Lékařská fakulta v Hradci Králové

 

Poslední příspěvky

  • Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway 

    Karabanovich, Galina; Fabiánová, Viktória; Vocat, Anthony; Dušek, Jan; Valášková, Lenka; Stolaříková, Jiřina; Kitson, Russell R. A.; Pávek, Petr; Vávrová, Kateřina; Djaout, Kamel; Mikušová, Katarína; Baulard, Alain R.; Cole, Stewart T.; Korduláková, Jana; Roh, Jaroslav (2024)
    3,5-Dinitrobenzylsulfanyl tetrazoles and 1,3,4-oxadiazoles, previously identified as having high in vitro activities against both replicating and nonreplicating mycobacteria and favorable cytotoxicity and genotoxicity ...

  • Nonprocedural bleeding after left atrial appendage closure versus direct oral anticoagulants: A subanalysis of the randomized PRAGUE-17 trial 

    Branny, Marian; Osmančík, Pavel; Kala, Petr; Poloczek, Martin; Heřman, Dalibor; Neužil, Petr; Hála, Pavel; Táborský, Miloš; Šťásek, Josef; Haman, Luděk; Chovančík, Jan; Červinka, Pavel; Holý, Jiří; Kovárník, Tomáš; Zemánek, David; Havránek, Štěpán; Vančura, Vlastimil; Peichl, Petr; Toušek, Petr; Hozman, Marek; Lekešová, Veronika; Jarkovský, Jiří; Nováčková, Martina; Benešová, Klára; Widimský, Petr; Reddy, Vivek Y (2023)
    INTRODUCTION: Observational studies have shown low bleeding rates in patients with atrial fibrillation (AF) treated by left atrial appendage closure (LAAC); however, data from randomized studies are lacking. This study ...

  • Is it a true left bundle branch block or not? 

    Čurila, Karol; Jurák, Pavel; Chelu, Mihail G.; Upadhyay, Gaurav; Sedláček, Kamil; Osmančík, Pavel (2023)
    Among patients with wide QRS complexes of nonRBBB morphologies on ECG, there are those with preserved left septal Purkinje activation, i.e., intraventricular conduction delay (IVCD). Unfortunately, twelve lead ECGs do not ...

  • Serious Immune-related Adverse Events Are Associated With Greater Efficacy of Nivolumab Therapy Against Non-small Cell Lung Cancer 

    Blažek, Jiří; Hošek, Petr; Hrabcova, Karolina; Bratova, Monika; Kultan, Juraj; Hrnčiarik, Michal; Černovská, Markéta; Zemanová, Petra; Krejčí, Jana; Koubková, Leona; Stastny, Marek; Svatoň, Martin (2023)
    BACKGROUND/AIM: The aim of this study was to investigate possible association between adverse events of nivolumab therapy and the effectiveness of treatment in patients with non-small cell lung cancer (NSCLC). Focusing on ...

  • The dynamics of telomere length in primary and metastatic colorectal cancer lesions 

    Kroupa, Michal; Kubeček, Ondřej; Tomášová, Kristýna; Hanak, Petr; Krůpová, Markéta; Červená, Klára; Šišková, Anna; Rosendorf, Jáchym; Hošek, Petr; Vodičková, Ludmila; Vodička, Pavel; Liška, Václav; John, Stanislav; Vymetálková, Veronika; Petera, Jiří (2023)
    Telomeric sequences, the structures comprised of hexanucleotide repeats and associated proteins, play a pivotal role in chromosome end protection and preservation of genomic stability. Herein we address telomere length ...

  • MUC13-miRNA-4647 axis in colorectal cancer: Prospects to identifications of risk factors and clinical outcomes 

    Sojka, Ladislav; Opattová, Alena; Bartu, Linda; Horák, Josef; Korenková, Vlasta; Novosadova, Vendula; Křížková, Věra; Brůha, Jan; Liška, Václav; Schneiderová, Michaela; Kubeček, Ondřej; Vodičková, Ludmila; Urbanova, Marketa; Simsa, Jaromir; Vodička, Pavel; Vymetálková, Veronika (2023)
    MUC13, a transmembrane mucin glycoprotein, is overexpressed in colorectal cancer (CRC), however, its regulation and functions are not fully understood. It has been shown that MUC13 protects colonic epithelial cells from ...

  • COVID-19 Vaccination among Czech Dentists 

    Schmidt, Jan; Peřina, Vojtěch; Treglerová, Jana; Pilbauerová, Nela; Suchánek, Jakub; Šmucler, Roman (2022)
    This work describes and evaluates vaccination against COVID-19 among members of the Czech Dental Chamber during the pre-booster vaccination phase. A cross-sectional online survey was conducted between 23 June and 4 September ...

  • Isoprenaline modified the lipidomic profile and reduced β-oxidation in HL-1 cardiomyocytes: In vitro model of takotsubo syndrome 

    Fišerová, Ivana; Trinh, Minh Duc; Elkalaf, Moustafa; Vacek, Lukáš; Heide, Marek; Martínková, Stanislava; Bechyňská, Kamila; Kosek, Vít; Hajšlová, Jana; Fišer, Ondřej; Toušek, Petr; Polák, Jan (2022)
    Recent studies have suggested a pathogenetic link between impaired mitochondria and Takotsubo syndrome (TTS), which is closely connected with catecholamine overstimulation, poor outcomes, and changes in lipid metabolism. ...

  • Type 1 diabetes incidence increased during the COVID-19 pandemic years 2020-2021 in Czechia: results from a large population-based paediatric register 

    Cinek, Ondřej; Slavenko, Matvei; Pomahačová, Renata; Venháčová, Petra; Petruželková, Lenka; Škvor, Jaroslav; Neumann, David; Konečná, Petra; Vosáhlo, Jan; Kocourková, Kamila; Strnadel, Jiří; Průhová, Štěpánka; Šumník, Zdeněk (2022)
    OBJECTIVE: To explore type 1 diabetes incidence patterns during the pandemic years 2020 and 2021 in Czechia, to compare them to the trends from previous decade, and to test its association with indicators of containment ...

  • Ursodeoxycholic acid use in lactating female patients is associated with clinically negligible concentrations of this bile acid in breast milk 

    Šimják, Patrik; Petr, Tomáš; Kaslová, Barbora; Fejfar, Tomáš; Hůlek, Petr; Pařízek, Antonín; Vítek, Libor (2022)
    In the literature on the safety of ursodeoxycholic acid (UDCA) during breastfeeding, insufficient data has been reported to date. Thus, the aim of our study was to analyze bile acid (BA) concentrations in breast milk in a ...