Role of the PML nuclear bodies and its associated histones chaperones in the remodeling of mouse polyomavirus minichromosomes

Abstract

Polyomaviruses (PyVs) are small non-enveloped viruses replicating in the host cell nucleus. Viral replication centers (VRCs) share features with cellular euchromatic or heterochromatic regions, depending on the stage of infection. In the mouse polyomavirus (MPyV) virions, the circular dsDNA genome and cellular histones are present in the form of a condensed minichromosome arranged into 24 nucleosomes. Here we studied the contribution of PML NBs and their chaperone complexes HIRA and ATRX/DAXX in remodeling MPyV chromatin.