Faculty of Medicine in Pilsen: Poslední příspěvky
Zobrazují se záznamy 21-40 z 75
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A recurrent synonymous L1CAM variant in a fetus with hydrocephalus
původní článek
open access
vydavatelská verze
2024
,Human Genome Variation
,11
(1)
We report the case of a hydrocephalic fetus in which clinical exome sequencing revealed a recurrent synonymous variant of unknown significance, c.453G>T, in the L1CAM gene. This report presents the second case of X-linked ...
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Large-Scale Development of Antibacterial Scaffolds: Gentamicin Sulfate-Loaded Biodegradable Nanofibers for Gastrointestinal Applications
původní článek
open access
vydavatelská verze
2023
,ACS Omega
,8
(43)
The ever-increasing demands of modern medicine drive the development of novel drug delivery materials. In particular, nanofibers are promising for such materials due to their favorable properties. However, most development ...
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Evaluation of human papillomavirus DNA in colorectal cancer and adjacent mucosal tissue samples
původní článek
open access
vydavatelská verze
2023
,Infectious Agents and Cancer
,18
(1)
Background: Although the role of viral agents, such as human papillomavirus (e.g. HPV16, HPV18) in colorectal cancer (CRC) has been previously investigated, results remain inconclusive. Methods: To further evaluate the ...
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Targeted long-read sequencing identified a causal structural variant in X-linked nephrogenic diabetes insipidus
původní článek
open access
vydavatelská verze
2024
,BMC Medical Genomics
,17
(1)
Background: X-linked nephrogenic diabetes insipidus (NDI) is a rare genetic renal disease caused by pathogenic variants in the AVPR2 gene. Single nucleotide variants and small insertions/deletions in AVPR2 are reliably ...
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Analysis of bacterial lipopolysaccharides ("serotyping") by MALDI-TOF mass spectometry: mission impossible?
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2023
,Czech Chemical Society Symposium Series
,21
In the last decade, the use of Matrix-Assisted Laser Desorption/Ionization Time Time-of-Flight mass spectrometry ( MALDI-TOF MS) revolutionary changed clinical microbiology. The technology allowed significant shortening ...
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Molecular pathology in diagnosis and prognostication of head and neck tumors
přehledový článek
open access
vydavatelská verze
2024
,Virchows Archiv
,484
(2)
Classification of head and neck tumors has evolved in recent decades including a widespread application of molecular testing in tumors of the salivary glands, sinonasal tract, oropharynx, nasopharynx, and soft tissue. ...
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ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines
původní článek
open access
vydavatelská verze
2023
,Genes
,14
(2)
A limited number of studies are devoted to regulating TRIP6 expression in cancer. Hence, we aimed to unveil the regulation of TRIP6 expression in MCF-7 breast cancer cells (with high TRIP6 expression) and taxane-resistant ...
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Nonprocedural bleeding after left atrial appendage closure versus direct oral anticoagulants: A subanalysis of the randomized PRAGUE-17 trial
původní článek
open access
vydavatelská verze
2023
,Journal of Cardiovascular Electrophysiology
,34
(9)
INTRODUCTION: Observational studies have shown low bleeding rates in patients with atrial fibrillation (AF) treated by left atrial appendage closure (LAAC); however, data from randomized studies are lacking. This study ...
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Trends in outcomes of women with myocardial infarction undergoing primary angioplasty - Analysis of randomized trials
původní článek
open access
vydavatelská verze
2023
,Frontiers in Cardiovascular Medicine
,9
(January)
Background: Sex- and gender-associated differences determine the disease response to treatment.Aim: The study aimed to explore the hypothesis that progress in the management of STE-myocardial infarction (STEMI) overcomes ...
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Autoimmune diseases as comorbidities for liver, gallbladder, and biliary duct cancers in Sweden
původní článek
open access
vydavatelská verze
2023
,Cancer
,129
(8)
BackgroundAutoimmune diseases are associated with many cancers but there is a lack of population-based studies with different autoimmune diseases that have a long follow-up. This is also true of hepatobiliary cancers, which ...
