Lékařská fakulta v Plzni
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Poslední příspěvky
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Clinicopathologic features of KRAS G12C-mutated non-small cell lung carcinomas:insights from 279 retrospective cases
původní článek
open access
vydavatelská verze
2026
,Springer
,Virchows Archiv
,489
(1)
KRAS G12C-mutated non-small cell lung carcinoma (NSCLC), caused by a glycine-to-cysteine substitution at codon 12, is associated with poor prognosis and is now targetable with specific inhibitors. We retrospectively analyzed ...
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Comparison of microbial profiles between hospital wastewater and river water
původní článek
open access
vydavatelská verze
2026
,Springer
,Molecular Genetics and Genomics
,301
(1)
This study aimed to compare the microbial profiles between hospital wastewater and river water to assess the dissemination of clinical isolates into the environment. Two types of water samples were collected from sampling ...
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HERA: a web server for host element reference-based aligner
původní článek
open access
vydavatelská verze
2026
,Information Retrieval
,Nucleic Acids Research
Plasmids play a central role in bacterial adaptation and in the dissemination of antimicrobial resistance, driving a growing need for accessible tools that support their comparative analysis without requiring local ...
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Familial cancers associated with cancers of the breast, prostate, colorectum and lung in Sweden
původní článek
open access
preprint
2026
Available epidemiological evidence shows that many cancers share familial risks, and this is increasingly confirmed by data on shared pathogenic germline gene variants between cancers. We decided to harness the world's ...
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An Updated Conceptual Framework for Myoepithelial Tumors of Soft tissues and Bone: Toward a Molecularly Informed Classification
přehledový článek
open access
vydavatelská verze
2026
,Elsevier Health
,Seminars in Diagnostic Pathology
,43
(3)
Myoepithelial tumors (MET) of soft tissue and bone comprise a rare group of neoplasms unified by partially overlapping morphology and so called myoepithelial immunophenotype. Historically, MET have long posed diagnostic ...
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Context-Dependent Prognostic Role of Neutrophils and Mast Cells in Primary Colorectal Cancer and Liver Metastases
původní článek
open access
preprint
2026
BACKGROUNDColorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Liver metastases (LM) are a major prognostic factor affecting survival and treatment outcomes. Distinguishing between synchronous ...
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Evolving Concepts in Salivary Duct Carcinoma: A Narrative Review
původní článek
open access
vydavatelská verze
2026
,Springer Internat. Publ.
,Oncology and Therapy
Salivary duct carcinoma (SDC) is an aggressive neoplasm that typically involves the major salivary glands. This rapidly growing tumor is known to recur and metastasize to the neck nodes and to distant sites. Given its poor ...
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Prognostic Role of Serum Neuron-Specific Enolase at Baseline and its Early Dynamics in Metastatic Castration-Resistant Prostate Cancer Treated With Androgen Receptor Signaling Inhibitors
původní článek
open access
vydavatelská verze
2026
,Wiley-Liss
,Prostate
,86
(11)
BACKGROUND: Outcomes of metastatic castration-resistant prostate cancer (mCRPC) treated with androgen receptor signaling inhibitors (ARSIs) vary widely and may not be fully reflected by PSA and standard clinicopathologic ...
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O čem také přemýšlejí naši medici. Sborník studentských prací (2026)
Thoughts of medical students. Collection of written projects (2026)
sborník
open access
vydavatelská verze
2026
,Plzeň
,Psychiatrická klinika, Lékařská fakulta v Plzni Univerzity Karlovy
Výběr nejlepších esejí napsaných studenty Lékařské fakulty v Plzni Univerzity Karlovy pro předmět Lékařská psychologie a etika v akademickém roce 2025/2026.
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Familial risks in prostate cancer between brothers and half-brothers as clues to germline genetic and environmental causes
původní článek
open access
vydavatelská verze
2026
,Kluwer
,Familial Cancer
,25
(2)
Swedish family and cancer data constitute the largest source on familial cancer in the world. We analyze here familial risks in prostate cancer (PC) with focus on multiple affected brothers and comparation of full-brothers ...
