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Recent Submissions
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5-(3,5-Dinitrophenyl)-1,3,4-oxadiazol-2-amine derivatives, their precursors, and analogues: Synthesis and evaluation of novel highly potent antitubercular agent
original article
open access
accepted version
2025
,PLoS One
,20
(5)
Drug resistance is a growing problem for many pathogens, including mycobacteria. Small heterocyclic molecules are among the leading scaffolds for developing potential antimycobacterial agents. Therefore, based on the ...
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Gut-microbiota-based ensemble model predicts prognosis of pediatric inflammatory bowel disease
original article
open access
published version
2024
,iScience
,27
(12)
Developing microbiome-based markers for pediatric inflammatory bowel disease (PIBD) is challenging. Here, we evaluated the diagnostic and prognostic potential of the gut microbiome in PIBD through a case-control study and ...
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How Affective Relationships and Classroom Norms Shape Perceptions of Aggressor, Victim, and Defender Roles
original article
open access
published version
2025
,Aggressive Behavior
,51
(1)
Reputational peer nominations are a common method for measuring involvement in aggression-related behaviors, encompassing the roles of aggressor, victim, and defender, but may be influenced by students' affective (dis)liking ...
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Veterans Day Celebration in a Hlučín Village: A Unique “Confirmatory” Military Reenactment Event
original article
open access
published version
2025
,Nationalities Affairs. New Series
,2024
(56)
The historical region around the town of Hlučín (Hultschin, Hulczyn), today in the Czech Republic and previously in Germany, is a space in which representations of national indifference as a principle of social organization ...
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Susceptibility of diverse sand fly species to Toscana virus
original article
open access
published version
2025
,PLoS Neglected Tropical Diseases
,19
(5)
Toscana virus (TOSV) is an emerging but neglected human pathogen currently circulating around the Mediterranean basin including North Africa. Human illness ranges from asymptomatic or mild flu-like syndromes to severe ...
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Altitude shapes gut microbiome composition accounting for diet, thyroid hormone levels, and host genetics in a subterranean blind mole rat
original article
open access
published version
2024
,Frontiers in Microbiology
,15
(November)
The animal gut microbiome acts as a crucial link between the host and its environment, playing a vital role in digestion, metabolism, physiology, and fitness. Using 16S rRNA metabarcoding, we investigated the effect of ...
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O čem také přemýšlejí naši medici. Sborník studentských prací (2025)
Thoughts of medical students. Collection of written projects (2025)
collection of papers
open access
published version
2025
,Plzeň
,Psychiatrická klinika, Lékařská fakulta v Plzni Univerzity Karlovy
Výbor nejlepších esejí napsaných studenty Lékařské fakulty Univerzity Karlovy v Plzni pro předmět Lékařská psychologie a etika v akademickém roce 2024/2025.
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The presence of multiple variants of IncF plasmid alleles in a single genome sequence can hinder accurate replicon sequence typing using in silico pMLST tools
original article
open access
accepted version
2025
,mSystems
IncF plasmids are mobile genetic elements found in bacteria from the Enterobacteriaceae family and often carry critical antibiotic and virulence gene cargo. The classification of IncF plasmids using the plasmid Multi-Locus ...
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Training of English prosody with acoustically modified voices
Trénování anglické prozodie pomocí akusticky modifikovaných hlasů
original article
open access
published version
2024
,Journal of Second Language Pronunciation
,10
(3)
The paper describes an innovative training of English phrasal prosody using participants' own speech as models, with their melodic and rhythmic patterns manipulated by means of PSOLA. After the training, the participants ...
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The impact of buried historical copper slags on contemporary soil contamination
original article
open access
published version
2025
,Journal of Geochemical Exploration
,273
(June)
This study focuses on the impact of historical metallurgical slags on contemporary soil and soil pore water contamination, and potential phytoavailibility of metal(loid)s based on the example of the former smelter (16th-18th ...
