Repozitář publikační činnosti UK: Poslední příspěvky
Zobrazují se záznamy 681-700 z 1813
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Revising pathogenesis of AP1S1-related MEDNIK syndrome: a missense variant in the AP1S1 gene as a causal genetic lesion
původní článek
open access
vydavatelská verze
2024
,Journal of Molecular Medicine
,102
(11)
MEDNIK syndrome is a rare autosomal recessive disease characterized by mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma, and caused by variants in the adaptor-related protein ...
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Distinct pattern of genomic breakpoints in CML and BCR::ABL1-positive ALL: analysis of 971 patients
původní článek
open access
vydavatelská verze
2024
,Molecular Cancer
,23
(1)
BACKGROUND: The BCR::ABL1 is a hallmark of chronic myeloid leukemia (CML) and is also found in acute lymphoblastic leukemia (ALL). Most genomic breaks on the BCR side occur in two regions - Major and minor - leading to ...
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Rewired glutamate metabolism diminishes cytostatic action of L-asparaginase
původní článek
open access
vydavatelská verze
2024
,Elsevier Science
,Cancer Letters
,605
(November)
Tumor cells often adapt to amino acid deprivation through metabolic rewiring, compensating for the loss with alternative amino acids/substrates. We have described such a scenario in leukemic cells treated with L-asparaginase ...
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Mouse polyomavirus infection induces lamin reorganisation
původní článek
open access
vydavatelská verze
2024
,FEBS Journal
,291
(23)
The nuclear lamina is a dense network of intermediate filaments beneath the inner nuclear membrane. Composed of A-type lamins (lamin A/C) and B-type lamins (lamins B1 and B2), the nuclear lamina provides a scaffold for the ...
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Italian peninsula as a hybridization zone of Ixodes inopinatus and I. ricinus and the prevalence of tick-borne pathogens in I. inopinatus, I. ricinus, and their hybrids
původní článek
open access
vydavatelská verze
2024
,Parasites & Vectors
,17
(1)
BACKGROUND: Ixodes inopinatus was described from Spain on the basis of morphology and partial sequencing of 16S ribosomal DNA. However, several studies suggested that morphological differences between I. inopinatus and ...
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Toscana virus – finding the new vectors
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2024
,New Orleans
,American Society of Tropical Medicine and Hygiene (ASTMH)
,ASTMH Abstract Book 2024
,2024
Arbovirus Phlebovirus toscanaense (TOSV) is an emerging but still neglected human pathogen that circulates in countries around the Mediterranean Sea. The manifestation of the disease varies from non-symptomatic forms through ...
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Religious-secular as non-competitive: Encouraging participative church in a Czech Catholic diocese
původní článek
embargo
vydavatelská verze
2024
,Social Compass
,71
(2)
The presented text builds upon 4 years of applied research intended to support the transformation of a Czech Catholic diocese into a more participative organisation, internally and externally. This process allowed us to ...
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Understanding users’ responses to disclosed vs. undisclosed customer service chatbots: a mixed methods study
původní článek
embargo
vydavatelská verze
2024
,AI & Society
,39
(6)
Due to huge advancements in natural language processing (NLP) and machine learning, chatbots are gaining significance in the field of customer service. For users, it may be hard to distinguish whether they are communicating ...
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Mouse PML protein isoforms and their role in innate antiviral immunity
abstrakt v elektronické podobě
open access
postprint
2024
Promyelocytic leukaemia nuclear bodies (PML NBs) are dynamic, multiprotein, membrane-less structures composed of the main scaffold PML protein and various stable or transient partner proteins. Beyond their diverse endogenous ...
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ASPH inhibition reveals differential gene expression patterns in HPV-positive and HPV-negative cell lines
abstrakt v elektronické podobě
open access
preprint
2024
,Boston
Cancer is associated with alterations in key cellular pathways, including the aspartate β-hydroxylase (ASPH) pathway. ASPH is an oncogene upregulated in various carcinomas, playing a vital role in tumor progression and ...
