Faculty of Medicine in Pilsen
Recent Submissions
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Clonal outbreak of an extensively drug-resistant NDM-1 producing Pseudomonas aeruginosa in a local hospital in the Czech Republic
original article
open access
accepted version
2025
,ASM Press
,Microbiology Spectrum
A clonal outbreak of 18 ST773 NDM-1 producing Pseudomonas aeruginosa strains has been detected for the first time in the Czech Republic. The strains were extremely drug-resistant (XDR) and resistant to serum killing. ...
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VAST INCREASE IN SECOND PRIMARY LUNG CANCERS IN SWEDEN
original article
open access
submitted version
2025
Background: We describe the occurrence of second primary lung cancers (SPLCs) and their determinant in Sweden.Methods: Nation-wide cancer registry from years 1961 to 2021 identified a total of 853 SPLCs.Results: The incidence ...
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Spatial Patterns and Prognostic Relevance of CD1aImmature and CD208 Mature Dendritic Cells inColorectal Cancer From Tumour-adjacent Mucosato Liver Metastases
original article
open access
submitted version
2025
Background. The prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired livermetastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a+ and matureCD208+ subsets across ...
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Macrophages in Colorectal Cancer: From Normal Mucosa to Distant Metastasis: Beyond the M1/M2 Paradigm
summarizing article
open access
submitted version
2025
Colorectal cancer (CRC) is the third most common malignancy and a leading cause of mortality worldwide. The tumor microenvironment (TME) strongly influences CRC growth, immune evasion, and metastasis. Among various immune ...
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Biomarkers, Omics and Artificial Intelligence for Early Detection of Pancreatic Cancer
original article
open access
published version
2025
,Academic Press
,Seminars in Cancer Biology
,111
(June)
Pancreatic ductal adenocarcinoma (PDAC) is frequently diagnosed in its late stages when treatment options are limited. Unlike other common cancers, there are no population-wide screening programmes for PDAC. Thus, early ...
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Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer
original article
open access
accepted version
2025
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...
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Relationship between MASLD and women's health: A review
summarizing article
open access
published version
2025
,SAGE Publications Ltd
,Women's Health
,21
(October)
Metabolic dysfunction-associated steatotic liver disease (MASLD; formerly non-alcoholic fatty liver disease, NAFLD) is a common chronic liver disease strongly linked to obesity, metabolic syndrome (MetS), and type 2 diabetes. ...
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Therapeutic pancreatic cancer biomarkers and pharmacogenetics
summarizing article
open access
published version
2025
,Academic Press
,Seminars in Cancer Biology
,116
(November)
FOLFIRINOX and gemcitabine plus nab-paclitaxel represent the most effective chemotherapy regimens for metastatic pancreatic cancer patients nowadays, but the median overall survival remains less than one year. Pharmacogenomics ...
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Mass spectrometric profiling of microbial polysaccharides using laser desorption/ionization – time-of-flight (LDI-TOF) and liquid chromatography-mass spectrometry (LC-MS): a novel method for structural fingerprinting and derivatization
original article
open access
published version
2025
,Frontiers Media S.A.
,Frontiers in Cellular and Infection Microbiology
,15
(October)
Introduction: Over the last two decades, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been introduced into the routine diagnostic practice of microbiological laboratories ...
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Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer
original article
open access
published version
2025
,Nature Medicine
,31
(7)
Associations between the gut microbiome and colorectal cancer (CRC) have been uncovered, but larger and more diverse studies are needed to assess their potential clinical use. We expanded upon 12 metagenomic datasets of ...
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One-Step Nucleic Acid Amplification Analysis of Sentinel Lymphatic Nodes in Endometrial Cancer Patients (EU-OSNA): A European Multicenter Diagnostic Accuracy Study
original article
open access
published version
2025
,Blackwell Publishing
,Cancer Medicine
,14
(18)
OBJECTIVE: This European multicenter study aimed to assess the diagnostic accuracy of one-step nucleic acid amplification (OSNA) as the primary endpoint by comparing this method with ultrastaging for the detection of ...
