Faculty of Medicine in Pilsen
Recent Submissions
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Therapeutic pancreatic cancer biomarkers and pharmacogenetics
summarizing article
open access
published version
2025
,Academic Press
,Seminars in Cancer Biology
,116
(November)
FOLFIRINOX and gemcitabine plus nab-paclitaxel represent the most effective chemotherapy regimens for metastatic pancreatic cancer patients nowadays, but the median overall survival remains less than one year. Pharmacogenomics ...
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Mass spectrometric profiling of microbial polysaccharides using laser desorption/ionization – time-of-flight (LDI-TOF) and liquid chromatography-mass spectrometry (LC-MS): a novel method for structural fingerprinting and derivatization
original article
open access
published version
2025
,Frontiers Media S.A.
,Frontiers in Cellular and Infection Microbiology
,15
(October)
Introduction: Over the last two decades, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been introduced into the routine diagnostic practice of microbiological laboratories ...
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Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer
original article
open access
published version
2025
,Nature Medicine
,31
(7)
Associations between the gut microbiome and colorectal cancer (CRC) have been uncovered, but larger and more diverse studies are needed to assess their potential clinical use. We expanded upon 12 metagenomic datasets of ...
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One-Step Nucleic Acid Amplification Analysis of Sentinel Lymphatic Nodes in Endometrial Cancer Patients (EU-OSNA): A European Multicenter Diagnostic Accuracy Study
original article
open access
published version
2025
,Blackwell Publishing
,Cancer Medicine
,14
(18)
OBJECTIVE: This European multicenter study aimed to assess the diagnostic accuracy of one-step nucleic acid amplification (OSNA) as the primary endpoint by comparing this method with ultrastaging for the detection of ...
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Sex specific familial risk in lung cancer through changing histologies in Sweden
original article
open access
published version
2025
,Wiley-Liss
,International Journal of Cancer
,157
(5)
Familial clustering of lung cancer (LC) is related to shared smoking habits but the contribution of other potential factors such as sex or histology is not well known, and these are the subjects of the present study in ...
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Familial risks and incidence rates for childhood nervous system tumors in Sweden
original article
open access
published version
2025
,Elsevier Ltd.
,EJC Paediatric Oncology
,6
(December)
Background: Childhood (< 20 years) nervous system tumors manifest in some rare cancer syndromes but how commonly they present with familial clustering between various histological types is not well known at a nation-wide ...
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Nucleotide composition shapes gene expression in Wolbachia pipientis: a role for MidA methyltransferase?
original article
open access
published version
2025
,American Society for Microbiology
,mSystems
,10
(9)
Wolbachia pipientis is an obligate intracellular bacterium, associated with several arthropods and filarial nematodes. Wolbachia establishes a variety of symbiotic relationships with its hosts, with consequent genomic ...
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Antibacterial activity of the novel peptide Pac-525 with the RGD motif against intracellular Escherichia coli
original article
open access
published version
2025
,Springer Nature
,Scientific Reports
,15
(1)
Infections caused by invasive intracellular bacteria pose major therapeutic challenges due to pathogen survival and growth inside of host cells as well as the low intracellular accessibility for conventional antibiotics. ...
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Non-viral HCC miRNA profiling reveals miR-1972 as a potential positive prognostic marker
original article
open access
published version
2025
,Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
,Non-coding RNA Research
,15
(December)
Background & Aims: Hepatocellular carcinoma (HCC) is the third deadliest cancer worldwide. Its high mortality is primarily attributed to late-stage diagnosis. While mutations in driver genes, such as those encoding β-catenin ...
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Pembrolizumab versus Pembrolizumab plus Chemotherapy in Non-small Cell Lung Cancer with High PD-L1 Expression - Multicenter Real-world Evidence Study
original article
open access
published version
2025
,Ivyspring International Publisher
,Journal of Cancer
,16
(10)
Background: Patients with non-small cell lung cancer (NSCLC) with PD-Ll expression ~ 50% can be treated with immunotherapy alone or with a combination of immunotherapy and chemotherapy. One of these options is treatment ...
