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Loss of ADAR1 protein induces changes in small RNA landscape in hepatocytes
original article
open access
published version
2024
,RNA
,30
(9)
In recent years, numerous evidence has been accumulated about the extent of A-to-I editing in human RNAs and the key role ADAR1 plays in the cellular editing machinery. It has been shown that A-to-I editing occurrence and ...
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Educate, not kill: treating cancer without triggering its defenses
original article
open access
published version
2024
,Trends in Molecular Medicine
,30
(7)
Traditionally, anticancer therapies focus on restraining uncontrolled proliferation. However, these cytotoxic therapies expose cancer cells to direct killing, instigating the process of natural selection favoring survival ...
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Suppression of the growth and metastasis of mouse melanoma by Taenia crassiceps and Mesocestoides corti tapeworms
original article
open access
published version
2024
,Frontiers in Immunology
,15
(20 March 2024)
Cancer is still one of the leading causes of death, with an estimated 19.3 million new cases every year. Our paper presents the tumor-suppressing effect of Taenia crassiceps and Mesocestoides corti on B16F10 melanoma, the ...
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Sand fly blood meal volumes and their relation to female body weight under experimental conditions
original article
open access
published version
2024
,Parasites & Vectors
,17
(1)
Background Sand fly females require a blood meal to develop eggs. The size of the blood meal is crucial for fecundity and affects the dose of pathogens acquired by females when feeding on infected hosts or during experimental ...
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Outcomes Of Patients With Myocardial Infarction And Cardiogenic Shock Treated With Culprit Vessel-Only Versus Multivessel Primary PCI
original article
open access
published version
2024
,Hellenic Journal of Cardiology
,76
(MAR-APR)
INTRODUCTION AND OBJECTIVES: Multivessel primary percutaneous coronary intervention (pPCI) is still often used in patients with ST-elevation myocardial infarction (STEMI) and cardiogenic shock (CS). The study aimed to ...
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Skin exposure to soil microbiota elicits changes in cell-mediated immunity to pneumococcal vaccine
original article
open access
published version
2024
,Scientific Reports
,14
(1)
A resilient immune system is characterized by its capacity to respond appropriately to challenges, such as infections, and it is crucial in vaccine response. Here we report a paired randomized intervention-control trial ...
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Multicenter benchmarking of short and long read wet lab protocols for clinical viral metagenomics
original article
open access
published version
2024
,Journal of Clinical Virology
,173
(August)
Metagenomics is gradually being implemented for diagnosing infectious diseases. However, in-depth protocol comparisons for viral detection have been limited to individual sets of experimental workflows and laboratories. ...
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Recenze knihy Soucit v medicíně
review
open access
published version
2024
,Ošetřovatelské perspektivy
,7
(1)
Kniha Soucit v medicíně, editorů Radka Ptáčka a Petra Bartůňka, navazuje na každoroční odbornou konferenci České lékařské komory a poskytuje ucelený a podrobný přehled příspěvků, ve kterých se jednotlivý autoři zamýšlejí ...
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Molecular characterization of carbapenem and ceftazidime-avibactam-resistant Enterobacterales and horizontal spread of blaNDM-5 gene at a Lebanese medical center
original article
open access
published version
2024
,Frontiers in Cellular and Infection Microbiology
,14
(19 June 2024)
Introduction: In the battle against multidrug-resistant bacterial infections, ceftazidime- avibactam (CZA) stands as a pivotal defense, particularly against carbapenemresistant (CR) Gram-negative pathogens. However, the ...
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Population-specific validation and comparison of the performance of 77- and 313-variant polygenic risk scores for breast cancer risk prediction
original article
open access
published version
2024
,Cancer
,130
(17)
Background: The polygenic risk score (PRS) allows the quantification of the polygenic effect of many low-penetrance alleles on the risk of breast cancer (BC). This study aimed to evaluate the performance of two sets ...