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Evaluation of various membranes for blood-feeding in nine sand fly species and artificial feeding challenges in Sergentomyia minuta
original article
open access
published version
2025
,Parasites & Vectors
,18
(1)
BackgroundWe evaluated various membranes for blood-feeding in nine sand fly species from different genera and subgenera. Most of these species are vectors of human-pathogenic Leishmania, whereas Sergentomyia minuta is a ...
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Phenotypic and genotypic characterization of Candida parapsilosis complex isolates from a Lebanese hospital
original article
open access
accepted version
2025
,Scientific Reports
,15
(1)
The opportunistic pathogen Candida parapsilosis is a major causative agent of candidiasis leading to death in immunocompromised individuals. Azoles are the first line of defense in their treatment. The purpose of this study ...
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Epigenetic Characterization of Squamous Cell Carcinoma and Mucoepidermoid Carcinoma Based on DNA Methylation Data: An In-Silico Study
abstract in journal
open access
published version
2025
,Oxford
,Elsevier Ltd.
,EJC Skin Cancer
,3
(S1)
Background: A recent study demonstrated that parotid squamous cell carcinomas (SCCs) are most potentially metastatic cutaneous SCCs. To define whether epigenetic alterations may explain the different molecular events between ...
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Letter to the Editor: Isolation of Carbapenemase-Producing Pseudomonas aeruginosa from a Waste-Water Sample Collected from a Greek University Hospital
letter to the editors
open access
accepted version
2025
,Microbial Drug Resistance
,31
(3)
The spread of carbapenemase-producing bacteria into clinical settings has dramatically worsen the public health situation. But, also, the isolation of such organisms from samples of environmental and wildlife origin has ...
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Visual presentation of age differences in relative survival of hematological neoplasms in Sweden and the neighboring countries
original article
open access
published version
2025
,Annals of Hematology
,104
(3)
For many hematological malignancies (HMs) survival among older patients is compromised. We want to test the most up-to-date age-group-specific survival differences in five hematological malignancies, Hodgkin lymphoma (HL), ...
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Genomic analysis of extended-spectrum beta-lactamase-producing E. coli from Czech diary calves and their caretakers
original article
open access
accepted version
2025
,Frontiers in Veterinary Science
,12
(March)
INTRODUCTION: The increasing prevalence of antimicrobial resistance in livestock, particularly the dissemination of extended-spectrum beta-lactamase-producing Escherichia coli, poses a significant zoonotic and public health ...
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Proof-of-concept MALDI-TOF-MS assay for the detection of Toxin B enzymatic activity in Clostridioides difficile infection
original article
open access
accepted version
2025
,Microbiology Spectrum
Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometers have become an integral part of all modern clinical microbiology laboratories. They serve as the key tool for pathogen identification ...
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Dietary influence and immune balance: Regulating CD4+IEL responses and MHCII in the gut
summarizing article
restricted access
published version
2025
,Mucosal Immunology
,18
(1)
Over the past decade, interest in CD4 positive intraepithelial lymphocytes (IELs) has been growing. This subset of long-overlooked helper T cell plays critical roles in intestinal homeostasis and in responses to intestinal ...
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Pozorovací a diagnostický nástroj pro zjišťování úrovně a podoby formativního hodnocení v českých školách
Observational and Diagnostic Tool for Determining the Level and Form of Formative Assessment in Czech Schools
original article
open access
published version
2024
,Edukácia
,7
(1)
Cílem tohoto článku je shrnout stávající nástroje pro měření formativního hodnocení a vytvořit nový diagnostický a pozorovací nástroj vhodný pro vzdělávací realitu českých základních škol a nižších stupňů víceletých gymnázií ...
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Activation of the 26S Proteasome to Reduce Proteotoxic Stress and Improve the Efficacy of PROTACs
summarizing article
open access
published version
2024
,ACS Pharmacology & Translational Science
,8
(1)
The 26S proteasome degrades the majority of cellular proteins and affects all aspects of cellular life. Therefore, the 26S proteasome abundance, proper assembly, and activity in different life contexts need to be precisely ...
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