1. Faculty of Medicine
Recent Submissions
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Virological characteristics of the SARS-CoV-2 BA.2.86 variant
original article
open access
published version
2024
,Cell Host and Microbe
,32
(2)
In late 2023, several SARS-CoV-2 XBB descendants, notably EG.5.1, were predominant worldwide. However, a distinct SARS-CoV-2 lineage, the BA.2.86 variant, also emerged. BA.2.86 is phylogenetically distinct from other Omicron ...
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Is speech function lateralised in the basal ganglia? Evidence from de novo Parkinson's disease
original article
open access
published version
2024
,Journal of Neurology, Neurosurgery and Psychiatry
,AHEAD OF PRINT
(Published Online First: 17 September)
Background: Research on the possible influence of lateralised basal ganglia dysfunction on speech in Parkinson's disease is scarce. This study aimed to compare speech in de-novo, drug-naive patients with Parkinson's disease ...
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Lipid measures are associated with cognitive functioning in multiple sclerosis patients
original article
open access
published version
2024
,Multiple Sclerosis and Related Disorders
,91
(November)
Background: An association between lipid measures and cognitive decline in patients with multiple sclerosis (MS) has been suggested. Objectives: This study aimed to investigate relationships between lipid profile and ...
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Iron chelators as mitophagy agents: Potential and limitations
summarizing article
open access
published version
2024
,Biomedicine & Pharmacotherapy
,179
(October)
Mitochondrial autophagy (mitophagy) is very important process for the maintenance of cellular homeostasis, functionality and survival. Its dysregulation is associated with high risk and progression numerous serious diseases ...
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Preoperative cognitive profile predictive of cognitive decline after subthalamic deep brain stimulation in Parkinson's disease
original article
open access
published version
2024
,European Journal of Neuroscience
,60
(7)
Cognitive decline represents a severe non-motor symptom of Parkinson's disease (PD) that can significantly reduce the benefits of subthalamic deep brain stimulation (STN DBS). Here, we aimed to describe post-surgery cognitive ...
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Simple 3D spheroid cell culture model for studies of prion infection
original article
open access
published version
2024
,European Journal of Neuroscience
,60
(4)
Mouse neuronal CAD 5 cell line effectively propagates various strains of prions. Previously, we have shown that it can also be differentiated into the cells morphologically resembling neurons. Here, we demonstrate that CAD ...
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Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk
original article
open access
published version
2024
,Human Genomics
,18
(February)
Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). ...
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Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance
original article
open access
published version
2024
,Blood Cancer Journal
,14
(1)
Genome-wide association studies (GWASs) based on common single nucleotide polymorphisms (SNPs) have identified several loci associated with the risk of monoclonal gammopathy of unknown significance (MGUS), a precursor ...
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Genetic And Environmental Associations Of Nonspecific Chromosomal Aberrations
summarizing article
restricted access
published version
2024
,Mutagenesis
Nonspecific structural chromosomal aberrations (CAs) are found in around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. CAs ...
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The biomolecular markers for the personalized prediction of the treatment effect in patients with head and neck cancer: Pilot study
abstract in e-form
open access
accepted version
2024
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,22
(6)
The clinical utility of liquid biopsies as diagnostic, predictive and prognostic biomarkers has been shown for several cancers. Our study analyses the dynamics of human papillomavirus (HPV) cell cell-free DNA (cfDNA) levels ...
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Relationship between yeast virus like elements and poxviruses at the transcriptional level
abstract in e-form
open access
accepted version
2024
,Czech Chemical Society Symposium Series
,22
(6)
Yeast cytoplasmic double-stranded DNA virus-like elements (VLEs, also known as linear plasmids) were found in a number of yeast species belonging to nine genera. The Kluyveromyces lactis pGKL1/2 plasmids, which serve as ...
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Parental views on their children’s smartphone use during personal and relational activities
original article
open access
published version
2024
,PLoS One
,19
(8)
Given the negative outcomes associated with smartphone use during personal and relational activities (SUPRA), parents strive to regulate its use among their children. However, media parenting recommendations lack knowledge ...
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Positive Effect of a Cooling Cap on Functional Performance in Thermosensitive People with Multiple Sclerosis: A Randomized Controlled Trial
original article
open access
published version
2024
,Acta Neurologica Scandinavica
,2024
(April)
Background. Up to 80% of people with MS experience worsening of their condition upon an increase in body temperature. Therefore, various options of cooling are being evaluated to help improve physical performance in people ...
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Adenotonsillar pathology in mucopolysaccharidoses - lysosomal storage predominates in paracortical CD63+ cells
original article
open access
published version
2024
,Virchows Archiv
,484
(1)
Despite the adenoids are regularly removed in patients with mucopolysaccharidoses (MPS), the underlying tissue and cellular pathologies remain understudied. We characterized an (immuno)histopathologic and ultrastructural ...
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A Fast HPLC/UV Method for Determination of Ketoprofen in Cellular Media
original article
open access
published version
2024
,ChemistryOpen
,13
(3)
A simple, sensitive and quick HPLC method was developed for the determination of ketoprofen in cell culture media (EMEM, DMEM, RPMI). Separation was performed using a gradient on the C18 column with a mobile phase of ...
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LysoGb3 quantification facilitates phenotypic categorization of Fabry disease patients: Insights gained by a novel MS/MS method
original article
open access
published version
2024
,Clinica Chimica Acta
,561
(July)
Background: Fabry disease (FD) is an X-linked lysosomal storage disease resulting from pathogenic variants in the GLA gene coding alpha-galactosidase A (AGAL) and cleaving terminal alpha-linked galactose. Globotriaosylceramide ...
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The Czech National MS Registry (ReMuS): Data trends in multiple sclerosis patients whose first disease-modifying therapies were initiated from 2013 to 2021
original article
open access
published version
2024
,Biomedical Papers
,168
(3)
AIMS: Multiple sclerosis treatment strategies are changing in the Czech Republic. According to data from 2013-2021, the proportion of patients starting high-efficacy disease-modifying therapies is increasing. In this survey, ...
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Structural and microstructural predictors of cognitive decline in deep brain stimulation of subthalamic nucleus in Parkinson's disease
original article
open access
published version
2024
,NeuroImage. Clinical
,42
(May)
BACKGROUND AND OBJECTIVES: The intricate relationship between deep brain stimulation (DBS) in Parkinson's disease (PD) and cognitive impairment has lately garnered substantial attention. The presented study evaluated pre-DBS ...
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Amiodarone but not propafenone impairs bioenergetics and autophagy of human myocardial cells
original article
open access
published version
2023
,Toxicology and Applied Pharmacology
,477
(October)
Cardiac and extra-cardiac side effects of common antiarrhythmic agents might be related to drug-induced mitochondrial dysfunction. Supratherapeutic doses of amiodarone have been shown to impair mitochondria in animal ...
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Mitochondrial HER2 stimulates respiration and promotes tumorigenicity
original article
open access
published version
2024
,European Journal of Clinical Investigation
,54
(6)
Background: Amplification of HER2, a receptor tyrosine kinase and a breast cancer-linked oncogene, is associated with aggressive disease. HER2 protein is localised mostly at the cell membrane, but a fraction translocates ...
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