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Poslední příspěvky
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Pro-cognitive effects of dual tacrine derivatives acting as cholinesterase inhibitors and NMDA receptor antagonists
původní článek
open access
vydavatelská verze
2024
,Biomedicine & Pharmacotherapy
,176
(July)
Therapeutic options for Alzheimer's disease are limited. Dual compounds targeting two pathways concurrently may enable enhanced effect. The study focuses on tacrine derivatives inhibiting acetylcholinesterase (AChE) and ...
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Discovery and characterization of novel DNA viruses in Apis mellifera: expanding the honey bee virome through metagenomic analysis
původní článek
open access
vydavatelská verze
2024
,mSystems
,9
(4)
To date, many viruses have been discovered to infect honey bees. In this study, we used high-throughput sequencing to expand the known virome of the honey bee, Apis mellifera, by identifying several novel DNA viruses. While ...
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Modification of the RTX domain cap by acyl chains of adapted length rules the formation of functional hemolysin pores
původní článek
open access
vydavatelská verze
2024
,Biochimica et Biophysica Acta - Biomembranes
,1866
(5)
The acylated pore-forming Repeats in ToXin (RTX) cytolysins alpha-hemolysin (HlyA) and adenylate cyclase toxin (CyaA) preferentially bind to beta 2 integrins of myeloid leukocytes but can also promiscuously bind and ...
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The Effect of Topography on Long-Term Spontaneous Development of Soil and Woody Cover on Graded and Untreated Overburden
původní článek
open access
vydavatelská verze
2020
,Forests [online]
,11
(5)
We studied the development of soil and soil fauna, as well as selected vegetation parameters important for litter input into soil, in two chronosequences of postmining sites after opencast lignite mining near the town of ...
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Heterogeneous Response of Tumor Cell Lines to Inhibition of Aspartate β-hydroxylase
původní článek
open access
vydavatelská verze
2024
,Journal of Cancer
,15
(11)
Background: Cancer development involves alterations in key cellular pathways, with aspartate β-hydroxylase (ASPH) emerging as an important player in tumorigenesis. ASPH is upregulated in various cancer types, where it ...
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Varroa destructor parasitism and Deformed wing virus infection in honey bees are linked to peroxisome-induced pathways
původní článek
open access
vydavatelská verze
2024
,Proteomics
,24
(9)
The ectoparasitic mite Varroa destructor transmits and triggers viral infections that have deleterious effects on honey bee colonies worldwide. We performed a manipulative experiment in which worker bees collected at ...
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Role of cryptic rearrangements of human chromosomes in the aetiology of schizophrenia
přehledový článek
open access
vydavatelská verze
2023
,Journal of Genetics
,102
(1)
Schizophrenia (SZ) is a highly inherited disease that affects similar to 0.5% of the population. The genetic and environmental factors are involved in its aetiology and they interact with each other. Combination of symptoms ...
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Validated WGS and WES protocols proved saliva-derived gDNA as an equivalent to blood-derived gDNA for clinical and population genomic analyses
původní článek
open access
vydavatelská verze
2024
,BMC Genomics
,25
(1)
Background: Whole exome sequencing (WES) and whole genome sequencing (WGS) have become standard methods in human clinical diagnostics as well as in population genomics (POPGEN). Blood-derived genomic DNA (gDNA) is routinely ...
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DNA from BK polyomavirus is sensed during infection of reservoir cells via cGAS-STING pathway
abstrakt v konferenčním sborníku
open access
postprint
2024
,Nizozemsko
,TOLL 2024 Road to translation
Human polyomaviruses (HPyVs) include 14 species that cause primary asymptomatic infections after which the virus persists in the host by a mechanism that is not well understood. Reactivation of the infection in immunosuppressed ...
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STING agonist induced-monocyte death combines apoptosis, pyroptosis and caspase 8 activation
abstrakt v konferenčním sborníku
open access
postprint
2024
,Nizozemsko
,TOLL 2024 Road to translation
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway isimportant for recognition of double-stranded DNA, a marker of infection or cell damage. ThecGAS-STING pathway activation leads to production ...
