1. lékařská fakulta
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Poslední příspěvky
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Decoding Evolutionary Dynamics and Beyond
abstrakt v časopisu
open access
vydavatelská verze
2024
,Praha
,Czech Chemical Society Symposium Series
,22
(6)
SARS-CoV-2 is continuously evolving to better adapt and stay ahead of the immune system's responses. Our goal is to uncover the evolutionary processes behind the changes in the Receptor Binding Domain (RBD), a hotspot for ...
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Genetic Risk Factors in Isolated Dystonia Escape Genome-Wide Association Studies
původní článek
open access
vydavatelská verze
2024
,Movement Disorders
,39
(11)
Background: Despite considerable heritability, previous smaller genome-wide association studies (GWASs) have not identified any robust genetic risk factors for isolated dystonia. Objective: The objective of this study was ...
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Disease-modifying treatment and disability progression in subclasses of patients with primary progressive MS: results from the Big MS Data Network
původní článek
open access
vydavatelská verze
2024
,Journal of Neurology, Neurosurgery and Psychiatry
,AHEAD OF PRINT
(First published December 6, 2024)
Background: Effectiveness of disease-modifying treatment (DMT) in people affected by primary progressive multiple sclerosis (PPMS) is limited. Whether specific subgroups may benefit more from DMT in a real-world setting ...
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Acute polyneuropathy: a serious complication of levodopa/ /carbidopa intestinal gel treatment for Parkinson's Disease
původní článek
open access
vydavatelská verze
2024
,Neurologia i Neurochirurgia Polska
,58
(6)
Aim of study. To determine whether a high dose of levodopa-carbidopa intestinal gel (LCIG), expressed as levodopa equivalent daily dose (LE daily dose), is a risk factor for acute polyneuropathy in patients treated with ...
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Disentangling Neurodegeneration From Aging in Multiple Sclerosis Using Deep Learning: The Brain-Predicted Disease Duration Gap
původní článek
open access
vydavatelská verze
2024
,Neurology
,103
(10)
Background and Objectives: Disentangling brain aging from disease-related neurodegeneration in patients with multiple sclerosis (PwMS) is increasingly topical. The brain-age paradigm offers a window into this problem but ...
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Injecting Hope: The Potential of Intratumoral Immunotherapy for Locally Advanced and Metastatic Cancer
přehledový článek
open access
preprint
2025
,Frontiers in Immunology
,15
(January)
Despite enormous progress, advanced cancers are still one of the most serious medical problems in current society. Although various agents and therapeutic strategies with anticancer activity are known and used, they often ...
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Risky online behavior in relation to social support, depression and anxiety in Czech adolescents
poster
open access
postprint
2024
In the current era of easily accessible technology and the internet, issues such as internet addiction, contact with dangerous individuals online, cyberbullying, and consumption of harmful content have become increasingly ...
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Pandemic COVID-19 as a challenge for telemedicine in the Czech Republic
původní článek
open access
vydavatelská verze
2025
,The International Journal of Health Planning and Management
,40
(1)
The COVID-19 Pandemic contributed to accelerating the process of using information and communication technologies and digital technologies in healthcare management and delivery within healthcare systems. At that time, the ...
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Microtubule-associated NAV3 regulates invasive phenotypes in glioblastoma cells
původní článek
open access
vydavatelská verze
2025
,Brain Pathology
,35
(1)
Glioblastomas are aggressive brain tumors for which effective therapy is still lacking, resulting in dismal survival rates. These tumors display significant phenotypic plasticity, harboring diverse cell populations ranging ...
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Circulating perturbation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) is associated to cardiac remodeling and NLRP3 inflammasome in cardiovascular patients with insulin resistance risk
původní článek
open access
vydavatelská verze
2024
,Experimental and Molecular Pathology
,137
(June)
Lipidome perturbation occurring during meta -inflammation is associated to left ventricle (LV) remodeling though the activation of the NLRP3 inflammasome, a key regulator of chronic inflammation in obesity -related disorders. ...
