Poslední příspěvky

  • Resilience českého zdravotnického systému v reakci na příchod válečných uprchlíků z Ukrajiny 

    The Czech Healthcare System’s Resilience in Response to the Arrival of Ukrainian War Refugees

    původní článek

    open access

    vydavatelská verze

    Creative Commons License Icon

    Creative Commons BY Icon

    Creative Commons NC Icon

    Dobiášová, Karolína

    ;

    Angelovská, Olga

    ;

    Kopsa Těšinová, Jolana

    ;

    Tulupova, Elena

    2025

    ,

    Sociologický časopis / Czech Sociological Review

    ,

    61

    (1)

    Příchod válečných uprchlíků z Ukrajiny prověřil odolnost českého zdravotnického systému. Koncept odolnosti zdravotnického systému chápeme jako schopnost zdravotnického systému v reakci na externí krizi nadále dobře fungovat ...

  • Radiation-Induced Lymphopoenia and Treatment Outcome in Hereditary Breast Cancer Patients 

    původní článek

    open access

    vydavatelská verze

    Creative Commons License Icon

    Creative Commons BY Icon

    Argalácsová, Soňa

    ;

    Křížová, Ľudmila

    ;

    Matějů, Martin

    ;

    Svobodová, Dominika

    ;

    Vočka, Michal

    2023

    ,

    Folia Biologica

    ,

    69

    (3)

    Many breast cancer (BC) predisposition genes encode proteins involved in DNA damage repair (DDR). Identification of germline pathogenic va-riants (PV) in DDR genes raises the question whether their presence can influence ...

  • Switch of Open-Source Automated Insulin Delivery (AID) System—AndroidAPS to Commercially Available AID Systems in Type 1 Diabetes: The Extension of the CODIAC Study 

    původní článek

    open access

    vydavatelská verze

    Creative Commons License Icon

    Creative Commons BY Icon

    Do, Quoc Dat

    ;

    Radovnická, Lucie

    ;

    Hásková, Aneta

    ;

    Konečná, Judita

    ;

    Horová, Eva

    ;

    Grunberger, George

    ;

    Prázný, Martin

    ;

    Parkin, Christopher G.

    ;

    Flekač, Milan

    ;

    Šoupal, Jan

    2025

    ,

    Mary Ann Liebert, Inc.

    ,

    Diabetes Technology & Therapeutics

    ,

    27

    (11)

    Objective: This study was designed to investigate the switch between the open-source automated insulin delivery (OS-AID) system AndroidAPS (AAPS) and commercially available AID systems Control-IQ (CIQ) and MiniMed 780G ...

  • Lysosomal Storage-Independent Fabry Disease Variants with α-Galactosidase A Misprocessing-Induced ER Stress and the Unfolded Protein Response 

    přehledový článek

    open access

    vydavatelská verze

    Creative Commons License Icon

    Creative Commons BY Icon

    Živná, Martina

    ;

    Lenders, Malte

    ;

    Kmoch, Stanislav

    2025

    ,

    Nephron

    ,

    149

    (10)

    Background: Clinical findings in Fabry disease have classically been attributed to loss-of-function variants in the GLA gene that result in alpha-galactosidase A deficiency, intracellular accumulation of globotriaosylceramides ...

  • Rivaroxaban, in combination with low-dose aspirin, is associated with a reduction in proinflammatory and prothrombotic circulating vesicle signatures in patients with cardiovascular disease 

    původní článek

    open access

    vydavatelská verze

    Creative Commons License Icon

    Creative Commons BY Icon

    Creative Commons NC Icon

    Creative Commons NC Icon

    Weiss, Luisa

    ;

    O'Doherty, Aideen

    ;

    Uhrig, Wido

    ;

    Szklanna, Paulina B.

    ;

    Hong-Minh, Molly

    ;

    Wynne, Kieran

    ;

    Blanco, Alfonso

    ;

    Živný, Jan

    ;

    Passos, Valeria Lima

    ;

    Kevane, Barry

    ;

    Murphy, Sean

    ;

    Ainle, Fionnuala Ni

    ;

    O'Donnell, Martin

    ;

    Maguire, Patricia B.

