EPIDEMIOLOGY OF CARB APENEMASE PRODUCING ENTEROBACTERALES IN THE CZECH REPUBLIC

Author
Papagiannitsis, Costa
Hostomský, Zdeněk
Vácha, Robert
Pichová, Iva
Šímová, Šárka
National Institute of Virology and Bacteriology (NIVB)
Publication date
2024Published in
NIVB Meeting - Book of abstractsISBN / ISSN
ISSN: 2336-7202Metadata
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Abstract
Carbapenemases are versatile β-lactamases capable of hydrolyzing carbapenem antibiotics. They are classified into Ambler classes A, B, and D. Class A carbapenemases, such as Klebsiella pneumoniaecarbapenemase (KPC) and Guyana extended-spectrum beta-lactamase (GES), hydrolyze penicillins, cephalosporins, carbapenems, and aztreonam. Class B carbapenemases, defined by their metallo-beta-lactamase (MBL) structures, hydrolyze all beta-lactams except aztreonam. While class D carbapenemases, including oxyacillin-hydrolyzing carbapenemase (OXA) enzymes, have decreased hydrolyzing activity against carbapenems and penicillins.
Keywords
Carbapenemases, antibiotic resistance, czech republic
Permanent link
https://hdl.handle.net/20.500.14178/2813License
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