cGAS-STING pathway
(Nizozemsko, Nizozemsko, 2024)Human polyomaviruses (HPyVs) include 14 species that cause primary asymptomatic infections after which the virus persists in the host by a mechanism that is not well understood. Reactivation of the infection in immunosuppressed ... -
STING agonist induced-monocyte death combines apoptosis, pyroptosis and caspase 8 activation
(Nizozemsko, Nizozemsko, 2024)The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway isimportant for recognition of double-stranded DNA, a marker of infection or cell damage. ThecGAS-STING pathway activation leads to production ... -
HBV-induced microenvironment reduces pDC response to TLR9 stimulation
(Nizozemsko, Nizozemsko, 2024)Hepatitis B virus (HBV) is a non-cytopathogenic virus with DNA genome. It causes an acute hepatitis that may develop into chronic hepatitis B, liver cirrhosis and hepatocellular carcinoma. HBV is described as "stealth ... -
Increased burden of rare protein-truncating variants in constrained, brain-specific and synaptic genes in extremely impulsively violent males with antisocial personality disorder
(2024)The genetic correlates of extreme impulsive violence are poorly understood, and there have been few studies that have characterized a large group of affected individuals both clinically and genetically. We performed whole ... -
METABOLOMIC ANALYSIS OF THE HUMAN PLACENTA REVEALS PERTURBATIONS IN AMINO ACIDS, PURINE METABOLITES, AND SMALL ORGANIC ACIDS IN SPONTANEOUS PRETERM BIRTH
(2024)Spontaneous preterm delivery presents one of the most complex challenges in obstetrics and is a leading cause of perinatal morbidity and mortality. Although it is a common endpoint for multiple pathological processes, the ... -
Pathological shifts in tryptophan metabolism in human term placenta exposed to LPS or poly I:C
(2024)Maternal immune activation during pregnancy is a risk factor for offspring neuropsychiatric disorders. Among the mechanistic pathways by which maternal inflammation can affect fetal brain development and programming, those ... -
The Europeanisation of Clean Sport: How the Council of Europe and the European Union Shape the Proportionality of Ineligibility in the World Anti-Doping Code
(Hart Publishing, Oxford, 2024)This chapter examines the role of the Council of Europe (CoE) and the European Union (EU) in shaping the proportionality of ineligibility for doping in the World Anti-Doping Code (WADC). It employs an empirical study of ... -
Digitisation and EU Competition Law - Time to Rethink the Basics?
(2024)The article reflects on the question to what extent the complex reality of online platforms undermines the foundations of EU competition law, which are the presuppositions of neoclassical economics and the targeting of ... -
Proportionality during Times of Crisis: Precautionary Application of Proportionality Analysis in the Judicial Review of Emergency Measures
(2024)The need for a standard of review even during times of crisis - proportionality analysis as the ideal and universally applicable standard of review - the problem of excessive stringency of proportionality analysis during ... -
ASSESSMENT OF PHYSICAL CAPACITY LEVEL IN RECREATIONAL ATHLETES
(2023)Introduction: In the majority of the available source materials, research on the level of physical capacity of athletes concernsmembers of sports clubs and national teams, in a word, professional athletes. Does this mean ... -
Simultaneous PCR detection of Paenibacillus larvae targeting insertion sequence IS256 and Melissococcus plutonius targeting pMP1 plasmid from hive specimens
(2024)Paenibacillus larvae and Melissococcus plutonius represent the most threatening bacterial diseases of honeybee (Apis mellifera)-American and European foulbrood, respectively. For efficient control of those diseases, rapid ... -
Lokálne politiky integrácie migrantov a ich štrukturálne mechanizmy
(Univerzita Komenského v Bratislave, Bratislava, 2023)Publikace se zabývá integrací migrantů v České republice, na Slovensku, v Belgii (Vlámsku) a v Německu (Bavorskou) s cílem přiblížit kontext integrace migrantů v jednotlivých zemích a najít příležitosti pro vzájemné učení ... -
Determinants of self-rated health among highly educated Ukrainian women refugees in Czechia: analysis based on cross-sectional study in 2022
(2024)Background: Russia's military aggression against Ukraine set in motion a large number of refugees. Considerable amount of them came and stayed in Czechia. Refugees represent special vulnerable individuals often affected ... -
Civil society organisations and labour market integration: barriers and enablers in seven European countries
(Bristol University Press, Bristol, 2023)This chapter discusses the role of civil society organisations (CSOs) in the labour market integration of migrants, refugees and asylum seekers (MRAs) in the selected countries addressed by the book. It examines the positions ... -
Turistický diskurs prizmatem narativních figur: Václav Havel jako ikona boje proti komunismu
(2021)Tématem studie jsou vypravěčské strategie, které uplatňujeme v turistickém diskurzu, když návštěvníkům Prahy přibližujeme postavu Václava Havla a jeho prostřednictvím i vhled do života v Československu v době tzv. komunismu. ... -
Strategie zvyšování reprodukovatelnosti kódování v kvalitativním výzkumu pomocí programu Requal
(Technologická agentura ČR, Praha, 2023)Zpráva shrnuje výsledky řešení projektu a ukazuje, jak lze pomocí porgramu Requal zvýšit reprodukovatelnost kvalitativního výzkumu, přesněji transparenci a reflexivitu kódování kvalitativních dat. -
Characterization of the evolutionary and virological aspects of mutations in the receptor binding motif of the SARS-CoV-2 spike protein
(2023)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has substantially diversified during the pandemic, resulting in the successive emergence of variants characterized by various mutations. It has been observed ... -
N-Pyrazinylhydroxybenzamides as biologically active compounds: a hit-expansion study and antimicrobial evaluation
(2023)Background: The development of novel antimicrobial drugs is an essential part of combatting the uprising of antimicrobial resistance. Proper hit-to-lead development is crucially needed. Methods & results: We present a ... -
Guerre et Londres. Pour une relecture contemporaine de Céline ?
(2023)En 2022, Gallimard publie deux romans inédits de Céline, racontant la convalescence du brigadier Ferdinand, grièvement blessé sur le front des Flandres (Guerre), et les pérégrinations ultérieures du même héros dans la ...