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Prognostic Role of Prostate-specific Antigen Isoforms and Their Early Kinetics in Patients With Metastatic Castration-resistant Prostate Cancer Receiving New Generation Androgen Receptor Targeted Agents
original article
open access
published version
2025
,Iōannīs G. Delīnasios
,In Vivo
,39
(2)
BACKGROUND/AIM: New generation androgen receptor-targeting agents (ARTA) have been in the spotlight for their efficacy in metastatic castration-resistant prostate cancer (mCRPC). Prostate-specific antigen (PSA) represents ...
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Impact of concomitant use of proton pump inhibitors or cardiovascular medication on survival outcomes of patients with metastatic renal cell carcinoma treated with nivolumab
original article
open access
published version
2025
,Clinical & Experimental Metastasis
,42
(5)
Renal cell cancer (RCC) is typically a disease of older adults, who often have comorbidities requiring the use of multiple concomitant medications. Even though the patients with metastatic RCC (mRCC) are often exposed to ...
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Native and decellularized porcine vena cava: Biomechanical and microstructural comparison
original article
open access
published version
2025
,Elsevier Ltd.
,Acta Biomaterialia
,201
(July)
Tissue decellularization has emerged as a technique to provide an acellular, non-immunogenic scaffold that preserves the morphological features of native tissue. To study the possible effects of decellularization, investigating ...
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Integrative miRNOMe profiling reveals the miR-195-5p–CHEK1 axis and its impact on luminal breast cancer outcomes
original article
open access
published version
2025
,John Wiley & Sons
,Molecular Oncology
,19
(11)
The luminal subtype (estrogen receptor-positive, ER+) is the most common and the most heterogeneous type of breast carcinoma (BC) in women. During our study, we determined expression levels of all microRNAs (miRNome) in ...
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Prioritization of predisposition genes for familial non-medullary thyroid cancer by whole-genome sequencing
original article
open access
published version
2025
,BioScientifica
,European Journal of Endocrinology
,192
(4)
OBJECTIVE: Thyroid cancer (TC) is the most common endocrine malignancy, with 90%-95% of the cases representing non-medullary thyroid cancer (NMTC). Familial cases account only for a few of all cases and the underlying ...
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Association of long-term treatment outcomes with changes in PET/MRI characteristics and the type of early treatment response during concurrent radiochemotherapy in patients with locally advanced cervical cancer
original article
open access
published version
2025
,Urban u. Vogel
,Strahlentherapie und Onkologie
,201
(5)
PURPOSE: We aimed to find predictive tumour characteristics as detected by interim positron-emission tomography/magnetic resonance imaging (PET/MRI) in cervical cancer patients. We also investigated the type of interim ...
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Search for germline gene variants in colorectal cancer families presenting with multiple primary colorectal cancers
original article
open access
published version
2025
,Wiley-Liss
,International Journal of Cancer
,156
(7)
A double primary colorectal cancer (CRC) in a familial setting signals a high risk of CRC. In order to identify novel CRC susceptibility genes, we whole-exome sequenced germline DNA from nine persons with a double primary ...
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Age-specific familial risks in cancer as clues to germline genetic and environmental causes: focus on colorectal, endometrial, prostate, kidney, breast and lung cancers
summarizing article
open access
published version
2025
,Termedia
,Hereditary Cancer in Clinical Practice
,23
(1)
BACKGROUND: The Swedish Family-Cancer Database (FCD) is the largest source of data on familial cancer in the world, including practically complete family structures and individual cancer diagnoses from the high-quality ...
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Exploring Virulence Characteristics of Clinical Escherichia coli Isolates from Greece
original article
open access
published version
2025
,MDPI
,Microorganisms
,13
(7)
The aim of this study was to examine the genetic characteristics that could be associated with the virulence characteristics of Escherichia coli collected from clinical samples. A collection of 100 non-repetitive E. coli ...
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Comparative genomics of multi-drug resistant Escherichia coli ST131 from human, animal, and environmental sources in the Czech Republic
original article
open access
published version
2025
,Ecotoxicology and Environmental Safety
,299
(July)
Globally, Escherichia coli is a leading cause of multiple drug-resistant (MDR) extraintestinal infections. ST131 is an MDR, pandemic sequence type that causes urinary tract and bloodstream infections in humans and companion ...
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