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Recent developments in salivary gland pathology after the WHO 2024 classification: new developments in existing entities and evolving new entities
přehledový článek
open access
vydavatelská verze
2026
,Springer
,Virchows Archiv
,488
(5)
Parallel to and after publication of the WHO 2024 classification of head and neck tumors, several developments concerning known existing salivary gland tumor entities, but also proposing new evolving tumor entities have ...
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SMARCA4-deficient carcinoma of the head and neck region: report of 8 new sinonasal and non-sinonasal cases and literature review
původní článek
open access
vydavatelská verze
2026
,Springer
,Virchows Archiv
,488
(5)
Neoplasms with inactivating mutations in SWI/SNF chromatin remodeling complex subunits gained attention in the head and neck (H&N) region due to their poor clinical outcomes. The sinonasal tract is a recognized "hot-spot" ...
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Integrated Genomic and Phenotypic Analyses Reveal Convergent Resistance Patterns in Clinical Candida tropicalis Isolates
původní článek
open access
vydavatelská verze
2026
,Blackwell
,Mycoses
,69
(5)
BACKGROUND: The incidence of Candida tropicalis isolation is increasing in hospital settings. High azole resistance and mortality rates make it a pathogen that requires further analysis. METHODS: Fourteen azole resistant ...
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Diagnosis of prostate cancer in brothers with signs of detection bias and related consequences
původní článek
open access
preprint
2026
Background: Swedish nationwide family and cancer data offer an unbiased opportunity to study familial prostate cancer (PC) and allow an assessment of the possible diagnostic bias that might have been introduced in the ...
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Does Lung Adenocarcinoma Subtyping Offer Clinical Benefits? A Population-Based Study from Sweden
původní článek
open access
preprint
2026
Purpose: Classification of lung adenocarcinoma into subtypes is relatively recent and not universally practiced. Consequently, large representative studies describing clinical outcomes are rare, failing to pervasively ...
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RECENT SURVIVAL TRENDS IN THE MOST FATAL CANCERS IN THE NORDIC COUNTRIES: GAINS IN SOME BUT NOT IN ALL
původní článek
open access
preprint
2026
BackgroundGlobal survival studies distinguish a group of solid cancers with especially poor survival, which in the Nordic countries are cancers of the hypopharynx, esophagus, stomach, liver, gallbladder, pancreas, lung and ...
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Three-generation familial risks in prostate cancer with a special focus on the early onset patients and their maternal and paternal relatives
původní článek
open access
preprint
2026
Background: Swedish nationwide family and cancer data extend through three generations providing a unique chance for study of familial cancer in PC between first-degree relatives (FDR) and second-degree relatives (SDR). ...
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One-year multicenter surveillance of Fosfomycin resistance Enterobacterales: the rise of FosA3-producing P. mirabilis
původní článek
open access
vydavatelská verze
2026
,Elsevier B.V.
,Current Research in Microbial Sciences
,10
(24 March)
The global rise of antimicrobial resistance has renewed interest in fosfomycin (FOS), an old antibiotic with activity against multidrug-resistant Enterobacterales . However, resistance to FOS is increasing, driven by ...
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Expanding the Molecular-genetic Spectrum of Canalicular Adenoma-like Subtype of Pleomorphic Adenoma of Salivary Glands
původní článek
open access
vydavatelská verze
2025
,Lippincott-Raven Publishers
,The American Journal of Surgical Pathology
,49
(6)
Canalicular tumors of the salivary glands have recently emerged as an entity characterized by distinct morphology and recurrent HMGA2 gene rearrangement. In this study, we analyzed 40 cases intending to elucidate their ...
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Analyses of ATP7B mRNA in Nasopharyngeal Swab Samples Increase Yields of Wilson Disease Molecular Genetic Diagnostics
původní článek
open access
vydavatelská verze
2026
,Wiley-Liss, Inc.
,Human Mutation
,2026
(1)
Wilson disease (WD) is an autosomal recessive disorder of copper transport caused by bi-allelic pathogenic variants in the ATPase copper transporting beta gene (ATP7B). Results of standard genetic diagnostics remain ...
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