Lékařská fakulta v Plzni
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Poslední příspěvky
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Dynamic changes in the plasmidome and resistome in the gastrointestinal tract of chickens
původní článek
open access
postprint
2026
,ASM Press
,Microbiology Spectrum
The expansion of intensive poultry farming has led to a substantial increase in antibiotic use, which, in turn, has promoted the accumulation of antibiotic resistance genes (ARGs). The chicken gut serves as a reservoir for ...
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Unraveling the telomere-mitochondrial axis in colorectal cancer: Results from a prospectively followed cohort
původní článek
open access
vydavatelská verze
2026
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
,32
(1)
Background Telomere shortening and mitochondrial dysfunction are well-known independent contributors to many diseases, but emerging evidence suggests a reciprocal relationship between the two processes. The role of the ...
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Familial risks in prostate cancer between brothers and half-brothers as clues to germline genetic and environmental causes
původní článek
open access
preprint
2026
Swedish family and cancer data constitute the largest source on familial cancer in the world. We analyze here familial risks in prostate cancer (PC) with focus on multiple affected brothers and comparation of full-brothers ...
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Familial Risks in 317 000 Patients With Prostate Cancer in Relation to Metastases and Survival-Guiding Diagnostics
původní článek
open access
vydavatelská verze
2026
,Elsevier B.V.
,European Urology Open Science
,87
(May)
BackgroundSwedish nationwide family and cancer data offer the largest global resource for study of familial cancer. We focus here on familial risks in prostate cancer (PC) with questions on risk in individuals from families ...
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Does motherhood increase the risk of developing subsequent malignant neoplasms after childhood cancer treatment?
původní článek
open access
vydavatelská verze
2026
,Elsevier Ltd.
,Cancer Epidemiology
,101
(April)
BACKGROUND: Most young women who have survived childhood cancer express a desire to have children. Many of them are concerned about the potential adverse impact of pregnancy on their health, which has been affected by prior ...
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Interplay Between 7-Ketocholesterol and Tamoxifen Shapes Stress Responses in Breast Cancer Cells
původní článek
open access
vydavatelská verze
2026
,Elsevier Ltd.
,Journal of Steroid Biochemistry and Molecular Biology
,260
(June)
7-ketocholesterol (7-KC) is a highly abundant and biologically active lipid oxidation product that perturbs membrane integrity, sterol homeostasis, mitochondrial function, and redox balance. In parallel, tamoxifen, a ...
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The Prognostic Role of Baseline and Early Dynamics of Peripheral Blood Cell Ratios in Metastatic Renal Cell Carcinoma Patients Treated With Nivolumab
původní článek
open access
vydavatelská verze
2026
,Iōannīs G. Delīnasios
,In Vivo
,40
(2)
BACKGROUND/AIM: Immune checkpoint inhibitors (ICI), including nivolumab, have become the cornerstone of systemic treatment in metastatic renal cell carcinoma (mRCC). Blood-derived biomarkers including neutrophil-to-lymphocyte ...
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Distribution and prognostic value of macrophages in colorectal cancer and adjacent mucosa in patient stages I-III vs IV
původní článek
open access
vydavatelská verze
2026
,Baishideng Publishing Group Inc
,World Journal of Gastroenterology
,32
(10)
BACKGROUND: Synchronous and metachronous liver metastases (LM) of colorectal cancer (CRC) drastically worsen the patient's survival. The biological and immunological mechanisms underlying these distinct metastatic trajectories ...
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Mitochondrial Transfer Rescues Respiration to Support De Novo Pyrimidine Biosynthesis and Tumor Progression
původní článek
open access
vydavatelská verze
2026
,American Association for Cancer Research
,Cancer Research
,86
(4)
Cancer cells with severe defects in mitochondrial DNA (mtDNA) can import mitochondria via horizontal mitochondrial transfer to restore respiration. Mitochondrial respiration is necessary for the activity of dihydroorotate ...
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Basal cell adenoma with S100 protein-positive "stroma": a distinct triphasic salivary gland neoplasm characterized by CTNNB1 mutation
původní článek
open access
vydavatelská verze
2026
,Springer
,Virchows Archiv
,488
(2)
Basal cell adenoma (BCA) is a benign salivary neoplasm that exhibits a divergent spectrum of growth patterns, including cribriform, tubular, trabecular, membranous, and solid. A subset of BCAs is characterized by the ...