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Sex specific familial risk in lung cancer through changing histologies in Sweden
original article
open access
published version
2025
,Wiley-Liss
,International Journal of Cancer
,157
(5)
Familial clustering of lung cancer (LC) is related to shared smoking habits but the contribution of other potential factors such as sex or histology is not well known, and these are the subjects of the present study in ...
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Familial risks and incidence rates for childhood nervous system tumors in Sweden
original article
open access
published version
2025
,Elsevier Ltd.
,EJC Paediatric Oncology
,6
(December)
Background: Childhood (< 20 years) nervous system tumors manifest in some rare cancer syndromes but how commonly they present with familial clustering between various histological types is not well known at a nation-wide ...
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Nucleotide composition shapes gene expression in Wolbachia pipientis: a role for MidA methyltransferase?
original article
open access
published version
2025
,American Society for Microbiology
,mSystems
,10
(9)
Wolbachia pipientis is an obligate intracellular bacterium, associated with several arthropods and filarial nematodes. Wolbachia establishes a variety of symbiotic relationships with its hosts, with consequent genomic ...
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Antibacterial activity of the novel peptide Pac-525 with the RGD motif against intracellular Escherichia coli
original article
open access
published version
2025
,Springer Nature
,Scientific Reports
,15
(1)
Infections caused by invasive intracellular bacteria pose major therapeutic challenges due to pathogen survival and growth inside of host cells as well as the low intracellular accessibility for conventional antibiotics. ...
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Non-viral HCC miRNA profiling reveals miR-1972 as a potential positive prognostic marker
original article
open access
published version
2025
,Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
,Non-coding RNA Research
,15
(December)
Background & Aims: Hepatocellular carcinoma (HCC) is the third deadliest cancer worldwide. Its high mortality is primarily attributed to late-stage diagnosis. While mutations in driver genes, such as those encoding β-catenin ...
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Pembrolizumab versus Pembrolizumab plus Chemotherapy in Non-small Cell Lung Cancer with High PD-L1 Expression - Multicenter Real-world Evidence Study
original article
open access
published version
2025
,Ivyspring International Publisher
,Journal of Cancer
,16
(10)
Background: Patients with non-small cell lung cancer (NSCLC) with PD-Ll expression ~ 50% can be treated with immunotherapy alone or with a combination of immunotherapy and chemotherapy. One of these options is treatment ...
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Prognostic Role of Prostate-specific Antigen Isoforms and Their Early Kinetics in Patients With Metastatic Castration-resistant Prostate Cancer Receiving New Generation Androgen Receptor Targeted Agents
original article
open access
published version
2025
,Iōannīs G. Delīnasios
,In Vivo
,39
(2)
BACKGROUND/AIM: New generation androgen receptor-targeting agents (ARTA) have been in the spotlight for their efficacy in metastatic castration-resistant prostate cancer (mCRPC). Prostate-specific antigen (PSA) represents ...
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Impact of concomitant use of proton pump inhibitors or cardiovascular medication on survival outcomes of patients with metastatic renal cell carcinoma treated with nivolumab
original article
open access
published version
2025
,Clinical & Experimental Metastasis
,42
(5)
Renal cell cancer (RCC) is typically a disease of older adults, who often have comorbidities requiring the use of multiple concomitant medications. Even though the patients with metastatic RCC (mRCC) are often exposed to ...
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Native and decellularized porcine vena cava: Biomechanical and microstructural comparison
original article
open access
published version
2025
,Elsevier Ltd.
,Acta Biomaterialia
,201
(July)
Tissue decellularization has emerged as a technique to provide an acellular, non-immunogenic scaffold that preserves the morphological features of native tissue. To study the possible effects of decellularization, investigating ...
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