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Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway
(2024)
3,5-Dinitrobenzylsulfanyl tetrazoles and 1,3,4-oxadiazoles, previously identified as having high in vitro activities against both replicating and nonreplicating mycobacteria and favorable cytotoxicity and genotoxicity ...
Development of ventricular trabeculae affects electrical conduction in the early endothermic heart
(2024)
Background: The ventricular trabeculae play a role, among others, in the impulse spreading in ectothermic hearts. Despite the morphological similarity with the early developing hearts of endotherms, this trabecular function ...
miRNA and lncRNA as Potential Tissue Biomarkers in Hepatocellular Carcinoma
(2024)
Hepatocellular carcinoma (HCC) is primary liver cancer, frequently diagnosed at advanced stages with limited therapeutic options. MicroRNAs (miRNAs) regulate target gene expression and through inhibitory competitive binding ...
Measuring and mapping the existence of phantom borders at a local scale: example of Sudetenland in Czechia
(2024)
This study presents an innovative methodological approach for quantitatively measuring and mapping the existence of phantom borders. Phantom borders are former political borders that have not existed for decades, but their ...
Synthesis and migrastatic activity of cytochalasin analogues lacking a macrocyclic moiety
(2024)
Cytochalasans are known as inhibitors of actin polymerization and for their cytotoxic and migrastatic activity. In this study, we synthesized a series of cytochalasin derivatives that lack a macrocyclic moiety, a structural ...
A recurrent synonymous L1CAM variant in a fetus with hydrocephalus
(2024)
We report the case of a hydrocephalic fetus in which clinical exome sequencing revealed a recurrent synonymous variant of unknown significance, c.453G>T, in the L1CAM gene. This report presents the second case of X-linked ...
Novel sulfonamide derivatives as a tool to combat methicillin-resistant Staphylococcus aureus
(2024)
Increasing resistance in Staphylococcus aureus has created a critical need for new drugs, especially those effective against methicillin-resistant strains (methicillin-resistant Staphylococcus aureus [MRSA]). Sulfonamides ...
Faecal bacteriome and metabolome profiles associated with decreased mucosal inflammatory activity upon anti-TNF therapy in paediatric Crohn's disease
(2024)
BACKGROUND AND AIMS: Treatment by anti-TNFα antibodies (anti-TNF) changes the dysbiotic faecal bacteriome in Crohn's disease (CD). However, it is not known whether these changes are due to decreasing mucosal inflammatory ...
Targeted long-read sequencing identified a causal structural variant in X-linked nephrogenic diabetes insipidus
(2024)
Background: X-linked nephrogenic diabetes insipidus (NDI) is a rare genetic renal disease caused by pathogenic variants in the AVPR2 gene. Single nucleotide variants and small insertions/deletions in AVPR2 are reliably ...
Parental involvement in shared book reading for preschoolers in China: Patterns and risks
(2024)
Previous studies have elucidated the positive effect of the quantity and onset age of shared book reading on children's language development. Few studies have addressed the profiles of parental involvement in terms of ...