Zobrazují se záznamy 1-20 z 2367

    • Design and Synthesis of Actin-Targeting 10-Phenoxy Cytochalasan Analogues: Balancing Cytotoxicity and Migrastatic Activity 

      původní článek

      open access

      vydavatelská verze

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      Javorská, Žaneta

      ;

      Volfová, Tereza

      ;

      Faivre, Johan

      ;

      Dehaen, Wim

      ;

      Rimpelová, Silvie

      ;

      Labíková, Magdaléna

      ;

      Rösel, Daniel

      ;

      Brábek, Jan

      ;

      Perlíková, Pavla

      2026

      ,

      American Chemical Society

      ,

      ACS Medicinal Chemistry Letters

      ,

      17

      (2)

      Cytochalasans are actin polymerization inhibitors with potent migrastatic activity, but their potential therapeutic use is limited by their cytotoxicity. Here, we describe a modular late-stage approach that introduces ...

    • Differential Expression of P-Element-Induced Wimpy Testis (PIWI)-Interacting RNAs in Glioblastoma Stem Cells Affects Their Biological Features: Implications for Tumor Progression and Patient Survival 

      původní článek

      open access

      vydavatelská verze

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      Siegl, Frantisek

      ;

      Garcia-Borja, Elena

      ;

      Mateu, Rosana

      ;

      Trachtova, Karolina

      ;

      Jasik, Matej

      ;

      Kopecky, Martin

      ;

      Vecera, Marek

      ;

      Radova, Lenka

      ;

      Hendrych, Michal

      ;

      Kazda, Tomas

      ;

      Fadrus, Pavel

      ;

      Šedo, Aleksi

      ;

      Slaby, Ondrej

      ;

      Bušek, Petr

      ;

      Sana, Jiri

      2026

      ,

      Elsevier

      ,

      Laboratory Investigation

      ,

      106

      (3)

      Glioblastoma isocitrate dehydrogenase-wild-type (GBM) is the most lethal and, concurrently, the most common malignant primary brain tumor. Its aggressive behavior is associated with the presence of a subpopulation of ...

    • The new role of abortion in the context of low fertility in Czechia and Slovakia 

      původní článek

      open access

      vydavatelská verze

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      Idlbeková, Bára

      ;

      Kocourková, Jiřina

      2026

      ,

      Springer Nature

      ,

      Scientific Reports

      ,

      16

      (1)

      This study examines how the role of abortion has evolved in the context of low fertility and delayed childbearing, with a focus on Czechia and Slovakia-two countries that experienced both high abortion rates and a demographic ...

    • Constitutional interpretation in emergencies in the Czech Republic: Searching for an adequate level of judicial deference to the executive 

      kapitola v kolektivní monografii

      omezený přístup

      vydavatelská verze

      Ikona Jiná licence

      Ondřejek, Pavel

      2026

      ,

      Abingdon

      ,

      Routledge

      ,

      Crises, Emergencies, and Constitutional Law. Interpretation and Adjudication in Europe

      This chapter begins by explaining the legal regimes and context that are important for understanding the main issues of constitutional interpretation in emergencies in the Czech Republic. The first question concerns the ...

    • Drought response of stem growth and canopy of seven Central European tree species across deposition gradients 

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      open access

      vydavatelská verze

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      Fišer, Petr

      ;

      Mašek, Jiří

      ;

      Vejpustkova, Monika

      ;

      Tumajer, Jan

      ;

      van der Maaten-theunissen, Marieke

      ;

      van der Maaten, Ernst

      ;

      Weise, Konstantin

      ;

      Treml, Václav

      2026

      ,

      Elsevier B.V.

      ,

      Trees, Forest and People

      ,

      28

      (November 2026)

      Tree growth is increasingly affected by more frequent and intense drought events associated with ongoing climate change. Tree-growth resistance and resilience to drought events may vary among species and between aboveground ...

    • PEDAGOGICAL CHALLENGES IN WORKING WITH STUDENTS WITH AUTISM SPECTRUM DISORDER – A QUALITATIVE INQUIRY INTO MUSIC EDUCATION 

      původní článek

      open access

      vydavatelská verze

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      Daněk, Alois

      ;

      Kmentová, Milena

      ;

      Mazurek, Jiří

      2026

      ,

      Natsionalno Izdatelstvo Az Buki

      ,

      Pedagogika

      ,

      98

      (1)

      Music education is an essential segment of the Czech school system. The main aim of the paper is to present qualitative research that used a case study method to explore the interaction of a student diagnosed with autism ...

