Fakulty: Poslední příspěvky
Zobrazují se záznamy 1-20 z 1699
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A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus
původní článek
open access
vydavatelská verze
2024
,Public Library of Science
,PLoS Neglected Tropical Diseases
,18
(12)
Leishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous ...
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Studies on the BK Polyomavirus Life Cycle and Virus- Induced Membrane Remodelling in Human Microvascular Endothelial Cells
abstrakt v elektronické podobě
open access
postprint
2025
,ABSTRACT BOOK
BK polyomavirus (BKPyV) is a small, nonenveloped human DNA virus that establisheslifelong, asymptomatic infections. However, it can reactivate underimmunosuppression, leading to severe diseases such as BKPyV-associatednephropathy. ...
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New antimycobacterial sulfonamide-based ureas
jiný příspěvek v konferenčním sborníku
open access
postprint
2025
,Praha
,Programme Book of Abstracts
Certain antimicrobial properties of sulfonamide-type compounds have been described many times.1 We focused our attention on a drug containing the aforementioned sulfonamide group, which originally had no antimicrobial ...
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SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF ACETOPHENONE-HYDRAZONE DERIVATIVES AGAINST RESISTANT MYCOBACTERIA
jiný příspěvek v konferenčním sborníku
open access
vydavatelská verze
2025
,Porto
,BOOK OF ABSTRACTS
According to the WHO, microbial resistance is among the most urgent global threats with serious health and economic consequences. In 2024, rifampicin-resistant Mycobacterium tuberculosis (Mtb), which is currently one of ...
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INVESTIGATION OF SULFONAMIDES AND THEIR ANALOGUES AS ANTIFUNGAL AGENTS
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2025
,Porto
,Book of abstracts
The rising incidence of fungal infections, together with increasing resistance to available antifungal drugs, represents a growing healthcare concern and underscores an urgent need for novel antifungal therapies with ...
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INVESTIGATION OF ISOXAZOLE-1,3,4-OXADIAZOLE HYBRIDS AS ANTIMYCOBACTERIAL AGENTS - A PILOT STUDY
jiný příspěvek v konferenčním sborníku
open access
vydavatelská verze
2025
,Porto
,Book of abstracts
Given the rising number of cases of both latent and drug-resistant tuberculosis, there is an urgent need for thedevelopment of novel, potent compounds capable of combating this global health threat1. In medicinalchemistry, ...
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Modulating Antimicrobial Efficacy Through Hybrid Compounds: Novel Linkers and Scaffold Switching from Isoniazid to 3,5-Dinitrobenzohydrazide
jiný příspěvek v konferenčním sborníku
open access
aktualizovaná vydavatelská verze
2025
,Praha
,Book of abstracts of the 12 th International Conference on Chemical Technology
Tuberculosis and non-tuberculous mycobacterial infections present significant treatment challenges due to rising drug resistance. Building on our previous success with (E)-2-(2-isonicotinoylhydrazineylidene)-N-phenylpropanamides,1 ...
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Nové látky a nové přístupy v terapii herpetických virů
jiný příspěvek v konferenčním sborníku
open access
vydavatelská verze
2025
,Hradec Králové
,SBORNÍK ABSTRAKT XXVII. HRADECKÉ VIROLOGICKÉ DNY Celostátní konference virologů
Infekce způsobené herpetickými viry (HSV-1, HSV-2, VZV, CMV, EBV aj.) stále představujívýznamný zdravotnický problém. Dosavadní terapie je založena zejména na nukleosidových/nukleotidových analozích (acyklovir, ganciklovir ...
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Repurposing sulfonamidů jako antifungálních léčiv aneb Starého psa novým kouskům naučíš
jiný příspěvek v konferenčním sborníku
open access
vydavatelská verze
2025
,Praha
,SBORNÍK ABSTRAKTŮ Konference 19. a 20. listopadu 2025
Narůstající rezistence mikroorganismů představuje závažnou hrozbu pro veřejné zdraví, což vytváří urgentní potřebu nových léčiv. Systémové mykózy jsou však v porovnání s bakteriálními infekcemi stále přehlíženy, ačkoli ...
