1. Faculty of Medicine: Poslední příspěvky
Zobrazují se záznamy 21-40 z 105
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Iron chelators as mitophagy agents: Potential and limitations
přehledový článek
open access
vydavatelská verze
2024
,Biomedicine & Pharmacotherapy
,179
(October)
Mitochondrial autophagy (mitophagy) is very important process for the maintenance of cellular homeostasis, functionality and survival. Its dysregulation is associated with high risk and progression numerous serious diseases ...
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Preoperative cognitive profile predictive of cognitive decline after subthalamic deep brain stimulation in Parkinson's disease
původní článek
open access
vydavatelská verze
2024
,European Journal of Neuroscience
,60
(7)
Cognitive decline represents a severe non-motor symptom of Parkinson's disease (PD) that can significantly reduce the benefits of subthalamic deep brain stimulation (STN DBS). Here, we aimed to describe post-surgery cognitive ...
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Simple 3D spheroid cell culture model for studies of prion infection
původní článek
open access
vydavatelská verze
2024
,European Journal of Neuroscience
,60
(4)
Mouse neuronal CAD 5 cell line effectively propagates various strains of prions. Previously, we have shown that it can also be differentiated into the cells morphologically resembling neurons. Here, we demonstrate that CAD ...
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Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk
původní článek
open access
vydavatelská verze
2024
,Human Genomics
,18
(February)
Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). ...
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Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance
původní článek
open access
vydavatelská verze
2024
,Blood Cancer Journal
,14
(1)
Genome-wide association studies (GWASs) based on common single nucleotide polymorphisms (SNPs) have identified several loci associated with the risk of monoclonal gammopathy of unknown significance (MGUS), a precursor ...
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Genetic And Environmental Associations Of Nonspecific Chromosomal Aberrations
přehledový článek
omezený přístup
vydavatelská verze
2024
,Mutagenesis
Nonspecific structural chromosomal aberrations (CAs) are found in around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. CAs ...
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The biomolecular markers for the personalized prediction of the treatment effect in patients with head and neck cancer: Pilot study
abstrakt v elektronické podobě
open access
postprint
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
The clinical utility of liquid biopsies as diagnostic, predictive and prognostic biomarkers has been shown for several cancers. Our study analyses the dynamics of human papillomavirus (HPV) cell cell-free DNA (cfDNA) levels ...
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Relationship between yeast virus like elements and poxviruses at the transcriptional level
abstrakt v elektronické podobě
open access
postprint
2024
,Czech Chemical Society Symposium Series
,22
(6)
Yeast cytoplasmic double-stranded DNA virus-like elements (VLEs, also known as linear plasmids) were found in a number of yeast species belonging to nine genera. The Kluyveromyces lactis pGKL1/2 plasmids, which serve as ...
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Parental views on their children’s smartphone use during personal and relational activities
původní článek
open access
vydavatelská verze
2024
,PLoS One
,19
(8)
Given the negative outcomes associated with smartphone use during personal and relational activities (SUPRA), parents strive to regulate its use among their children. However, media parenting recommendations lack knowledge ...
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Positive Effect of a Cooling Cap on Functional Performance in Thermosensitive People with Multiple Sclerosis: A Randomized Controlled Trial
původní článek
open access
vydavatelská verze
2024
,Acta Neurologica Scandinavica
,2024
(April)
Background. Up to 80% of people with MS experience worsening of their condition upon an increase in body temperature. Therefore, various options of cooling are being evaluated to help improve physical performance in people ...
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Adenotonsillar pathology in mucopolysaccharidoses - lysosomal storage predominates in paracortical CD63+ cells
původní článek
open access
vydavatelská verze
2024
,Virchows Archiv
,484
(1)
Despite the adenoids are regularly removed in patients with mucopolysaccharidoses (MPS), the underlying tissue and cellular pathologies remain understudied. We characterized an (immuno)histopathologic and ultrastructural ...
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A Fast HPLC/UV Method for Determination of Ketoprofen in Cellular Media
původní článek
open access
vydavatelská verze
2024
,ChemistryOpen
,13
(3)
A simple, sensitive and quick HPLC method was developed for the determination of ketoprofen in cell culture media (EMEM, DMEM, RPMI). Separation was performed using a gradient on the C18 column with a mobile phase of ...
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LysoGb3 quantification facilitates phenotypic categorization of Fabry disease patients: Insights gained by a novel MS/MS method
původní článek
open access
vydavatelská verze
2024
,Clinica Chimica Acta
,561
(July)
Background: Fabry disease (FD) is an X-linked lysosomal storage disease resulting from pathogenic variants in the GLA gene coding alpha-galactosidase A (AGAL) and cleaving terminal alpha-linked galactose. Globotriaosylceramide ...
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The Czech National MS Registry (ReMuS): Data trends in multiple sclerosis patients whose first disease-modifying therapies were initiated from 2013 to 2021
původní článek
open access
vydavatelská verze
2024
,Biomedical Papers
,168
(3)
AIMS: Multiple sclerosis treatment strategies are changing in the Czech Republic. According to data from 2013-2021, the proportion of patients starting high-efficacy disease-modifying therapies is increasing. In this survey, ...
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Structural and microstructural predictors of cognitive decline in deep brain stimulation of subthalamic nucleus in Parkinson's disease
původní článek
open access
vydavatelská verze
2024
,NeuroImage. Clinical
,42
(May)
BACKGROUND AND OBJECTIVES: The intricate relationship between deep brain stimulation (DBS) in Parkinson's disease (PD) and cognitive impairment has lately garnered substantial attention. The presented study evaluated pre-DBS ...
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Amiodarone but not propafenone impairs bioenergetics and autophagy of human myocardial cells
původní článek
open access
vydavatelská verze
2023
,Toxicology and Applied Pharmacology
,477
(October)
Cardiac and extra-cardiac side effects of common antiarrhythmic agents might be related to drug-induced mitochondrial dysfunction. Supratherapeutic doses of amiodarone have been shown to impair mitochondria in animal ...
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Mitochondrial HER2 stimulates respiration and promotes tumorigenicity
původní článek
open access
vydavatelská verze
2024
,European Journal of Clinical Investigation
,54
(6)
Background: Amplification of HER2, a receptor tyrosine kinase and a breast cancer-linked oncogene, is associated with aggressive disease. HER2 protein is localised mostly at the cell membrane, but a fraction translocates ...
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Correlation of genotype, phenotype and mitochondrial metabolism of patients with Friedreich's ataxia with the aim of implementing innovative therapies
poster
omezený přístup
postprint
2022
Title: Presentation of a cohort of 40 Czech and Slovak patients with Friedreich's ataxia with the aim of introducing innovative therapiesBackground and objectives: Friedreich's ataxia (FA) is an autosomal recessive inherited ...
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Educate, not kill: treating cancer without triggering its defenses
původní článek
open access
vydavatelská verze
2024
,Trends in Molecular Medicine
,30
(7)
Traditionally, anticancer therapies focus on restraining uncontrolled proliferation. However, these cytotoxic therapies expose cancer cells to direct killing, instigating the process of natural selection favoring survival ...
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Suppression of the growth and metastasis of mouse melanoma by Taenia crassiceps and Mesocestoides corti tapeworms
původní článek
open access
vydavatelská verze
2024
,Frontiers in Immunology
,15
(20 March 2024)
Cancer is still one of the leading causes of death, with an estimated 19.3 million new cases every year. Our paper presents the tumor-suppressing effect of Taenia crassiceps and Mesocestoides corti on B16F10 melanoma, the ...
