1. Faculty of Medicine
Recent Submissions
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Microtubule-associated NAV3 regulates invasive phenotypes in glioblastoma cells
original article
open access
published version
2025
,Brain Pathology
,35
(1)
Glioblastomas are aggressive brain tumors for which effective therapy is still lacking, resulting in dismal survival rates. These tumors display significant phenotypic plasticity, harboring diverse cell populations ranging ...
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Circulating perturbation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) is associated to cardiac remodeling and NLRP3 inflammasome in cardiovascular patients with insulin resistance risk
original article
open access
published version
2024
,Experimental and Molecular Pathology
,137
(June)
Lipidome perturbation occurring during meta -inflammation is associated to left ventricle (LV) remodeling though the activation of the NLRP3 inflammasome, a key regulator of chronic inflammation in obesity -related disorders. ...
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Electrical remodeling of atrioventricular junction: a study on retrogradely perfused chick embryonic heart
original article
open access
published version
2024
,American Journal of Physiology - Heart and Circulatory Physiology
,327
(3)
Atrioventricular (AV) accessory pathways (APs) provide additional electrical connections between the atria and ventricles, resulting in severe electrical disturbances. It is generally accepted that APs originate in the ...
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Expanding clinical spectrum of PAICS deficiency: Comprehensive analysis of two sibling cases
original article
open access
published version
2024
,European Journal of Human Genetics
,AHEAD OF PRINT
(Published online: 27 November 2024)
De novo synthesis of purines (DNPS) is a biochemical pathway that provides the purine bases for synthesis of essential biomolecules such as nucleic acids, energy transfer molecules, signaling molecules and various cofactors. ...
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Clinical Features, Outcomes, and Response to Corticosteroid Treatment of Acute Tubulointerstitial Nephritis: A Single-Centre Retrospective Cohort Study in the Czech Republic
original article
open access
published version
2024
,Kidney & Blood Pressure Research
,49
(1)
Introduction: Acute tubulointerstitial nephritis (ATIN) is a well-recognized cause of acute kidney injury (AKI) due to the tubulointerstitial inflammation. The aim of this study was to explore the clinical features, outcomes, ...
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Rewired glutamate metabolism diminishes cytostatic action of L-asparaginase
original article
open access
published version
2024
,Cancer Letters
,605
(November)
Tumor cells often adapt to amino acid deprivation through metabolic rewiring, compensating for the loss with alternative amino acids/substrates. We have described such a scenario in leukemic cells treated with L-asparaginase ...
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The RNA-dependent association of phosphatidylinositol 4,5-bisphosphate with intrinsically disordered proteins contribute to nuclear compartmentalization
original article
open access
published version
2024
,PLoS Genetics
,20
(12)
The RNA content is crucial for the formation of nuclear compartments, such as nuclear speckles and nucleoli. Phosphatidylinositol 4,5-bisphosphate (PIP2) is found in nuclear speckles, nucleoli, and nuclear lipid islets and ...
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Investigating antibacterial and anti-inflammatory properties of synthetic curcuminoids
original article
open access
published version
2024
,Frontiers in Medicine
,11
(October)
The concept of intratumoral microbiota is gaining attention in current research. Tumor-associated microbiota can activate oncogenic signaling pathways such as NF-kappa B, thereby promoting tumor development and progression. ...
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The perinucleolar compartment and the oncogenic super-enhancers are part of the same phase-separated structure filled with phosphatidylinositol 4,5bisphosphate and long noncoding RNA HANR
original article
open access
published version
2024
,Advances in Biological Regulation
,AHEAD OF PRINT
(Available online 30 November 2024)
The liquid-liquid phase separation in the cell nucleus regulates various processes such as gene regulation and transcription control, chromatin organization, and DNA repair. A plethora of proteins and RNAs contribute to ...
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Lipid and brain volumetric measures in multiple sclerosis patients: findings from a large observational study
original article
open access
published version
2024
,Acta Neurologica Belgica
,124
(6)
Objectives This study aimed to investigate relationships between cholesterol profile, brain volumetric MRI, and clinical measures in a large observational cohort of multiple sclerosis (MS) patients. Materials and methods ...
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Myocardial regeneration after embryonic cryoinjury influenced by epicardium
poster
open access
submitted version
2023
One of the unexplored topics of medicine that could significantly affect the treatment of myocardial infarction is the regenerative potential of the epicardium. The embryonic epicardium is the outermost layer of the heart, ...
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Dystonia: A novel sign of the Smith-Magenis syndrome – A three-case report
casuistics
open access
published version
2024
,Clinical Parkinsonism & Related Disorders
,11
(August)
The Smith-Magenis syndrome (SMS) is a rare genetic disorder caused by a microdeletion in the 17p11.2. region or a pathogenic variant of the RAI1 (retinoic acid-induced), which is located in the 17p11.2 area. In most cases, ...
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Tetralogy of Fallot: Physiological and morphological changes in conditional Jagged1 mutant mice
poster
open access
published version
2024
The Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism essential for embryonic development in mammals. Mutations in the human Jagged1 (Jag1) gene, which encodes a ligand for the Notch, ...
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Virological characteristics of the SARS-CoV-2 BA.2.86 variant
original article
open access
published version
2024
,Cell Host and Microbe
,32
(2)
In late 2023, several SARS-CoV-2 XBB descendants, notably EG.5.1, were predominant worldwide. However, a distinct SARS-CoV-2 lineage, the BA.2.86 variant, also emerged. BA.2.86 is phylogenetically distinct from other Omicron ...
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Iron chelators as mitophagy agents: Potential and limitations
summarizing article
open access
published version
2024
,Biomedicine & Pharmacotherapy
,179
(October)
Mitochondrial autophagy (mitophagy) is very important process for the maintenance of cellular homeostasis, functionality and survival. Its dysregulation is associated with high risk and progression numerous serious diseases ...
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Is speech function lateralised in the basal ganglia? Evidence from de novo Parkinson's disease
original article
open access
published version
2024
,Journal of Neurology, Neurosurgery and Psychiatry
,AHEAD OF PRINT
(Published Online First: 17 September)
Background: Research on the possible influence of lateralised basal ganglia dysfunction on speech in Parkinson's disease is scarce. This study aimed to compare speech in de-novo, drug-naive patients with Parkinson's disease ...
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Lipid measures are associated with cognitive functioning in multiple sclerosis patients
original article
open access
published version
2024
,Multiple Sclerosis and Related Disorders
,91
(November)
Background: An association between lipid measures and cognitive decline in patients with multiple sclerosis (MS) has been suggested. Objectives: This study aimed to investigate relationships between lipid profile and ...
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Preoperative cognitive profile predictive of cognitive decline after subthalamic deep brain stimulation in Parkinson's disease
original article
open access
published version
2024
,European Journal of Neuroscience
,60
(7)
Cognitive decline represents a severe non-motor symptom of Parkinson's disease (PD) that can significantly reduce the benefits of subthalamic deep brain stimulation (STN DBS). Here, we aimed to describe post-surgery cognitive ...
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Simple 3D spheroid cell culture model for studies of prion infection
original article
open access
published version
2024
,European Journal of Neuroscience
,60
(4)
Mouse neuronal CAD 5 cell line effectively propagates various strains of prions. Previously, we have shown that it can also be differentiated into the cells morphologically resembling neurons. Here, we demonstrate that CAD ...
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Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk
original article
open access
published version
2024
,Human Genomics
,18
(February)
Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). ...
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