Faculty of Medicine in Pilsen: Recent submissions
Now showing items 1-20 of 179
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Recent developments in salivary gland pathology after the WHO 2024 classification: new developments in existing entities and evolving new entities
summarizing article
open access
published version
2026
,Springer
,Virchows Archiv
,488
(5)
Parallel to and after publication of the WHO 2024 classification of head and neck tumors, several developments concerning known existing salivary gland tumor entities, but also proposing new evolving tumor entities have ...
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SMARCA4-deficient carcinoma of the head and neck region: report of 8 new sinonasal and non-sinonasal cases and literature review
original article
open access
published version
2026
,Springer
,Virchows Archiv
,488
(5)
Neoplasms with inactivating mutations in SWI/SNF chromatin remodeling complex subunits gained attention in the head and neck (H&N) region due to their poor clinical outcomes. The sinonasal tract is a recognized "hot-spot" ...
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Integrated Genomic and Phenotypic Analyses Reveal Convergent Resistance Patterns in Clinical Candida tropicalis Isolates
original article
open access
published version
2026
,Blackwell
,Mycoses
,69
(5)
BACKGROUND: The incidence of Candida tropicalis isolation is increasing in hospital settings. High azole resistance and mortality rates make it a pathogen that requires further analysis. METHODS: Fourteen azole resistant ...
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Diagnosis of prostate cancer in brothers with signs of detection bias and related consequences
original article
open access
submitted version
2026
Background: Swedish nationwide family and cancer data offer an unbiased opportunity to study familial prostate cancer (PC) and allow an assessment of the possible diagnostic bias that might have been introduced in the ...
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Does Lung Adenocarcinoma Subtyping Offer Clinical Benefits? A Population-Based Study from Sweden
original article
open access
submitted version
2026
Purpose: Classification of lung adenocarcinoma into subtypes is relatively recent and not universally practiced. Consequently, large representative studies describing clinical outcomes are rare, failing to pervasively ...
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RECENT SURVIVAL TRENDS IN THE MOST FATAL CANCERS IN THE NORDIC COUNTRIES: GAINS IN SOME BUT NOT IN ALL
original article
open access
submitted version
2026
BackgroundGlobal survival studies distinguish a group of solid cancers with especially poor survival, which in the Nordic countries are cancers of the hypopharynx, esophagus, stomach, liver, gallbladder, pancreas, lung and ...
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Three-generation familial risks in prostate cancer with a special focus on the early onset patients and their maternal and paternal relatives
original article
open access
submitted version
2026
Background: Swedish nationwide family and cancer data extend through three generations providing a unique chance for study of familial cancer in PC between first-degree relatives (FDR) and second-degree relatives (SDR). ...
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One-year multicenter surveillance of Fosfomycin resistance Enterobacterales: the rise of FosA3-producing P. mirabilis
original article
open access
published version
2026
,Elsevier B.V.
,Current Research in Microbial Sciences
,10
(24 March)
The global rise of antimicrobial resistance has renewed interest in fosfomycin (FOS), an old antibiotic with activity against multidrug-resistant Enterobacterales . However, resistance to FOS is increasing, driven by ...
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Expanding the Molecular-genetic Spectrum of Canalicular Adenoma-like Subtype of Pleomorphic Adenoma of Salivary Glands
original article
open access
published version
2025
,Lippincott-Raven Publishers
,The American Journal of Surgical Pathology
,49
(6)
Canalicular tumors of the salivary glands have recently emerged as an entity characterized by distinct morphology and recurrent HMGA2 gene rearrangement. In this study, we analyzed 40 cases intending to elucidate their ...
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Analyses of ATP7B mRNA in Nasopharyngeal Swab Samples Increase Yields of Wilson Disease Molecular Genetic Diagnostics
original article
open access
published version
2026
,Wiley-Liss, Inc.
,Human Mutation
,2026
(1)
Wilson disease (WD) is an autosomal recessive disorder of copper transport caused by bi-allelic pathogenic variants in the ATPase copper transporting beta gene (ATP7B). Results of standard genetic diagnostics remain ...