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Parallel DNA/RNA NGS Using an Identical Target Enrichment Panel in the Analysis of Hereditary Cancer Predisposition
original article
open access
published version
2024
,Folia Biologica
,70
(1)
Germline DNA testing using the next-gene-ration sequencing (NGS) technology has become the analytical standard for the diagnostics of hereditary diseases, including cancer. Its increasing use places high demands on correct ...
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Nuclear patterns of phosphatidylinositol 4,5- and 3,4-bisphosphate revealed by super-resolution microscopy differ between the consecutive stages of RNA polymerase II transcription
original article
open access
published version
2024
,FEBS Journal
,AHEAD OF PRINT
(First published: 11 May 2024)
Phosphatidylinositol phosphates are powerful signaling molecules that orchestrate signaling and direct membrane trafficking in the cytosol. Interestingly, phosphatidylinositol phosphates also localize within the membrane-less ...
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Nanofibers prepared from synthetic polymers and biopolymers as advanced extraction materials for sample preparation prior to liquid chromatography
summarizing article
open access
published version
2024
,Trends in Analytical Chemistry
,180
(November)
Since the beginning of this millennium, there has been an increasing interest in nanofiber-based sorbents for extraction due to their accessibility, scalability, ease of handling, high surface area, variety of chemistries ...
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Leader vs. the party dilemma: the case of a party rebirth in Czechia
original article
embargoed access
published version
2024
,East European Politics
,Neuveden
(Neuveden)
Influential individuals gaining political weight at the expense of their parties are succeeding. Through case studies of two Czech parties, we explore the role of personalised party leadership. The puzzling set of events ...
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Náhradní výživné jako nedostupná dávka? (Emoční) bariéry jejího čerpání z perspektivy mladých dospělých dětí
Compensatory child alimony as an unavailable benefit? (Emotional) barriers to its access from the perspective of young adults
original article
open access
published version
2024
,Fórum sociální politiky
,18
(1)
Studie se věnuje problematice náhradního výživného, které je relativně novou dávkou české sociální politiky, ve vztahu k mladým dospělým - zletilým "nezaopatřeným" studujícím dětem, které mají nárok na výživné, ale nedostávají ...
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High incidence of occult familial SDHD cases amongst Czech patients with head and neck paragangliomas
original article
open access
published version
2023
,Frontiers in Endocrinology
,14
(December)
INTRODUCTION: Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors, which are mostly benign in nature. Amongst all genes, Succinate Dehydrogenase Subunit D (SDHD) is the most commonly mutated in familial ...
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Momentum-dependent intraband high harmonic generation in a photodoped indirect semiconductor
original article
open access
published version
2024
,Communications Physics
,7
(1)
Nonlinear optical response of solid-state materials exposed to strong non-resonant light fields leads to the generation of harmonic frequencies as a consequence of interband polarization and coherent intraband dynamics of ...
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Constitutional and acquired genetic variants in ARID5B in pediatric B-cell precursor acute lymphoblastic leukemia
original article
open access
published version
2024
,Genes, Chromosomes & Cancer
,63
(5)
Constitutional polymorphisms in ARID5B are associated with an increased risk of developing high hyperdiploid (HeH; 51-67 chromosomes) pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL). Here, we investigated ...
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The gray area of RQ-PCR-based measurable residual disease: subdividing the "positive, below quantitative range" category
letter to the editors
open access
published version
2024
,Leukemia
,38
(7)
Detection of measurable residual disease (MRD) in hematological malignancies is crucial for prognostication and treatment decisions. Real-time quantitative PCR (RQ-PCR), which targets immunoglobulin (IG) and T-cell receptor ...
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Postnatal origin of the chromosomal gains in older patients with high hyperdiploid acute lymphoblastic leukemia
letter to the editors
open access
published version
2024
,Haematologica
,109
(6)
We show that there is a marked difference in the percentage of BTRI/all SNVsbetween young children and older children, adolescents, and adults in HeH ALL. We interpret this asmost HeH ALL occurring in patients <10 years ...
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