Faculty of Medicine in Pilsen: Recent submissions
Now showing items 1-20 of 200
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Discordant familial risks between rare cancers
original article
open access
submitted version
2026
Background: Recent large-scale DNA sequencing data indicate extensive genetic sharing between different types of cancer. Familial clustering of cancers at different sites was also confirmed by earlier population-wide ...
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Familial histology-specific risks for 22 rare solid cancers in Sweden
original article
open access
submitted version
2026
Recognition of familial cancer has become increasingly important in oncology as it can help guide treatment and find individuals at risk. However, reliable data on the prevalence and risk of familial cancer are limited to ...
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Spatial comparison and prognostic significance of macrophages in matched primary colorectal cancer and liver metastases: a retrospective study
original article
open access
published version
2026
,Springer Nature
,Scientific Reports
,16
(1)
Analyzing the spatial distribution and prognostic significance of tumor-associated macrophages (TAMs) in primary colorectal cancer (pCRC) and matched liver metastases (LM) may provide insights into the immunological ...
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Spatial Profiling and Prognostic Role of CD169+ Macrophages in Colorectal Cancer From Adjacent Nontumor Mucosa to Liver Metastasis
original article
open access
published version
2026
,Hindawi
,Journal of Immunology Research
,2026
(1)
BACKGROUND: CD169+ cells represent a distinct subset of macrophages with potential immunomodulatory roles, but their function in colorectal cancer (CRC) progression remains unclear. This study focuses on the spatial profiling ...
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Increase in second primary lung cancers in a nation-wide cohort study from Sweden
original article
open access
published version
2026
,BMJ
,Thorax
,81
(10)
Background: We describe the occurrence of second primary lung cancers (SPLCs) and their determinant in Sweden. Methods: Nation-wide cancer registry from years 1961 to 2021 identified a total of 853 SPLCs. Results: The ...
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Catheter-Directed Thrombolysis in Intermediate-High-Risk Pulmonary Embolism
original article
embargoed access
accepted version
2026
,Massachusetts Medical Society
,The New England Journal of Medicine
,E-PUB
BACKGROUND: Whether catheter-directed thrombolysis improves clinical outcomes in patients with intermediate-high-risk pulmonary embolism, as compared with anticoagulation alone, is uncertain. METHODS: In this multicenter, ...
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Estimating clinical manifestations in cell biology teaching is a suitable active element for teaching beginning medical students
original article
open access
published version
2026
,Libertas Academica Ltd.
,Journal of Medical Education and Curricular Development
,13
(September)
Objective: Cell biology courses in medical education often emphasize molecular detail without sufficient clinical integration, which can reduce student motivation and hinder application of knowledge. Embedding diagnostic ...
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GWAS meta-analysis provides new insights into uveal melanoma risk
original article
open access
published version
2026
,Scientific and Medical Division, Macmillan Press
,British Journal of Cancer
,135
(6)
OBJECTIVE: The aim of this research is to identify germline genetic variants that predispose to uveal melanoma (UM) using data from nine studies involving 5839 individuals with UM (3853 novel) and 349,863 healthy controls. ...
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Clinicopathological, Molecular, and DNA Methylation Analysis of Ossifying Fibromyxoid Tumors Delineates the ZC3H7B::BCOR Subset as a Distinct Entity
original article
open access
published version
2026
,Nature Publishing Group
,Modern Pathology
,39
(8)
Ossifying fibromyxoid tumor (OFMT) is a rare mesenchymal neoplasm of uncertain lineage of differentiation driven by a broad spectrum of gene fusions. It manifests primarily in soft tissues of the extremities. In this study, ...
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Recent survival trends in the most fatal cancers in the Nordic countries: gains in some but not in all
original article
open access
published version
2026
,Acta Oncologica
,Acta Oncologica
,65
(29 June)
Background Global survival studies distinguish a group of solid cancers with especially poor survival, which in the Nordic countries are cancers of the hypopharynx, esophagus, stomach, liver, gallbladder, pancreas, lung ...