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Migrastatic therapy as a potential game-changer in adaptive cancer treatment
původní článek
open access
postprint
2026
,Springer Nature
,Scientific Reports
Adaptive therapy, which anticipates and counters the evolution of resistance in cancer cells, has gained significant traction, especially following the success of the Zhang et al.'s protocol in treating metastatic ...
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Validity and reliability of the Czech adaptation of the Sport Motivation Scale-6
poster
omezený přístup
draft
2025
This study examined the factorial validity and reliability of the Czech adaptation of the Sport Motivation Scale-6 (SMS-6) in a sample of 303 competitive athletes. Confirmatory factor analysis supported the six-factor ...
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The role of myotubularin-related lipid phosphatases in cancer pathogenesis
přehledový článek
open access
vydavatelská verze
2026
,Academic Press
,Experimental and Molecular Pathology
,145
(leden 2026)
Myotubularin-related proteins (MTMRs) comprise a family of lipid phosphatases using phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate as their substrate. Several members have a well-established ...
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Adenosine promotes trophoblast proliferation without inducing differentiation or apoptosis
původní článek
open access
vydavatelská verze
2025
,Harcourt
,Placenta
,172
(December)
Objective: Adenosine and other nucleosides are essential regulators of cellular processes, but their specific roles in trophoblast growth and regulation remain incompletely defined. This study investigated the effects of ...
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Structure-Activity Relationships of Novel Pyrimidine Derivatives as potential antimycobacterial Agents
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains the leading cause of death from a single infectious agent, exerting severe health and economic burdens, particularly in Sub-Saharan Africa and South-East ...
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Monitoring the Alternative Pathway of Meropenem Degradation by OXA-48-Type Carbapenemases
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
Background:Overuse of carbapenems has been associated with an increasing prevalence of resistance, particularly among the Enterobacterales, Pseudomonasspp., and Acinetobacter spp. Resistance is mediated by the ...
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Prenatal paroxetine dysregulates monoamine homeostasis and affects placental hemodynamics in the rat fetoplacental unit
původní článek
open access
vydavatelská verze
2025
,Elsevier
,Biomedicine & Pharmacotherapy
,192
(November)
Antidepressant use during pregnancy is increasingly common, with selective serotonin reuptake inhibitors (SSRIs) widely prescribed for maternal depression. However, growing evidence links prenatal SSRI exposure to adverse ...
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Integrating Long-Read Nanopore Sequencing for Precision Resolution of Genomic Variants in Dystonia
původní článek
open access
vydavatelská verze
2025
,John Wiley & Sons
,Movement Disorders
,online AoP
(30 September 2025)
Background: Although many individuals with dystonia present with features indicative of single-gene etiologies, obtaining definitive genetic diagnoses can be challenging. Objective: We assessed the value of nanopore-based ...
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Quality of Life and Its Associates In Narcolepsy 1 and 2 Types and Idiopathic Hypersomnia
původní článek
open access
vydavatelská verze
2025
,Sleep Medicine
,129
(May)
Objective and background: Health-related quality of life (HRQoL) is reduced in narcolepsy type 1 (NT1), but proper information on HRQoL in narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH) is lacking. This study ...
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Atlas-Guided Tractography for Segmentation of Striatal Subregions in Early Parkinson’s Disease
příspěvek v recenzovaném konferenčním sborníku
open access
vydavatelská verze
2025
,EDP Sciences
,Bio Web of Conferences
,195
Parkinson’s disease (PD) and isolated REM sleep behaviour disorder (iRBD) are neurodegenerative conditions associated with alterations in the striatum, a subcortical structure essential for motor and cognitive functions. ...
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Blood and cerebrospinal fluid metallomics uncover mercury, chromium, and iron alterations in de novo Parkinson's disease
původní článek
open access
vydavatelská verze
2025
,IOS Press
,Journal of Parkinson's Disease
,15
(8)
Background: Given the increasing global prevalence of Parkinson's disease (PD) and its complex etiopathogenesis, understanding the role of environmental factors is crucial. Prior investigations suggested a potential link ...