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Electrical remodeling of atrioventricular junction: a study on retrogradely perfused chick embryonic heart
původní článek
open access
vydavatelská verze
2024
,American Journal of Physiology - Heart and Circulatory Physiology
,327
(3)
Atrioventricular (AV) accessory pathways (APs) provide additional electrical connections between the atria and ventricles, resulting in severe electrical disturbances. It is generally accepted that APs originate in the ...
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Expanding clinical spectrum of PAICS deficiency: Comprehensive analysis of two sibling cases
původní článek
open access
vydavatelská verze
2024
,European Journal of Human Genetics
,AHEAD OF PRINT
(Published online: 27 November 2024)
De novo synthesis of purines (DNPS) is a biochemical pathway that provides the purine bases for synthesis of essential biomolecules such as nucleic acids, energy transfer molecules, signaling molecules and various cofactors. ...
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Clinical Features, Outcomes, and Response to Corticosteroid Treatment of Acute Tubulointerstitial Nephritis: A Single-Centre Retrospective Cohort Study in the Czech Republic
původní článek
open access
vydavatelská verze
2024
,Kidney & Blood Pressure Research
,49
(1)
Introduction: Acute tubulointerstitial nephritis (ATIN) is a well-recognized cause of acute kidney injury (AKI) due to the tubulointerstitial inflammation. The aim of this study was to explore the clinical features, outcomes, ...
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Rewired glutamate metabolism diminishes cytostatic action of L-asparaginase
původní článek
open access
vydavatelská verze
2024
,Cancer Letters
,605
(November)
Tumor cells often adapt to amino acid deprivation through metabolic rewiring, compensating for the loss with alternative amino acids/substrates. We have described such a scenario in leukemic cells treated with L-asparaginase ...
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The RNA-dependent association of phosphatidylinositol 4,5-bisphosphate with intrinsically disordered proteins contribute to nuclear compartmentalization
původní článek
open access
vydavatelská verze
2024
,PLoS Genetics
,20
(12)
The RNA content is crucial for the formation of nuclear compartments, such as nuclear speckles and nucleoli. Phosphatidylinositol 4,5-bisphosphate (PIP2) is found in nuclear speckles, nucleoli, and nuclear lipid islets and ...
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Investigating antibacterial and anti-inflammatory properties of synthetic curcuminoids
původní článek
open access
vydavatelská verze
2024
,Frontiers in Medicine
,11
(October)
The concept of intratumoral microbiota is gaining attention in current research. Tumor-associated microbiota can activate oncogenic signaling pathways such as NF-kappa B, thereby promoting tumor development and progression. ...
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The perinucleolar compartment and the oncogenic super-enhancers are part of the same phase-separated structure filled with phosphatidylinositol 4,5-bisphosphate and long non-coding RNA HANR
původní článek
open access
vydavatelská verze
2025
,Advances in Biological Regulation
,95
(January)
The liquid-liquid phase separation in the cell nucleus regulates various processes such as gene regulation and transcription control, chromatin organization, and DNA repair. A plethora of proteins and RNAs contribute to ...
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Lipid and brain volumetric measures in multiple sclerosis patients: findings from a large observational study
původní článek
open access
vydavatelská verze
2024
,Acta Neurologica Belgica
,124
(6)
Objectives This study aimed to investigate relationships between cholesterol profile, brain volumetric MRI, and clinical measures in a large observational cohort of multiple sclerosis (MS) patients. Materials and methods ...
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Myocardial regeneration after embryonic cryoinjury influenced by epicardium
poster
open access
preprint
2023
One of the unexplored topics of medicine that could significantly affect the treatment of myocardial infarction is the regenerative potential of the epicardium. The embryonic epicardium is the outermost layer of the heart, ...
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Dystonia: A novel sign of the Smith-Magenis syndrome – A three-case report
kazuistika
open access
vydavatelská verze
2024
,Clinical Parkinsonism & Related Disorders
,11
(August)
The Smith-Magenis syndrome (SMS) is a rare genetic disorder caused by a microdeletion in the 17p11.2. region or a pathogenic variant of the RAI1 (retinoic acid-induced), which is located in the 17p11.2 area. In most cases, ...
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