    • Context-Dependent Prognostic Role of Neutrophils and Mast Cells in Primary Colorectal Cancer and Liver Metastases 

      původní článek

      open access

      vydavatelská verze

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      Ye, Wenjing

      ;

      Ali, Esraa

      ;

      Pavlov, Sergii

      ;

      Červenková, Lenka

      ;

      Ambrożkiewicz, Filip

      ;

      Vyčítal, Ondřej

      ;

      Hošek, Petr

      ;

      Daum, Ondřej

      ;

      Liška, Václav

      ;

      Hemminki, Kari Jussi

      ;

      Trailin, Andriy

      2026

      ,

      Baishideng Publishing Group

      ,

      World Journal of Gastrointestinal Oncology

      ,

      18

      (10)

      BACKGROUND Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Liver metastases (LM) are a major prognostic factor affecting survival and treatment outcomes. Distinguishing between synchronous ...

    • Victory, Homogeneity and International Order: Czechoslovakia’s Violent Paths to National Democracy in 1918, 1945 and 1989 

      kapitola v monografii

      open access

      vydavatelská verze

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      Konrád, Ota

      2026

      ,

      New York

      ,

      Berghahn Books

      ,

      Political Crisis in Central Europe in the Interwar Period and Today Temporality Semantics and Logic of Crises in Poland Czechoslovakia Hungary and Romania

      This chapter examines the role of conflict and political violence in shaping democratic resilience in Czechoslovakia and the Czech Republic across three major political transitions: the establishment of Czechoslovakia in ...

    • Between Ritualisation and Reflection: the Holocaust, Postcolonial Challenges, and History Education in Germany 

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      vydavatelská verze

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      Konrád, Ota

      2026

      ,

      Carfax

      ,

      Comparative education

      This article examines how Holocaust remembrance, migration, andpostcolonial critique have reshaped history education in Germany.Situating the German case within a wider European context, itreconstructs three pedagogical ...

    • Predictors of COVID-19 vaccination status: a nationwide linkage study in Czechia 

      původní článek

      open access

      vydavatelská verze

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      Dzúrová, Dagmar

      ;

      Benešová, Klára

      ;

      Bernard, Josef

      ;

      Hulíková Tesárková, Klára

      ;

      Jarkovský, Jiří

      ;

      Kahoun, Lukáš

      ;

      Kšiňanová, Gabriela

      ;

      Mužík, Jan

      ;

      Netrdová, Pavlína

      ;

      Szabo, Daniel

      ;

      Bobák, Martin

      2026

      ,

      Oxford University Press

      ,

      Journal of Public Health

      ,

      48

      (3)

      Objectives The evidence on coronavirus disease 2019 (COVID-19) vaccine uptake in Central and Eastern Europe remains sparse. We examined predictors of COVID-19 vaccination status in Czechia, using linkage of multiple routine ...

    • Historical Evolution of Terminology and Current Classification of Neuroendocrine Neoplasms of the Larynx and Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms (MiNENs): A Narrative Review 

      přehledový článek

      open access

      vydavatelská verze

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      Bradová, Martina

      ;

      Agaimy, Abbas

      ;

      Ferlito, Alfio

      2026

      ,

      MDPI

      ,

      Diagnostics

      ,

      16

      (17)

      This is a narrative review that describes the evolution of terminology and classification schemes of neuroendocrine tumors (NETs), neuroendocrine carcinomas (NECs), mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs), ...

    • The 2025 Czech parliamentary election 

      původní článek

      open access

      vydavatelská verze

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      Buben, Radek

      ;

      Kouba, Karel

      2026

      ,

      F. Cass

      ,

      West European Politics

      ,

      49

      (6)

      The 2025 election to the Czech Chamber of Deputies marked a continuation of long-term transformations rather than a rupture in the country's political development. The contest reaffirmed the electoral dominance of ...

