Přírodovědecká fakulta
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Poslední příspěvky
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Mouse polyomavirus infection induces lamin reorganisation
původní článek
open access
vydavatelská verze
2024
,FEBS Journal
,291
(23)
The nuclear lamina is a dense network of intermediate filaments beneath the inner nuclear membrane. Composed of A-type lamins (lamin A/C) and B-type lamins (lamins B1 and B2), the nuclear lamina provides a scaffold for the ...
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Italian peninsula as a hybridization zone of Ixodes inopinatus and I. ricinus and the prevalence of tick-borne pathogens in I. inopinatus, I. ricinus, and their hybrids
původní článek
open access
vydavatelská verze
2024
,Parasites & Vectors
,17
(1)
BACKGROUND: Ixodes inopinatus was described from Spain on the basis of morphology and partial sequencing of 16S ribosomal DNA. However, several studies suggested that morphological differences between I. inopinatus and ...
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Toscana virus – finding the new vectors
jiný příspěvek v konferenčním sborníku
open access
vydavatelská verze
2024
,New Orleans
,American Society of Tropical Medicine and Hygiene
,ASTMH Abstract Book 2024
,2024
Arbovirus Phlebovirus toscanaense (TOSV) is an emerging but still neglected human pathogen that circulates in countries around the Mediterranean Sea. The manifestation of the disease varies from non-symptomatic forms through ...
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Mouse PML protein isoforms and their role in innate antiviral immunity
abstrakt v elektronické podobě
open access
postprint
2024
Promyelocytic leukaemia nuclear bodies (PML NBs) are dynamic, multiprotein, membrane-less structures composed of the main scaffold PML protein and various stable or transient partner proteins. Beyond their diverse endogenous ...
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ASPH inhibition reveals differential gene expression patterns in HPV-positive and HPV-negative cell lines
abstrakt v elektronické podobě
open access
preprint
2024
,Boston
Cancer is associated with alterations in key cellular pathways, including the aspartate β-hydroxylase (ASPH) pathway. ASPH is an oncogene upregulated in various carcinomas, playing a vital role in tumor progression and ...
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HPV Infection: Present and Future of Diagnostic and Prognostic Surveys
abstrakt v elektronické podobě
open access
postprint
2024
High-risk types of Human Papillomavirus (HPV) are closely associated with various human malignancies. The ability to detect precancerous stages early significantly impacts patient outcomes, yet challenges remain in the ...
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Identification of processes in Cu-ore heap leaching using Cu isotopes and leachate chemistry at Tschudi mine, northern Namibia
původní článek
open access
vydavatelská verze
2024
,Hydrometallurgy
,228
(October)
Copper isotopic fractionation (in δ(65)Cu) and leachate characterization were studied in the context of heap leaching at the Tschudi copper mine in northern Namibia. The leached solution is of Mg-SO4 type with high Al and ...
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Contribution of chemical toxicity to the overall toxicity of microplastic particles: A review
přehledový článek
open access
vydavatelská verze
2024
,Science of the Total Environment
,957
(December)
Nanoplastics and microplastics are of growing research interest due to their persistence in the environment and potential harm to organisms through physical damage, such as abrasions or blockages, and chemical harm from ...
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Thallium in Technosols from Allchar (North Macedonia): Isotopic and speciation insights
původní článek
open access
vydavatelská verze
2024
,Environmental Pollution
,357
(September)
Allchar (North Macedonia) mining area is known for anomalous background Tl concentrations. In this study, we combine accurate detection of Tl stable isotope ratios with data on mineralogy/speciation and chemical extraction ...
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Metal(loid)s in urban soil from historical municipal solid waste landfill: Geochemistry, source apportionment, bioaccessibility testing and human health risks
původní článek
open access
vydavatelská verze
2024
,Chemosphere
,362
(August)
Landfills, especially those poorly managed, can negatively affect the environment and human beings through chemical contamination of soils and waters. This study investigates the soils of a historical municipal solid waste ...
