3. Faculty of Medicine
Recent Submissions
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Isokalorická KETOgenní dieta ZLEPŠUJE insulinovou senzitivitu U OBÉZNÍCH ŽEN
poster
open access
published version
2023
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Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk
original article
open access
published version
2024
,Human Genomics
,18
(February)
Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). ...
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Adenotonsillar pathology in mucopolysaccharidoses - lysosomal storage predominates in paracortical CD63+ cells
original article
open access
published version
2024
,Virchows Archiv
,484
(1)
Despite the adenoids are regularly removed in patients with mucopolysaccharidoses (MPS), the underlying tissue and cellular pathologies remain understudied. We characterized an (immuno)histopathologic and ultrastructural ...
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The Czech National MS Registry (ReMuS): Data trends in multiple sclerosis patients whose first disease-modifying therapies were initiated from 2013 to 2021
original article
open access
published version
2024
,Biomedical Papers
,168
(3)
AIMS: Multiple sclerosis treatment strategies are changing in the Czech Republic. According to data from 2013-2021, the proportion of patients starting high-efficacy disease-modifying therapies is increasing. In this survey, ...
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Amiodarone but not propafenone impairs bioenergetics and autophagy of human myocardial cells
original article
open access
published version
2023
,Toxicology and Applied Pharmacology
,477
(October)
Cardiac and extra-cardiac side effects of common antiarrhythmic agents might be related to drug-induced mitochondrial dysfunction. Supratherapeutic doses of amiodarone have been shown to impair mitochondria in animal ...
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Outcomes Of Patients With Myocardial Infarction And Cardiogenic Shock Treated With Culprit Vessel-Only Versus Multivessel Primary PCI
original article
open access
published version
2024
,Hellenic Journal of Cardiology
,76
(MAR-APR)
INTRODUCTION AND OBJECTIVES: Multivessel primary percutaneous coronary intervention (pPCI) is still often used in patients with ST-elevation myocardial infarction (STEMI) and cardiogenic shock (CS). The study aimed to ...
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High incidence of occult familial SDHD cases amongst Czech patients with head and neck paragangliomas
original article
open access
published version
2023
,Frontiers in Endocrinology
,14
(December)
INTRODUCTION: Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors, which are mostly benign in nature. Amongst all genes, Succinate Dehydrogenase Subunit D (SDHD) is the most commonly mutated in familial ...
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Molecular Screening in Anaplastic Lymphoma Kinase–Positive Anaplastic Large Cell Lymphoma: Anaplastic Lymphoma Kinase Analysis, Next-Generation Sequencing Fusion Gene Detection, and T-Cell Receptor Immunoprofiling
original article
open access
published version
2024
,Modern Pathology
,37
(3)
Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALK+ ALCL) originates from the T-lineage and is marked by rearrangements of the ALK gene. Over ten fusion partners with the ALK gene are known, with the ...
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Frentizole derivatives with mTOR inhibiting and senomorphic properties
original article
open access
published version
2023
,Biomedicine & Pharmacotherapy
,167
(November)
Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole's potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in ...
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Pro-cognitive effects of dual tacrine derivatives acting as cholinesterase inhibitors and NMDA receptor antagonists
original article
open access
published version
2024
,Biomedicine & Pharmacotherapy
,176
(July)
Therapeutic options for Alzheimer's disease are limited. Dual compounds targeting two pathways concurrently may enable enhanced effect. The study focuses on tacrine derivatives inhibiting acetylcholinesterase (AChE) and ...
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How to invasively assess left ventricular function and its efficiency of work
summarizing article
open access
published version
2024
,Cor et Vasa
,66
(1)
Effective performance of the left ventricle requires the maintenance of a cardiac output as demanded by the systemic circulation without a high hemodynamic cost or pressure and without a high metabolic cost or oxygen demand ...
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The role of adipogenic capacity and dysfunctional subcutaneous adipose tissue in the inheritance of type 2 diabetes mellitus: cross-sectional study
original article
open access
published version
2024
,Obesity
,32
(3)
OBJECTIVE: This study tested the hypothesis that limited subcutaneous adipose tissue (SAT) expansion represents a primary predisposition to the development of type 2 diabetes mellitus (T2DM), independent of obesity, and ...
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Utilization of healthcare services in acute myocardial infarction and the risk of out-of-hospital cardiac death
letter to the editors
open access
published version
2024
,Panminerva Medica
,66
(1)
COVID-19 represented a significant challenge to cardiovascular (cV) medicine research, treatment, prevention, and, to a considerable extent, case management. The global pandemic viral infection increased the risk of ...
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The Czech Home Parenteral Nutrition Registry REDNUP: Comprehensive Analysis of Adult Patients' Data
original article
open access
published version
2024
,Annals of Nutrition & Metabolism
,80
(3)
INTRODUCTION: Home parenteral nutrition (HPN) is the primary treatment modality for patients with chronic intestinal failure, one of the least common organ failures. This article provides a retrospective analysis of the ...
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Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression
original article
open access
published version
2024
,International Journal of Cancer
,155
(1)
High-grade serous ovarian carcinoma (HGSC) is the most common subtype of ovarian cancer and is among the most fatal gynecological malignancies worldwide, due to late diagnosis at advanced stages and frequent therapy ...
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Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma
original article
open access
published version
2024
,iScience
,27
(2)
Pancreatic cancer is a severe malignancy with increasing incidence and high mortality due to late diagnosis and low sensitivity to treatments. Search for the most appropriate drugs and therapeutic regimens is the most ...
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Nutritional practices and experiences of people on vegan diet with healthcare system: a qualitative study
summarizing article
open access
published version
2023
,Central European Journal of Public Health
,31
(3)
OBJECTIVES: The growing popularity of diets that restrict the consumption of animal-based foods is an important new challenge for the public healthcare system in Czechia. While the environmental and health-related benefits ...
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Atrial fibrillation therapy and stroke prevention in hemodialysis patients
summarizing article
open access
published version
2023
,Kardiologia Polska
,81
(12)
The prevalence of atrial fibrillation (AF) in patients with chronic kidney disease (CKD), especially on hemodialysis (HD) is higher compared to the general population without CKD and reaches ~20%. The risk of ischemic ...
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Microdialysis as a tool for antibiotic assessment in patients with diabetic foot: a review
summarizing article
embargoed access
published version
2023
,Frontiers in Endocrinology
,14
(April)
Diabetic foot is a serious late complication frequently caused by infection and ischaemia. Both require prompt and aggressive treatment to avoid lower limb amputation. The effectiveness of peripheral arterial disease therapy ...
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Impaired renal autoregulation and pressure-natriuresis: any role in the development of heart failure in normotensive and angiotensin II-dependent hypertensive rats?
original article
embargoed access
published version
2023
,Hypertension Research
,46
(9)
The aim of the present study was to assess the autoregulatory capacity of renal blood flow (RBF) and of the pressure-natriuresis characteristics in the early phase of heart failure (HF) in rats, normotensive and with ...
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