Lékařská fakulta v Plzni
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Poslední příspěvky
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O čem také přemýšlejí naši medici. Sborník studentských prací (2024)
Thoughts of medical students. Collection of written projects (2024)
sborník
open access
vydavatelská verze
2024
,Plzeň
,Psychiatrická klinika, Lékařská fakulta v Plzni Univerzity Karlovy
Výbor nejlepších esejí napsaných studenty Lékařské fakulty Univerzity Karlovy v Plzni pro předmět Lékařská psychologie a etika v akademickém roce 2023/2024.
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Emerging Role of Circulating Cell-Free RNA as a Non-Invasive Biomarker for Hepatocellular Carcinoma
původní článek
open access
vydavatelská verze
2024
,Critical Reviews in Oncology/Hematology
,200
(August)
Hepatocellular carcinoma (HCC) is a severe neoplastic disease associated with high morbidity and mortality rates. HCC is often detected at advanced stages leading to ineffective curative treatments. Recently, liquid biopsy ...
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Major improvement in thyroid cancer survival of elderly patients in the Nordic countries
původní článek
open access
vydavatelská verze
2024
,European Journal of Endocrinology
,190
(3)
Objectives We describe age-specific survival in thyroid cancer (TC) from Denmark, Finland, Norway, and Sweden over a 50-year period.Design Population-based survival study.Methods Relative 5-year survival data were obtained ...
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Concomitant antihypertensive medication and outcome of patients with metastatic castration-resistant prostate cancer receiving enzalutamide or abiraterone acetate
původní článek
open access
vydavatelská verze
2024
,Cancer Medicine
,13
(1)
BACKGROUND: The introduction of novel hormonal therapies represented by enzalutamide (ENZ) and abiraterone acetate (ABI) has reached a great progress in the treatment of metastatic castration-resistant prostate cancer ...
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Utilization of healthcare services in acute myocardial infarction and the risk of out-of-hospital cardiac death
letter to the editors
open access
vydavatelská verze
2024
,Panminerva Medica
,66
(1)
COVID-19 represented a significant challenge to cardiovascular (cV) medicine research, treatment, prevention, and, to a considerable extent, case management. The global pandemic viral infection increased the risk of ...
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Learning Support Systems: A Practical Guide to E-learning at CU
necertifikovaná metodika
open access
draft
2024
,Praha
,Univerzita Karlova, Nakladatelství Karolinum
This guide introduces the e-learning support tools that are used most frequently at Charles University and that you may encounter during your studies. It will also help you to avoid the most common obstacles associated ...
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FosA8-producing E. coli ST131: clinical cases in Italy, February 2023
původní článek
open access
vydavatelská verze
2024
,Eurosurveillance
,29
(21)
Fosfomycin-resistant FosA8-producing Enterobacterales are uncommon strains with extremely low incidence in Europe, based on only three reports in the literature. We detected FosA8-producing Escherichia coli ST131 in clinical ...
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A unique human cord blood CD8(+)CD45RA(+)CD27(+)CD161(+) T-cell subset identified by flow cytometric data analysis using Seurat
původní článek
open access
vydavatelská verze
2024
,Immunology
Advances in single-cell level analytical techniques, especially cytometric approaches, have led to profound innovation in biomedical research, particularly in the field of clinical immunology. This has resulted in an ...
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Spread of carbapenemase-producing Morganella spp from 2013 to 2021: a comparative genomic study
původní článek
open access
vydavatelská verze
2024
,The Lancet Microbe
,5
(6)
BACKGROUND: Morganella spp are opportunistic pathogens involved in various infections. Intrinsic resistance to multiple antibiotics (including colistin) combined with the emergence of carbapenemase producers reduces the ...
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Sequential Induction of Drug Resistance and Characterization of an Initial Candida albicans Drug-Sensitive Isolate
původní článek
open access
vydavatelská verze
2024
,Journal of Fungi
,10
(5)
BACKGROUND: The pathogenic fungus Candida albicans is a leading agent of death in immunocompromised individuals with a growing trend of antifungal resistance. METHODS: The purpose is to induce resistance to drugs in a ...