    • Q-metoda: možnosti ve výuce občanské výchovy 

      Q-method: possibilities in teaching civics

      původní článek

      open access

      preprint

      Gratis Apen Access Icon

      Sotáková, Hana

      ;

      Ondráček, Vojtěch

      ;

      Smetáčková, Irena

      2026

      ,

      Masarykova univerzita

      ,

      Komenský

      ,

      150

      (2)

      Q-metoda představuje specifickou diskusní techniku, kterou lze využít jako výzkumnou, ale i výukovou metodu. Prostřednictvím strukturované práce s výroky ve skupinách totiž umožňuje dosáhnout vysoké didaktické efektivity. ...

    • Q-metoda: možnosti ve výuce občanské výchovy 

      Q-method: possibilities in teaching civics

      původní článek

      open access

      preprint

      Gratis Apen Access Icon

      Sotáková, Hana

      ;

      Ondráček, Vojtěch

      ;

      Smetáčková, Irena

      2026

      ,

      Masarykova univerzita

      ,

      Komenský

      ,

      150

      (2)

      Q-metoda představuje specifickou diskusní techniku, kterou lze využít jako výzkumnou, ale i výukovou metodu. Prostřednictvím strukturované práce s výroky ve skupinách totiž umožňuje dosáhnout vysoké didaktické efektivity. ...

    • Hidden cytotoxicity and mitochondrial dysfunction in 3D-printing polymers: evidence from FLEX, PETG and PC 

      původní článek

      open access

      vydavatelská verze

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      Dejmek, Jiří

      ;

      Jedlička, Jan

      2026

      ,

      Springer Nature

      ,

      Scientific Reports

      ,

      16

      (1)

      Despite the widespread use of 3D printing, the toxicological profile of commercially available filaments remains largely uncharacterized across both consumer and scientific communities. The persistent lack of comprehensive ...

    • Resultados al año del tratamiento hospitalario del trastorno por consumo de alcohol: Un programa de siete semanas en la República Checa 

      One-year outcomes of inpatient treatment for alcohol use disorder: A seven-week programme in the Czech Republic

      původní článek

      open access

      vydavatelská verze

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      Skorkovský, Tomáš

      ;

      Beniš, Milan

      ;

      Podlipný, Jiří

      ;

      Hošek, Petr

      ;

      Miovský, Michal

      ;

      Vevera, Jan

      2026

      ,

      Socidrogalcohol

      ,

      Adicciones

      ,

      38

      (3)

      Los resultados a largo plazo del tratamiento hospitalario del trastorno por consumo de alcohol (TCA) siguen siendo insuficientemente estudiados en Europa Central y Oriental. Este estudio examinó los resultados a los 12 ...

    • Outbreak investigation of extensively drug-resistant Acinetobacter baumannii of ST2 in the intensive care unit of a Lebanese hospital 

      původní článek

      open access

      vydavatelská verze

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      Sourenian, Tsolaire

      ;

      Finianos, Marc

      ;

      Ftouni, Mohammed

      ;

      Najem, Zeinab

      ;

      Bonaiti, Clara

      ;

      Medlej, Abdallah

      ;

      Hrabák, Jaroslav

      ;

      Papagiannitsis, Costas C

      ;

      Bitar, Ibrahim

      2026

      ,

      Frontiers Media S.A.

      ,

      Frontiers in Cellular and Infection Microbiology

      ,

      16

      (24 September 2026)

      BACKGROUND: The aim of the study is to investigate an XDR Acinetobacter baumannii outbreak in the ICU of a tertiary hospital in Lebanon. METHODS: A total of 39 swabs were sampled from the ICU room (n=34; environmental ...

    • Diverse genetic pathways drive convergent fluconazole and caspofungin resistance phenotypes in Candida albicans 

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      Abbas, Mounzer

      ;

      Fattouh, Nour

      ;

      Chedraoui, Christy

      ;

      El Hachem, Setrida

      ;

      Sourenian, Tsolaire

      ;

      Bitar, Ibrahim

      ;

      Khalaf, Roy A

      2026

      ,

      Public Library of Science

      ,

      PLoS One

      ,

      21

      (10)

      The emergence of antifungal resistance in Candida albicans is a major worldwide public health threat, particularly for immunocompromised patients. Antifungal resistance may arise through uniform resistance mechanisms or ...