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Sclerosing mucoepidermoid carcinoma of salivary glands
původní článek
open access
vydavatelská verze
2025
,Springer
,Virchows Archiv
,487
(1)
Sclerosing mucoepidermoid carcinoma (SMEC) of the salivary glands is a rare variant of low-grade mucoepidermoid carcinoma with scanty cellular atypia characterized by marked fibrosis/sclerosis and a rich inflammatory ...
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Sinonasal adenosquamous carcinomas arising in seromucinous hamartoma or respiratory epithelial adenomatoid hamartoma with atypical features: Report of five detailed clinicopathological and molecular characterisation of rare entity
původní článek
open access
vydavatelská verze
2025
,Blackwell Science
,Histopathology
,86
(4)
AIMS: Sinonasal adenosquamous carcinoma (ASC) is a rare tumour classified as a variant of squamous cell carcinoma, exhibiting both squamous and glandular differentiation. ASC has a poorer prognosis compared to sinonasal ...
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Molecular Profiling of Sinonasal Adenoid Cystic Carcinoma: Canonical and Noncanonical Gene Fusions and Mutation
původní článek
open access
vydavatelská verze
2025
,Lippincott-Raven Publishers
,American Journal of Surgical Pathology
,49
(3)
Adenoid cystic carcinomas (AdCC) of salivary gland origin have long been categorized as fusion-defined carcinomas owing to the almost universal presence of the gene fusion MYB::NFIB, or less commonly MYBL1::NFIB. Sinonasal ...
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Sinonasal adenoid cystic carcinomas accompanied by seromucinous hamartoma and/or atypical sinonasal glands arising from seromucinous hamartoma: insight into their histogenesis
původní článek
open access
vydavatelská verze
2025
,Springer
,Virchows Archiv
,486
(6)
The pathology of reactive, dysplastic, and neoplastic sinonasal seromucinous glands is complex, and their contribution to tumorigenesis of sinonasal carcinomas remains controversial. In our practice, we have observed the ...
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Oncocytic Tumors in the Salivary Gland: A Tri-Focal Review - Integrated Cytopathological, Pathological, and Molecular Features
přehledový článek
open access
vydavatelská verze
2025
,S. Karger
,Acta Cytologica
,69
(5)
Background: Primary oncocytic salivary gland tumors and oncocytic subtypes of traditionally non-oncocytic salivary gland neoplasms are occasionally encountered in fine needle aspiration specimens, biopsies, and resections. ...
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Hidden carriers: multidrug-resistant bacteria in hedgehogs from a wildlife rescue centre
původní článek
open access
vydavatelská verze
2026
,Frontiers Media SA
,Frontiers in Veterinary Science
,13
(January)
Introduction Antimicrobial resistance (AMR) represents a growing One Health challenge at the human-animal-environment interface. Wildlife rescue centres may represent potential, underrecognized settings where resistant ...
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Comparative analysis of telomere length in peripheral blood of breast cancer BRCA1 mutation carriers and non-carriers
původní článek
open access
vydavatelská verze
2026
,Springer
,Discover Oncology
,17
(1)
INTRODUCTION: Breast cancer is the most prevalent malignancy among women worldwide. A significant portion of patients possess homologous recombination deficiency (HRD), often caused by BRCA1/2 mutations, which may sensitize ...
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SHARED AND NON-SHARED MUTATIONS IN APC AND TP53 GENES IN PAIRED PRIMARY AND METASTATIC COLORECTAL CANCER FROM SYNCHRONOUS AND METACHRONOUS PATIENTS
původní článek
open access
preprint
2026
BackgroundMutational cascades in colorectal cancer (CRC) between the primary tumor (pCRC) and liver metasta-sis (LM) are poorly understood in individual patients. We focused on differences in specific APC and TP53 mutations ...
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Spatial Profiling and Prognostic Role of Tumor-Infiltrating CD8+T and CD20+B Cells in Metastatic Clear Cell Renal Cell Carcinoma Treated with Sequential Tyrosine Kinase Inhibitors and Nivolumab
původní článek
open access
vydavatelská verze
2026
,Ivyspring International Publisher
,Journal of Cancer
,17
(2)
Background: Tumor-infiltrating lymphocytes (TILs) are known to influence disease progression and treatment response in clear cell renal cell carcinoma. This study aimed at evaluating the prognostic and predictive relevance ...
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Familial colorectal cancer: search for novel predisposition genes
původní článek
open access
vydavatelská verze
2026
,Henry Stewart Publications
,Human Genomics
,20
(1)
BACKGROUND: Family history of colorectal cancer (CRC) and multiple primary CRCs in a single person may indicate inherited CRC predisposition. METHODS: In the present study, we performed whole exome/genome sequencing on ...
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