1. Faculty of Medicine: Poslední příspěvky
Zobrazují se záznamy 1-20 z 164
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Komunikační zdravotní gramotnost válečných uprchlíků z Ukrajiny v Česku
Communication health literacy of war refugees from Ukraine in the Czech Republic
původní článek
embargo
vydavatelská verze
2025
,Česká lékařská společnost J.E. Purkyně
,Časopis lékařů českých
,164
(1)
Komunikační zdravotní gramotnost je klíčová pro efektivní interakci mezi pacienty a zdravotníky. Její omezení může vést k nerovnostem v oblasti zdraví. Ukrajinští váleční uprchlíci čelí překážkám při přístupu ke zdravotní ...
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The role of glycolytic condensates in the cellular stress response during cancer progression
přehledový článek
open access
vydavatelská verze
2025
,Elsevier
,Advances in Biological Regulation
,98
(December)
Biomolecular condensates are key organizers of the intracellular environment, which are formed through liquid-liquid phase separation. Glycolytic condensates constitute a subtype of biomolecular condensates that enable ...
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Unveiling the role of biomolecular condensates in cellular function and cancer
přehledový článek
open access
vydavatelská verze
2025
,Elsevier
,Advances in Biological Regulation
,98
(December)
Biomolecular condensates (BMCs) are membrane-less organelles formed through liquid-liquid phase separation, primarily driven by multivalent interactions between scaffold and client molecules. These dynamic compartments ...
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Vaccinia virus mRNAs containing long 5'-poly(A)-leaders lack a canonical 5'-methylguanosine cap
původní článek
open access
vydavatelská verze
2025
,Nature Publishing Group
,Nature Communications
,16
(1)
The vaccinia virus (VACV) is a prototypical poxvirus that was originally used to eradicate smallpox. Half a century ago, investigation into VACV mRNA substantially contributed to the fundamental discovery of the 5' mRNA ...
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Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab
původní článek
open access
preprint
2025
,Springer Nature
,Scientific Reports
The role of eosinophils in patients with cancer receiving systemic therapy based on immune checkpoint inhibitors (ICIs) has become a subject of increasing interest. The aim of the present study was to assess the prognostic ...
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Resilience českého zdravotnického systému v reakci na příchod válečných uprchlíků z Ukrajiny
The Czech Healthcare System’s Resilience in Response to the Arrival of Ukrainian War Refugees
původní článek
open access
vydavatelská verze
2025
,Sociologický časopis / Czech Sociological Review
,61
(1)
Příchod válečných uprchlíků z Ukrajiny prověřil odolnost českého zdravotnického systému. Koncept odolnosti zdravotnického systému chápeme jako schopnost zdravotnického systému v reakci na externí krizi nadále dobře fungovat ...
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Radiation-Induced Lymphopoenia and Treatment Outcome in Hereditary Breast Cancer Patients
původní článek
open access
vydavatelská verze
2023
,Folia Biologica
,69
(3)
Many breast cancer (BC) predisposition genes encode proteins involved in DNA damage repair (DDR). Identification of germline pathogenic va-riants (PV) in DDR genes raises the question whether their presence can influence ...
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Switch of Open-Source Automated Insulin Delivery (AID) System—AndroidAPS to Commercially Available AID Systems in Type 1 Diabetes: The Extension of the CODIAC Study
původní článek
open access
vydavatelská verze
2025
,Mary Ann Liebert, Inc.
,Diabetes Technology & Therapeutics
,27
(11)
Objective: This study was designed to investigate the switch between the open-source automated insulin delivery (OS-AID) system AndroidAPS (AAPS) and commercially available AID systems Control-IQ (CIQ) and MiniMed 780G ...
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Lysosomal Storage-Independent Fabry Disease Variants with α-Galactosidase A Misprocessing-Induced ER Stress and the Unfolded Protein Response
přehledový článek
open access
vydavatelská verze
2025
,Nephron
,149
(10)
Background: Clinical findings in Fabry disease have classically been attributed to loss-of-function variants in the GLA gene that result in alpha-galactosidase A deficiency, intracellular accumulation of globotriaosylceramides ...