    2025

    ,

    Journal of Thrombosis and Haemostasis

    ,

    23

    (2)

    Background: Despite secondary prevention with aspirin, patients with stable cardiovascular disease (CVD) remain at elevated long-term risk of major adverse cardiovascular events. The Cardiovascular Outcomes in People Using ...

  • NGS-MRD negativity in post-HSCT ALL spares unnecessary therapeutic interventions triggered by borderline qPCR results without an increase in relapse risk 

    původní článek

    open access

    vydavatelská verze

    Creative Commons License Icon

    Creative Commons BY Icon

    Creative Commons NC Icon

    Creative Commons NC Icon

    Šeferna, Kryštof

    ;

    Svatoň, Michael

    ;

    Rennerová, Andrea

    ;

    Skotnicová, Aneta

    ;

    Řezníčková, Leona

    ;

    Valová, Taťána

    ;

    Sedláček, Petr

    ;

    Říha, Petr

    ;

    Formánková, Renata

    ;

    Keslová, Petra

    ;

    Šrámková, Lucie

    ;

    Starý, Jan

    ;

    Zuna, Jan

    ;

    Kolenova, Alexandra

    ;

    Šálek, Cyril

    ;

    Trka, Jan

    ;

    Froňková, Eva

    2025

    ,

    HemaSphere

    ,

    9

    (4)

    Monitoring of minimal residual disease (MRD) after hematopoietic stem cell transplantation (HSCT) in patients with acute lymphoblastic leukemia (ALL) is vital for timely therapeutic intervention planning. However, interpreting ...

  • Compulsive exercise and physical activity in eating disorders 

    původní článek

    open access

    vydavatelská verze

    Creative Commons License Icon

    Creative Commons BY Icon

    Vítková, Tereza

    ;

    Comoutos, Nikolaos

    ;

    Minařík, Petr

    ;

    Walter, Nadja

    2025

    ,

    Meyer & Meyer Sport

    ,

    International Journal of Sport and Exercise Psychology

    ,

    online AoP

    (03 Jul 2025)

    Compulsive exercise and extensive physical activity are significant symptoms of eating disorders. Compulsive exercise is one of the most persistent symptoms associated with a higher risk of relapse, chronicity, and prolonged ...

  • Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer 

    původní článek

    open access

    postprint

    Creative Commons License Icon

    Creative Commons BY Icon

    Danešová, Natálie

    ;

    Horak, Josef

    ;

    Valíčková, Anna

    ;

    Gil-Korilis, Adrian

    ;

    Ergui-Arbizu, Jorge

    ;

    Pálek, Richard

    ;

    Brůha, Jan

    ;

    Levý, Miroslav

    ;

    Škrobánek, Pavel

    ;

    Král, Jan

    ;

    Jungwirth, Jiří

    ;

    Neužil, Jiří

    ;

    Vymetálková, Veronika

    ;

    Vodička, Pavel

    ;

    Vodenková, Soňa

    ;

    Tomášová, Kristýna

    2025

    ,

    North Shore-Long Island Jewish Research Institute

    ,

    Molecular Medicine

    BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...

  • The role of aspartate beta-hydroxylase in tumors associated with human papillomaviruses 

    abstrakt v konferenčním sborníku

    open access

    postprint

    Creative Commons License Icon

    Creative Commons BY Icon

    Kanwal, Madiha

    ;

    Šmahelová, Jana

    ;

    Johari, Shweta Dilip

    ;

    Poláková, Ingrid

    ;

    Žucha, Barbora

    ;

    Mark, Olsen

    ;

    Krausová, Kateřina

    ;

    Pokrývková, Barbora

    ;

    Madureira Trufen, Carlos Eduardo

    ;

    Nunvář, Jaroslav

    ;

    Šťovíčková, Eliška

    ;

    Grega, Marek

    ;

    Vencálek, Ondřej

    ;

    Koucký, Vladimír

    ;

    Maléřová, Simona

    ;

    Klozar, Jan

    ;

    Kasi, Murtaza Khan

    ;

    Tachezy, Ruth

    ;

    Šmahel, Michal

    2025

    ,

    Praha

    ,

    Česká společnost chemická

    ,

    Czech Chemical Society Symposium Series

    ,

    23

    (4)

    Aspartate beta-hydroxylase (ASPH) is a transmembrane protein that is localized in the endoplasmic reticulum. It is not produced in most normal cells, but the expression is increased in tumor cells, where it can be localized ...

