Faculty of Medicine in Pilsen: Poslední příspěvky
Zobrazují se záznamy 41-60 z 75
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Clinically relevant antibiotic resistance in Escherichia coli from black kites in southwestern Siberia: a genetic and phenotypic investigation
původní článek
embargo
postprint
2023
,mSphere
,8
(4)
Wild birds including raptors can act as vectors of clinically relevant bacteria with antibiotic resistance. The aim of this study was to investigate the occurrence of antibiotic-resistant Escherichia coli in black kites ...
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Fosfomycin resistance mechanisms in Enterobacterales: an increasing threat
přehledový článek
embargo
vydavatelská verze
2023
,Frontiers in Cellular and Infection Microbiology
,13
(July)
Antimicrobial resistance is well-known to be a global health and development threat. Due to the decrease of effective antimicrobials, re-evaluation in clinical practice of old antibiotics, as fosfomycin (FOS), have been ...
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Metodika pro detekci Paenibacillus larvae a Melissococcus plutonius pomocí PCR v reálném čase
Methods for the detection of Paenibacillus larvae and Melissococcus plutonius using real-time PCR
certifikovaná metodika
open access
vydavatelská verze
2023
Metodika je určena laboratořím, které se zabývají diagnostikou nákaz včel. Detekce původců moru včelího plodu (Paenibacillus larvae) a hniloby včelího plodu (Melissococcus plutonius) je nezbytná pro prevenci šíření těchto ...
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Serum Metabolite Biomarkers for Pancreatic Tumors: Neuroendocrine and Pancreatic Ductal Adenocarcinomas-A Preliminary Study
původní článek
open access
vydavatelská verze
2023
,Cancers
,15
(12)
BACKGROUND: Pancreatic cancer is the most common pancreatic solid malignancy with an aggressive clinical course and low survival rate. There are a limited number of reliable prognostic biomarkers and a need to understand ...
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DNA Repair Pathway in Ovarian Cancer Patients Treated with HIPEC
původní článek
open access
vydavatelská verze
2023
,International Journal of Molecular Sciences
,24
(10)
DNA repair pathways are essential for maintaining genome stability, and understanding the regulation of these mechanisms may help in the design of new strategies for treatments, the prevention of platinum-based chemoresistance, ...
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Editorial: Mobile genetic elements as dissemination drivers of multidrug-resistant Gram-negative bacteria
jiný článek
embargo
vydavatelská verze
2023
,Frontiers in Cellular and Infection Microbiology
,13
(March)
Mobile genetic elements as dissemination drivers of multidrug-resistant Gram-negative bacteria - no abstract available
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Gut Microbiome Diversity of Porcine Peritonitis Model of Sepsis
abstrakt v konferenčním sborníku
embargo
vydavatelská verze
2022
,Czech Chemical Society Symposium Series
,20
(6)
Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant ...
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Survival in Lung Cancer in the Nordic Countries Through A Half Century
původní článek
embargo
vydavatelská verze
2023
,Clinical Epidemiology
,15
(May)
Objective: Lung cancer is often diagnosed at an advanced stage and survival has been poor, although long-term studies have been rare. We analyzed data on survival in lung cancer from Denmark, Finland, Norway, and Sweden ...
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Survival in melanoma in the nordic countries into the era of targeted and immunological therapies
původní článek
embargo
vydavatelská verze
2023
,European Journal of Cancer
,186
(June)
Objectives: Survival in melanoma has been increasing and the most recent interest is to observe the population-level impact of novel targeted therapies and immunotherapy. We analysed survival in melanoma from Denmark (DK), ...
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The dynamics of telomere length in primary and metastatic colorectal cancer lesions
původní článek
embargo
vydavatelská verze
2023
,Scientific Reports
,13
(1)
Telomeric sequences, the structures comprised of hexanucleotide repeats and associated proteins, play a pivotal role in chromosome end protection and preservation of genomic stability. Herein we address telomere length ...
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Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases
abstrakt v konferenčním sborníku
embargo
vydavatelská verze
2022
,Czech Chemical Society Symposium Series
,20
(6)
The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems ...
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Epidemic spread of KPC-producing bacteria in the Czech Republic
abstrakt v konferenčním sborníku
embargo
vydavatelská verze
2022
,Czech Chemical Society Symposium Series
,20
(6)
Carbapenems are currently last-resort antibiotics for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. Therefore, the resistence to those drugs represents a significant threat of current ...
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Experimental Treatment with Edaravone in a Mouse Model of Spinocerebellar Ataxia 1
původní článek
open access
vydavatelská verze
2023
,International Journal of Molecular Sciences
,24
(13)
Edaravone is a mitochondrially targeted drug with a suggested capability to modify the course of diverse neurological diseases. Nevertheless, edaravone has not been tested yet in the context of spinocerebellar ataxia 1 ...
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Theranostics Nanomedicine Applications for Colorectal Cancer and Metastasis: Recent Advances
původní článek
open access
vydavatelská verze
2023
,International Journal of Molecular Sciences
,24
(9)
Colorectal cancer (CRC) is the third most common cancer worldwide, and metastatic CRC is a fatal disease. The CRC-affected tissues show several molecular markers that could be used as a fresh strategy to create newer methods ...
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Personal comorbidities and their subsequent risks for liver, gallbladder and bile duct cancers
původní článek
open access
vydavatelská verze
2023
,International Journal of Cancer
,152
(6)
Many environmental risk factors for hepatobiliary cancers are known but whether they are associated with specific cancer types is unclear. We present here a novel approach of assessing standardized incidence ratios (SIRs) ...
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Long-term survival trends in solid cancers in the Nordic countries marking timing of improvements
původní článek
open access
vydavatelská verze
2023
,International Journal of Cancer
,152
(9)
Survival studies are an important indicator of the success of cancer control. We analyzed the 5-year relative survival in 23 solid cancers in Denmark, Finland, Norway and Sweden over a 50-year period (1970-2019) at the ...
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O čem také přemýšlejí naši medici. Sborník studentských prací (2023)
Thoughts of medical students. Collection of written projects (2023)
sborník
open access
vydavatelská verze
2023
,Plzeň
,Psychiatrická klinika, Lékařská fakulta v Plzni Univerzity Karlovy
Výbor nejlepších esejí, které odevzdali studenti Lékařské fakulty Univerzity Karlovy v Plzni v akademickém roce 2022/2023 v rámci předmětu Lékařská psychologie a etika.
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Polyclonal Spread of Fosfomycin Resistance among Carbapenemase-Producing Members of the Enterobacterales in the Czech Republic
původní článek
embargo
postprint
2023
,Microbiology spectrum
,11
(3)
Fosfomycin (FOS) has been recently reintroduced into clinical practice, but its effectiveness against multidrug-resistant (MDR) Enterobacterales is reduced due to the emergence of FOS resistance. The copresence of ...
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The rapid detection of procalcitonin in septic serum using immunoaffinity MALDI chips
původní článek
omezený přístup
vydavatelská verze
2023
,Clinical Proteomics
,20
(1)
Background: Sepsis is a common worldwide health condition with high mortality. It is caused by a dysregulated immune response to the pathogen. Severe infections resulting in sepsis can be also determined by monitoring ...
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Unicentric form of Castleman´s disease, pitfalls of diagnosis and surgical treatment
přehledový článek
open access
vydavatelská verze
2023
,Frontiers in Oncology
,13
(January)
Background:Castleman's disease is an extremely rare heterogenous lymphoproliferative pathology with a mostly benign behavior. It is a localized or generalized lymph node enlargement of an unknown aetiology. Unicentric form ...
