Faculty of Science
Recent Submissions
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N-Aryl-N-Lactosylamides as Potent and Highly Selective Inhibitors of Galectin-3 with Antifibrotic Activity
original article
open access
published version
2025
,ACS Publications
,Journal of Medicinal Chemistry
,68
(22)
Galectin-3 (Gal-3) is a galactose-binding lectin involved in pathologies such as inflammation, fibrosis, heart disease, and tumor progression. Here, we report N-aryl-N-(thio)lactosylamides as a novel class of Gal-3 inhibitors. ...
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Herbicides vs herbicidal ionic liquids - does the herbicide application form affect the properties of active components?
original article
open access
published version
2025
,ELSEVIER
,Journal of Hazardous Materials
,19
(August 2025)
Despite extensive research on ionic liquids (ILs), their environmental fate remains poorly understood. Cation toxicity is generally considered the primary determinant of the final properties of the ILs. However, the relevance ...
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MiR-146a secreted via EVs modulates TLR9 signalling in a cell model of chronic HBV infection
abstract in journal
open access
accepted version
2025
,CzeSEV 2025 Meeting 2025
Hepatitis B virus (HBV) infection remains a major global health threat, with more than 250 million people chronically infected and at risk of cirrhosis and hepatocellular carcinoma. Infected hepatocytes release large amounts ...
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COVID-19 mortality data and level of democracy in post-communist countries: Data sources and accuracy
original article
open access
published version
2025
,Institute of Geonics, Czech Academy of Sciences v.v.i.
,Moravian Geographical Reports
,33
(3)
Emerging studies highlight the potential influence of different political regimes on COVID-19 mortality statistics reliability. This study has two objectives: first, to analyze COVID-19 mortality datasets and identify ...
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Decoding life expectancy gaps: a long-term decomposition analysis of three WHO European Region country groups
original article
open access
published version
2025
,Taylor & Francis
,Cogent Social Sciences
,11
(1)
Life expectancy at birth serves as a proxy measure of community health, indicating socio-economic development, healthcare accessibility, and the success of health policies. Observed differences in life expectancy among ...
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Reverse Genetics as a Key to Understanding Toscana Virus – Sand Fly Dynamics
abstract in conference proceedings
open access
accepted version
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(24)
The Toscana virus (TOSV), a member of the genus Phlebovirus Phenuiviridae, Hareavirales ), is a neglected human pathogen that can cause febrile illness, severe infection of the CNS, or remain asymptomatic. It is distributed ...
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Sand fly saliva reprograms skin fibroblasts to enhance arbovirus infection
original article
open access
published version
2025
,Cell Press, Elsevier, Inc.
,iScience
,28
(11)
Arbovirus transmission by sand flies is a growing public health concern, yet the early skin events shaping infection outcomes remain undefined. We establish a mouse model of Toscana virus (TOSV) infection that incorporates ...
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Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer
original article
open access
accepted version
2025
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...
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Yeast linear plasmid transcripts mimic viral mRNAs: evidence for a cap-independent mechanism
abstract in e-form
open access
accepted version
2025
,EMBL
,Protein synthesis and translational control
Linear plasmids have been identified in various yeast species, notably the Kluyveromyceslactis pGKL1/2 plasmids, which are cytoplasmic and serve as models for this class. Theseplasmids carry terminal proteins, compact ...
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An investigation into the splicing variants of human eIF4E isoforms and their distinct roles in stress
abstract in e-form
open access
accepted version
2025
,EMBL
,Protein synthesis and translational control
The eukaryotic translation initiation factor 4E (eIF4E) binds to the 5' mRNA cap and plays apivotal role in the control of cap-dependent translation initiation. The human eIF4E proteinfamily comprises canonical eIF4E1 ...
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STING AGONISTS INDUCE PYROPTOTIC APOPTOSIS IN HUMAN MONOCYTES
abstract in conference proceedings
open access
accepted version
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
Regulated cell death (RCD) represents a key outcome ofthe cyclic GMP GMP-AMP synthase (cGAS) cGAS)-stimulator ofinterferon genes (STING) activation in human monocytes, inaddition to its canonical role in sensing cytoplasmic ...
