Educate, not kill: treating cancer without triggering its defenses
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Autor
Bizzarri, Mariano
Datum vydání
2024Publikováno v
Trends in Molecular MedicineRočník / Číslo vydání
30 (7)ISBN / ISSN
ISSN: 1471-4914ISBN / ISSN
eISSN: 1471-499XMetadata
Zobrazit celý záznamTato publikace má vydavatelskou verzi s DOI 10.1016/j.molmed.2024.04.003
Abstrakt
Traditionally, anticancer therapies focus on restraining uncontrolled proliferation. However, these cytotoxic therapies expose cancer cells to direct killing, instigating the process of natural selection favoring survival of resistant cells that become the foundation for tumor progression and therapy failure. Recognizing this phenomenon has prompted the development of alternative therapeutic strategies. Here we propose strategies targeting cancer hallmarks beyond proliferation, aiming at re-educating cancer cells towards a less malignant phenotype. These strategies include controlling cell dormancy, transdifferentiation therapy, normalizing the cancer microenvironment, and using migrastatic therapy. Adaptive resistance to these educative strategies does not confer a direct proliferative advantage to resistant cells, as non-resistant cells are not subject to eradication, thereby delaying or preventing the development of therapy-resistant tumors.
Klíčová slova
anticancer therapies, cytotoxic therapies, resistant cells, tumor progression, therapy failure, migrastatic therapy
Trvalý odkaz
https://hdl.handle.net/20.500.14178/2600Licence
Licence pro užití plného textu výsledku: Creative Commons Uveďte původ-Neužívejte dílo komerčně 4.0 International