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Genomic characterization of ST38 NDM-5-producing Escherichia coli isolates from an outbreak in the Czech Republic
původní článek
open access
postprint
2024
,Antimicrobial Agents and Chemotherapy
,68
(6)
A 2-year national genomic screening in the Czech Republic identified a notable prevalence of the New Delhi metallo-β-lactamase 5 (NDM-5)-producing Escherichia coli sequence type 38 (ST38) in the city of Brno. Forty-two ...
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Simultaneous PCR detection of Paenibacillus larvae targeting insertion sequence IS256 and Melissococcus plutonius targeting pMP1 plasmid from hive specimens
původní článek
open access
postprint
2024
,Folia Microbiologica
,69
(2)
Paenibacillus larvae and Melissococcus plutonius represent the most threatening bacterial diseases of honeybee (Apis mellifera)-American and European foulbrood, respectively. For efficient control of those diseases, rapid ...
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Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression
původní článek
open access
vydavatelská verze
2024
,International Journal of Cancer
,155
(1)
High-grade serous ovarian carcinoma (HGSC) is the most common subtype of ovarian cancer and is among the most fatal gynecological malignancies worldwide, due to late diagnosis at advanced stages and frequent therapy ...
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A recurrent synonymous L1CAM variant in a fetus with hydrocephalus
původní článek
open access
vydavatelská verze
2024
,Human Genome Variation
,11
(1)
We report the case of a hydrocephalic fetus in which clinical exome sequencing revealed a recurrent synonymous variant of unknown significance, c.453G>T, in the L1CAM gene. This report presents the second case of X-linked ...
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Large-Scale Development of Antibacterial Scaffolds: Gentamicin Sulfate-Loaded Biodegradable Nanofibers for Gastrointestinal Applications
původní článek
open access
vydavatelská verze
2023
,ACS Omega
,8
(43)
The ever-increasing demands of modern medicine drive the development of novel drug delivery materials. In particular, nanofibers are promising for such materials due to their favorable properties. However, most development ...
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Evaluation of human papillomavirus DNA in colorectal cancer and adjacent mucosal tissue samples
původní článek
open access
vydavatelská verze
2023
,Infectious Agents and Cancer
,18
(1)
Background: Although the role of viral agents, such as human papillomavirus (e.g. HPV16, HPV18) in colorectal cancer (CRC) has been previously investigated, results remain inconclusive. Methods: To further evaluate the ...
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Targeted long-read sequencing identified a causal structural variant in X-linked nephrogenic diabetes insipidus
původní článek
open access
vydavatelská verze
2024
,BMC Medical Genomics
,17
(1)
Background: X-linked nephrogenic diabetes insipidus (NDI) is a rare genetic renal disease caused by pathogenic variants in the AVPR2 gene. Single nucleotide variants and small insertions/deletions in AVPR2 are reliably ...
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Analysis of bacterial lipopolysaccharides ("serotyping") by MALDI-TOF mass spectometry: mission impossible?
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2023
,Czech Chemical Society Symposium Series
,21
In the last decade, the use of Matrix-Assisted Laser Desorption/Ionization Time Time-of-Flight mass spectrometry ( MALDI-TOF MS) revolutionary changed clinical microbiology. The technology allowed significant shortening ...
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Molecular pathology in diagnosis and prognostication of head and neck tumors
přehledový článek
open access
vydavatelská verze
2024
,Virchows Archiv
,484
(2)
Classification of head and neck tumors has evolved in recent decades including a widespread application of molecular testing in tumors of the salivary glands, sinonasal tract, oropharynx, nasopharynx, and soft tissue. ...
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ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines
původní článek
open access
vydavatelská verze
2023
,Genes
,14
(2)
A limited number of studies are devoted to regulating TRIP6 expression in cancer. Hence, we aimed to unveil the regulation of TRIP6 expression in MCF-7 breast cancer cells (with high TRIP6 expression) and taxane-resistant ...
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