Lékařská fakulta v Plzni
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Poslední příspěvky
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Diagnosis of prostate cancer in brothers with signs of detection bias and related consequences
původní článek
open access
preprint
2026
Background: Swedish nationwide family and cancer data offer an unbiased opportunity to study familial prostate cancer (PC) and allow an assessment of the possible diagnostic bias that might have been introduced in the ...
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Does Lung Adenocarcinoma Subtyping Offer Clinical Benefits? A Population-Based Study from Sweden
původní článek
open access
preprint
2026
Purpose: Classification of lung adenocarcinoma into subtypes is relatively recent and not universally practiced. Consequently, large representative studies describing clinical outcomes are rare, failing to pervasively ...
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RECENT SURVIVAL TRENDS IN THE MOST FATAL CANCERS IN THE NORDIC COUNTRIES: GAINS IN SOME BUT NOT IN ALL
původní článek
open access
preprint
2026
BackgroundGlobal survival studies distinguish a group of solid cancers with especially poor survival, which in the Nordic countries are cancers of the hypopharynx, esophagus, stomach, liver, gallbladder, pancreas, lung and ...
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Three-generation familial risks in prostate cancer with a special focus on the early onset patients and their maternal and paternal relatives
původní článek
open access
preprint
2026
Background: Swedish nationwide family and cancer data extend through three generations providing a unique chance for study of familial cancer in PC between first-degree relatives (FDR) and second-degree relatives (SDR). ...
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One-year multicenter surveillance of Fosfomycin resistance Enterobacterales: the rise of FosA3-producing P. mirabilis
původní článek
open access
vydavatelská verze
2026
,Elsevier B.V.
,Current Research in Microbial Sciences
,10
(24 March)
The global rise of antimicrobial resistance has renewed interest in fosfomycin (FOS), an old antibiotic with activity against multidrug-resistant Enterobacterales . However, resistance to FOS is increasing, driven by ...
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Expanding the Molecular-genetic Spectrum of Canalicular Adenoma-like Subtype of Pleomorphic Adenoma of Salivary Glands
původní článek
open access
vydavatelská verze
2025
,Lippincott-Raven Publishers
,The American Journal of Surgical Pathology
,49
(6)
Canalicular tumors of the salivary glands have recently emerged as an entity characterized by distinct morphology and recurrent HMGA2 gene rearrangement. In this study, we analyzed 40 cases intending to elucidate their ...
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Analyses of ATP7B mRNA in Nasopharyngeal Swab Samples Increase Yields of Wilson Disease Molecular Genetic Diagnostics
původní článek
open access
vydavatelská verze
2026
,Wiley-Liss, Inc.
,Human Mutation
,2026
(1)
Wilson disease (WD) is an autosomal recessive disorder of copper transport caused by bi-allelic pathogenic variants in the ATPase copper transporting beta gene (ATP7B). Results of standard genetic diagnostics remain ...
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The ABC-LD@4EU+: enhanced version of the ABC Learning Design workshop tailored for the European University Alliance’s needs
kapitola v kolektivní monografii
open access
vydavatelská verze
2026
,London
,UCL Press
,ABC Learning Design. Active, blended, connected and beyond
The chapter shows how the 4EU+ Alliance adapted the original ABC Learning Design method for collaborative course design across eight European universities with different traditions, languages, and pedagogical cultures.Its ...
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From ecology to evolution: plasmid- and colicin-mediated persistence of antibiotic-resistant Escherichia coli in gulls
původní článek
open access
postprint
2026
,American Society for Microbiology
,mSystems
,11
(2)
Antimicrobial resistance (AMR) in wildlife is an emerging concern within the One Health concept. Gulls, due to their synanthropic behavior and long-distance migration, are recognized as vectors and secondary reservoirs of ...
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Dynamic changes in the plasmidome and resistome in the gastrointestinal tract of chickens
původní článek
open access
postprint
2026
,ASM Press
,Microbiology Spectrum
The expansion of intensive poultry farming has led to a substantial increase in antibiotic use, which, in turn, has promoted the accumulation of antibiotic resistance genes (ARGs). The chicken gut serves as a reservoir for ...