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UNCONVENTIONAL mRNA PROCESSING AND CAP-INDEPENDENT TRANSLATION IN YEAST LINEAR PLASMIDS
abstract in conference proceedings
open access
accepted version
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
Linear plasmids have been identified in various yeastspecies, notably the Kluyveromyces lactis pGKL1/2 plasmids,which are cytoplasmic and serve as models for this class.These plasmids carry terminal proteins, compact ...
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THE ROLE OF ASPARTATE BETA-HYDROXYLASE IN TUMORS ASSOCIATED WITH HUMAN PAPILLOMAVIRUSES
abstract in conference proceedings
open access
accepted version
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
Aspartate beta-hydroxylase (ASPH) is a transmembraneprotein that is localized in the endoplasmic reticulum. It is notproduced in most normal cells, but the expression is increasedin tumor cells, where it can be localized ...
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CELL-FREE HPV DNA AS A BIOMARKER FOR THE TREATMENT RESPONSE MONITORING IN OROPHARYNGEAL CANCER PATIENTS IN THE CZECH REPUBLIC
abstract in conference proceedings
open access
accepted version
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
Cell-free tumor DNA (cfDNA) in liquid biopsies is apromising diagnostic and prognostic biomarker for cancers,including human papillomavirus (HPV)-driven oropharyngealcarcinoma (OPC). Monitoring cfHPV DNA dynamics in plasmaor ...
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THE ROLE OF MIRNA MIRNA-146A IN ANTIVIRAL IMMUNE RESPONSE TO TLR9 STIMULATION IN PERIFERAL BLOOD MONONUCLEAR CELLS
abstract in conference proceedings
open access
accepted version
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
Hepatitis B virus (HBV) is a major global health threat,causing acute and chronic liver disease, leading cirrhosis, andhepatocellular carcinoma, with nearly one million deaths eachyear. Over 250 million people worldwide ...
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THE ROLE OF β-2-MICROGLOBULIN IN TUMOR DEVELOPMENT
abstract in conference proceedings
open access
accepted version
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
The tumor microenvironment (TME) is a dynamicecosystem where cancer cells interact with the immunesystem to either promote or inhibit tumor progression.A crucial aspect of this interaction involves the majorhistocompatibility ...
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DECODING INTERFERON REGULATION IN BKPYV BKPYV-INFECTED BLADDER END OTHELIAL CELLS
abstract in conference proceedings
open access
accepted version
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
BK polyomavirus (BKPyV) infects approximately 80%of the human population, typically establishing persistenceduring childhood by replicating at low levels in the urinarytract. Low Low-level activation of innate immune ...
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TRAF6 DRIVES PARALLEL INNATE IMMUNE RESPONSES VIA TLR4 AND CGAS-STING DURING MPYV INFECTION
abstract in conference proceedings
open access
accepted version
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
Polyomaviruses are small DNA viruses linked to a range of human diseases, including cancer. The murine polyomavirus (MPyV) serves as a well-established model for exploring the biology of human polyomaviruses. MPyV activates ...
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Cross-border Reproductive Care in Czechia: Insights from National Registry Data
original article
open access
published version
2025
,Bundesinstitut für Bevölkerungsforschung
,Comparative Population Studies
,50
(16.09.2025)
This article analyses cross-border reproductive care (CBRC) in Czechia using comprehensive data from the National Registry of Assisted Reproduction (2016-2019). It identifies the main patient source countries, highlights ...
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Associations between psychological or biological stress indicators and gut microbiota in pregnant women – findings from a prospective longitudinal study
original article
embargoed access
published version
2025
,BioMed Central
,BMC Microbiology
,25
(1)
The perinatal period has been linked with higher vulnerability to stress and symptoms of depression and anxiety, as well as with dynamic changes in the composition of maternal gut microbiota. While recent studies indicated ...
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