1. Faculty of Medicine: Poslední příspěvky
Zobrazují se záznamy 21-40 z 59
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Fibroblast activation protein as a potential theranostic target in brain metastases of diverse solid tumours
původní článek
open access
vydavatelská verze
2023
,Pathology
,55
(6)
Brain metastases are a very common and serious complication of oncological diseases. Despite the vast progress in multimodality treatment, brain metastases significantly decrease the quality of life and prognosis of patients. ...
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Faecal bacteriome and metabolome profiles associated with decreased mucosal inflammatory activity upon anti-TNF therapy in paediatric Crohn's disease
původní článek
open access
vydavatelská verze
2024
,Journal of Crohn's and Colitis
,18
(1)
BACKGROUND AND AIMS: Treatment by anti-TNFα antibodies (anti-TNF) changes the dysbiotic faecal bacteriome in Crohn's disease (CD). However, it is not known whether these changes are due to decreasing mucosal inflammatory ...
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Heterogeneous response to TGF-β1/3 isoforms in fibroblasts of different origins: implications for wound healing and tumorigenesis
původní článek
open access
vydavatelská verze
2023
,Histochemistry and Cell Biology
,160
(6)
Identification of therapeutic targets for treating fibrotic diseases and cancer remains challenging. Our study aimed to investigate the effects of TGF-β1 and TGF-β3 on myofibroblast differentiation and extracellular matrix ...
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A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study
původní článek
open access
vydavatelská verze
2023
,Gastroenterology
,165
(3)
BACKGROUND & AIMS: Fecal tests currently used for colorectal cancer (CRC) screening show limited accuracy in detecting early tumors or precancerous lesions. In this respect, we comprehensively evaluated stool microRNA ...
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Serious Immune-related Adverse Events Are Associated With Greater Efficacy of Nivolumab Therapy Against Non-small Cell Lung Cancer
původní článek
open access
vydavatelská verze
2023
,In Vivo
,37
(5)
BACKGROUND/AIM: The aim of this study was to investigate possible association between adverse events of nivolumab therapy and the effectiveness of treatment in patients with non-small cell lung cancer (NSCLC). Focusing on ...
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The detection of hypoxia markers in non-HPV and HPV-associated head and neck cancers: implications to patient survival
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2023
,Czech Chemical Society Symposium Series
,21
(5)
In the microenvironment of growing solid tumors, oxygen level often decreases and a hypoxic state is induced. This can lead to a worse treatment response and poor patient prognosis. One of the hypoxia-responsive genes ...
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Absence of 5' methylguanosine cap in postreplicative genes' transcripts of Vaccinia virus
abstrakt v konferenčním sborníku
open access
postprint
2023
,Czech Chemical Society Symposium Series
,21
(5)
The Vaccinia virus (VACV) played a pivotal role in the discovery of the 5' mRNA. Over the past decades, VACV investigation has contributed extensively to understanding the mechanism behind 5' mRNA cap synthesis. ...
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TET protein inhibitors: Potential and limitations
přehledový článek
open access
vydavatelská verze
2023
,Biomedicine & Pharmacotherapy
,166
(October)
TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene expression. Dysregulation of their activity is associated with many serious pathogenic states such as oncological diseases. ...
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Serum but not cerebrospinal fluid levels of allantoin are increased in de novo Parkinson's disease
původní článek
open access
vydavatelská verze
2023
,NPJ Parkinsons Disease
,9
(1)
Oxidative stress supposedly plays a role in the pathogenesis of Parkinson's disease (PD). Uric acid (UA), a powerful antioxidant, is lowered in PD while allantoin, the oxidation product of UA and known biomarker of oxidative ...
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Magnetic susceptibility changes in the brainstem reflect REM sleep without atonia severity in isolated REM sleep behavior disorder
původní článek
open access
vydavatelská verze
2023
,NPJ Parkinsons Disease
,9
(1)
REM sleep without atonia (RWA) is the hallmark of isolated REM sleep behavior disorder (iRBD) and is caused by neurodegeneration of brainstem structures. Previously, quantitative susceptibility mapping (QSM) was shown to ...