  • Cell-free HPV DNA as a biomarker for the treatment response monitoring in oropharyngeal cancer patients in the Czech Republic 

    abstrakt v konferenčním sborníku

    open access

    postprint

    Creative Commons License Icon

    Creative Commons BY Icon

    Šmahelová, Jana

    ;

    Vojtěchová, Zuzana

    ;

    Milt, Petr

    ;

    Saláková, Martina

    ;

    Lohynská, Radka

    ;

    Lacek, Michal

    ;

    Čoček, Aleš

    ;

    Krátká, Zuzana

    ;

    Tachezy, Ruth

    2025

    ,

    Praha

    ,

    Česká společnost chemická

    ,

    Czech Chemical Society Symposium Series

    ,

    23

    (4)

    Cell-free tumor DNA (cfDNA) in liquid biopsies is a promising diagnostic and prognostic biomarker for cancers, including human papillomavirus (HPV)-driven oropharyngeal carcinoma (OPC). Monitoring cfHPV DNA dynamics in ...

  • Associations between psychological or biological stress indicators and gut microbiota in pregnant women – findings from a prospective longitudinal study 

    původní článek

    embargo

    vydavatelská verze

    Creative Commons License Icon

    Creative Commons BY Icon

    Kreisinger, Jakub

    ;

    Kaňková, Šárka

    ;

    Dlouhá, Daniela

    ;

    Ullmann, Jana

    ;

    Nouzová, Kamila

    ;

    Hrbáčková, Hana

    ;

    Schmiedová, Lucie

    ;

    Takács, Lea

    2025

    ,

    BioMed Central

    ,

    BMC Microbiology

    ,

    25

    (1)

    The perinatal period has been linked with higher vulnerability to stress and symptoms of depression and anxiety, as well as with dynamic changes in the composition of maternal gut microbiota. While recent studies indicated ...

  • Blinatumomab in induction therapy improves molecular response in untreated adults with Ph- B-cell precursor acute lymphoblastic leukemia 

    letter to the editors

    open access

    vydavatelská verze

    Creative Commons License Icon

    Creative Commons BY Icon

    Creative Commons NC Icon

    Šálek, Cyril

    ;

    Hrabovsky, Stepan

    ;

    Folber, Frantisek

    ;

    Koristek, Zdenek

    ;

    Horáček, Jan Miloš

    ;

    Froňková, Eva

    ;

    Rezková Řezníčková, Leona

    ;

    Pecherkova, Pavla

    ;

    Soukup, Petr

    ;

    Dluhosova, Barbora

    ;

    Polivkova, Vaclava

    ;

    Krizkova, Jitka

    ;

    Polakova Machova, Katerina

    ;

    Vrzalova, Zuzana

    ;

    Halamova, Hana

    ;

    Trka, Jan

    ;

    Cetkovský, Petr

    ;

    Doubek, Michael

    2025

    ,

    Haematologica

    ,

    110

    (7)

    Blinatumomab, a bispecific anti-CD3/CD19 T-cell engager, is effective in treating relapsed or refractory B-cell precursor acute lymphoblastic leukemia (B-ALL), though most patients relapse despite achieving measurable ...