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High-risk lineages shape the resistome and virulome of multidrug-resistant Pseudomonas aeruginosa
original article
open access
published version
2026
,Frontiers Media SA
,Frontiers in Cellular and Infection Microbiology
,16
(June)
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa strains remain a major threat in clinical settings, yet no contemporary genomic data are available from the Olomouc region, Czech Republic. ...
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Clinicopathologic features of KRAS G12C-mutated non-small cell lung carcinomas:insights from 279 retrospective cases
original article
open access
published version
2026
,Springer
,Virchows Archiv
,489
(1)
KRAS G12C-mutated non-small cell lung carcinoma (NSCLC), caused by a glycine-to-cysteine substitution at codon 12, is associated with poor prognosis and is now targetable with specific inhibitors. We retrospectively analyzed ...
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Comparison of microbial profiles between hospital wastewater and river water
original article
open access
published version
2026
,Springer
,Molecular Genetics and Genomics
,301
(1)
This study aimed to compare the microbial profiles between hospital wastewater and river water to assess the dissemination of clinical isolates into the environment. Two types of water samples were collected from sampling ...
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HERA: a web server for host element reference-based aligner
original article
open access
published version
2026
,Information Retrieval
,Nucleic Acids Research
,54
(W1)
Plasmids play a central role in bacterial adaptation and in the dissemination of antimicrobial resistance, driving a growing need for accessible tools that support their comparative analysis without requiring local ...
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Familial cancers associated with cancers of the breast, prostate, colorectum and lung in Sweden
original article
open access
submitted version
2026
Available epidemiological evidence shows that many cancers share familial risks, and this is increasingly confirmed by data on shared pathogenic germline gene variants between cancers. We decided to harness the world's ...
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An Updated Conceptual Framework for Myoepithelial Tumors of Soft tissues and Bone: Toward a Molecularly Informed Classification
summarizing article
open access
published version
2026
,Elsevier Health
,Seminars in Diagnostic Pathology
,43
(3)
Myoepithelial tumors (MET) of soft tissue and bone comprise a rare group of neoplasms unified by partially overlapping morphology and so called myoepithelial immunophenotype. Historically, MET have long posed diagnostic ...
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Context-Dependent Prognostic Role of Neutrophils and Mast Cells in Primary Colorectal Cancer and Liver Metastases
original article
open access
submitted version
2026
BACKGROUNDColorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Liver metastases (LM) are a major prognostic factor affecting survival and treatment outcomes. Distinguishing between synchronous ...
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Evolving Concepts in Salivary Duct Carcinoma: A Narrative Review
original article
open access
published version
2026
,Springer Internat. Publ.
,Oncology and Therapy
Salivary duct carcinoma (SDC) is an aggressive neoplasm that typically involves the major salivary glands. This rapidly growing tumor is known to recur and metastasize to the neck nodes and to distant sites. Given its poor ...
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Prognostic Role of Serum Neuron-Specific Enolase at Baseline and its Early Dynamics in Metastatic Castration-Resistant Prostate Cancer Treated With Androgen Receptor Signaling Inhibitors
original article
open access
published version
2026
,Wiley
,Prostate
,86
(11)
BACKGROUND: Outcomes of metastatic castration-resistant prostate cancer (mCRPC) treated with androgen receptor signaling inhibitors (ARSIs) vary widely and may not be fully reflected by PSA and standard clinicopathologic ...
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O čem také přemýšlejí naši medici. Sborník studentských prací (2026)
Thoughts of medical students. Collection of written projects (2026)
collection of papers
open access
published version
2026
,Plzeň
,Psychiatrická klinika, Lékařská fakulta v Plzni Univerzity Karlovy
Výběr nejlepších esejí napsaných studenty Lékařské fakulty v Plzni Univerzity Karlovy pro předmět Lékařská psychologie a etika v akademickém roce 2025/2026.
