Fakulty: Poslední příspěvky
Zobrazují se záznamy 1-20 z 1665
-
Vaccinia virus mRNAs containing long 5'-poly(A)-leaders lack a canonical 5'-methylguanosine cap
původní článek
open access
vydavatelská verze
2025
,Nature Publishing Group
,Nature Communications
,16
(1)
The vaccinia virus (VACV) is a prototypical poxvirus that was originally used to eradicate smallpox. Half a century ago, investigation into VACV mRNA substantially contributed to the fundamental discovery of the 5' mRNA ...
-
Investigating NFE2L1 Activators for Targeted Protein Aggregate Clearance: A Follow-Up Study
původní článek
open access
vydavatelská verze
2025
,Royal Society of Chemistry
,RSC Medicinal Chemistry
,16
(12)
Disruption of protein homeostasis (proteostasis), whether by acute proteotoxic stress or chronic expression of mutantproteins, can lead to the accumulation of toxic protein aggregates. Such aggregation is a hallmark of ...
-
Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab
původní článek
open access
preprint
2025
,Springer Nature
,Scientific Reports
The role of eosinophils in patients with cancer receiving systemic therapy based on immune checkpoint inhibitors (ICIs) has become a subject of increasing interest. The aim of the present study was to assess the prognostic ...
-
Acute and Short-Term Hemodynamic and Echocardiography Changes During and After Left Atrial Appendage Closure
původní článek
open access
vydavatelská verze
2025
,Hindawi Limited
,Journal of Interventional Cardiology
,2025
(December)
Background: The left atrial appendage (LAA) plays an important role as a reservoir and has endocrine functions. This study aimed to assess the acute hemodynamic effects associated with LAA closure (LAAC) and ensuing ...
-
Second Primary Lung Cancer Associated With Family History of Lung Cancer
původní článek
open access
vydavatelská verze
2025
,Blackwell Publishing
,Cancer Medicine
,14
(23)
BACKGROUND: Familial clustering of initial primary lung cancer (IPLC) may be related to shared smoking habits, other environmental exposures and hereditary factors, but whether familial risk also influences the risk of ...
-
Macrophages in Colorectal Cancer: From Normal Mucosa to Distant Metastasis: Beyond the M1/M2 Paradigm
přehledový článek
open access
vydavatelská verze
2025
,Ivyspring International Publisher
,Journal of Cancer
,17
(1)
Colorectal cancer (CRC) is the third most common malignancy and a leading cause of mortality worldwide. The tumor microenvironment (TME) strongly influences CRC growth, immune evasion, and metastasis. Among various immune ...
-
Novel heat exchanger in extracorporeal circuit: technical and biological feasibility
původní článek
open access
vydavatelská verze
2025
,Springer Nature
,Scientific Reports
,15
(1)
To evaluate a novel anticoagulation strategy in an extracorporeal circuit, we introduce a device that induces local hypothermia as blood flows through the circuit. Using a pig model, we assessed its technical feasibility, ...
-
Familial risks in 317,000 prostate cancer patients in relation to metastases and survival guiding diagnostics
původní článek
open access
preprint
2025
Background: Swedish nationwide family and cancer data offer the largest global resource for study of familial cancer. We focus here on familial risks in prostate cancer (PC) with questions on risk in individuals from ...
-
Resilience českého zdravotnického systému v reakci na příchod válečných uprchlíků z Ukrajiny
The Czech Healthcare System’s Resilience in Response to the Arrival of Ukrainian War Refugees
původní článek
open access
vydavatelská verze
2025
,Sociologický časopis / Czech Sociological Review
,61
(1)
Příchod válečných uprchlíků z Ukrajiny prověřil odolnost českého zdravotnického systému. Koncept odolnosti zdravotnického systému chápeme jako schopnost zdravotnického systému v reakci na externí krizi nadále dobře fungovat ...
-
Circulation of Anaplasma phagocytophilum among invasive and native carnivore species living in sympatry in Poland
původní článek
open access
vydavatelská verze
2023
,BMC
,Parasites & Vectors
,16
(1)
Background Anaplasma phagocytophilum is characterized by a worldwide distribution and distinguished from other Anaplasmataceae by the broadest range of mammalian hosts and high genetic diversity. The role carnivores play ...