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The ABC-LD@4EU+: enhanced version of the ABC Learning Design workshop tailored for the European University Alliance’s needs
chapter in a collective monograph
open access
published version
2026
,London
,UCL Press
,ABC Learning Design. Active, blended, connected and beyond
The chapter shows how the 4EU+ Alliance adapted the original ABC Learning Design method for collaborative course design across eight European universities with different traditions, languages, and pedagogical cultures.Its ...
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From ecology to evolution: plasmid- and colicin-mediated persistence of antibiotic-resistant Escherichia coli in gulls
original article
open access
accepted version
2026
,American Society for Microbiology
,mSystems
,11
(2)
Antimicrobial resistance (AMR) in wildlife is an emerging concern within the One Health concept. Gulls, due to their synanthropic behavior and long-distance migration, are recognized as vectors and secondary reservoirs of ...
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Dynamic changes in the plasmidome and resistome in the gastrointestinal tract of chickens
original article
open access
accepted version
2026
,ASM Press
,Microbiology Spectrum
,14
(5)
The expansion of intensive poultry farming has led to a substantial increase in antibiotic use, which, in turn, has promoted the accumulation of antibiotic resistance genes (ARGs). The chicken gut serves as a reservoir for ...
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Unraveling the telomere-mitochondrial axis in colorectal cancer: Results from a prospectively followed cohort
original article
open access
published version
2026
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
,32
(1)
Background Telomere shortening and mitochondrial dysfunction are well-known independent contributors to many diseases, but emerging evidence suggests a reciprocal relationship between the two processes. The role of the ...
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Familial risks in prostate cancer between brothers and half-brothers as clues to germline genetic and environmental causes
original article
open access
submitted version
2026
Swedish family and cancer data constitute the largest source on familial cancer in the world. We analyze here familial risks in prostate cancer (PC) with focus on multiple affected brothers and comparation of full-brothers ...
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Familial Risks in 317 000 Patients With Prostate Cancer in Relation to Metastases and Survival-Guiding Diagnostics
original article
open access
published version
2026
,Elsevier B.V.
,European Urology Open Science
,87
(May)
BackgroundSwedish nationwide family and cancer data offer the largest global resource for study of familial cancer. We focus here on familial risks in prostate cancer (PC) with questions on risk in individuals from families ...
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Does motherhood increase the risk of developing subsequent malignant neoplasms after childhood cancer treatment?
original article
open access
published version
2026
,Elsevier Ltd.
,Cancer Epidemiology
,101
(April)
BACKGROUND: Most young women who have survived childhood cancer express a desire to have children. Many of them are concerned about the potential adverse impact of pregnancy on their health, which has been affected by prior ...
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The Prognostic Role of Baseline and Early Dynamics of Peripheral Blood Cell Ratios in Metastatic Renal Cell Carcinoma Patients Treated With Nivolumab
original article
open access
published version
2026
,Iōannīs G. Delīnasios
,In Vivo
,40
(2)
BACKGROUND/AIM: Immune checkpoint inhibitors (ICI), including nivolumab, have become the cornerstone of systemic treatment in metastatic renal cell carcinoma (mRCC). Blood-derived biomarkers including neutrophil-to-lymphocyte ...
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Distribution and prognostic value of macrophages in colorectal cancer and adjacent mucosa in patient stages I-III vs IV
original article
open access
published version
2026
,Baishideng Publishing Group Inc
,World Journal of Gastroenterology
,32
(10)
BACKGROUND: Synchronous and metachronous liver metastases (LM) of colorectal cancer (CRC) drastically worsen the patient's survival. The biological and immunological mechanisms underlying these distinct metastatic trajectories ...
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Mitochondrial Transfer Rescues Respiration to Support De Novo Pyrimidine Biosynthesis and Tumor Progression
original article
open access
published version
2026
,American Association for Cancer Research
,Cancer Research
,86
(4)
Cancer cells with severe defects in mitochondrial DNA (mtDNA) can import mitochondria via horizontal mitochondrial transfer to restore respiration. Mitochondrial respiration is necessary for the activity of dihydroorotate ...