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Rivaroxaban, in combination with low-dose aspirin, is associated with a reduction in proinflammatory and prothrombotic circulating vesicle signatures in patients with cardiovascular disease
původní článek
open access
vydavatelská verze
2025
,Journal of Thrombosis and Haemostasis
,23
(2)
Background: Despite secondary prevention with aspirin, patients with stable cardiovascular disease (CVD) remain at elevated long-term risk of major adverse cardiovascular events. The Cardiovascular Outcomes in People Using ...
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NGS-MRD negativity in post-HSCT ALL spares unnecessary therapeutic interventions triggered by borderline qPCR results without an increase in relapse risk
původní článek
open access
vydavatelská verze
2025
,HemaSphere
,9
(4)
Monitoring of minimal residual disease (MRD) after hematopoietic stem cell transplantation (HSCT) in patients with acute lymphoblastic leukemia (ALL) is vital for timely therapeutic intervention planning. However, interpreting ...
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Compulsive exercise and physical activity in eating disorders
původní článek
open access
vydavatelská verze
2025
,Meyer & Meyer Sport
,International Journal of Sport and Exercise Psychology
,online AoP
(03 Jul 2025)
Compulsive exercise and extensive physical activity are significant symptoms of eating disorders. Compulsive exercise is one of the most persistent symptoms associated with a higher risk of relapse, chronicity, and prolonged ...
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Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer
původní článek
open access
postprint
2025
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...
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The role of aspartate beta-hydroxylase in tumors associated with human papillomaviruses
abstrakt v konferenčním sborníku
open access
postprint
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
Aspartate beta-hydroxylase (ASPH) is a transmembrane protein that is localized in the endoplasmic reticulum. It is not produced in most normal cells, but the expression is increased in tumor cells, where it can be localized ...
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Cell-free HPV DNA as a biomarker for the treatment response monitoring in oropharyngeal cancer patients in the Czech Republic
abstrakt v konferenčním sborníku
open access
postprint
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
Cell-free tumor DNA (cfDNA) in liquid biopsies is a promising diagnostic and prognostic biomarker for cancers, including human papillomavirus (HPV)-driven oropharyngeal carcinoma (OPC). Monitoring cfHPV DNA dynamics in ...
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Associations between psychological or biological stress indicators and gut microbiota in pregnant women – findings from a prospective longitudinal study
původní článek
embargo
vydavatelská verze
2025
,BioMed Central
,BMC Microbiology
,25
(1)
The perinatal period has been linked with higher vulnerability to stress and symptoms of depression and anxiety, as well as with dynamic changes in the composition of maternal gut microbiota. While recent studies indicated ...
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Blinatumomab in induction therapy improves molecular response in untreated adults with Ph- B-cell precursor acute lymphoblastic leukemia
letter to the editors
open access
vydavatelská verze
2025
,Haematologica
,110
(7)
Blinatumomab, a bispecific anti-CD3/CD19 T-cell engager, is effective in treating relapsed or refractory B-cell precursor acute lymphoblastic leukemia (B-ALL), though most patients relapse despite achieving measurable ...
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Unveiling the complexity of pml nuclear bodies: identification of novel PML isoforms
abstrakt v konferenčním sborníku
open access
postprint
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
Promyeloctic leukemia protein (PML) provides structural scaffolding within multiprotein, membraneless organelles known as PML nuclear bodies. Originally discovered as a tumor suppressor, PML is associated with diverse ...
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Long-term adaptation of lymphoma cell lines to hypoxia is mediated by diverse molecular mechanisms that are targetable with specific inhibitors
původní článek
open access
vydavatelská verze
2025
,Cell Death Discovery
,11
(1)
A large body of evidence suggests that hypoxia drives aggressive molecular features of malignant cells irrespective of cancer type. Non-Hodgkin lymphomas (NHL) are the most common hematologic malignancies characterized by ...
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Fundamental prognostic difference of ATM gene mutation and deletion in newly diagnosed mantle cell lymphoma
původní článek
open access
vydavatelská verze
2025
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
,31
(1)
Background: Previous studies have suggested that, after acquisition of t(11;14), mantle cell lymphoma (MCL) pathogenesis may proceed via several different genetic second hits, which may shape different mutational profiles ...
