Repozitář publikační činnosti UK: Poslední příspěvky
Zobrazují se záznamy 841-860 z 1819
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Characterization of STING agonist-induced monocyte cell death reveals combination of apoptosis, pyroptosis and caspase 8 activation
abstrakt v konferenčním sborníku
open access
postprint
2024
,Hoboken
,Wiley-VCH
,European Journal of Immunology
,54
(S1)
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway senses double-stranded DNA in cytoplasm, a signal of invading pathogens or cell damage. The activation of the cGAS-STING pathway induces ...
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Correlation of genotype, phenotype and mitochondrial metabolism of patients with Friedreich's ataxia with the aim of implementing innovative therapies
poster
omezený přístup
postprint
2022
Title: Presentation of a cohort of 40 Czech and Slovak patients with Friedreich's ataxia with the aim of introducing innovative therapiesBackground and objectives: Friedreich's ataxia (FA) is an autosomal recessive inherited ...
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The Marital Fertility of Men and Women in Czechia before the First Demographic Transition and in the Current Population
původní článek
open access
vydavatelská verze
2024
,Demografie
,66
(2)
The aim of this study is to analyse the changes in the marital fertility of men and women in Czechia before the first demographic transition (data obtained by excerpting the parish registers of Škvorec manor in the years ...
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The fertility timing gap: the intended and real timing of childbirth
původní článek
open access
vydavatelská verze
2024
,Journal of Biosocial Science
,56
(3)
The fertility gap, which indicates the difference between the planned and actual number of children born, can be explained by the shift in parenthood to older ages and is associated with the non-attainment of one's intended ...
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Why and how to construct an epistemic justification of machine learning?
původní článek
embargo
vydavatelská verze
2024
,Synthese
,204
(2)
Consider a set of shuffled observations drawn from a fixed probability distribution over some instance domain. What enables learning of inductive generalizations which proceed from such a set of observations? The scenario ...
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Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions
přehledový článek
open access
vydavatelská verze
2024
,Bioconjugate Chemistry
,35
(8)
Targeted protein degradation or TPD, is rapidly emerging as a treatment that utilizes small molecules to degrade proteins that cause diseases. TPD allows for the selective removal of disease-causing proteins, including ...
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Germline pathogenic variants in the MRE11, RAD50, and NBN (MRN) genes in cancer predisposition: A systematic review and meta-analysis
původní článek
open access
vydavatelská verze
2024
,Wiley-Liss
,International Journal of Cancer
,155
(9)
The MRE11, RAD50, and NBN genes encode the MRN complex sensing DNA breaks and directing their repair. While carriers of biallelic germline pathogenic variants (gPV) develop rare chromosomal instability syndromes, the cancer ...
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Loss of ADAR1 protein induces changes in small RNA landscape in hepatocytes
původní článek
open access
vydavatelská verze
2024
,RNA
,30
(9)
In recent years, numerous evidence has been accumulated about the extent of A-to-I editing in human RNAs and the key role ADAR1 plays in the cellular editing machinery. It has been shown that A-to-I editing occurrence and ...
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Educate, not kill: treating cancer without triggering its defenses
původní článek
open access
vydavatelská verze
2024
,Elsevier Ltd.
,Trends in Molecular Medicine
,30
(7)
Traditionally, anticancer therapies focus on restraining uncontrolled proliferation. However, these cytotoxic therapies expose cancer cells to direct killing, instigating the process of natural selection favoring survival ...
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Suppression of the growth and metastasis of mouse melanoma by Taenia crassiceps and Mesocestoides corti tapeworms
původní článek
open access
vydavatelská verze
2024
,Frontiers Media SA
,Frontiers in Immunology
,15
(20 March 2024)
Cancer is still one of the leading causes of death, with an estimated 19.3 million new cases every year. Our paper presents the tumor-suppressing effect of Taenia crassiceps and Mesocestoides corti on B16F10 melanoma, the ...
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Sand fly blood meal volumes and their relation to female body weight under experimental conditions
původní článek
open access
vydavatelská verze
2024
,Parasites & Vectors
,17
(1)
Background Sand fly females require a blood meal to develop eggs. The size of the blood meal is crucial for fecundity and affects the dose of pathogens acquired by females when feeding on infected hosts or during experimental ...
