Lékařská fakulta v Hradci Králové
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Poslední příspěvky
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Basal cell adenoma with S100 protein-positive "stroma": a distinct triphasic salivary gland neoplasm characterized by CTNNB1 mutation
původní článek
open access
vydavatelská verze
2026
,Springer
,Virchows Archiv
,488
(2)
Basal cell adenoma (BCA) is a benign salivary neoplasm that exhibits a divergent spectrum of growth patterns, including cribriform, tubular, trabecular, membranous, and solid. A subset of BCAs is characterized by the ...
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Sclerosing mucoepidermoid carcinoma of salivary glands
původní článek
open access
vydavatelská verze
2025
,Springer
,Virchows Archiv
,487
(1)
Sclerosing mucoepidermoid carcinoma (SMEC) of the salivary glands is a rare variant of low-grade mucoepidermoid carcinoma with scanty cellular atypia characterized by marked fibrosis/sclerosis and a rich inflammatory ...
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Sinonasal adenosquamous carcinomas arising in seromucinous hamartoma or respiratory epithelial adenomatoid hamartoma with atypical features: Report of five detailed clinicopathological and molecular characterisation of rare entity
původní článek
open access
vydavatelská verze
2025
,Blackwell Science
,Histopathology
,86
(4)
AIMS: Sinonasal adenosquamous carcinoma (ASC) is a rare tumour classified as a variant of squamous cell carcinoma, exhibiting both squamous and glandular differentiation. ASC has a poorer prognosis compared to sinonasal ...
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Molecular Profiling of Sinonasal Adenoid Cystic Carcinoma: Canonical and Noncanonical Gene Fusions and Mutation
původní článek
open access
vydavatelská verze
2025
,Lippincott-Raven Publishers
,American Journal of Surgical Pathology
,49
(3)
Adenoid cystic carcinomas (AdCC) of salivary gland origin have long been categorized as fusion-defined carcinomas owing to the almost universal presence of the gene fusion MYB::NFIB, or less commonly MYBL1::NFIB. Sinonasal ...
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Sinonasal adenoid cystic carcinomas accompanied by seromucinous hamartoma and/or atypical sinonasal glands arising from seromucinous hamartoma: insight into their histogenesis
původní článek
open access
vydavatelská verze
2025
,Springer
,Virchows Archiv
,486
(6)
The pathology of reactive, dysplastic, and neoplastic sinonasal seromucinous glands is complex, and their contribution to tumorigenesis of sinonasal carcinomas remains controversial. In our practice, we have observed the ...
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SHARED AND NON-SHARED MUTATIONS IN APC AND TP53 GENES IN PAIRED PRIMARY AND METASTATIC COLORECTAL CANCER FROM SYNCHRONOUS AND METACHRONOUS PATIENTS
původní článek
open access
preprint
2026
BackgroundMutational cascades in colorectal cancer (CRC) between the primary tumor (pCRC) and liver metasta-sis (LM) are poorly understood in individual patients. We focused on differences in specific APC and TP53 mutations ...
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Prenatal paroxetine dysregulates monoamine homeostasis and affects placental hemodynamics in the rat fetoplacental unit
původní článek
open access
vydavatelská verze
2025
,Elsevier
,Biomedicine & Pharmacotherapy
,192
(November)
Antidepressant use during pregnancy is increasingly common, with selective serotonin reuptake inhibitors (SSRIs) widely prescribed for maternal depression. However, growing evidence links prenatal SSRI exposure to adverse ...
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Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab
původní článek
open access
postprint
2026
,Springer Nature
,Scientific Reports
,16
(1)
The role of eosinophils in patients with cancer receiving systemic therapy based on immune checkpoint inhibitors (ICIs) has become a subject of increasing interest. The aim of the present study was to assess the prognostic ...
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Dexamethasone Acetate-Loaded PLGA Nanospheres Targeting Liver Macrophages
původní článek
open access
vydavatelská verze
2025
,Wiley-VCH-Verl.
,Macromolecular Bioscience
,25
(2)
Glucocorticoids are potent anti-inflammatory drugs, although their use is associated with severe side effects. Loading glucocorticoids into suitable nanocarriers can significantly reduce these undesirable effects. Macrophages ...
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Blinatumomab in induction therapy improves molecular response in untreated adults with Ph- B-cell precursor acute lymphoblastic leukemia
letter to the editors
open access
vydavatelská verze
2025
,Haematologica
,110
(7)
Blinatumomab, a bispecific anti-CD3/CD19 T-cell engager, is effective in treating relapsed or refractory B-cell precursor acute lymphoblastic leukemia (B-ALL), though most patients relapse despite achieving measurable ...