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The RNA-dependent association of phosphatidylinositol 4,5-bisphosphate with intrinsically disordered proteins contribute to nuclear compartmentalization
původní článek
open access
vydavatelská verze
2024
,Public Library of Science
,PLoS Genetics
,20
(12)
The RNA content is crucial for the formation of nuclear compartments, such as nuclear speckles and nucleoli. Phosphatidylinositol 4,5-bisphosphate (PIP2) is found in nuclear speckles, nucleoli, and nuclear lipid islets and ...
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Investigating antibacterial and anti-inflammatory properties of synthetic curcuminoids
původní článek
open access
vydavatelská verze
2024
,Frontiers Media SA
,Frontiers in Medicine
,11
(October)
The concept of intratumoral microbiota is gaining attention in current research. Tumor-associated microbiota can activate oncogenic signaling pathways such as NF-kappa B, thereby promoting tumor development and progression. ...
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The perinucleolar compartment and the oncogenic super-enhancers are part of the same phase-separated structure filled with phosphatidylinositol 4,5-bisphosphate and long non-coding RNA HANR
původní článek
open access
vydavatelská verze
2025
,Advances in Biological Regulation
,95
(January)
The liquid-liquid phase separation in the cell nucleus regulates various processes such as gene regulation and transcription control, chromatin organization, and DNA repair. A plethora of proteins and RNAs contribute to ...
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The long-term impact of biogenic volatile organic compound emissions on urban ozone patterns over central Europe: contributions from urban and rural vegetation
původní článek
open access
vydavatelská verze
2024
,Atmospheric Chemistry and Physics
,24
(10. 12. 2024)
The impact of biogenic emissions of hydrocarbons from vegetation on ozone, as well as on overall oxidative capacity of air, is analyzed for central European cities for a present-day period using a chemistry transport model. ...
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HPV Infection: Present and Future of Diagnostic and Prognostic Surveys
abstrakt v elektronické podobě
open access
postprint
2024
High-risk types of Human Papillomavirus (HPV) are closely associated with various human malignancies. The ability to detect precancerous stages early significantly impacts patient outcomes, yet challenges remain in the ...
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Post-COVID health policy responses to healthcare workforce capacities: a comparative analysis of health system resilience in six European countries
původní článek
open access
vydavatelská verze
2024
,Elsevier
,Health Policy
,139
(January)
A cross countries in Europe, health policy is seeking to adapt to the post-pandemic 'permacrisis', where high demands on the healthcare workforce and shortages continue and combine with climate change, and war. The success ...
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Expert, experts et expertise pendant la crise de la COVID-19 – le cas tchèque
Experts, experts and expertise during the COVID-19 crisis - the Czech case
kapitola v kolektivní monografii
open access
vydavatelská verze
2024
,Stockholm
,Stockholm University Press
,Comparing the place of experts during the first waves of the COVID-19 pandemic
La crise de la COVID-19 a mis en lumière une catégorie d'experts déja bien connue en République tchèque, mais longtemps négligée et sous-financée : les épidémiologistes. Face a des défis que personne n'aurait pu prévoir, ...
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Československá sociologická společnost při ČSAV v zrcadle svých Zpráv (1964–69)
The Czechoslovak Sociological Society of the Czechoslovak Academy of Sciences Reflected by its Periodical Zprávy (1964–69)
původní článek
open access
vydavatelská verze
2024
,Lidé města / Urban People
,26
(3)
Autor analyzuje interní bullerin/časopis Československé sociologické společnosti, vycházející v letech 1965-69, a ukazuje, že ačkoli periodikum bylo velmi otevřené, tato otevřenost měla své limity, stejně jako nebylo plně ...
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Lipid and brain volumetric measures in multiple sclerosis patients: findings from a large observational study
původní článek
open access
vydavatelská verze
2024
,Springer Verlag Italia
,Acta Neurologica Belgica
,124
(6)
Objectives This study aimed to investigate relationships between cholesterol profile, brain volumetric MRI, and clinical measures in a large observational cohort of multiple sclerosis (MS) patients. Materials and methods ...
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Tidal Heating in a Subsurface Magma Ocean on Io Revisited
původní článek
open access
vydavatelská verze
2024
,Geophysical Research Letters
,51
(10)
We investigate the tidal dissipation in Io's hypothetical fluid magma ocean using a new approach based on the solution of the 3D Navier-Stokes equations. Our results indicate that the presence of a shallow magma ocean on ...
