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Validated WGS and WES protocols proved saliva-derived gDNA as an equivalent to blood-derived gDNA for clinical and population genomic analyses
(2024)Background: Whole exome sequencing (WES) and whole genome sequencing (WGS) have become standard methods in human clinical diagnostics as well as in population genomics (POPGEN). Blood-derived genomic DNA (gDNA) is routinely ... -
DNA from BK polyomavirus is sensed during infection of reservoir cells via cGAS-STING pathway
(Nizozemsko, Nizozemsko, 2024)Human polyomaviruses (HPyVs) include 14 species that cause primary asymptomatic infections after which the virus persists in the host by a mechanism that is not well understood. Reactivation of the infection in immunosuppressed ... -
STING agonist induced-monocyte death combines apoptosis, pyroptosis and caspase 8 activation
(Nizozemsko, Nizozemsko, 2024)The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway isimportant for recognition of double-stranded DNA, a marker of infection or cell damage. ThecGAS-STING pathway activation leads to production ... -
HBV-induced microenvironment reduces pDC response to TLR9 stimulation
(Nizozemsko, Nizozemsko, 2024)Hepatitis B virus (HBV) is a non-cytopathogenic virus with DNA genome. It causes an acute hepatitis that may develop into chronic hepatitis B, liver cirrhosis and hepatocellular carcinoma. HBV is described as "stealth ... -
Determinants of self-rated health among highly educated Ukrainian women refugees in Czechia: analysis based on cross-sectional study in 2022
(2024)Background: Russia's military aggression against Ukraine set in motion a large number of refugees. Considerable amount of them came and stayed in Czechia. Refugees represent special vulnerable individuals often affected ... -
Using Raman spectroscopy to detect scytonemin of epiliths and endoliths from marble, serpentinite and gypsum
(2023)Here, we present Raman spectra showing the presence and distribution of scytonemin and carotenoids in epilithic and endolithic colonisations from temperate locations in Central Europe and Sicily. In the Bohemian Massif, ... -
Raman study of several Cu-bearing complex minerals from the guano deposit at Pabellón de Pica, Tarapaca region, Chile
(2023)Pabellón de Pica, Tarapaca, Chile, is a former guano mine exploited in the late 19th and early 20th centuries. Guano is in a direct contact with Cu sulfide mineralization leading to the formation of minerals with a highly ... -
More than urns: A multi-method pipeline for analyzing cremation burials
(2023)Burial rites of archaeological populations are frequently interpreted based on cremated remains of the human body and the urn they were deposited in. In comparison to inhumations, information about the deceased is much ... -
Silver isotopes: A tool to trace smelter-derived contamination
(2023)Here, for the first time, we report the concentrations and isotopic data of Ag in a variety of ore and metallurgical samples and forest soils that have been polluted due to Ag-Pb smelter emissions. Similar to the Ag ... -
Gypsum endolithic phototrophs under moderate climate (Southern Sicily): their diversity and pigment composition
(2023)In this study, we used microscopic, spectroscopic, and molecular analysis to characterize endolithic colonization in gypsum (selenites and white crystalline gypsum) from several sites in Sicily. Our results showed that the ... -
Provenance Analysis of Marbles by Combination of Cathodoluminescence Spectroscopy and Electron Microprobe Analyses-Methodological Comments
(2023)Various marbles from historic quarries of the Czech Republic were examined by means of cathodoluminescence (CL) spectroscopy (quantitative data) to determine the possible inclusion of the method in marble provenance studies. ... -
The Recent Discovery, Research, and Restoration of Medieval and Renaissance Frescoes in Riga Castle — A Treasure to the Baltic Region
(2023)One of the most important castles of the medieval Teutonic Order-Riga Castle in Latvia-is currently undergoing extensive reconstruction work. This study attempts to summarize recent information about the medieval fresco ... -
Impact of Mining and Ore Processing on Soil, Drainage and Vegetation in the Zambian Copperbelt Mining Districts: A Review
(2023)The regional environmental-geochemical surveying of the long-term impacts of mining and ore processing on a large part of the Zambian Copperbelt mining district was carried out by the Czech Research Group with cooperation ... -
The analysis of two historic fired artificial stonewares: Coade stone (18th–19th centuries) and a recent discovery from Oxnead Hall, Norfolk (16th–17th centuries)
(2023)Coade stone has played a significant role in architectural and ornamental design since its inception in the early 18th century. It is well known that earlier, experimental, architectural stoneware products existed, but few ... -
Characterization of the input material quality for the production of tisagenlecleucel by multiparameter flow cytometry and its relation to the clinical outcome
(2023)Tisagenlecleucel (tisa-cel) is a CD19(-)specific CAR-T cell product approved for the treatment of relapsed/refractory (r/r) DLBCL or B-ALL. We have followed a group of patients diagnosed with childhood B-ALL (n = 5), adult ... -
Flood Simulations Using a Sensor Network and Support Vector Machine Model
(2023)This study aims to couple the support vector machine (SVM) model with a hydrometeorological wireless sensor network to simulate different types of flood events in a montane basin. The model was tested in the mid-latitude ... -
Automatic forest cover classification using Sentinel-2 multispectral satellite data and machine learning algorithms in Google Earth Engine
(2023)Forest cover plays an essential role in maintaining ecological equilibrium, mitigating climate change, and securing a sustainable future for both humanity and the planet. Most countries conduct forest inventory or remote ... -
Dendrometers challenge the 'moon wood concept' by elucidating the absence of lunar cycles in tree stem radius oscillation
(2023)Wood is a sustainable natural resource and an important global commodity. According to the 'moon wood theory', the properties of wood, including its growth and water content, are believed to oscillate with the lunar cycle. ... -
Reprogramming of the developing heart by Hif1a-deficient sympathetic system and maternal diabetes exposure
(2024)Introduction: Maternal diabetes is a recognized risk factor for both short-term and long-term complications in offspring. Beyond the direct teratogenicity of maternal diabetes, the intrauterine environment can influence ... -
Metodika tvorby textů v otevřeném internetovém prostoru pro vysokoškolské vzdělávání formou e-learningu
(2012)Metodika tvorby textů v otevřeném internetovém prostoru poskytuje základní teoretický i praktický rámec pro využití otevřeného internetového prostoru jako nástroje pro výuku studentů na vysokých školách, která je vedena ...