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Combined Approach to Leukemic Differentiation Using Transcription Factor PU.1-Enhancing Agents
původní článek
open access
vydavatelská verze
2022
,International Journal of Molecular Sciences [online]
,23
(12)
The transcription factor PU.1 (Purine-rich DNA binding, SPI1) is a key regulator of hematopoiesis, whose level is influenced by transcription through its enhancers and its post-transcriptional degradation via microRNA-155 ...
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CSF Markers of Oxidative Stress Are Associated with Brain Atrophy and Iron Accumulation in a 2-Year Longitudinal Cohort of Early MS
původní článek
embargo
postprint
2023
,International Journal of Molecular Sciences [online]
,24
(12)
In this prospective longitudinal study, we quantified regional brain volume and susceptibility changes during the first two years after the diagnosis of multiple sclerosis (MS) and identified their association with ...
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Transcripts of vaccinia virus postreplicative genes do not contain a 5' methylguanosine cap
abstrakt v elektronické podobě
open access
postprint
2023
,The 28th Annual Meeting of the RNA Society
Vaccinia virus (VACV) is a prototypical poxvirus originally used for eradication of smallpox. Investigation into VACV mRNAs carried out almost half a century agosubstantially contributed to the fundamental discovery of the ...
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Sequencing-based analysis of clonal evolution of 25 mantle cell lymphoma patients at diagnosis and after failure of standard immunochemotherapy
původní článek
open access
vydavatelská verze
2023
,American Journal of Hematology
,98
(10)
Our knowledge of genetic aberrations, that is, variants and copy number variations (CNVs), associated with mantle cell lymphoma (MCL) relapse remains limited. A cohort of 25 patients with MCL at diagnosis and the first ...
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Health inequalities in post-COVID-19 outcomes among adults aged 50+ in Europe: has COVID-19 exposed divide between postcommunist countries and Western Europe?
původní článek
open access
vydavatelská verze
2023
,Journal of Epidemiology and Community Health
,77
(9)
Background: COVID-19 affected people and countries disproportionately and continues to impact the health of people. The aim is to investigate protective health and socio-geographical factors for post-COVID-19 conditions ...
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Pathways to eating disorder care: A European multicenter study
původní článek
open access
vydavatelská verze
2023
,European Psychiatry
,66
(1)
Background: The aim of this study was to assess barriers and facilitators in the pathways toward specialist care for eating disorders (EDs). Methods: Eleven ED services located in seven European countries recruited patients ...
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Prevalence of Dual Diagnoses among Children and Adolescents with Mental Health Conditions
původní článek
embargo
vydavatelská verze
2023
,Children-Basel [online]
,10
(2)
Background: The World Health Organisation defines dual diagnosis as the co-occurrence in the same individual of a psychoactive substance use disorder and another psychiatric disorder. Children and adolescents with dual ...
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The dynamics of telomere length in primary and metastatic colorectal cancer lesions
původní článek
embargo
vydavatelská verze
2023
,Scientific Reports
,13
(1)
Telomeric sequences, the structures comprised of hexanucleotide repeats and associated proteins, play a pivotal role in chromosome end protection and preservation of genomic stability. Herein we address telomere length ...
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MUC13-miRNA-4647 axis in colorectal cancer: Prospects to identifications of risk factors and clinical outcomes
původní článek
open access
vydavatelská verze
2023
,Oncology Letters
,25
(2)
MUC13, a transmembrane mucin glycoprotein, is overexpressed in colorectal cancer (CRC), however, its regulation and functions are not fully understood. It has been shown that MUC13 protects colonic epithelial cells from ...
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Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration
původní článek
open access
vydavatelská verze
2022
,Biomedicine & Pharmacotherapy
,154
(October)
Mitochondria generate energy and building blocks required for cellular growth and function. The notion that mitochondria are not involved in the cancer growth has been challenged in recent years together with the emerging ...