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Faecal bacteriome and metabolome profiles associated with decreased mucosal inflammatory activity upon anti-TNF therapy in paediatric Crohn's disease
původní článek
open access
vydavatelská verze
2024
,Journal of Crohn's and Colitis
,18
(1)
BACKGROUND AND AIMS: Treatment by anti-TNFα antibodies (anti-TNF) changes the dysbiotic faecal bacteriome in Crohn's disease (CD). However, it is not known whether these changes are due to decreasing mucosal inflammatory ...
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Population-Attributable Fractions of Personal Comorbidities for Liver, Gallbladder, and Bile Duct Cancers
původní článek
open access
vydavatelská verze
2023
,Cancers
,15
(12)
Simple Summary Liver cancer is often used as a general term for cancers of the liver (hepatocellular carcinoma, HCC), the gallbladder, and the bile ducts. The well-known risk factors are alcohol and viral hepatitis, but ...
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Association of lncRNA and transcriptome intersections with response to targeted therapy in metastatic renal cell carcinoma
původní článek
open access
vydavatelská verze
2023
,Oncology Letters
,26
(3)
Long non-coding RNAs (lncRNAs) serve an important role in cancer progression and may be used as efficient molecular biomarkers. The present study aimed to identify lncRNAs associated with the response to the receptor ...
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miRNA and lncRNA as Potential Tissue Biomarkers in Hepatocellular Carcinoma
přehledový článek
open access
vydavatelská verze
2024
,Non-coding RNA Research
,9
(1)
Hepatocellular carcinoma (HCC) is primary liver cancer, frequently diagnosed at advanced stages with limited therapeutic options. MicroRNAs (miRNAs) regulate target gene expression and through inhibitory competitive binding ...
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Serious Immune-related Adverse Events Are Associated With Greater Efficacy of Nivolumab Therapy Against Non-small Cell Lung Cancer
původní článek
open access
vydavatelská verze
2023
,In Vivo
,37
(5)
BACKGROUND/AIM: The aim of this study was to investigate possible association between adverse events of nivolumab therapy and the effectiveness of treatment in patients with non-small cell lung cancer (NSCLC). Focusing on ...
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Branchioma with a nested/organoid morphology: molecular profiling of a distinctive potentially misleading variant and reappraisal of potential relationship to CD34-positive/Rb1-deficient tumors of the neck
původní článek
open access
vydavatelská verze
2023
,Virchows Archiv
,483
(4)
Branchioma (previously called ectopic hamartomatous thymoma, branchial anlage mixed tumor, or thymic anlage tumor) is a rare lower neck lesion with an adult male predominance and an uncertain histogenesis. Except for 4 ...
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Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases
původní článek
open access
vydavatelská verze
2023
,Cancer Cell International
,23
(1)
Background: Colorectal cancer is a highly prevalent and deadly. The most common metastatic site is the liver. We performed a whole exome sequencing analysis of a series of metachronous colorectal cancer liver metastases ...
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Blood parasites (Trypanosoma, Leucocytozoon, Haemoproteus) in the Eurasian sparrowhawk (Accipiter nisus): diversity, incidence and persistence of infection at the individual level
původní článek
open access
vydavatelská verze
2023
,Parasites & Vectors
,16
(1)
Background :A high prevalence of parasites may result from life-long persistence of infection or from high reinfection rates. We have studied blood parasites in a breeding population of the accipitrid raptor, Eurasian ...
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Genetic analysis challenges the presence of Ixodes inopinatus in Central Europe: Development of a multiplex PCR to distinguish I. inopinatus from I. ricinus
původní článek
open access
vydavatelská verze
2023
,Parasites & Vectors
,16
(1)
Background Ixodes ricinus is an important vector of several pathogens, primarily in Europe. Recently, Ixodes inopinatus was described from Spain, Portugal, and North Africa and then reported from several European countries. ...
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Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery
původní článek
open access
vydavatelská verze
2023
,Diagnostics
,13
(20)
In our study, the effect of the use of autofluorescence (Visually Enhanced Lesion Scope-VELscope) on increasing the success rate of surgical treatment in oral squamous carcinoma (OSCC) was investigated. Our hypothesis was ...