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Impact of Asaia bacteria on Leishmania major development in sand flies: implications for vector control strategies
původní článek
open access
vydavatelská verze
2025
,BioMed Central
,Parasites & Vectors
,18
(1)
Background: Asaia spp., bacteria originally isolated from tropical plants, have also been identified in various insect species, including blood-feeding ones. Their ability to colonize different host tissues and transmit ...
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Arterial wall enhancement indicates higher reperfusion rates in non-ruptured aneurysms after endovascular treatment with stent-assisted coiling
původní článek
open access
preprint
2025
,Neuroradiology
,67
(9)
Background and purpose: There are differing results in recent literature concerning aneurysmal wall enhancement (AWE) after endovascular treatment (ET) of intracranial aneurysms (IAs). The aim of this retrospective study ...
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Low prevalence of neural autoantibodies in perioperative cerebrospinal fluid samples of epilepsy surgery patients: A multicenter prospective study
původní článek
open access
vydavatelská verze
2024
,Epilepsia
,65
(3)
OBJECTIVE: Refractory epilepsy may have an underlying autoimmune etiology. Our aim was to assess the prevalence of neural autoantibodies in a multicenter national prospective cohort of patients with drug-resistant epilepsy ...
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Neural processing of speech sounds at premature and term birth: ERPs and MMR between 32 and 42 weeks of gestation
původní článek
open access
vydavatelská verze
2024
,Developmental Cognitive Neuroscience
,70
(DEC)
Prenatal listening experience reportedly modulates how humans process speech at birth, but little is known about how speech perception develops throughout the perinatal period. The present experiment assessed the neural ...
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The Czech National MS Registry (ReMuS): Data trends in multiple sclerosis patients whose first disease-modifying therapies were initiated from 2013 to 2021
původní článek
open access
vydavatelská verze
2024
,Palacký University
,Biomedical Papers
,168
(3)
AIMS: Multiple sclerosis treatment strategies are changing in the Czech Republic. According to data from 2013-2021, the proportion of patients starting high-efficacy disease-modifying therapies is increasing. In this survey, ...
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Motion onset VEPs can see through the blur
původní článek
open access
vydavatelská verze
2024
,Scientific Reports
,14
(1)
MMotion-onset visual evoked potentials (MO VEPs) are robust to dioptric blur when low contrast and low spatial frequency patterns are used for stimulation. To reveal mechanisms of MO VEPs robustness, we studied whether the ...
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Outcomes Of Patients With Myocardial Infarction And Cardiogenic Shock Treated With Culprit Vessel-Only Versus Multivessel Primary PCI
původní článek
open access
vydavatelská verze
2024
,Hellenic Journal of Cardiology
,76
(MAR-APR)
INTRODUCTION AND OBJECTIVES: Multivessel primary percutaneous coronary intervention (pPCI) is still often used in patients with ST-elevation myocardial infarction (STEMI) and cardiogenic shock (CS). The study aimed to ...
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The Czech Home Parenteral Nutrition Registry REDNUP: Comprehensive Analysis of Adult Patients' Data
původní článek
open access
vydavatelská verze
2024
,S. Karger
,Annals of Nutrition & Metabolism
,80
(3)
INTRODUCTION: Home parenteral nutrition (HPN) is the primary treatment modality for patients with chronic intestinal failure, one of the least common organ failures. This article provides a retrospective analysis of the ...
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Nonprocedural bleeding after left atrial appendage closure versus direct oral anticoagulants: A subanalysis of the randomized PRAGUE-17 trial
původní článek
open access
vydavatelská verze
2023
,Journal of Cardiovascular Electrophysiology
,34
(9)
INTRODUCTION: Observational studies have shown low bleeding rates in patients with atrial fibrillation (AF) treated by left atrial appendage closure (LAAC); however, data from randomized studies are lacking. This study ...
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Is it a true left bundle branch block or not?
letter to the editors
open access
vydavatelská verze
2023
,Journal of Interventional Cardiac Electrophysiology
,66
(6)
Among patients with wide QRS complexes of nonRBBB morphologies on ECG, there are those with preserved left septal Purkinje activation, i.e., intraventricular conduction delay (IVCD). Unfortunately, twelve lead ECGs do not ...
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