Search

Now showing items 1-10 of 12

Long Non-Coding RNA and microRNA Interplay in Colorectal Cancer and Their Effect on the Tumor Microenvironment

summarizing article

embargoed access

published version

Rajtmajerová, Marie

;

Trailin, Andriy

;

Liška, Václav

;

Hemminki, Kari Jussi

;

Ambrożkiewicz, Filip

2022

,

Cancers

,

14

(21)

As the current staging and grading systems are not sufficient to stratify patients for therapy and predict the outcome of the disease, there is an urgent need to understand cancer in its complexity. The mutual relationship ...

Gut Microbiome Diversity of Porcine Peritonitis Model of Sepsis

abstract in conference proceedings

embargoed access

published version

Chalupová, Miroslava

;

Horák, Jan

;

Kramná, Lenka

;

Nalos, Lukáš

;

Štengl, Milan

;

Chudějová, Kateřina

;

Kraftová, Lucie

;

Cinek, Ondřej

;

Klein, Pavel

;

Matějovič, Martin

;

Hrabák, Jaroslav

2022

,

Czech Chemical Society Symposium Series

,

20

(6)

Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant ...

Whole Exome Sequencing of Epithelial Ovarian Carcinomas Differing in Resistance to Platinum Therapy

original article

embargoed access

published version

Hlaváč, Viktor

;

Holý, Petr

;

Václavíková, Radka

;

Rob, Lukáš

;

Hruda, Martin

;

Mrhalová, Marcela

;

Černaj, Petr

;

Bouda, Jiří

;

Souček, Pavel

2022

,

Life Science Alliance

,

5

(12)

Epithelial ovarian carcinoma (EOC) is highly fatal because of the risk of resistance to therapy and recurrence. We performed whole-exome sequencing of blood and tumor tissue pairs of 50 patients with surgically resected ...

Gut microbiome diversity of porcine peritonitis model of sepsis

original article

embargoed access

published version

Chalupová, Miroslava

;

Horák, Jan

;

Kramná, Lenka

;

Nalos, Lukáš

;

Štengl, Milan

;

Chudějová, Kateřina

;

Kraftová, Lucie

;

Cinek, Ondřej

;

Klein, Pavel

;

Matějovič, Martin

;

Hrabák, Jaroslav

2022

,

Scientific Reports

,

12

(1)

Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant variability in the ...

Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases

abstract in conference proceedings

embargoed access

published version

Študentová, Vendula

;

Sudová, Vendula

;

Bitar, Ibrahim

;

Pašková, Veronika

;

Moravec, Jiří

;

Pompach, Petr

;

Volný, Michael

;

Novák, Petr

;

Hrabák, Jaroslav

2022

,

Czech Chemical Society Symposium Series

,

20

(6)

The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems ...

Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases

original article

embargoed access

published version

Študentová, Vendula

;

Sudová, Vendula

;

Bitar, Ibrahim

;

Pašková, Veronika

;

Moravec, Jiří

;

Pompach, Petr

;

Volný, Michael

;

Novák, Petr

;

Hrabák, Jaroslav

2022

,

Scientific Reports

,

12

(1)

The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems ...

Type 1 diabetes incidence increased during the COVID-19 pandemic years 2020-2021 in Czechia: results from a large population-based paediatric register

original article

embargoed access

published version

Cinek, Ondřej

;

Slavenko, Matvei

;

Pomahačová, Renata

;

Venháčová, Petra

;

Petruželková, Lenka

;

Škvor, Jaroslav

;

Neumann, David

;

Konečná, Petra

;

Vosáhlo, Jan

;

Kocourková, Kamila

;

Strnadel, Jiří

;

Průhová, Štěpánka

;

Šumník, Zdeněk

2022

,

Pediatric Diabetes

,

23

(7)

OBJECTIVE: To explore type 1 diabetes incidence patterns during the pandemic years 2020 and 2021 in Czechia, to compare them to the trends from previous decade, and to test its association with indicators of containment ...

Genomic Characterization of Mutli-Drug Resistant Pseudomonas aeruginosa Clinical Isolates: Evaluation and Determination of Ceftolozane/Tazobactam Activity and Resistance Mechanisms

original article

restricted access

published version

Bitar, Ibrahim

;

Salloum, Tamara

;

Merhi, Georgi

;

Hrabák, Jaroslav

;

Araj, George F.

;

Tokajian, Sima

2022

,

Frontiers in Cellular and Infection Microbiology

,

12

(June)

Resistance to ceftolozane/tazobactam (C/T) in Pseudomonas aeruginosa is a health concern. In this study, we conducted a whole-genome-based molecular characterization to correlate resistance patterns and β-lactamases with ...

Activated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role as a Potential Target for Future Therapies

summarizing article

embargoed access

published version

Ali, Esraa

;

Trailin, Andriy

;

Ambrożkiewicz, Filip

;

Liška, Václav

;

Hemminki, Kari Jussi

2022

,

International Journal of Molecular Sciences

,

23

(23)

Hepatocellular carcinoma (HCC) is a global healthcare challenge, which affects more than 815,000 new cases every year. Activated hepatic stellate cells (aHSCs) remain the principal cells that drive HCC onset and growth. ...

Oral presentation of paraneoplastic pemphigus as the first sign of tonsillar HPV associated squamous cell carcinoma. A case report

casuistics

open access

published version

Liška, Jan

;

Lišková, Veronika

;

Trčka, Ondřej

;

Ondič, Ondrej

;

Hauer, Lukáš

;

Baxa, Jan

;

Kacerovská, Denisa

2022

,

Biomedical Papers

,

166

(4)

Background: Paraneoplastic pemphigus (PNP) in the oral cavity is a rare variant of blistering pemphigus disease closely associated with mostly malignant tumors. The diagnosis may even precede an underlying malignancy ...

1
2