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Outcomes Of Patients With Myocardial Infarction And Cardiogenic Shock Treated With Culprit Vessel-Only Versus Multivessel Primary PCI
původní článek
open access
vydavatelská verze
2024
,Hellenic Journal of Cardiology
,76
(MAR-APR)
INTRODUCTION AND OBJECTIVES: Multivessel primary percutaneous coronary intervention (pPCI) is still often used in patients with ST-elevation myocardial infarction (STEMI) and cardiogenic shock (CS). The study aimed to ...
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Skin exposure to soil microbiota elicits changes in cell-mediated immunity to pneumococcal vaccine
původní článek
open access
vydavatelská verze
2024
,Scientific Reports
,14
(1)
A resilient immune system is characterized by its capacity to respond appropriately to challenges, such as infections, and it is crucial in vaccine response. Here we report a paired randomized intervention-control trial ...
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Multicenter benchmarking of short and long read wet lab protocols for clinical viral metagenomics
původní článek
open access
vydavatelská verze
2024
,Journal of Clinical Virology
,173
(August)
Metagenomics is gradually being implemented for diagnosing infectious diseases. However, in-depth protocol comparisons for viral detection have been limited to individual sets of experimental workflows and laboratories. ...
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Recenze knihy Soucit v medicíně
recenze
open access
vydavatelská verze
2024
,Ošetřovatelské perspektivy
,7
(1)
Kniha Soucit v medicíně, editorů Radka Ptáčka a Petra Bartůňka, navazuje na každoroční odbornou konferenci České lékařské komory a poskytuje ucelený a podrobný přehled příspěvků, ve kterých se jednotlivý autoři zamýšlejí ...
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Molecular characterization of carbapenem and ceftazidime-avibactam-resistant Enterobacterales and horizontal spread of blaNDM-5 gene at a Lebanese medical center
původní článek
open access
vydavatelská verze
2024
,Frontiers in Cellular and Infection Microbiology
,14
(19 June 2024)
Introduction: In the battle against multidrug-resistant bacterial infections, ceftazidime- avibactam (CZA) stands as a pivotal defense, particularly against carbapenemresistant (CR) Gram-negative pathogens. However, the ...
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Population-specific validation and comparison of the performance of 77- and 313-variant polygenic risk scores for breast cancer risk prediction
původní článek
open access
vydavatelská verze
2024
,American Cancer Society
,Cancer
,130
(17)
Background: The polygenic risk score (PRS) allows the quantification of the polygenic effect of many low-penetrance alleles on the risk of breast cancer (BC). This study aimed to evaluate the performance of two sets ...
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Parallel DNA/RNA NGS Using an Identical Target Enrichment Panel in the Analysis of Hereditary Cancer Predisposition
původní článek
open access
vydavatelská verze
2024
,Univerzita Karlova v Praze, 1. lékařská fakulta
,Folia Biologica
,70
(1)
Germline DNA testing using the next-gene-ration sequencing (NGS) technology has become the analytical standard for the diagnostics of hereditary diseases, including cancer. Its increasing use places high demands on correct ...
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Nuclear patterns of phosphatidylinositol 4,5- and 3,4-bisphosphate revealed by super-resolution microscopy differ between the consecutive stages of RNA polymerase II transcription
původní článek
open access
vydavatelská verze
2024
,Wiley-Blackwell
,FEBS Journal
,291
(19)
Phosphatidylinositol phosphates are powerful signaling molecules that orchestrate signaling and direct membrane trafficking in the cytosol. Interestingly, phosphatidylinositol phosphates also localize within the membrane-less ...
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Nanofibers prepared from synthetic polymers and biopolymers as advanced extraction materials for sample preparation prior to liquid chromatography
přehledový článek
open access
vydavatelská verze
2024
,Trends in Analytical Chemistry
,180
(November)
Since the beginning of this millennium, there has been an increasing interest in nanofiber-based sorbents for extraction due to their accessibility, scalability, ease of handling, high surface area, variety of chemistries ...