  • Unveiling the complexity of pml nuclear bodies: identification of novel PML isoforms 

    abstrakt v konferenčním sborníku

    open access

    postprint

    Creative Commons License Icon

    Creative Commons BY Icon

    Anderová, Karolína

    ;

    Horníková, Lenka

    ;

    Šroller, Vojtěch

    ;

    Rjabčenko, Boris

    ;

    Pánek, Dalibor

    ;

    Andrikopoulos, Prokopios

    ;

    Zahradník, Jiří

    ;

    Forstová, Jitka

    ;

    Huerfano Meneses, Sandra

    2025

    ,

    Praha

    ,

    Česká společnost chemická

    ,

    Czech Chemical Society Symposium Series

    ,

    23

    (4)

    Promyeloctic leukemia protein (PML) provides structural scaffolding within multiprotein, membraneless organelles known as PML nuclear bodies. Originally discovered as a tumor suppressor, PML is associated with diverse ...

  • Long-term adaptation of lymphoma cell lines to hypoxia is mediated by diverse molecular mechanisms that are targetable with specific inhibitors 

    původní článek

    open access

    vydavatelská verze

    Creative Commons License Icon

    Creative Commons BY Icon

    Daumová, Lenka

    ;

    Manakov, Dmitry

    ;

    Petrák, Jiří

    ;

    Sovilj, Dana

    ;

    Běhounek, Matěj

    ;

    Andera, Ladislav

    ;

    Vít, Ondřej

    ;

    Součková, Olga

    ;

    Havránek, Ondřej

    ;

    Dolníková, Alexandra

    ;

    Renešová, Nicol

    ;

    Tušková, Liliana

    ;

    Winkowska, Lucie

    ;

    Bettazová, Nardjas

    ;

    Kupcová, Kristýna

    ;

    Hubálek Kalbáčová, Marie

    ;

    Sikorová, Miriama

    ;

    Trněný, Marek

    ;

    Klener, Pavel

    2025

    ,

    Cell Death Discovery

    ,

    11

    (1)

    A large body of evidence suggests that hypoxia drives aggressive molecular features of malignant cells irrespective of cancer type. Non-Hodgkin lymphomas (NHL) are the most common hematologic malignancies characterized by ...

  • Fundamental prognostic difference of ATM gene mutation and deletion in newly diagnosed mantle cell lymphoma 

    původní článek

    open access

    vydavatelská verze

    Creative Commons License Icon

    Creative Commons BY Icon

    Obr, Ales

    ;

    Maláriková, Diana

    ;

    Kriegova, Eva

    ;

    Urbankova, Helena

    ;

    Zemanová, Zuzana

    ;

    Manakova, Jirina

    ;

    Petrackova, Anna

    ;

    Vatolikova, Michaela

    ;

    Berková, Adéla

    ;

    Forsterová, Kristina

    ;

    Furst, Tomas

    ;

    Hruskova, Andrea

    ;

    Flodr, Patrik

    ;

    Hanackova, Veronika

    ;

    Prochazka, Vit

    ;

    Papajik, Tomas

    ;

    Trněný, Marek

    ;

    Klener, Pavel

    2025

    ,

    North Shore-Long Island Jewish Research Institute

    ,

    Molecular Medicine

    ,

    31

    (1)

    Background: Previous studies have suggested that, after acquisition of t(11;14), mantle cell lymphoma (MCL) pathogenesis may proceed via several different genetic second hits, which may shape different mutational profiles ...

  • Discovery of uncapped and 5 polyadenylated mRNAs in poxviruses and yeast virus-like elements comparison and similarities of both models 

    abstrakt v elektronické podobě

    open access

    postprint

    Creative Commons License Icon

    Creative Commons BY Icon

    Vopálenský, Václav

    ;

    Sýkora, Michal

    ;

    Mělková, Zora

    ;

    Barvík, Ivan

    ;

    Netušilová, Kristýna

    ;

    Horáčková, Kamila

    ;

    Pospíšek, Martin

    2025

    ,

    Second Polish RNA Biology Meeting

    Cytoplasmic double-stranded DNA virus-like elements (VLEs) are present in yeast species across nine genera. VLE archetypes are linear DNA elements pGKL1/2 from the yeast Kluyveromyces lactis. They exhibit unique features, ...

