STING regulation in polyomavirus infections
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Author
Lišková, Jitka
Šnejdarová, Aneta
Publication date
2024Published in
ICGEB DNA Tumour Virus MeetingPublisher / Publication place
Gianni Cinello, Lithostampa SrL, Udine (Itálie)Metadata
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Abstract
Stimulator of interferon genes (STING) is an indispensable component of cGAS-STING signalization pathway that plays a key role in the innate immune response to polyomavirus infection. Infection of cells by polyomaviruses resulted in cGAS-STING pathway activation but only moderate interferon beta production was detected indicating possible regulation of the pathway during the infection. STING is a transmembrane protein that predominantly resides in the endoplasmic reticulum (ER). After binding to cGAMP di-nucleotide, STING oligomerizes. Oligomers translocate from ER to trans Golgi reticulum which leads to TBK1 and IRF3 phosphorylation and subsequent interferon-beta production. Later, STING is degraded in proteasomes or autophagosomes.
Keywords
STING, polyomavirus, infection
Permanent link
https://hdl.handle.net/20.500.14178/2560License
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