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Integrating vMAGs and Amplicon Sequencing: Bridging Gaps in Illumina-Based Assembly of Novel Large Viruses from Honey Bee Viromes
poster
open access
vydavatelská verze
2024
The study of viromes has been revolutionized by advanced bioinformatics methodologies that enable the precise identification of novel viruses. However, assembling complete genomes of large viruses is still challenging. To ...
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Multiparametric analysis of the specific immune response against SARS-CoV-2
původní článek
open access
vydavatelská verze
2024
,Infectious Diseases
,56
(10)
Background: SARS-CoV-2, which causes COVID-19, has killed more than 7 million people worldwide. Understanding the development of postinfectious and postvaccination immune responses is necessary for effective treatment and ...
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Infekce lidským papilomavirem (HPV) a gravidita
Human papillomavirus (HPV) infection and pregnancy
původní článek
open access
vydavatelská verze
2024
,Epidemiologie, mikrobiologie, imunologie
,73
(1)
Lidský papilomavirus (HPV) je celosvětově nejběžnější sexuálně přenosnou virovou infekcí, která může vést ke vzniku benigních lézí nebo maligních nádorů. Prevalence HPV infekce je u těhotných žen dvakrát vyšší než u ...
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Enhancing Proteasome Function Through NRF1 Activation: Novel Small-Molecule Compounds for Treating Neurodegenerative Diseases
abstrakt v elektronické podobě
open access
preprint
2024
The degradation of intracellular proteins is a strictly regulated process vital formaintaining cellular homeostasis and ensuring optimal functionality of the cell. Over90% of cytosolic proteins undergo degradation via the ...
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Analysis of the yeast linear plasmid mRNAs revealed unusual addition of the non-template nucleotides to their 5' ends and suggested a novel mechanism of translation initiation
abstrakt v elektronické podobě
open access
vydavatelská verze
2024
,Abstracts of papers presented at the 2024 meeting on TRANSLATIONAL CONTROL
Linear plasmids were found in a number of yeast species belonging to nine genera. The Kluyveromyces lactis pGKL1/2 plasmids, which serve as archetypes of yeast linear plasmids, are peculiar in many respects. Both plasmids ...
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ADAR1 knockout leads to global deregulation of translation and to translational shutdown upon IFN-α/β treatment in human Huh7.5 hepatocytes
abstrakt v elektronické podobě
open access
vydavatelská verze
2024
,Abstracts of papers presented at the 2024 meeting on TRANSLATIONAL CONTROL
In recent years, numerous evidence has been accumulated about the extent of A-to-I editing in human RNAs and the key role ADAR1 plays in the cellular editing machinery. It has been shown that A-to-I editing occurrence and ...
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Two pathogens in one vector
abstrakt v elektronické podobě
open access
postprint
2024
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
Sand flies (Diptera: Phlebotominae) are tiny hematophagous insects that play a critical role in the circulation of various pathogens. To explore pathogens interaction within their shared vector, Phlebotomus tobbi, we ...
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Modulation of Leishmania infection in sand flies by insect ́s midgut microbiota
abstrakt v elektronické podobě
open access
postprint
2024
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
The midgut microbiota of insect vectors has been recognized as a critical factor influencing the transmission dynamics of vector-borne pathogens1-3. Sand flies (Diptera: Phlebotominae), tiny blood ...
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The biomolecular markers for the personalized prediction of the treatment effect in patients with head and neck cander: pilot study
abstrakt v elektronické podobě
open access
vydavatelská verze
2024
,26th Annual Conference of the European Society for Clinical Virology
The clinical utility of liquid biopsies as diagnostic, predictive and prognostic biomarkers has been shown for several cancers. Our study focuses on analyzing the dynamics of HPV cell-free DNA (cfDNA) levels during the ...
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Trends in Healthy Life Years Between 2005 and 2019 in 31 European Countries: The Compression or Expansion of Morbidity?
původní článek
open access
vydavatelská verze
2024
,International Journal of Public Health
,69
(October)
Objectives: Our objective was to assess morbidity trends in Europe and to classify European countries based on population ageing theories: the compression, expansion and dynamic equilibrium of morbidity.Methods: The ...
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