Faculty of Science
Recent Submissions
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Loss of ADAR1 protein induces changes in small RNA landscape in hepatocytes
original article
open access
published version
2024
,RNA
,30
(9)
In recent years, numerous evidence has been accumulated about the extent of A-to-I editing in human RNAs and the key role ADAR1 plays in the cellular editing machinery. It has been shown that A-to-I editing occurrence and ...
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Educate, not kill: treating cancer without triggering its defenses
original article
open access
published version
2024
,Trends in Molecular Medicine
,30
(7)
Traditionally, anticancer therapies focus on restraining uncontrolled proliferation. However, these cytotoxic therapies expose cancer cells to direct killing, instigating the process of natural selection favoring survival ...
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Suppression of the growth and metastasis of mouse melanoma by Taenia crassiceps and Mesocestoides corti tapeworms
original article
open access
published version
2024
,Frontiers in Immunology
,15
(20 March 2024)
Cancer is still one of the leading causes of death, with an estimated 19.3 million new cases every year. Our paper presents the tumor-suppressing effect of Taenia crassiceps and Mesocestoides corti on B16F10 melanoma, the ...
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Sand fly blood meal volumes and their relation to female body weight under experimental conditions
original article
open access
published version
2024
,Parasites & Vectors
,17
(1)
Background Sand fly females require a blood meal to develop eggs. The size of the blood meal is crucial for fecundity and affects the dose of pathogens acquired by females when feeding on infected hosts or during experimental ...
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Population-specific validation and comparison of the performance of 77- and 313-variant polygenic risk scores for breast cancer risk prediction
original article
open access
published version
2024
,Cancer
,130
(17)
Background: The polygenic risk score (PRS) allows the quantification of the polygenic effect of many low-penetrance alleles on the risk of breast cancer (BC). This study aimed to evaluate the performance of two sets ...
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Parallel DNA/RNA NGS Using an Identical Target Enrichment Panel in the Analysis of Hereditary Cancer Predisposition
original article
open access
published version
2024
,Folia Biologica
,70
(1)
Germline DNA testing using the next-gene-ration sequencing (NGS) technology has become the analytical standard for the diagnostics of hereditary diseases, including cancer. Its increasing use places high demands on correct ...
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Nuclear patterns of phosphatidylinositol 4,5- and 3,4-bisphosphate revealed by super-resolution microscopy differ between the consecutive stages of RNA polymerase II transcription
original article
open access
published version
2024
,FEBS Journal
,AHEAD OF PRINT
(First published: 11 May 2024)
Phosphatidylinositol phosphates are powerful signaling molecules that orchestrate signaling and direct membrane trafficking in the cytosol. Interestingly, phosphatidylinositol phosphates also localize within the membrane-less ...
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STING regulation in polyomavirus infections
abstract in e-form
open access
published version
2024
,Itálie
,Gianni Cinello, Lithostampa SrL, Udine
,ICGEB DNA Tumour Virus Meeting
Stimulator of interferon genes (STING) is an indispensable component of cGAS-STING signalization pathway that plays a key role in the innate immune response to polyomavirus infection. Infection of cells by polyomaviruses ...
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Aspartate-β-hydroxylase and hypoxia marker expression in head and neck carcinomas: implications for HPV-associated tumors
original article
open access
published version
2024
,Infectious Agents and Cancer
,19
(1)
BACKGROUND: A proportion of head and neck carcinomas (HNSCCs) are induced by high-risk human papillomaviruses (HPVs) and are associated with better patient outcomes compared to patients with HNSCCs related to tobacco and ...
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Pro-cognitive effects of dual tacrine derivatives acting as cholinesterase inhibitors and NMDA receptor antagonists
original article
open access
published version
2024
,Biomedicine & Pharmacotherapy
,176
(July)
Therapeutic options for Alzheimer's disease are limited. Dual compounds targeting two pathways concurrently may enable enhanced effect. The study focuses on tacrine derivatives inhibiting acetylcholinesterase (AChE) and ...
