1. lékařská fakulta
Procházet dle
Poslední příspěvky
-
Increased burden of rare protein-truncating variants in constrained, brain-specific and synaptic genes in extremely impulsively violent males with antisocial personality disorder
(2024)The genetic correlates of extreme impulsive violence are poorly understood, and there have been few studies that have characterized a large group of affected individuals both clinically and genetically. We performed whole ... -
Characterization of the evolutionary and virological aspects of mutations in the receptor binding motif of the SARS-CoV-2 spike protein
(2023)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has substantially diversified during the pandemic, resulting in the successive emergence of variants characterized by various mutations. It has been observed ... -
Characterization of the input material quality for the production of tisagenlecleucel by multiparameter flow cytometry and its relation to the clinical outcome
(2023)Tisagenlecleucel (tisa-cel) is a CD19(-)specific CAR-T cell product approved for the treatment of relapsed/refractory (r/r) DLBCL or B-ALL. We have followed a group of patients diagnosed with childhood B-ALL (n = 5), adult ... -
Fibrosis and expression of extracellular matrix proteins in human interventricular septum in aortic valve stenosis and regurgitation
(2024)Valvular heart disease leads to ventricular pressure and/or volume overload. Pressure overload leads to fibrosis, which might regress with its resolution, but the limits and details of this reverse remodeling are not known. ... -
Reprogramming of the developing heart by Hif1a-deficient sympathetic system and maternal diabetes exposure
(2024)Introduction: Maternal diabetes is a recognized risk factor for both short-term and long-term complications in offspring. Beyond the direct teratogenicity of maternal diabetes, the intrauterine environment can influence ... -
Specific Immunity to SARS-CoV-2 Infection
(Česká zemědělská univerzita, Praha, 2024)The SARS-CoV-2 coronavirus, causing COVID-19 disease, has killed almost 7 million people worldwide.For effective treatment and introduction of appropriate anti-pandemic measures, it is necessary tounderstand the development ... -
Díla Jana Marka Marci z Kronlandu ve fondu 1. lékařské fakulty Univerzity Karlovy
(2020)Soubor šesti svazků (deseti děl) Jana Marka Marci z Kronlandu na 1. lékařské fakultě Univerzity Karlovy lze plným právem označit za průřezovou sbírku jeho děl. Vyznačují se vysokou uměleckou úrovní a dobrou typografií. ... -
Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells
(2024)Small noncoding RNAs play an important role in various disease states, including cancer. PIWI proteins, a subfamily of Argonaute proteins, and PIWI-interacting RNAs (piRNAs) were originally described as germline-specific ... -
Factors Influencing the Involvement of Nurses in Preventive Care and Health Literacy in the Czech Republic
(2023)The aims of this article were to discuss the position of Czech nurses in the country's health care system, to assess their role in the preventive care and health literacy (HL) promotion and to define main factors, which ... -
Nonprocedural bleeding after left atrial appendage closure versus direct oral anticoagulants: A subanalysis of the randomized PRAGUE-17 trial
(2023)INTRODUCTION: Observational studies have shown low bleeding rates in patients with atrial fibrillation (AF) treated by left atrial appendage closure (LAAC); however, data from randomized studies are lacking. This study ... -
Protective Effect of Vegan Microbiota on Liver Steatosis Is Conveyed by Dietary Fiber: Implications for Fecal Microbiota Transfer Therapy
(2023)Fecal microbiota transfer may serve as a therapeutic tool for treating obesity and related disorders but currently, there is no consensus regarding the optimal donor characteristics. We studied how microbiota from vegan ... -
Trends in outcomes of women with myocardial infarction undergoing primary angioplasty - Analysis of randomized trials
(2023)Background: Sex- and gender-associated differences determine the disease response to treatment.Aim: The study aimed to explore the hypothesis that progress in the management of STE-myocardial infarction (STEMI) overcomes ... -
Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery
(2023)Background: The aim of this prospective study was to evaluate the role of serum IL-6 as a potential predictive biomarker of postoperative complications (POC) in elective colorectal surgery. Method: A total of 115 patients ... -
Fibroblast activation protein as a potential theranostic target in brain metastases of diverse solid tumours
(2023)Brain metastases are a very common and serious complication of oncological diseases. Despite the vast progress in multimodality treatment, brain metastases significantly decrease the quality of life and prognosis of patients. ... -
Faecal bacteriome and metabolome profiles associated with decreased mucosal inflammatory activity upon anti-TNF therapy in paediatric Crohn's disease
(2024)BACKGROUND AND AIMS: Treatment by anti-TNFα antibodies (anti-TNF) changes the dysbiotic faecal bacteriome in Crohn's disease (CD). However, it is not known whether these changes are due to decreasing mucosal inflammatory ... -
Heterogeneous response to TGF-β1/3 isoforms in fibroblasts of different origins: implications for wound healing and tumorigenesis
(2023)Identification of therapeutic targets for treating fibrotic diseases and cancer remains challenging. Our study aimed to investigate the effects of TGF-β1 and TGF-β3 on myofibroblast differentiation and extracellular matrix ... -
A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study
(2023)BACKGROUND & AIMS: Fecal tests currently used for colorectal cancer (CRC) screening show limited accuracy in detecting early tumors or precancerous lesions. In this respect, we comprehensively evaluated stool microRNA ... -
Serious Immune-related Adverse Events Are Associated With Greater Efficacy of Nivolumab Therapy Against Non-small Cell Lung Cancer
(2023)BACKGROUND/AIM: The aim of this study was to investigate possible association between adverse events of nivolumab therapy and the effectiveness of treatment in patients with non-small cell lung cancer (NSCLC). Focusing on ... -
The detection of hypoxia markers in non-HPV and HPV-associated head and neck cancers: implications to patient survival
(2023)In the microenvironment of growing solid tumors, oxygen level often decreases and a hypoxic state is induced. This can lead to a worse treatment response and poor patient prognosis. One of the hypoxia-responsive genes ... -
Absence of 5' methylguanosine cap in postreplicative genes' transcripts of Vaccinia virus
(2023)The Vaccinia virus (VACV) played a pivotal role in the discovery of the 5' mRNA. Over the past decades, VACV investigation has contributed extensively to understanding the mechanism behind 5' mRNA cap synthesis. ...