-
Intratumoral MHC-I Heterogeneity: Spatiotemporal Insights into the Immune Microenvironment
abstrakt v elektronické podobě
open access
postprint
2025
,ESMO Immuno-Oncology 2025 Abstract Book
The loss of major histocompatibility complex class I (MHC-I) molecules on tumor cells is a critical mechanism of resistance to cancer immunotherapy. However, the role of tumor MHC-I heterogeneity in shaping the immune ...
-
From consensus to domination: inductive theorizing of the mechanisms of mini-publics deliberation on climate change
původní článek
omezený přístup
vydavatelská verze
2025
,Kluwer
,Climatic Change
,178
(48)
Mini-publics, including citizen panels, assemblies, and juries are increasingly being used as a way to build a bridge between elite level politics and ordinary citizens, especially on divisive and complex issues such as ...
-
Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania
původní článek
open access
vydavatelská verze
2023
,SPRINGER
,Parasitology Research
,122
(10)
RNA viruses play an important role in Leishmania biology and virulence. Their presence was documented in three (out of four) Leishmania subgenera. Sauroleishmania of reptiles remained the only underinvestigated group. In ...
-
Radiation-Induced Lymphopoenia and Treatment Outcome in Hereditary Breast Cancer Patients
původní článek
open access
vydavatelská verze
2023
,Folia Biologica
,69
(3)
Many breast cancer (BC) predisposition genes encode proteins involved in DNA damage repair (DDR). Identification of germline pathogenic va-riants (PV) in DDR genes raises the question whether their presence can influence ...
-
Switch of Open-Source Automated Insulin Delivery (AID) System—AndroidAPS to Commercially Available AID Systems in Type 1 Diabetes: The Extension of the CODIAC Study
původní článek
open access
vydavatelská verze
2025
,Mary Ann Liebert, Inc.
,Diabetes Technology & Therapeutics
,27
(11)
Objective: This study was designed to investigate the switch between the open-source automated insulin delivery (OS-AID) system AndroidAPS (AAPS) and commercially available AID systems Control-IQ (CIQ) and MiniMed 780G ...
-
Exploring the Links Between Coaches’ Education, Psychological Training and the Use of Mental Strategies in Swimming
poster
omezený přístup
draft
2025
This study investigated the relationships between coaches' education, psychological training and the use of mental strategies among 54 Czech swimming coaches. Using a modified TOPS 2 questionnaire, no significant differences ...
-
Lysosomal Storage-Independent Fabry Disease Variants with α-Galactosidase A Misprocessing-Induced ER Stress and the Unfolded Protein Response
přehledový článek
open access
vydavatelská verze
2025
,Nephron
,149
(10)
Background: Clinical findings in Fabry disease have classically been attributed to loss-of-function variants in the GLA gene that result in alpha-galactosidase A deficiency, intracellular accumulation of globotriaosylceramides ...
-
Rivaroxaban, in combination with low-dose aspirin, is associated with a reduction in proinflammatory and prothrombotic circulating vesicle signatures in patients with cardiovascular disease
původní článek
open access
vydavatelská verze
2025
,Journal of Thrombosis and Haemostasis
,23
(2)
Background: Despite secondary prevention with aspirin, patients with stable cardiovascular disease (CVD) remain at elevated long-term risk of major adverse cardiovascular events. The Cardiovascular Outcomes in People Using ...
-
Clonal outbreak of an extensively drug-resistant NDM-1 producing Pseudomonas aeruginosa in a local hospital in the Czech Republic
původní článek
open access
vydavatelská verze
2025
,ASM Press
,Microbiology Spectrum
A clonal outbreak of 18 ST773 NDM-1 producing Pseudomonas aeruginosa strains has been detected for the first time in the Czech Republic. The strains were extremely drug-resistant (XDR) and resistant to serum killing. ...
-
Health and care workforce preparedness in response to the influx of Ukrainian refugees: a qualitative study from the Czech Republic
původní článek
open access
vydavatelská verze
2026
,Elsevier
,Health Policy
,163
(January)
Background: Health and care workforces across Europe face overlapping crises that test their resilience and governance capacities. In the Czech Republic, the COVID-19 pandemic was swiftly followed by a major influx of ...