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HBV-induced microenvironment reduces pDC response to TLR9 stimulation
abstrakt v konferenčním sborníku
open access
postprint
2024
,Nizozemsko
,TOLL 2024 Road to translation
Hepatitis B virus (HBV) is a non-cytopathogenic virus with DNA genome. It causes an acute hepatitis that may develop into chronic hepatitis B, liver cirrhosis and hepatocellular carcinoma. HBV is described as "stealth ...
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Determinants of self-rated health among highly educated Ukrainian women refugees in Czechia: analysis based on cross-sectional study in 2022
původní článek
open access
vydavatelská verze
2024
,BMC Women's Health
,24
(1)
Background: Russia's military aggression against Ukraine set in motion a large number of refugees. Considerable amount of them came and stayed in Czechia. Refugees represent special vulnerable individuals often affected ...
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Using Raman spectroscopy to detect scytonemin of epiliths and endoliths from marble, serpentinite and gypsum
původní článek
open access
vydavatelská verze
2023
,Journal of Raman Spectroscopy
,54
(11)
Here, we present Raman spectra showing the presence and distribution of scytonemin and carotenoids in epilithic and endolithic colonisations from temperate locations in Central Europe and Sicily. In the Bohemian Massif, ...
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Raman study of several Cu-bearing complex minerals from the guano deposit at Pabellón de Pica, Tarapaca region, Chile
původní článek
open access
vydavatelská verze
2023
,Journal of Raman Spectroscopy
,54
(11)
Pabellón de Pica, Tarapaca, Chile, is a former guano mine exploited in the late 19th and early 20th centuries. Guano is in a direct contact with Cu sulfide mineralization leading to the formation of minerals with a highly ...
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More than urns: A multi-method pipeline for analyzing cremation burials
původní článek
open access
vydavatelská verze
2023
,PLoS One
,18
(8)
Burial rites of archaeological populations are frequently interpreted based on cremated remains of the human body and the urn they were deposited in. In comparison to inhumations, information about the deceased is much ...
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Silver isotopes: A tool to trace smelter-derived contamination
původní článek
open access
vydavatelská verze
2023
,Environmental Pollution
,337
(November)
Here, for the first time, we report the concentrations and isotopic data of Ag in a variety of ore and metallurgical samples and forest soils that have been polluted due to Ag-Pb smelter emissions. Similar to the Ag ...
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Gypsum endolithic phototrophs under moderate climate (Southern Sicily): their diversity and pigment composition
původní článek
open access
vydavatelská verze
2023
,Frontiers in Microbiology
,14
(July)
In this study, we used microscopic, spectroscopic, and molecular analysis to characterize endolithic colonization in gypsum (selenites and white crystalline gypsum) from several sites in Sicily. Our results showed that the ...
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Provenance Analysis of Marbles by Combination of Cathodoluminescence Spectroscopy and Electron Microprobe Analyses-Methodological Comments
původní článek
open access
vydavatelská verze
2023
,Minerals
,13
(2)
Various marbles from historic quarries of the Czech Republic were examined by means of cathodoluminescence (CL) spectroscopy (quantitative data) to determine the possible inclusion of the method in marble provenance studies. ...
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The Recent Discovery, Research, and Restoration of Medieval and Renaissance Frescoes in Riga Castle — A Treasure to the Baltic Region
původní článek
open access
vydavatelská verze
2023
,Heritage
,6
(3)
One of the most important castles of the medieval Teutonic Order-Riga Castle in Latvia-is currently undergoing extensive reconstruction work. This study attempts to summarize recent information about the medieval fresco ...
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Impact of Mining and Ore Processing on Soil, Drainage and Vegetation in the Zambian Copperbelt Mining Districts: A Review
přehledový článek
open access
vydavatelská verze
2023
,Minerals
,13
(3)
The regional environmental-geochemical surveying of the long-term impacts of mining and ore processing on a large part of the Zambian Copperbelt mining district was carried out by the Czech Research Group with cooperation ...
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