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Discovery and characterization of novel DNA viruses in Apis mellifera: expanding the honey bee virome through metagenomic analysis
original article
open access
published version
2024
,mSystems
,9
(4)
To date, many viruses have been discovered to infect honey bees. In this study, we used high-throughput sequencing to expand the known virome of the honey bee, Apis mellifera, by identifying several novel DNA viruses. While ...
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Modification of the RTX domain cap by acyl chains of adapted length rules the formation of functional hemolysin pores
original article
open access
published version
2024
,Biochimica et Biophysica Acta - Biomembranes
,1866
(5)
The acylated pore-forming Repeats in ToXin (RTX) cytolysins alpha-hemolysin (HlyA) and adenylate cyclase toxin (CyaA) preferentially bind to beta 2 integrins of myeloid leukocytes but can also promiscuously bind and ...
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The Effect of Topography on Long-Term Spontaneous Development of Soil and Woody Cover on Graded and Untreated Overburden
original article
open access
published version
2020
,Forests [online]
,11
(5)
We studied the development of soil and soil fauna, as well as selected vegetation parameters important for litter input into soil, in two chronosequences of postmining sites after opencast lignite mining near the town of ...
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Heterogeneous Response of Tumor Cell Lines to Inhibition of Aspartate β-hydroxylase
original article
open access
published version
2024
,Journal of Cancer
,15
(11)
Background: Cancer development involves alterations in key cellular pathways, with aspartate β-hydroxylase (ASPH) emerging as an important player in tumorigenesis. ASPH is upregulated in various cancer types, where it ...
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Varroa destructor parasitism and Deformed wing virus infection in honey bees are linked to peroxisome-induced pathways
original article
open access
published version
2024
,Proteomics
,24
(9)
The ectoparasitic mite Varroa destructor transmits and triggers viral infections that have deleterious effects on honey bee colonies worldwide. We performed a manipulative experiment in which worker bees collected at ...
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Role of cryptic rearrangements of human chromosomes in the aetiology of schizophrenia
summarizing article
open access
published version
2023
,Journal of Genetics
,102
(1)
Schizophrenia (SZ) is a highly inherited disease that affects similar to 0.5% of the population. The genetic and environmental factors are involved in its aetiology and they interact with each other. Combination of symptoms ...
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Validated WGS and WES protocols proved saliva-derived gDNA as an equivalent to blood-derived gDNA for clinical and population genomic analyses
original article
open access
published version
2024
,BMC Genomics
,25
(1)
Background: Whole exome sequencing (WES) and whole genome sequencing (WGS) have become standard methods in human clinical diagnostics as well as in population genomics (POPGEN). Blood-derived genomic DNA (gDNA) is routinely ...
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DNA from BK polyomavirus is sensed during infection of reservoir cells via cGAS-STING pathway
abstract in conference proceedings
open access
accepted version
2024
,Nizozemsko
,TOLL 2024 Road to translation
Human polyomaviruses (HPyVs) include 14 species that cause primary asymptomatic infections after which the virus persists in the host by a mechanism that is not well understood. Reactivation of the infection in immunosuppressed ...
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STING agonist induced-monocyte death combines apoptosis, pyroptosis and caspase 8 activation
abstract in conference proceedings
open access
accepted version
2024
,Nizozemsko
,TOLL 2024 Road to translation
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway isimportant for recognition of double-stranded DNA, a marker of infection or cell damage. ThecGAS-STING pathway activation leads to production ...
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HBV-induced microenvironment reduces pDC response to TLR9 stimulation
abstract in conference proceedings
open access
accepted version
2024
,Nizozemsko
,TOLL 2024 Road to translation
Hepatitis B virus (HBV) is a non-cytopathogenic virus with DNA genome. It causes an acute hepatitis that may develop into chronic hepatitis B, liver cirrhosis and hepatocellular carcinoma. HBV is described as "stealth ...
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