    • Persistent spread of carbapenemase-producing Klebsiella pneumoniae in acute care hospitals in 36 European countries (the CCRE survey): a prospective, multicentre, cross-sectional, epidemiological, microbiological, and genomic surveillance study 

      původní článek

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      Fröding, Inga

      ;

      David, Sophia

      ;

      Yeats, Corin

      ;

      Abu-Dahab, Khalil

      ;

      Albiger, Barbara

      ;

      Alikhan, Nabil Fareed

      ;

      Alm, Erik

      ;

      Byfors, Sara

      ;

      Couto, Natacha

      ;

      Diaz Caballero, Julio

      ;

      Giske, Christian G.

      ;

      Matuschek, Erika

      ;

      Linkevicius, Marius

      ;

      Palm, Daniel

      ;

      Svartström, Olov

      ;

      Struelens, Marc J.

      ;

      Tegmark Wisell, Karin

      ;

      Monnet, Dominique L.

      ;

      Brolund, Alma

      ;

      Aanensen, David M.

      ;

      Kohlenberg, Anke

      ;

      Koraqi, Andi

      ;

      Bego, Artan

      ;

      Apfalter, Petra

      ;

      Hartl, Rainer

      ;

      Huang, Te Din

      ;

      Latour, Katrien

      ;

      Travar, Maja

      ;

      Sabtcheva, Stefana

      ;

      Tambić-Andrašević, Arjana

      ;

      Hrabák, Jaroslav

      ;

      Žemličková, Helena

      ;

      Charalambous, Panayiota Maikanti

      ;

      Hammerum, Anette M.

      ;

      Bilozor, Anastasia

      ;

      Jürna-Ellam, Marika

      ;

      Jalava, Jari

      ;

      Räisänen, Kati

      ;

      Dortet, Laurent

      ;

      Noll, Ines

      ;

      Pfennigwerth, Niels

      ;

      Tryfinopoulou, Kyriaki

      ;

      Vatopoulos, Alkiviadis

      ;

      Tóth, Ákos

      ;

      Helgason, Kristjan Orri

      ;

      Cormican, Martin

      ;

      Errico, Giulia

      ;

      Monaco, Monica

      ;

      Kurti, Arsim

      ;

      Raka, Lul

      ;

      Niedre-Otomere, Baiba

      ;

      Razmuk, Jelena

      ;

      Sinotova, Jekaterina

      ;

      Meo, Marie

      ;

      Perrin, Monique

      ;

      Micallef, Denise

      ;

      Nestorova, Nina

      ;

      Lopičić, Milena

      ;

      Vuksanović, Vineta

      ;

      Notermans, Daan

      ;

      Vendrik, Karuna E.W.

      ;

      Kaftandzieva, Ana

      ;

      Osmani, Dugagjin

      ;

      Samuelsen, Ørjan

      ;

      Literacka, Elżbieta

      ;

      Caniça, Manuela

      ;

      Manageiro, Vera

      ;

      Codita, Irina

      ;

      Lixandru, Brandusa

      ;

      Ćirković, Ivana

      ;

      Medić, Deana

      ;

      Nikš, Milan

      ;

      Pirš, Mateja

      ;

      Cañada-García, Javier E.

      ;

      Pérez-Vázquez, María

      ;

      Edquist, Petra

      ;

      Westmo, Karin

      ;

      Şimşek, Hüsniye

      ;

      Yildiz, Serap Süzük

      ;

      Hopkins, Katie L.

      ;

      Meunier, Danièle

      2026

      ,

      Elsevier Ltd.

      ,

      The Lancet Microbe

      ,

      7

      (6)

      Background Carbapenem-resistant Enterobacterales pose a substantial threat to patients and health-care systems. We conducted a survey of carbapenem-resistant and/or colistin-resistant Enterobacterales (CCRE survey) in 37 ...

    • Genomic diversity, antimicrobial resistance, and virulence-associated characteristics of Escherichia coli recovered from poultry hatchery-box material 

      původní článek

      open access

      vydavatelská verze

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      Papoušková, Aneta

      ;

      Masaříková, Martina

      ;

      Palkovičová, Jana

      ;

      Dolejská, Monika

      ;

      Čížek, Alois

      2026

      ,

      Poultry Science Association

      ,

      Poultry Science

      ,

      105

      (12)

      Hatcheries are early points of exposure of newly hatched chicks to Escherichia coli from eggshell debris, dust, meconium, and the hatchery environment. This study used descriptive genomic surveillance to characterize ...