Faculty of Medicine in Pilsen
Recent Submissions
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EPIDEMIOLOGY OF CARB APENEMASE PRODUCING ENTEROBACTERALES IN THE CZECH REPUBLIC
abstract in conference proceedings
open access
published version
2024
,NIVB Meeting - Book of abstracts
Carbapenemases are versatile β-lactamases capable of hydrolyzing carbapenem antibiotics. They are classified into Ambler classes A, B, and D. Class A carbapenemases, such as Klebsiella pneumoniaecarbapenemase (KPC) ...
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In vivo evaluation of selenium-tellurium based nanoparticles as a novel treatment for bovine mastitis
original article
embargoed access
accepted version
2024
,Journal of Animal Science and Biotechnology
,15
(1)
Background Bovine mastitis is one of the main causes of reduced production in dairy cows. The infection of the mammary gland is mainly caused by the bacterium Staphylococcus aureus, whose resistant strains make the treatment ...
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Multidrug-resistant ESBL-producing Klebsiella pneumoniae complex in Czech hospitals, wastewaters and surface waters
original article
embargoed access
accepted version
2024
,Antimicrobial Resistance and Infection Control
,13
(1)
BACKGROUND: Multidrug-resistant (MDR) bacteria pose a significant challenge to the treatment of infectious diseases. Of particular concern are members of the Klebsiella pneumoniae species complex (KpSC), which are frequently ...
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Changing dynamics of antibiotic resistant Escherichia in Caspian gulls shows the importance of longitudinal environmental studies
original article
embargoed access
accepted version
2024
,Environment International
,186
(April)
This study is focused on Escherichia spp. isolates resistant to critically important antibiotics (cefotaxime, ciprofloxacin and colistin) among Caspian gull's (Larus cachinnans) chicks nesting in the Nove Mlyny Water ...
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Antibiotic-resistant Escherichia coli from treated municipal wastewaters and Black-headed Gull nestlings on the recipient river
original article
embargoed access
accepted version
2024
,One Health
,19
(December)
Wastewaters belong among the most important sources of environmental pollution, including antibiotic-resistant bacteria. The aim of the study was to evaluate treated wastewaters as a possible transmission pathway for ...
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The faecal microbiome of the Australian silver gull contains phylogenetically diverse ExPEC, aEPEC and Escherichia coli carrying the transmissible locus of stress tolerance
original article
embargoed access
accepted version
2024
,Science of the Total Environment
,919
(April)
Wildlife are implicated in the dissemination of antimicrobial resistance, but their roles as hosts for Escherichia coli that pose a threat to human and animal health is limited. Gulls (family Laridae) in particular, are ...
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Survival in Thyroid Cancer in Sweden From 1999 To 2018
original article
open access
published version
2024
,Clinical Epidemiology
,16
(2 October 2024)
INTRODUCTION: Thyroid cancer (TC) is diagnosed in several histological types which differ in their clinical characteristics and survival. We aim to describe how they influence TC survival in Sweden. METHODS: Cancer data ...
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Complex Relationships between Diagnostics and Survival in Chronic Lymphocytic Leukemia in Denmark, Finland, Norway, and Sweden
original article
open access
published version
2024
,Cancers
,16
(18)
BACKGROUND: Chronic lymphocytic leukemia (CLL) is a common hematological malignancy with highly variable clinical presentation. Many patients never require any treatment but for the others, chemotherapy, immunochemotherapy, ...
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A novel F type plasmid encoding mcr-10 in a clinical Enterobacter ludwigii strain from a tertiary hospital in Czech Republic
original article
open access
published version
2024
,Journal of Global Antimicrobial Resistance
,37
(June)
Objective: Here we describe a novel IncFIA plasmid harboring mcr-10 gene in a clinical Enterobacter ludwigii strain isolated at the University Hospital in Pilsen in the Czech Republic.Methods: The strain was subjected to ...
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Percutaneous transthoracic needle biopsy of lung lesions is a safe method associated with a very low risk of pleural recurrence
original article
open access
published version
2024
,Biomedical Papers
,168
AIM: Percutaneous transthoracic needle biopsy (PTNB), an alternative to bronchoscopic confirmation of lung lesions, is today being associated with a risk of pneumothorax and hemorrhage. Further, there are no data on the ...
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Emergence of Escherichia coli ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024
original article
open access
accepted version
2024
,Eurosurveillance
,29
(47)
Analysis of 594 isolates of Escherichia coli sequence type (ST)131 and its single locus variants carrying carbapenemase genes from 17 European Union/European Economic Area countries revealed acquisition of 18 carbapenemase ...
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Co-introduction into a delicate island ecosystem: metastrongyloid nematodes (superfamily Metastrongyloidea) of veterinary and medical importance circulating in aquatic and terrestrial environments of Tenerife (Canary Islands)
original article
open access
accepted version
2024
,Parasitology Research
,123
(10)
Metastrongyloid nematodes typically reside as adults in the cardiopulmonary systems of their mammalian definitive hosts, potentially causing severe diseases. Of particular concern are Angiostrongylus cantonensis and A. ...
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Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk
original article
open access
published version
2024
,Human Genomics
,18
(February)
Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). ...
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Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance
original article
open access
published version
2024
,Blood Cancer Journal
,14
(1)
Genome-wide association studies (GWASs) based on common single nucleotide polymorphisms (SNPs) have identified several loci associated with the risk of monoclonal gammopathy of unknown significance (MGUS), a precursor ...
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Survival improvements in esophageal and gastric cancers in the Nordic countries favor younger patients
original article
open access
published version
2024
,Cancer Medicine
,13
(15)
Esophageal cancer (EC) and gastric cancer (GC) are fatal cancers with a relatively late age of onset. Age is a negative risk factor for survival in many cancers and our aim was to analyze age-specific survival in EC and ...
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Survival in oral and pharyngeal cancers is catching up with laryngeal cancer in the NORDIC countries through a half century
original article
open access
published version
2024
,Cancer Medicine
,13
(1)
Background: Cancers of the head and neck (HN) are heterogeneous tumors with incidence rates varying globally. In Northern Europe oral and oropharyngeal cancers are the most common individual types. Survival for HN varies ...
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Survival in Elderly Ovarian Cancer Remains Challenging in the Nordic Countries
original article
open access
published version
2024
,Cancers
,16
(12)
BACKGROUND: Despite treatment having improved through intensive surgical procedures and chemotherapy-and more recently, targeted therapies-ovarian cancer is the most fatal female cancer. As such, we wanted to analyze ...
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Secukinumab Causing Medication-Related Osteonecrosis of the Jaw, in a Patient Diagnosed with Psoriasis and Rheumatoid Arthritis
casuistics
open access
published version
2024
,Psoriasis
,14
(23 September 2024)
The use of antiangiogenic and antiresorptive medications, particularly in patients with cancer or osteoporosis, can lead to osteonecrosis of the jaw following tooth extraction, trauma or arising spontaneously- A condition ...
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Genetic And Environmental Associations Of Nonspecific Chromosomal Aberrations
summarizing article
restricted access
published version
2024
,Mutagenesis
Nonspecific structural chromosomal aberrations (CAs) are found in around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. CAs ...
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FosA3 emerging in clinical carbapenemase-producing C. freundii
original article
open access
published version
2024
,Frontiers in Cellular and Infection Microbiology
,14
(06 August 2024)
Fosfomycin (FOS) is an effective antibiotic against multidrug-resistant Enterobacterales, but its effectiveness is reducing. Little is known on the current prevalence of FosA enzymes in low-risk pathogens, such as Citrobacter ...
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