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Unraveling the telomere-mitochondrial axis in colorectal cancer: Results from a prospectively followed cohort
původní článek
open access
vydavatelská verze
2026
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
,32
(1)
Background Telomere shortening and mitochondrial dysfunction are well-known independent contributors to many diseases, but emerging evidence suggests a reciprocal relationship between the two processes. The role of the ...
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Familial risks in prostate cancer between brothers and half-brothers as clues to germline genetic and environmental causes
původní článek
open access
preprint
2026
Swedish family and cancer data constitute the largest source on familial cancer in the world. We analyze here familial risks in prostate cancer (PC) with focus on multiple affected brothers and comparation of full-brothers ...
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Familial Risks in 317 000 Patients With Prostate Cancer in Relation to Metastases and Survival-Guiding Diagnostics
původní článek
open access
vydavatelská verze
2026
,Elsevier B.V.
,European Urology Open Science
,87
(May)
BackgroundSwedish nationwide family and cancer data offer the largest global resource for study of familial cancer. We focus here on familial risks in prostate cancer (PC) with questions on risk in individuals from families ...
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Does motherhood increase the risk of developing subsequent malignant neoplasms after childhood cancer treatment?
původní článek
open access
vydavatelská verze
2026
,Elsevier Ltd.
,Cancer Epidemiology
,101
(April)
BACKGROUND: Most young women who have survived childhood cancer express a desire to have children. Many of them are concerned about the potential adverse impact of pregnancy on their health, which has been affected by prior ...
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Interplay Between 7-Ketocholesterol and Tamoxifen Shapes Stress Responses in Breast Cancer Cells
původní článek
open access
vydavatelská verze
2026
,Elsevier Ltd.
,Journal of Steroid Biochemistry and Molecular Biology
,260
(June)
7-ketocholesterol (7-KC) is a highly abundant and biologically active lipid oxidation product that perturbs membrane integrity, sterol homeostasis, mitochondrial function, and redox balance. In parallel, tamoxifen, a ...
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The Prognostic Role of Baseline and Early Dynamics of Peripheral Blood Cell Ratios in Metastatic Renal Cell Carcinoma Patients Treated With Nivolumab
původní článek
open access
vydavatelská verze
2026
,Iōannīs G. Delīnasios
,In Vivo
,40
(2)
BACKGROUND/AIM: Immune checkpoint inhibitors (ICI), including nivolumab, have become the cornerstone of systemic treatment in metastatic renal cell carcinoma (mRCC). Blood-derived biomarkers including neutrophil-to-lymphocyte ...
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Distribution and prognostic value of macrophages in colorectal cancer and adjacent mucosa in patient stages I-III vs IV
původní článek
open access
vydavatelská verze
2026
,Baishideng Publishing Group Inc
,World Journal of Gastroenterology
,32
(10)
BACKGROUND: Synchronous and metachronous liver metastases (LM) of colorectal cancer (CRC) drastically worsen the patient's survival. The biological and immunological mechanisms underlying these distinct metastatic trajectories ...
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Mitochondrial Transfer Rescues Respiration to Support De Novo Pyrimidine Biosynthesis and Tumor Progression
původní článek
open access
vydavatelská verze
2026
,American Association for Cancer Research
,Cancer Research
,86
(4)
Cancer cells with severe defects in mitochondrial DNA (mtDNA) can import mitochondria via horizontal mitochondrial transfer to restore respiration. Mitochondrial respiration is necessary for the activity of dihydroorotate ...
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Basal cell adenoma with S100 protein-positive "stroma": a distinct triphasic salivary gland neoplasm characterized by CTNNB1 mutation
původní článek
open access
vydavatelská verze
2026
,Springer
,Virchows Archiv
,488
(2)
Basal cell adenoma (BCA) is a benign salivary neoplasm that exhibits a divergent spectrum of growth patterns, including cribriform, tubular, trabecular, membranous, and solid. A subset of BCAs is characterized by the ...
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Sclerosing mucoepidermoid carcinoma of salivary glands
původní článek
open access
vydavatelská verze
2025
,Springer
,Virchows Archiv
,487
(1)
Sclerosing mucoepidermoid carcinoma (SMEC) of the salivary glands is a rare variant of low-grade mucoepidermoid carcinoma with scanty cellular atypia characterized by marked fibrosis/sclerosis and a rich inflammatory ...
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