  • Interaction of Selected Anthracycline and Tetracycline Chemotherapeutics with Poly(I:C) Molecules 

    původní článek

    open access

    vydavatelská verze

    Creative Commons License Icon

    Creative Commons BY Icon

    Skaličková, Markéta

    ;

    Abramenko, Nikita

    ;

    Charnavets, Tatsiana

    ;

    Vellieux, Frédéric

    ;

    Leischner Fialová, Jindřiška

    ;

    Kučnirová, Kateřina

    ;

    Kejík, Zdeněk

    ;

    Masařík, Michal

    ;

    Martásek, Pavel

    ;

    Pacak, Karel

    ;

    Pacák, Tomáš

    ;

    Jakubek, Milan

    2025

    ,

    American Chemical Society

    ,

    ACS Omega

    ,

    10

    (16)

    Despite the natural ability of the immune system to recognize cancer and, in some patients, even to eliminate it, cancer cells have acquired numerous evading mechanisms. With the increasing knowledge and focus shifting ...

  • The potential of exosomes in regenerative medicine and in the diagnosis and therapies of neurodegenerative diseases and cancer 

    přehledový článek

    open access

    vydavatelská verze

    Creative Commons License Icon

    Creative Commons BY Icon

    Odehnalová, Nikola

    ;

    Šandriková, Viera

    ;

    Hromádka, Róbert

    ;

    Skaličková, Markéta

    ;

    Dytrych, Petr

    ;

    Hoskovec, David

    ;

    Kejík, Zdeněk

    ;

    Hajduch, Jan

    ;

    Vellieux, Frédéric

    ;

    Koziar Vašáková, Martina

    ;

    Martásek, Pavel

    ;

    Jakubek, Milan

    2025

    ,

    Frontiers in Medicine

    ,

    12

    (March)

    Exosomes, nanosized extracellular vesicles released by various cell types, are intensively studied for the diagnosis and treatment of cancer and neurodegenerative diseases, and they also display high usability in regenerative ...

  • Circulating tumour DNA as a predictor of survival of patients with diffuse large B-cell lymphoma in a daily practice 

    letter to the editors

    open access

    vydavatelská verze

    Creative Commons License Icon

    Creative Commons BY Icon

    Vodička, Prokop

    ;

    Hamová, Iva

    ;

    Veľasová, Adriana

    ;

    Kupcová, Kristýna

    ;

    Zemánková, Petra

    ;

    Nehasil, Petr

    ;

    Tkachenko, Anton

    ;

    Lochovská, Kateřina

    ;

    Mužíková, Šárka

    ;

    Hrabětová, Šárka

    ;

    Dlouhá, Jitka

    ;

    Blahovcová, Petra

    ;

    Frouz, Tomáš

    ;

    Seňavová, Jana

    ;

    Dlouhá, Lucie

    ;

    Polgárová, Kamila

    ;

    Klánová, Magdalena

    ;

    Šálková, Jana

    ;

    Benešová, Kateřina

    ;

    Klener, Pavel

    ;

    Trněný, Marek

    ;

    Havránek, Ondřej

    2025

    ,

    Blackwell

    ,

    British Journal of Haematology

    ,

    207

    (5)

    Diffuse large B-cell lymphoma (DLBCL) is a relatively well treatable disease with long-term cure rates between 60% and 70% following standard front-line immunochemotherapy R-CHOP (i.e. rituximab, cyclophosphamide, doxorubicin, ...

  • Dissecting Isoform-Specific Functions of PML in Innate Antiviral Immunity Using a Murine Polyomavirus Model 

    abstrakt v elektronické podobě

    open access

    postprint

    Creative Commons License Icon

    Creative Commons BY Icon

    Anderová, Karolína

    ;

    Šroller, Vojtěch

    ;

    Rjabčenko, Boris

    ;

    Horníková, Lenka

    ;

    Mališová, Pavla

    ;

    Andrikopoulos, Prokopios

    2025

    ,

    UNIL

    ,

    Immunobiology of Pattern Recognition Receptors

    The promyelocytic leukemia (PML/TRIM19) protein, a member of the TRIM family, serves as the main scaffold component of PML nuclear bodies (PML NBs), dynamic, multiprotein organelles involved in diverse cellular processes ...

Zobrazit další